Precision computerised cognitive behavioural therapy (cCBT) intervention for adolescents with depression (SPARX-UK): protocol for the process evaluation of a pilot randomised contr... by Charlotte Lucy Hall, Chris Hollis, Kareem Khan, Peter Fonagy, Kirsty Sprange, Cathy Creswell, Yi Yang, Vibhore Prasad, Kapil Sayal, Nitish Jawahar, Ellen Townsend, Dorothee Auer, Praveetha Patalay, Aja Murray, Yvonne Kelly, Boliang Guo, Christopher R Tench, Paul Stallard, Louise Arseneault, Sieun Lee, Sally Merry, Charlotte Hall, Jo Gregory, Rory O’Connor, Emma Nielsen, Edmund Sonuga-Barke, Hannah Wright, Petr Slovak, Emily Lloyd, Josimar De Alcantara Mendes, Carolyn Ten Holter, Marina Jirotka, Aaron Kandola, Sonia Livingstone, Kasia Kostryka-Allchorne, Jake Bourgaize, Mariya Stoilova, Marianne Etherson, Chris Greenhalgh, Jim Warren, Vajisha Wanniarachchi, Kevin Glover, Mathijs Lucassen, Karolina Stasiak, Camilla Babbage, Adam Parker, Joanna Lockwood, Elvira Perez Vallejos, Rebecca Woodcock, Sarah Doherty, Lucy-Paige Willingham, Camilla May Babbage, Matthew Jeffery, Peiyao Tang, Holly Griffiths, Lily Roberts, A. Jess Williams, Lucy Hitcham

“…This protocol paper describes the rationale, aims and methodology of the SPARX-UK trial process evaluation.Methods and analysis The process evaluation will use a mixed-methods design following the UK Medical Research Council’s 2015 guidelines, comprising quantitative and qualitative data collection. …”
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Comparative analysis of the multi-element and pharmacological composition of Gastrodia elata blume from different geographic origins by Yujie Shang, Shunqiang Yang, Qinxiang Chang, Kaize Shen, Shaoning Chen, Zongsuo Liang

“…Multivariate statistical methods, including cluster heatmap, principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA), were employed to assess compositional differences and identify potential biomarkers. …”
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Genetic and codon usage analyses reveal the evolution of the seoul virus by Yamei Wei, Yamei Wei, Yanan Cai, Yanan Cai, Xu Han, Zhanying Han, Yanbo Zhang, Yonggang Xu, Caixiao Jiang, Qi Li, Qi Li

“…However, its molecular evolutionary dynamics and codon usage patterns remain poorly understood.MethodsThis study integrated coding sequences from GenBank and previously acquired SEOV strains to systematically analyze genetic evolution and codon usage bias.ResultsIt revealed that SEOV evolved seven clades (A-G) with distinct amino acid variation sites and geographic clustering. …”
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Normal range of motion at the hip show different pressure behavior in the lateral and acetabular compartments: a cadaveric investigation by Marc‐Olivier St‐Pierre, Félix‐Antoine Lavoie, Marion Hoffmann, Mickaël Begon, Antony Bertrand‐Grenier, Stéphane Sobczak

“…The movements assessed are used in clinical practice to evaluate hip integrity and might bring pain. The pressure variations throughout the entire range of motion are a relevant information during hip clinical assessment and might help clinicians to better understand the manifestations of pain.…”
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Purine Nucleoside Phosphorylase (PNP) as a Biomarker and Therapeutic Target in Muscle-Invasive Bladder Cancer by Yanfei Chen, Peiyi Xian, Jianming Lu, Le Zhang, Chao Cai, Weide Zhong

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A study on the impact of neoadjuvant therapy on molecular subtype conversion in breast cancer by Run-Ze Zhang, Dong Liu, Yuan Ke, Wen-Qi Cai, Lin-Hui Zheng, Chao-Yan Wu, Hai-Jun Yu

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Infertility trends in China: analyzing temporal changes, public demand, and demographic differences based on Baidu index by Xun Li, Mengmeng Wei, Jingrui Zou, Jin Wei, Xin Lai, Xun Gong, Hong Hu, Xuanxuan Wang

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Oceanographic and trophodynamic underpinnings of anchovy success in the northern California Current by Kelsey Swieca, Kelsey Swieca, Su Sponaugle, Su Sponaugle, Moritz S. Schmid, Jami Ivory, Robert K. Cowen

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Regional insights into the relationship between metabolic associated steatotic liver disease and chronic kidney disease: a socioeconomic perspective on disease correlation by Jiang Bai, Lijuan Zhang, Mingyan Zhang, Yifan Hao, Zhen Yi, Yun Zhou

“…Methods This analysis integrates MASLD and country-level CKD data from the Global Burden of Disease study 2021. …”
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NeuroFuzzXAI: A Hybrid Artificial Intelligence Framework for Epileptic Seizure Detection by Flavia COSTI, Emanuel COVACI, Ovidiu ROMAN, Darian ONCHIS

“…The objective is to enhance transparency in decision-making by identifying key EEG features and providing an interpretable risk assessment. Materials and Methods: This study utilizes the publicly available Epileptic Seizure Recognition dataset [i], which consists of EEG recordings from 500 subjects, segmented into 11,500 one-second windows, each described by 178 features. …”
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Hyperspectral Imaging for Non-Destructive Moisture Prediction in Oat Seeds by Peng Zhang, Jiangping Liu

“…To further refine the predictive model, three feature selection methods—successive projections algorithm (SPA), competitive adaptive reweighted sampling (CARS), and principal component analysis (PCA)—were assessed. …”
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Hazard Assessment of Extreme Compound Flood Hazards in Coastal Cities under Climate Change: A Case Study of Haikou City by Liu Qing, Wu Guofeng, Yao Qian, Xu Hanqing, Niu Yiying, Wei Xuchen, Wang Jun, Li Mengya

“…Although numerous studies have focused on individual flood drivers, integrated analyses of the spatiotemporal variations and compound effects remain limited. …”
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Single-cell and spatial transcriptomic analysis reveals tumor cell heterogeneity and underlying molecular program in colorectal cancer by Teng Wang, Zhaoming Chen, Wang Wang, Wang Wang, Heng Wang, Shenglong Li

“…However, this heterogeneity offers opportunities for personalized therapy.MethodsThe consensus non-negative matrix factorization algorithm was employed to analyze single-cell transcriptomic data from CRC, which helped identify malignant cell expression programs (MCEPs). …”
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Agenda-setting Policy Analysis on Iranian Physical Activity Promotion Policies: An application of Kingdon’s Multiple Streams Framework by Behrouz Fathi, Rahim Khodayari-Zarnaq, Sara Pourazavi, Haidar Nadrian, Ahmad Kousha

“…This study was conducted to analyze the process of change in the adoption of policies which aim at promoting PA in setting the policy agenda.Methods: This qualitative study was conducted using document reviews and semi-structured interviews. …”
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A preliminary attempt to harmonize using physics-constrained deep neural networks for multisite and multiscanner MRI datasets (PhyCHarm) by Gawon Lee, Dong Hye Ye, Se-Hong Oh

“…The proposed physics constraints could be integrated with unsupervised methods, paving the way for more sophisticated harmonization qualities.…”
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Diversity and Distribution Patterns of Amphibians in the Huangshan Mountain Region: The Roles of Climate and Human Activities by Fei Hong, Dapeng Pang, Xiaojia Lin, Weixin Huang, Jie Fang, Wenbo Li

“…In this study, we applied field survey methods, the MaxEnt model, and integrated climate and human activity data to predict potential changes in the diversity and distribution of amphibian species in Huangshan Mountain, China. …”
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Nutrigenomics and personalized diets - Tailoring nutrition for optimal health by Divya Chaudhary, Diksha Guleria, Himanshi Aggarwal, Vaibhav Mishra, Abhishek Chauhan, Laurent Dufossé, Naveen Chandra Joshi

“…In addition, systems biology tools like proteomics, transcriptomics, and metabolomics work alongside statistical methods to analyse genetic variation and gut microflora differences that influence metabolic health through food bioactives. …”
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Identification, Geographical Traceability, and Thermal Oxidation and Photodegradation Studies of Camellia Oil Based on Raman Spectroscopy by Boxue Chang, Jingyue Huang, Qingli Xie, Yinlan Ruan, Rukuan Liu

“…However, its high market value and regional variations have led to frequent adulteration, highlighting the need for rapid, non-destructive methods for authentication, geographical traceability, and quality assessment. …”
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Identification of multicohort-based predictive signature for NMIBC recurrence reveals SDCBP as a novel oncogene in bladder cancer by Chen Zhang, Hubin Yin, Tinghao Li, Junrui Chen, Weiyang He, Ke Ren, Bo Li, Xudong Liu

“…Traditional clinical characteristics alone are inadequate for accurately assessing the risk of NMIBC recurrence, necessitating the development of novel predictive tools.Methods We analyzed microarray data of NMIBC samples obtained from the ArrayExpress and GEO databases. …”
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Three-dimensional visualization and navigation for micro-noninvasive uterine fibroid surgery based on MRI and ultrasound image fusion by Ting Wang, Yingang Wen, Zhibiao Wang, Zhibiao Wang, Xi Li

“…ObjectiveTo address the challenges of low surgical precision and poor consistency in focused ultrasound ablation surgery (FUAS) for uterine fibroids, which are often caused by variations in clinical experience and operator fatigue, this study aims to develop an intelligent three-dimensional (3D) visualization and navigation system by integrating magnetic resonance imaging (MRI) with real-time ultrasound (US) imaging, thereby improving the accuracy and efficiency of uterine fibroid surgery.MethodsMRI and US images from 638 patients were annotated by experienced clinicians. …”
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