Impact of IgG subclass on monoclonal antibody developability by Paul Cain, Lihua Huang, Yu Tang, Victor Anguiano, Yiqing Feng

“…We thus conducted a systematic study of 12 mAbs derived from three sets of unrelated variable regions, each cloned into IgG1, an IgG1 variant with diminished effector functions, IgG2, and a stabilized IgG4 variant with further reduced FcγR interaction, to evaluate the impact of IgG subclass on manufacturability and high concentration stability in a common formulation buffer matrix. …”
Get full text

Novel pyrochlores in the Bi2O3–MgO–Ta2O5 (BMT) system: Synthesis optimisation, phase equilibria and dielectric properties by K.B. Tan, P.Y. Tan, Y. Feng, C.C. Khaw, V. Raman, H.C. Ananda Murthy, R. Balachandran, S.K. Chen, O.J. Lee, K.Y. Chan, D. Zhou, M. Lu

Get full text

An Empirical Analysis of Herding Behavior in the Stock Market: Evidence from Various Economic and Social Conditions in Iran by Majid Aghaei

“…This approach models the response of the dependent variable to the independent variable at various quantiles, denoted as "τ," making it an effective tool for analyzing non-normal distributions. …”
Get full text

Effects of electron beam irradiation on microbial loads, physicochemical properties, stability of active ingredients, and antioxidant activity in Angelica sinensis Radix by Yunxia Hu, Haijun Wang, Zhijun Xin, Wensheng Gou, Zhuanzi Wang, Xiao Liu, Xihong Lu, Aimei Yang, Xuehu Li, Libin Zhou

“…As the demand for safe, wholesome, and high-quality food continues to rise, more research is being done on innovative food processing technologies that maximize efficiency while reducing negative effects on food quality. …”
Get full text

Investigating the influence of soil organic carbon on pore structure within aggregates by Jingjing Liu, Yu Tian, Chiara Pasut, Mark Farrell, Shenggao Lu

“…The results revealed that the hydrogen peroxide treatment variably reduced organic carbon in soil aggregates, with Cambisol samples showing a higher removal efficiency (38.58–63.31%) compared to Ultisol samples (27.33–45.74%). …”
Get full text

Optimizing processing methods for maximum bioactive retention: comparative metabolomic analysis of dried loquat (Eriobotrya japonica) flowers and their powdered extracts by Mingzheng Duan, Jieming Feng, Jing-Han Feng, Xi Wang, Xu Xiao, Shirong He, Hengcui Guo, Wenyan Zhang, Zhumao Jiang, Tongfa Wan, Muhammad Junaid Rao

“…These insights guide the development of standardized loquat flower products, balancing bioactive preservation with processing efficiency for functional food and herbal medicine applications.…”
Get full text

Complete sequencing of the mitochondrial genome of tea plant Camellia sinensis cv. ‘Baihaozao’: multichromosomal structure, phylogenetic relationships, and adaptive evolutionary an... by Zhiyin Chen, Zhiyin Chen, Zhiyin Chen, Zhiyin Chen, Zixu Wang, Zixu Wang, Zixu Wang, Zixu Wang, Wei Zhou, Wei Zhou, Wei Zhou, Wei Zhou, Sijie Liu, Sijie Liu, Sijie Liu, Sijie Liu, Yuxin Xiao, Yuxin Xiao, Yuxin Xiao, Yuxin Xiao, Yihui Gong, Yihui Gong, Yihui Gong, Yihui Gong

“…Adaptive evolutionary analysis, based on Ka/Ks ratios, was performed to investigate gene selection pressures.ResultsThe mitochondrial genome consists of 11 linear chromosomes, with a total length of 909,843 bp and a GC content of 45.62%. A total of 73 functional genes were annotated, among which 14 variable genes (e.g., ribosomal protein coding genes) retain intact functions without pseudogenization, which is rare among Theaceae plants. …”
Get full text

FVPNet: A Fuzzy Visual Positioning Perception Network for Small Object Segmentation in Remote Sensing Images by Yu Yan, Jindong Xu, Qianpeng Chong, Guangyi Wei, Zhixiang Wang

“…Furthermore, grayscale variability intensifies boundary uncertainty, complicating accurate segmentation. …”
Get full text

Recent Advances in Vitamin E TPGS-Based Organic Nanocarriers for Enhancing the Oral Bioavailability of Active Compounds: A Systematic Review by Chee Ning Wong, Siew-Keah Lee, Yang Mooi Lim, Shi-Bing Yang, Yik-Ling Chew, Ang-Lim Chua, Kai Bin Liew

“…Despite using the same excipient, variability in particle size, zeta potential, and encapsulation efficiency among nanocarriers indicates the need for tailored formulations. …”
Get full text

Synergistic co-metabolism enhancing the crude oil degradation by Acinetobacter oleivorans DR1 and its metabolic potential by Lairenjam Paikhomba Singha, Renuka Kumari, Keisam Malabika Singha, Piyush Pandey, Pratyoosh Shukla

“…ABSTRACT Bacterial degradation of hydrocarbons during co-metabolism with glucose often resulted in variable degradation efficiency. This study explored the mechanistic understanding of the metabolic response during co-metabolism in Acinetobacter oleivorans DR1 using a metabolomics approach. …”
Get full text

Enhanced neurological anomaly detection in MRI images using deep convolutional neural networks by Ahmed Mateen Buttar, Zubair Shaheen, Abdu H. Gumaei, Mogeeb A. A. Mosleh, Mogeeb A. A. Mosleh, Indrajeet Gupta, Samah M. Alzanin, Muhammad Azeem Akbar

“…The model employs Rectified Linear Unit (ReLU) activation functions, the Adam optimizer, and a random search strategy to fine-tune hyper-parameters like learning rate, batch size, and the number of neurons in fully connected layers. …”
Get full text

Unveiling Theranostics: Nanocomplex-Assisted Photodynamic Eradication of Aggressive Cancer Cells and Modulation of Tumor-Associated Macrophages by Butkute A, Kazlauske E, Mlynska A, Peciukaityte E, Karabanovas V, Rotomskis R, Steponkiene S

“…The nanocomplex accumulated efficiently and uniformly across all CRC cell lines, regardless of their aggressiveness or drug sensitivity. …”
Get full text

Neutralizing monoclonal antibodies protect against human adenovirus type 55 infection in transgenic mice and tree shrews by Xinglong Liu, Zhengfeng Li, Xiao Li, Xiaoyan Zhang, Yali Zheng, Wan Su, Ying Feng, Yutong Liu, Weixuan Wu, Xikui Sun, Nana Wang, Xianmiao Ye, Zhichao Zhou, Wenkuan Liu, Jun He, Wei Wang, Linbing Qu, Rong Zhou, Ling Chen, Liqiang Feng

“…These mAbs recognized the hyper-variable-region (HVR) 1, 2, or 7 of viral hexon protein, or the fibre knob. …”
Get full text

Engineering safe anti-CD19-CD28ζ CAR T cells with CD8a hinge domain in serum-free media for adoptive immunotherapy by Muthuganesh Muthuvel, Muthuganesh Muthuvel, Thamizhselvi Ganapathy, Trent Spencer, Sunil S. Raikar, Saravanabhavan Thangavel, Alok Srivastava, Alok Srivastava, Alok Srivastava, Sunil Martin

“…CARs are modular synthetic antigen receptors integrating the single-chain variable fragment (scFv) of an immunoglobulin molecule to the TCR signaling. …”
Get full text

Development of blood-brain barrier-penetrating antibodies for neutralizing tick-borne encephalitis virus in the brain by Mizuki Fukuta, Sayo Fukano, Naoya Maekawa, Shintaro Kobayashi, Shunsuke Okamoto, Minato Hirano, Junko Nio-Kobayashi, Hiroaki Kariwa, Shigeru Kawakami, Satoru Konnai, Kentaro Yoshii

Get full text

Sensitivity Analysis of Soil Hydraulic Parameters for Improved Flow Predictions in an Atlantic Forest Watershed Using the MOHID-Land Platform by Dhiego da Silva Sales, Jader Lugon Junior, David de Andrade Costa, Renata Silva Barreto Sales, Ramiro Joaquim Neves, Antonio José da Silva Neto

“…The hydraulic soil parameters of VGM are dependent on soil type and are typically estimated from experimental data; however, they are often obtained using pedotransfer functions, which carry significant uncertainty. As a result, calibration is frequently required to account for both the natural spatial variability of soil and uncertainties estimation. …”
Get full text

Spatial Differentiation and Correlation of Ecological Stoichiometric Characteristics of Cynodon dactylon and Soil in the Water-level Fluctuation Zone of the Three Gorges Reservoir... by XU Liwen, ZHANG Yuewei, JIAN Chen, ZHANG Yuanyuan, WANG Xiaofeng

“…However, the variability in C/N and C/P ratios in roots and stems were slightly stronger than that in leaves, suggesting that C. dactylon has evolved a strategy for maintaining stable physiological functions in leaves. 4) There were significant correlations of the nutrient contents between C. dactylon and soil, with the nitrogen supply of soil being the key factor influencing the variation of nutrient contents in C. dactylon. …”
Get full text

MiR-216a-3p inhibits the cytotoxicity of primary natural killer cells by Rowan Abdelbary, Rowan Abdelbary, Manon Ragheb, Manon Ragheb, Shereen A. El Sobky, Nagwa El-Badri, Nourhan Aboud, Ahmed Tawheed, Asmaa Gomaa, Mona Zidan, Ramy K. Aziz, Abd Elrahman Abouzid, Radwa Ayman Salah, Mohamed El-Kassas, Imam Waked, Ahmed Moustafa, Ahmed Moustafa, Injie Omar Fawzy, Nada El-Ekiaby, Ahmed Ihab Abdelaziz

“…IntroductionThe role of miRNAs in regulating variable molecular functions has been sought by scientists for its promising utility in regulating the immune response and, hence, in treating various diseases. …”
Get full text

Hierarchical GraphCut Phase Unwrapping Based on Invariance of Diffeomorphisms Framework by Xiang Gao, Xinmu Wang, Zhou Zhao, Junqi Huang, Xianfeng David Gu

“…However, the presence of noise, occlusions, and piecewise continuous phase functions induced by complex 3D surface geometry makes the inverse reconstruction of the true phase extremely challenging. …”
Get full text

Sustainable forest management: success and challenges in Ethiopia by Rusha Begna Wakweya

“…The outcomes of local-level forest governance depend on the quality, efficiency, and effectiveness of local policymaking and decision-making processes, as well as how power and authority are exercised locally. …”
Get full text