Novel variant alters splicing of TGFB2 in family with features of Loeys-Dietz syndrome by Emily R. Gordon, Stephanie A. Felker, Stephanie A. Felker, Tanner F. Coleman, Tanner F. Coleman, Nadiya Sosonkina, Jada Pugh, Jada Pugh, Meagan E. Cochran, Meagan E. Cochran, Anna C. E. Hurst, Sara J. Cooper

“…Significant clinical variability has been noted for both related and unrelated individuals with the same pathogenic variant. …”
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Optimized Dual-Battery System with Intelligent Auto-Switching for Reliable Soil Nutrient Monitoring in Remote IoT Applications by Doan Perdana, Pascal Lorenz, Bagus Aditya

“…Implementing the DLB–PAO algorithm elevates the average reliability to 91.7% over 120 h, whereas the DLB–GA algorithm achieves near-perfect reliability (99.9%) for over 170 h, exhibiting minimal variability (standard deviation: 0.9%). The integration of intelligent auto-switching mechanisms and metaheuristic optimisation algorithms demonstrates a marked enhancement in both reliability and energy efficiency for soil nutrient monitoring systems. …”
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Expanding a Health Technology Solution to Address Therapist Challenges in Implementing Homework With Adult Clients: Mixed Methods Study by Brian E Bunnell, Kaitlyn R Schuler, Julia Ivanova, Lea Flynn, Janelle F Barrera, Jasmine Niazi, Dylan Turner, Brandon M Welch

“… BackgroundHomework is implemented with variable effectiveness in real-world therapy settings, indicating a need for innovative solutions to homework challenges. …”
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The Model of Fundamental Chemical Training of Bachelors of Technical and Technological Directions in the Conditions of Blended Learning by N. M. Vostrikova

“…The concept and the structural-functional model of the fundamental chemical training of bachelors in the information-and-activity-based educational environment of blended learning have been proposed. …”
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Impact of IgG subclass on monoclonal antibody developability by Paul Cain, Lihua Huang, Yu Tang, Victor Anguiano, Yiqing Feng

“…We thus conducted a systematic study of 12 mAbs derived from three sets of unrelated variable regions, each cloned into IgG1, an IgG1 variant with diminished effector functions, IgG2, and a stabilized IgG4 variant with further reduced FcγR interaction, to evaluate the impact of IgG subclass on manufacturability and high concentration stability in a common formulation buffer matrix. …”
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Development and Validation of Quantile Regression Forests for Prediction of Reference Quantiles in Handgrip and Chair‐Stand Test by Giulia Giordano, Luca Mastrantoni, Francesco Landi, The Lookup 8+ Study Group

“…The predictive outputs of these models may serve as surrogate biomarkers of the aging process, capturing functional decline.…”
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Deletion of genes linked to the C1-fixing gene cluster affects growth, by-products, and proteome of Clostridium autoethanogenum by Ugochi Jennifer Nwaokorie, Kristina Reinmets, Lorena Azevedo de Lima, Pratik Rajendra Pawar, Kurshedaktar Majibullah Shaikh, Audrey Harris, Michael Köpke, Kaspar Valgepea

“…However, our understanding of the functionalities of the genes involved in the C1-fixing gene cluster and its closely-linked genes is incomplete. …”
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Optimal control for high-precision repeat ground-track orbits via convex optimization by Yanchao HE, Lei ZHANG, Yijun YANG, Qian CHEN

“…The results show that the design approach enables the realization of high-precision RGT orbit designs and that the orbit control strategy is efficient.…”
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Bayesian inference for peak feature extraction and prediction of material property in X-ray diffraction data by Ryo Murakami, Taisuke T. Sasaki, Hideki Yoshikawa, Yoshitaka Matsushita, Keitaro Sodeyama, Tadakatsu Ohkubo, Hiroshi Shinotsuka, Kenji Nagata

“…We challenge peak feature extraction in the situation where only the peak function profile is known a priori, without knowledge of the measurement material or crystal structure factor. …”
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MCL-SWT: Mirror Contrastive Learning with Sliding Window Transformer for Subject-Independent EEG Recognition by Qi Mao, Hongke Zhu, Wenyao Yan, Yu Zhao, Xinhong Hei, Jing Luo

“…Inspired by left/right hand motor imagery inducing event-related desynchronization (ERD) in the contralateral sensorimotor cortex, we develop a mirror contrastive loss function. It segregates feature spaces of EEG signals from contralateral ERD locations while curtailing variability in signals sharing similar ERD locations. …”
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Fast 3D localization of nano-objects in wide-field interferometric scattering microscopy via vectorial diffraction model-derived analytical fitting by Liaoliao Wei, Caroline Livan Anyi, Huakun Li, Haitao Nie, Bihan Wen, Tong Ling

“…The simplified analytic function includes a quadratically scaling amplitude term and a linearly scaling phase term, both of which change with the nano-object’s axial position. …”
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SSR loci potentially associated with high amylopectine content in maize kernel endosperm by S. I. Vakula, O. A. Orlovskaya, L. V. Khotyleva, A. V. Kilchevsky

“…As a component of functional nutrition, maize cultivars with “non-traditional” kernel composition (waxy, oilbearing, sugar, opaque, etc. phenotypic variants) are promising. …”
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Identification and leveling of factors affecting the acceptance of excellence model in Islamic Azad University by Seyedeh Somayeh Mousavi Siah Deleh, Samad Jabbari Asl, Musa Rezvani Chaman Zamin

“…The concept of institutional excellence in higher education institutions as mentioned by Kok & McDonald (2017) refers to behavior that leads to excellence in all research, teaching and social service functions through excellence in strategy and shared values, leadership, Organizational culture. …”
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Characterization and treatment monitoring of ureagenesis disorders using stable isotopes by Gabriella Allegri, Martin Poms, Nadia Zürcher, Véronique Rüfenacht, Nicole Rimann, Déborah Mathis, Beat Thöny, Matthias Gautschi, Ralf A. Husain, Daniela Karall, Karolina Orchel-Szastak, Francesco Porta, Dominique Roland, Barbara Siri, Carlo Dionisi-Vici, René Santer, Johannes Häberle

“…Thus, the method proved to be safe and efficient to monitor UCD patients of variable severity pre- and post-therapy, being suitable as physiological endpoint for development of therapies.…”
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An Hfq-dependent post-transcriptional mechanism fine tunes RecB expression in Escherichia coli by Irina Kalita, Ira Alexandra Iosub, Lorna McLaren, Louise Goossens, Sander Granneman, Meriem El Karoui

“…This fine-tuning Hfq-mediated mechanism might have the underlying physiological function of maintaining RecB protein levels within an optimal range.…”
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Systematic Evaluation of Isolation Techniques and Freeze‐Thaw Effects on Plasma Extracellular Vesicle Heterogeneity and Subpopulation Profiling by Xueqi Li, Xiangyu Li, Lingjun Tong, Liqiao Hu, Yanfen Hong, Ruoyu Zhou, Zonghong Li, Ming Dong, Junjie Hou, Tao Xu, Wen Zhong

“…However, standardizing blood‐derived EV isolation remains challenging due to the heterogeneity of EV populations and variability among isolation techniques. In this study, we systematically evaluated three distinct EV isolation methods, including asymmetrical flow field‐flow fractionation (AF4), size‐exclusion chromatography (SEC) and automated centrifugal microfluidic disc system combined with functionalized membranes (Exo‐CMDS), to compare their efficiency in isolating EVs from both freshly frozen and freeze‐thawed plasma samples. …”
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Structural network topologies are associated with deep brain stimulation outcomes in Meige syndrome by Bin Liu, Zhiqi Mao, Xinyuan Yan, Hang Yang, Junpeng Xu, Zhebin Feng, Yanyang Zhang, Xinguang Yu

“…However, the DBS efficacy varies across MS patients and the factors contributing to the variable responses remain enigmatic. We aim to explain the difference in DBS efficacy from a network perspective. …”
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Investigating the influence of soil organic carbon on pore structure within aggregates by Jingjing Liu, Yu Tian, Chiara Pasut, Mark Farrell, Shenggao Lu

“…The results revealed that the hydrogen peroxide treatment variably reduced organic carbon in soil aggregates, with Cambisol samples showing a higher removal efficiency (38.58–63.31%) compared to Ultisol samples (27.33–45.74%). …”
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FVPNet: A Fuzzy Visual Positioning Perception Network for Small Object Segmentation in Remote Sensing Images by Yu Yan, Jindong Xu, Qianpeng Chong, Guangyi Wei, Zhixiang Wang

“…Furthermore, grayscale variability intensifies boundary uncertainty, complicating accurate segmentation. …”
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Optimizing Load Frequency Control of Multi-Area Power Renewable and Thermal Systems Using Advanced Proportional–Integral–Derivative Controllers and Catch Fish Algorithm by Saleh A. Alnefaie, Abdulaziz Alkuhayli, Abdullah M. Al-Shaalan

“…Renewable energy sources (RESs) are increasingly combined into the power system due to market liberalization and environmental and economic benefits, but their weather-dependent variability causes power production and demand mismatches, leading to issues like frequency and regional power transmission fluctuations. …”
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