Evaluating the association of transient receptor potential cation channel subfamily A member 1 gene polymorphisms with pain sensitivity: results from an adaptive recall by genotype... by Aidan P. Nickerson, Laura J. Corbin, Nicholas J. Timpson, Megan Nott, Oliver Blanshard, Katie Foy, Fang Fang Quek, Christopher Geddie, Keith Phillips, Frances M.K. Williams, Anthony E. Pickering, James P. Dunham

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Delivering a national de-adoption programme: a documentary analysis of local commissioning policy compliance with England's Evidence-based Interventions programme (EBI) by Carmel Conefrey, Nicola Farrar, Maeve Coyle, Mike Bell, Jane Blazeby, Christopher Burton, Jenny Donovan, Andy Gibson, Joel Glynn, Tim Jones, Angus McNair, Josie Morley, Amanda Owen-Smith, Ellen Rule, Gail Thornton, Victoria Tucker, Iestyn Williams, William Hollingworth, Leila Rooshenas

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Characteristics of serum bile acid profiles among individuals with metabolic dysfunction-associated steatotic liver disease by Sheng Lyu, Jiani Yang, Xin Xin, Qinmei Sun, Beiyu Cai, Xin Wang, Ziming An, Jian Sun, Yiyang Hu, Lei Shi, Qin Feng, Xiaojun Gou

“…In this multicenter clinical study, we aimed to characterize serum BA profiles in patients with MASLD and identify specific alterations compared to healthy controls. Methods All MASLD cases were sourced from the gastroenterology outpatient departments of Shanghai Baoshan Hospital of Integrated Chinese and Western Medicine, Shanghai Baoshan District Songnan Community Health Service Center, and Lianyungang Oriental Hospital between June 2015 and December 2019. …”
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Defining Nephritic Factors as Diverse Drivers of Systemic Complement Dysregulation in C3 Glomerulopathy by Jill J. Hauer, Yuzhou Zhang, Renee Goodfellow, Amanda Taylor, Nicole C. Meyer, Sarah Roberts, Dingwu Shao, Lauren Fergus, Nicolo Ghiringhelli Borsa, Monica Hall, Carla M. Nester, Richard J.H. Smith

“…However, disease heterogeneity and rarity make accurately defining characteristics of the C3G population difficult. Methods: Here, we present a retrospective analysis of the Molecular Otolaryngology and Renal Research Laboratories C3G cohort. …”
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Re‐Striking the Indications in the Improvement of Avoidable Caesarian Section: A Cluster Randomized Control Trial by Fatema Ashraf, Jobaida Sultana, MSA Mansur Ahmed, Khadija Mannan, Moomtahina Fatima, Mintu Chowdhury, Jinnat Ara Islam, Khandaker Shehneela Tasmin, Adneen Moureen, Md. Abdullah Yusuf, Redoy Ranjan, Md. Nazmul Karim

“…The aim of this study is to identify whether re‐striking the indications of CS can reduce the rate of unnecessary procedures at a system level, whilst preserving maternal and fetal outcomes. Methods This cluster randomized controlled trial recruited 277 Bangladeshi antenatal patients between 2020 and 2021, evaluating them in two groups: 138 individuals in the intervention group and 139 in the control group. …”
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Cathepsin L in Lung Adenocarcinoma: Prognostic Significance and Immunotherapy Response Through a Multi Omics Perspective by Jianming Lu, Jiaqi Liang, Gang Xiao, Zitao He, Guifang Yu, Le Zhang, Chao Cai, Gao Yi, Jianjiang Xie

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Master protocol for a series of cohort-based randomized controlled trials to test tools to communicate research results to study participants and others with relevant lived experie... by Brett D. Thombs, Claire Adams, Elsa-Lynn Nassar, Marie-Eve Carrier, Meira Golberg, Kanika Bharthi, Amanda Wurz, Annabelle South, Linda Kwakkenbos, Sabrina Hoa, Danielle B. Rice, Geneviève Guillot, Amanda Lawrie-Jones, Maureen Sauvé, Susan J. Bartlett, Catherine Fortune, Amy Gietzen, Karen Gottesman, Marie Hudson, Laura K. Hummers, Vanessa L. Malcarne, Maureen D. Mayes, Michelle Richard, James Stempel, Robyn K. Wojeck, Kathleen Blagrave, Jill T. Boruff, Vanessa Cook, Nicole Culos-Reed, Ole Fröbert, Katie Gillies, Vera Granikov, Lars G. Hemkens, Elizabeth Yakes Jimenez, Agnes Kocher, Catarina Leite, Mathew A. W. T. Lim, Nancy Maltez, John Michalski, Tracy Mieszczak, Mwidimi Ndosi, Janet Pope, François Rannou, Ken Rozee, Sharon E. Straus, Matthew R. Sydes, Lehana Thabane, John Varga, Tami Yap, Merrick Zwarenstein, Luc Mouthon, Andrea Benedetti, SPIN Investigators

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AI-driven online adaptive radiotherapy in prostate cancer treatment: considerations on activity time and dosimetric benefits by Francesco Preziosi, Althea Boschetti, Francesco Catucci, Claudio Votta, Luca Vellini, Sebastiano Menna, Flaviovincenzo Quaranta, Elisa Pilloni, Andrea D’Aviero, Michele Aquilano, Carmela Di Dio, Martina Iezzi, Alessia Re, Antonio Piras, Marco Marras, Francesca Gruosso, Domenico Piro, Danila Piccari, Luca Tagliaferri, Maria Antonietta Gambacorta, Luca Indovina, Gian Carlo Mattiucci, Davide Cusumano

“…This study investigates the dosimetric advantage of implementing AI-driven oART in prostate cancer. Methods A total of 31 prostate cancer patients treated with oART on an AI-integrated Linac were analyzed. …”
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Robust Image Population Based Stain Color Normalization: How Many Reference Slides Are Enough? by Jose L. Agraz, Caleb M. Grenko, Andrew A. Chen, Angela N. Viaene, MacLean D. Nasrallah, Sarthak Pati, Tahsin Kurc, Joel Saltz, Michael D. Feldman, Hamed Akbari, Parth Sharma, Russell T. Shinohara, Spyridon Bakas

“…Current state-of-the-art normalization methods employ a single WSI as reference, but selecting a single WSI representative of a complete WSI-cohort is infeasible, inadvertently introducing normalization bias. …”
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Numerical and experimental evaluation of shear strength and consolidation properties of cohesive soils in high water table areas by Nauman Izhar, Muhammad Adeel Khan, Muhammad Salman Khan, Asad Khan, Mahmood Ahmad, Mahmood Ahmad, Mohanad Muayad Sabri Sabri, Muriuzs Necurzac, Abdullah Alzlfawi

“…The numerical results from PLAXIS offered a more accurate understanding of soil behavior compared to the traditional Meyerhof and Vesic methods, highlighting the necessity of integrating advanced numerical techniques with conventional approaches. …”
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MentalAId: an improved DenseNet model to assist scalable psychosis assessment by Muxi Li, Farong Liu, Fei Du, Guolin Hong, Qing Hu, Zhi-Liang Ji, Pan You

“…Regretfully, traditional symptom-based, one-to-one assessment face inherent limitations in large-scale and longitudinal screening, likely delaying early intervention. Methods We developed MentalAId, an improved densely connected convolutional network (DenseNet) model, to assist automated psychosis recognition, leveraging accessible routine laboratory data without requiring additional specialized tests. …”
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Dental biofilm serves as an ecological reservoir of acidogenic pathobionts in head and neck cancer patients with radiotherapy-related caries by Julia S. Bruno, Vitor Heidrich, Felipe C. F. Restini, Tatiana M. M. T. Alves, Wanessa Miranda-Silva, Franciele H. Knebel, Elisangela M. Cóser, Lilian T. Inoue, Paula F. Asprino, Anamaria A. Camargo, Eduardo R. Fregnani

“…However, the etiology of RRC is not fully established, and there are no clinically validated methods for preventing it. To gain a better understanding of the risk factors and the microbiome’s role in causing RRC, we compared clinicopathological characteristics, oncological treatment regimens, oral health condition, and the oral microbiota at three different oral sites of radiotherapy-treated patients with (RRC+) and without radiotherapy-related caries (RRC−). …”
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Characterising developmental dynamics of adult epigenetic clock sitesResearch in context by Rosa H. Mulder, Alexander Neumann, Janine F. Felix, Matthew Suderman, Charlotte A.M. Cecil

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Approach to signal loss in intraoperative nerve monitoring in thyroid surgery questionnaire: a Turkish surgical perspective by Yalin Iscan, Irem Karatas, Nurcihan Aygun, Ahmet Cem Dural, Serkan Teksoz, Ozer Makay, Ali Uğur Emre, Fatih Tunca, Mehmet Uludag, Gökhan İçöz, Yasemin Giles Senyürek, Adnan Işgör, Mehmet Haciyanli

“…PurposeThis study aimed to evaluate surgeons’ use of intraoperative nerve monitoring (IONM) during thyroidectomy and their approach to loss of signal (LOS) in various clinical scenarios.Materials and MethodsA survey was conducted by the Turkish Endocrine Surgery Society on members of the Society in February 2020 and consisted of 16 questions. …”
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Single-cell transcriptomic profiling reveals the heterogeneity of epithelial cells in lung adenocarcinoma lymph node metastasis and develops a prognostic signature by Qiuqiao Mu, Qiuqiao Mu, Qiuqiao Mu, Han Zhang, Ying Shi, Mengli Xue, Jingxian Wang, Yun Ding, Lin Tan, Hui Yuan, Xin Li, Xin Li, Daqiang Sun, Daqiang Sun, Daqiang Sun

“…BackgroundLymph node metastasis markedly worsens prognosis in lung adenocarcinoma (LUAD); however, the evolutionary dynamics and regulatory mechanisms underlying the heterogeneity of malignant epithelial cells during this process remain poorly understood and warrant comprehensive investigation.MethodsWe performed a comprehensive single-cell transcriptomic analysis of epithelial cells from 18 samples comprising normal lung tissue and lymph node metastases. …”
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New insights into Wiskott-Aldrich syndrome: ten novel WAS mutations and their clinical impact in a Brazilian cohort by Lucas W. Santos, Samuel S. Medina, Jéssica O. Frade-Guanaes, Lúcia H. Siqueira, Luiz Gustavo R. de Lima, Luiz Gustavo R. de Lima, Bruna Chati, Bruna Chati, Marcos T. Nolasco da Silva, Marcos T. Nolasco da Silva, Adriana G. L. Riccetto, Adriana G. L. Riccetto, Paula Lyra, Ana Carla A. M. Falcão, Pedro P. A. Santos, Regina S. W. Di Gesu, Bianca Stefanello, Bianca Stefanello, Gabriela G. Yamaguti-Hayakawa, Carmem M. S. Bonfim, Maria M. S. Vilela, Maria M. S. Vilela, Margareth C. Ozelo, Margareth C. Ozelo

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Comparison of Fractional Anisotropy Variances in the Trigeminal Nerve at Root Entry and Cisternal Segment Zones in Patients with and without Clinical Features of Trigeminal Neuralg... by Athota Sai Preethi, Vadana Balamurali Krishna, Velicheti Sandeep, Hanumanthu Manasa Mayukha, Marineni Anveeksha, Kondragunta chandrasekhar

“…Materials and Methods: A cross-sectional study was conducted in the Radiology Department, Dr. …”
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Effects of high dietary threonine supplementation on growth performance, health biomarkers, and intestinal histology in cyclic heat-stressed broilers by Abia Khalid, Sania Bashir, Asma Kalsoom, Hafiz Faseeh Ur Rehman, Muhammad Afzal Rashid, Mansur Abdullah Sandhu, Habib Ur Rehman, Muhammad Shahbaz Yousaf

“…In jejunal histology, acidic goblet cells increased, and intraepithelial lymphocyte infiltration decreased in birds supplemented with 175%–200% threonine, indicating enhanced gut integrity. Meat quality attributes, including crude protein and oxidative stability, showed minor but inconsistent variations across treatments. …”
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Vertical stratification-enabled early monitoring of cotton Verticillium wilt using in-situ leaf spectroscopy via machine learning models by Yi Gao, Yi Gao, Changping Huang, Changping Huang, Xia Zhang, Ze Zhang, Bing Chen

“…Three feature selection methods, Relief-F, Lasso, and Random Forest (RF), were integrated with five machine learning models, including LightGBM, ANN, XGBoost, RF, and SVM. …”
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Development of indicator system for early warning of clinical nursing critical values in general wards: a Delphi study by Weixin Xiong, Fenglan Xie, Qin Li, Ying Chen, Hongmei Yang, Jieli Wu, Jianying Li, Zhihao Chen, Xiaoqin Hu, Lijing Hu

“…There remains a lack of consensus regarding early warning systems for critical nursing values in general wards, along with a shortage of effective and practical quantitative indicators for nursing risk prevention. Methods This study employed an integrative research approach combining literature review, theoretical analysis, and qualitative methodology. …”
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