A novel structural modeling magnitude and orientation radiomic descriptor for evaluating response to neoadjuvant therapy in rectal cancers via MRI by Charlems Alvarez-Jimenez, Jacob T. Antunes, Thomas DeSilvio, Zhouping Wei, Marwa Ismail, Joseph E. Willis, Emily Steinhagen, Andrei Purysko, David Liska, Smitha Krishnamurthi, Marka Crittenden, Michael Gough, Kristina Young, Anant Madabhushi, Eduardo Romero, Pallavi Tiwari, Satish E. Viswanath

“…Combined with traditional radiomic texture features, StODeO showed superior performance in distinguishing pathologic response groups of rectal cancer patients post-chemoradiation (hold-out validation AUC 0.77) as well as segregating composite response groups in a clinical trial of immune checkpoint inhibitors (external validation accuracy 0.71; NCT02688712). The integrated StODeO-texture signature demonstrated robustness across annotation sources and imaging variations, intuitive modeling of therapy-associated structural changes, and statistical associations with tumor-immune biology, including macrophages and CD8+ T-cells from multiplexed biopsy analysis. …”
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Global, Regional, and National Burden of Breast Cancer, 1990–2021, and Projections to 2050: A Systematic Analysis of the Global Burden of Disease Study 2021 by Tong Deng, Hao Zi, Xing‐Pei Guo, Li‐Sha Luo, Ya‐Long Yang, Jin‐Xuan Hou, Rui Zhou, Qian‐Qian Yuan, Qing Liu, Qiao Huang, Gao‐Song Wu

“…ABSTRACT Background This study analyzes the global burden of breast cancer (BC) over the past 30 years, identifies key risk factors, and projects future incidence and mortality through 2050. Methods Data were sourced from the 2021 Global Burden of Disease (GBD) database. …”
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Hypertension and Atrial Fibrillation: Bridging the Gap Between Mechanisms, Risk, and Therapy by Ibrahim Antoun, Georgia R. Layton, Ali Nizam, Joseph Barker, Ahmed Abdelrazik, Mahmoud Eldesouky, Abdulmalik Koya, Edward Y. M. Lau, Mustafa Zakkar, Riyaz Somani, Ghulam André Ng

“…Hypertension, a primary modifiable cardiovascular risk factor, is a well-established risk factor for AF that facilitates structural and electrical changes in the atria, including dilation, fibrosis, and pressure overload. <i>Material and Methods:</i> we conducted a literature search regarding the shared mechanisms, risks and treatments of hypertension and atrial fibrillation. …”
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Leveraging Promotional Strategies to Enhance Hospital Influence on Social Media: Cross-Sectional Study by Xinyun Zhong, Yiyuan Ma, Haiyue Yu

“…MethodsData were collected from 721 officially verified hospital Weibo accounts and integrated with multidimensional hospital characteristics from the DXY National Hospital Database. …”
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Short- and long-term weekly patient-reported outcomes prediction undergoing radiotherapy: single-patient time series model vs. transformer-based multi-patient time series model by Yang Yan, Zhong Chen, Xinglei Shen, Ronald C. Chen, Hao Gao

“…Results Key experimental results on prostate cancer patients demonstrate that (1) VAR-Inc demonstrated superior performance (lower MAE/RMSE) over VAR, highlighting the importance of incremental PRO updates. (2) TFT significantly outperformed both VAR models in long-term prediction, with statistical significance, by utilizing multi-patient data. (3) TFT effectively captured weekly PRO trends and variations, aligning closely with ground truth. (4) Unlike single-patient models, TFT built robust predictive frameworks by integrating cross-patient similarities and complementary patients’ PRO information. …”
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Comparative efficacy of teriparatide and bisphosphonates or denosumab vs. teriparatide monotherapy in osteoporosis: a meta-analysis by Huan Jin, Huan Jin, Cai Huang, Yan Zhang, Ying Dong, Qi Xiong, Di Wang, Di Wang, Ziyi He, Ziyi He, Lin Shen, Chen Ma, Zixian Wang, Bo Shuai

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Investigating causal effects of income on health using two-sample Mendelian randomisation by Erik Igelström, Marcus R. Munafò, Ben M. Brumpton, Neil M. Davies, George Davey Smith, Pekka Martikainen, Desmond Campbell, Peter Craig, Jim Lewsey, S. Vittal Katikireddi

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Precision diagnosis of tomato diseases for sustainable agriculture through deep learning approach with hybrid data augmentation by Kamaldeep Joshi, Sahil Hooda, Archana Sharma, Humira Sonah, Rupesh Deshmukh, Narendra Tuteja, Sarvajeet Singh Gill, Ritu Gill

“…Traditional disease identification methods are slow and require expertise, limiting their practicality in large-scale farming. …”
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Evaluating temporal changes in water quality due to urbanization: a multi-year observational study in Khalid Khor, Sharjah, UAE by Norhan Ahmed, Areej Mohammad, Sandra L. Knuteson, Sandra L. Knuteson, Fatin Samara, Fatin Samara, Fatin Samara

“…This study investigates the long-term temporal variations in key water quality parameters in Khalid Khor, Sharjah, UAE, from 2007 to 2023, to assess the influence of urban development on the aquatic environment.MethodsWater quality indicators including pH, dissolved oxygen (DO), total dissolved solids (TDS), electrical conductivity, temperature, and coliform concentrations were analyzed. …”
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A network meta-analysis of mind–body exercise interventions for internet addiction symptoms in young adults by Shiguan Jia, Zhihao Du, Dengshan Chu, Jiayi Yao, Haozhe Wang, Wenjia Chen, Dazhong Zhang, Xin Zang

“…Though these interventions show promise, their therapeutic efficacy exhibits considerable variation across different modalities. Currently, there exists a significant research gap, as no comprehensive clinical investigations have systematically evaluated the comparative therapeutic outcomes of distinct mind–body practices among individuals diagnosed with internet addiction.ObjectiveTo conduct a network meta-analytic investigation comparing the therapeutic efficacy of diverse mind–body exercise interventions for addressing symptoms associated with internet addiction disorder.MethodsData were retrieved from Web of Science, PubMed, CNKI, and VIP databases. …”
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Breast cancer scoring based on a multiplexed profiling of soluble and cell-associated (immune) markers facilitates the prediction of pembrolizumab therapy by Verena Schweihofer, Christina Bruss, Stephan Seitz, Gunther Glehr, Madeleine Hetterich, Florian Weber, Maria Hatzipanagiotou, Miriam Fernández-Pacheco Álvarez, Olaf Ortmann, Gero Brockhoff, Richard J. Bauer, Anja Kathrin Wege

“…Abstract Background The immune checkpoint targeting is nowadays an integral part of cancer therapies. However, only a minority of patients experience long-term benefits. …”
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Predicting relative efficacy of anthracyclines and taxanes in breast cancer neoadjuvant AC-T chemotherapy using longitudinal MRI radiomic model by Kaiwen Liu, Ran Zheng, Jiulou Zhang, Siqi Wang, Yingying Jin, Feiyun Wu, Jue Wang, Shouju Wang, Xiaoming Zha, Yuxia Tang

“…Therefore, this study aimed to evaluate the feasibility of developing magnetic resonance imaging (MRI) radiomic models for predicting the relative efficacy of AC versus T treatments.MethodsThis retrospective study included 190 breast cancer patients, who were randomly allocated into a training set (n=133) and a test set (n=57). …”
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A Comparative Analysis of Genetic and Epigenetic Factors in METH Addiction: A Focus on SLC (SLC6A4) and COMT Genes by Haider K. Hussain, Yolanda Loarce Tejada, Anna Barbaro

“…Thus, understanding the molecular mechanisms involved is crucial for developing targeted prevention and treatment strategies. Methods: A systematic literature review was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. …”
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Community readiness and acceptance for the implementation of the malaria vaccine among caretakers of at-risk children in sub-Saharan Africa: a systematic review and meta-analysis by Eustes Kigongo, Sean Steven Puleh, Amir Kabunga, Stella Immaculate Akech, Francis Ocen, Marc Sam Opollo, Moses Ebong

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Clinical features and hematological and biochemical blood parameters of dogs with hepatobiliary disorders by Nguyen Vu Thuy Hong Loan, Nguyen Van Chao, Tran Thi Nhung

“…This study aimed to characterize the clinical manifestations and hematobiochemical profiles of dogs diagnosed with hepatobiliary disorders in Ho Chi Minh City, Vietnam. Materials and Methods: Eighty client-owned dogs diagnosed with hepatobiliary disorders through histopathological confirmation were retrospectively evaluated. …”
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MSFA-YOLO: A Multi-Scale SAR Ship Detection Algorithm Based on Fused Attention by Zhao Liangjun, Ning Feng, Xi Yubin, Liang Gang, He Zhongliang, Zhang Yuanyang

“…Leveraging the excellent feature representation capabilities of neural networks, deep learning methods have been widely adopted for object detection in synthetic aperture radar (SAR) images. …”
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Spatial, temporal and demographic distribution characteristics of adenomyosis symptom clusters from the perspective of traditional Chinese medicine: a multicenter cross-sectional s... by Xin Wang, Yu Tao, YuDan Fu, XinChun Yang, RuiHua Zhao

“…ObjectiveThis study aimed to explore the differences in symptom clusters of adenomyosis (AM) patients across spatial, temporal, and age-stratified dimensions based on the theory of “Treatment in Accordance with Three Categories of Etiologic Factors”.MethodsA cross-sectional study was conducted in China from 2020 to 2022, involving 1,816 AM patients. …”
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Differential gene expression in patients with anal fistula reveals high levels of prolactin recepetor by Song Yi-Huan, Qiu Jian-Ming, Yang Guan-Gen, Wang Dong, Lin A-Li, Xu Kan

“…The aim of the present study was to examine prolactin receptors (PRLR) as inflammatory markers and to correlate their expression with both the complexity of anal fistulas and the likelihood of fistula recurrence. Methods. Microarray was used to screen the differentially expressed gene profile of anal fistula using anal mucosa samples with hemorrhoids with ageand sex-matched patients as controls and then a prospective analysis of 65 patients was conducted with anal fistulas. …”
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Systematic review on the cost of seasonal malaria chemoprevention (SMC) by Anika Ruisch, Miranda Iodice, Ishani Mathur, Sara Harris, Damian G. Walker, Richmond Owusu, Justice Nonvignon, Colin Gilmartin

“…This systematic literature review aims to assess the evidence on the cost and cost-effectiveness of SMC delivery. Methods Following PRISMA guidelines, five databases were systematically reviewed to identify evidence on SMC costs and cost-effectiveness published between 2012 and 2023. …”
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Major medical events in patients with acute coronary syndrome during helicopter emergency medical service operations by Julian Ganter, Hans-Jörg Busch, Alina Henis, Florian Reifferscheid, Jörg Braun, Sebastian Heinrich

“…The objective of this study is to evaluate the incidence of medical events and to assess risk stratification using scoring systems. Methods This retrospective observational cohort study analyzed prehospital records from 38,473 HEMS operations with “ACS” coding conducted between 2012 and 2024 in Germany. …”
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