Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition by Mie K. Jakobsen, Sofie Traynor, Aaraby Y. Nielsen, Christina Dahl, Mette Staehr, Simon T. Jakobsen, Maria S. Madsen, Rasmus Siersbaek, Mikkel G. Terp, Josefine B. Jensen, Christina B. Pedersen, Anup Shrestha, Jonathan R. Brewer, Pascal H. G. Duijf, Odd L. Gammelgaard, Henrik J. Ditzel, Alexei F. Kirkin, Per Guldberg, Morten F. Gjerstorff

“…Results We show that breast cancer tumors and cell cultures exhibit a highly heterogenous response to DNA methyltransferase inhibitors, persisting even under high drug concentrations and efficient DNA methyltransferase depletion. The observed variability in response to DNA methyltransferase inhibitors was independent of cancer-associated aberrations and clonal genetic diversity. …”
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Adaptability to Teleworking in European Countries by Aniela Bălăcescu, Aurelia Pătrașcu, Loredana Maria Păunescu

“…The limits of the research are related to the involvement of only six variables, the analysis can be extended in future research to other variables as well.…”
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Cost-effective model of building construction based on GREENSHIP rating assessment using value engineering and lifecycle cost analysis methods by Sutikno Sutikno, Sarwono Hardjomuljadi, Henny Wiyanto

“…Abstract Regulation No. 21 of 2021, issued by the Minister of Public Works and Public Housing, mandates green building performance assessments for Building Approval (PBG) and Certificate of Functional Worthiness (SLF). However, many stakeholders perceive green building investments as costly. …”
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Classification of medical imaging technologies: results from Türkiye by Hakan Temiz, Tuncay Kara

“…It also suggests that regional utilization patterns may align more with functional similarities than with geographic proximity. …”
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On a Solution of a Third Kind Mixed Integro-Differential Equation with Singular Kernel Using Orthogonal Polynomial Method by Ahmad Alalyani, M. A. Abdou, M. Basseem

“…While when using the separation method, we are able to obtain FIE with time coefficients, and these functions are described as an integral operator in time. …”
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Factors Influencing Telemedicine Adoption Among Health Care Professionals: Qualitative Interview Study by Fiona Schürmann, Daniel Westmattelmann, Gerhard Schewe

“…Perceived benefits encompassed convenience through reduced travel time (5/14, 36%), improved care quality due to higher accessibility (8/14, 57%), and operational efficiency (7/14, 50%). Trust referents played a pivotal role; trust in technology was linked to functionality (6/14, 43%) and reliability (5/14, 36%), while trust in treatment depended on effective collaboration (9/14, 64%). …”
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Grid-connected PV inverter system control optimization using Grey Wolf optimized PID controller by Monika Gupta, P. M. Tiwari, R. K. Viral, Ashish Shrivastava, Basem Abu Zneid, Iryna Hunko

“…Conventional controllers such as P and PI are widely used in PV applications due to their simplicity, but they exhibit notable limitations in dynamic environments, including increased Total Harmonic Distortion (THD), slower transient response, and poor voltage regulation—particularly under variable irradiance conditions. The proposed GWO-PID method overcomes these limitations by leveraging the GWO algorithm’s global search capability to dynamically optimize the PID gains (Kp, Ki, Kd) based on a composite fitness function that minimizes Mean Squared Error (MSE) and THD. …”
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Impacts of early postpartum behavioral patterns on the fertility and milk production of tropical dairy cows by Aqeel Raza, Kumail Abbas, Theerawat Swangchan-Uthai, Henk Hogeveen, Chaidate Inchaisri

“…Reproductive performance was analyzed using Cox proportional hazard models, while lactation dynamics were modeled using the Wood function to estimate peak yield, peak time, and persistency. …”
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Finding the optimal probe state for multiparameter quantum metrology using conic programming by Masahito Hayashi, Yingkai Ouyang

“…The algorithm involves a conic program, which minimizes a linear objective function subject to conic constraints on a operator-valued variable. …”
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Rapid global fitting of large fluorescence lifetime imaging microscopy datasets. by Sean C Warren, Anca Margineanu, Dominic Alibhai, Douglas J Kelly, Clifford Talbot, Yuriy Alexandrov, Ian Munro, Matilda Katan, Chris Dunsby, Paul M W French

“…This approach is often considered to be prohibitively slow and/or computationally expensive but we present here a computationally efficient global analysis algorithm for the analysis of time-correlated single photon counting (TCSPC) or time-gated FLIM data based on variable projection. …”
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Strain-specific properties and T cells regulate the susceptibility to papilloma induction by Mus musculus papillomavirus 1. by Alessandra Handisurya, Patricia M Day, Cynthia D Thompson, Michael Bonelli, Douglas R Lowy, John T Schiller

“…Thus, the functional cooperation of CD4+ and CD8+ T cells is required to protect this strain. …”
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Fuzzy rank fusion of deep neural networks for weed identification in groundnut crop by Akshay Dheeraj, Rajnish Kumar Chaturvedi, Sapna Nigam, Md. Ashraful Haque, Sudeep Marwaha

“…By combining selective and variable rate spraying, the smart herbicide sprayer effectively manages herbicide amounts. …”
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Evaluating Sensitivity of the Ranking of Forest Fuel Treatments to Manager’s Risk Attitudes and the Importance of Treatment Objectives, Montana, USA by Tony Prato, Travis Paveglio

“…The conceptual framework involves (1) defining a utility function on an index that is a weighted average of fuel treatment objectives and incorporates a manager’s risk attitude; (2) using the utility function to calculate utility values for FTSs; (3) applying the stochastic efficiency with respect to a function method to utility values to obtain certainty equivalents (CEs); and (4) ranking FTSs based on statistically significant differences in median CEs for pairs of FTSs. …”
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Vibration Analysis of Rotating Tapered Timoshenko Beams by a New Finite Element Model by Bulent Yardimoglu

“…A new finite element model is developed and subsequently used for transverse vibrations of tapered Timoshenko beams with rectangular cross-section. The displacement functions of the finite element are derived from the coupled displacement field (the polynomial coefficients of transverse displacement and cross-sectional rotation are coupled through consideration of the differential equations of equilibrium) approach by considering the tapering functions of breadth and depth of the beam. …”
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A MODEL OF AGE–STRUCTURED POPULATION UNDER STOCHASTIC PERTURBATION OF DEATH AND BIRTH RATES by Maxim A. Alshanskiy

“…Under consideration is construction of a model of age-structured population reflecting random oscillations of the death and birth rate functions. We arrive at an Itô-type difference equation in a Hilbert space of functions which can not be transformed into a proper Itô equation via passing to the limit procedure due to the properties of the operator coefficients. …”
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The Effectiveness of Using the Reggio Emilia Approach on the Experimental Science Lesson for Third-Grade Elementary Students by Batool Sabzeh, Farangis Ghalavand, Seyedamir Ghasemtabar

“…Results of the normality test for the research variables (level 1, 2, and 3 science learning) in third-grade students indicated that all variables, both pre-test and post-test, met the assumption of normality, with significance levels greater than 0.05. …”
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Reliability analysis of landing gear operation based on improved support vector machine-based decomposed-coordinated by ZHANG Lei, CHEN Junyu, FENG Jun, FENG Yunwen, LIU Lei

“…The case results show that the proposed ISVM-DC can accurately decompose and coordinate the architecture of landing gear operational failure, and efficiently construct and solve the reliability performance function.…”
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Correlation method of processing the image of the surface microrelief to determine its roughness by Alexey D. Abramov, Dmitry S. Klyuev

“…For these functions, the average amplitudes Ucp of the variable components of the correlation coefficients are calculated and the analytical dependence of the GOST roughness parameter Ra on Ucp is constructed. …”
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Forecasting water quality indices using generalized ridge model, regularized weighted kernel ridge model, and optimized multivariate variational mode decomposition by Marjan Kordani, Mohsen Bagheritabar, Iman Ahmadianfar, Arvin Samadi-Koucheksaraee

“…Statistical metrics confirmed that the proposed OMVMD-GRKR model, concerning the best efficiency in the Ahvaz (R = 0.987, RMSE = 0.761, and U95% = 2.108) and Molasani (R = 0.963, RMSE = 1.379, and U95% = 3.828) stations, outperformed the OMVMD and simple-based methods such as ridge regression (Ridge), least squares support vector machine (LSSVM), deep random vector functional link (DRVFL), and deep extreme learning machine (DELM). …”
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同轴全铰链双输出脉冲发生机构尺度综合与优化 by 杜力, 邹昌平, 冯俊, 向成宣, 黄茂林

“…In order to enhance the efficiency,stability and simplify the structure of the mechanism,the dimension synthesis of the full hinge coaxial two-output function generator is performed by using group-synthesis scheme and regarding the six-bar mechanism as the parallel mechanism of a set of basic four-bar mechanism and a set of equivalent four-bar mechanism.Firstly,a basic four-bar mechanism synthetic model is established and solved based on two position synthesis and equal instantaneous transmission ratio.Then the dimensional parameters of an equivalent four-bar mechanism（a five-bar loop） is solved by using equivalent principle of a variable link-length four-bar mechanism based on the basic four-bar mechanism.By this scheme,the dimensional synthesis of high order of motion parameter can be solved with good results,and the results show that the pulse data of the full hinge coaxial two-output function generator is only six percent.…”
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