Toward generalizable prediction of antibody thermostability using machine learning on sequence and structure features by Ameya Harmalkar, Roshan Rao, Yuxuan Richard Xie, Jonas Honer, Wibke Deisting, Jonas Anlahr, Anja Hoenig, Julia Czwikla, Eva Sienz-Widmann, Doris Rau, Austin J. Rice, Timothy P. Riley, Danqing Li, Hannah B. Catterall, Christine E. Tinberg, Jeffrey J. Gray, Kathy Y. Wei

“…In this work, we show two machine learning approaches – one with pre-trained language models (PTLM) capturing functional effects of sequence variation, and second, a supervised convolutional neural network (CNN) trained with Rosetta energetic features – to better classify thermostable scFv variants from sequence. …”
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Natural Diversity of <i>Crataegus monogyna</i> Jacq. in Northeastern Türkiye Encompassing Morphological, Biochemical, and Molecular Features by Bora Erkek, Mehmet Yaman, Ahmet Sümbül, Serap Demirel, Fatih Demirel, Ömer Faruk Coşkun, Ahmet Say, Barış Eren, Adnan Aydin, Ayten Eroglu

“…The Jaccard similarity coefficient ranged from 0.04 (M9 and M16) to 0.63 (M17 and M3), indicating substantial genetic variability. …”
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Long-term conservation tillage breaks the plough pan and promotes the development of preferential flow by Jinze Han, Jianye Li, Qiang Chen, Xingyi Zhang

“…Macropores and preferential flow critically regulate soil hydrological functions and ecosystem services in agricultural systems. …”
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Spatiotemporal changes of ecosystem health and the impact of its driving factors on the Loess Plateau in China by Xuepeng Zhang, Taixia Wu, Qiqi Du, Ninglei Ouyang, Wei Nie, Yang Liu, Peng Gou, Guangchao Li

“…Based on this idea, a new framework for assessing EH is proposed. The efficient machine learning model (light gradient boosting machine model) and the variable explanation model (SHapley Additive exPlanation model) are combined to quantify the functional relationships between various driving factors and EH, thereby exploring the impacts of climatic factors, socioeconomic development (SED), and ecological restoration projects (ERP) on EH. …”
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Quantifying Watershed Protection Potential and Determining Impact Mechanisms in the Shiyang River System Using Hybrid Land Use-Hydrology Modeling by Cao Jinjun, Ren Zhiwei, Li Haohao

“…This research provides a visual tool for evaluating the efficient use and conservation of water resources and for enhancing water source preservation functions…”
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Elucidating the role of mind–body connection profiles in emotional reactivity and regulation amongst typically developed adults by Kristen Van Bael, Jessica Scarfo, Emra Suleyman, Michelle Ball

“…Abstract Background Adaptive emotional functioning necessitates a strong mind–body connection. …”
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Identifying confounders and estimating the causal effect of antenatal care on age-specific childhood vaccination by Ashagrie Sharew Iyassu, Ashagrie Sharew Iyassu, Haile Mekonnen Fenta, Haile Mekonnen Fenta, Zelalem G. Dessie, Zelalem G. Dessie, Temesgen T. Zewotir

“…BackgroundImmunization is an efficient and cost-effective public health program. …”
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Drying kinetics and thermodynamic analysis; enhancing quinoa (Chenopodium quinoa Willd.) quality profile via pre-treatments assisted germination and processing by Jabir Khan, Palwasha Gul, Qingyun Li, Kunlun Liu

“…Principal Component Analysis revealed significant correlations between analyses, explaining 80.37 % variability. The intensity of functional groups decreased in the infrared spectra, although the transmission of signals was greater in pretreated samples than in control. …”
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Emerging Healthcare Technologies in Gastrointestinal Endoscopy: 75 Years of Evolution by Irina Florina CHERCIU HARBIYELI, Elena Daniela BURTEA, Vlad IOVANESCU, Dan Nicolae FLORESCU, Ion ROGOVEANU, Dan Ionut GHEONEA, Adrian SAFTOIU

“…Future capsules will feature AI-driven lesion detection and therapeutic functions, higher-resolution imaging, wider fields of view, controllable movement bringing the concept of "swallowing the gastroenterologist" closer to reality. …”
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Application of multi-objective neural network algorithm in industrial polymerization reactors for reducing energy cost and maximising productivity by Fakhrony Sholahudin Rohman, Sharifah Rafidah Wan Alwi, Dinie Muhammad, Ashraf Azmi, Zainuddin Abd Manan, Jeng Shiun Lim, Hong An Er, Siti Nor Azreen Ahmad Termizi

“…Optimization on an industrial scale is a complex task that involves fine-tuning the performance of large-scale systems and applications to make them more efficient and effective. This process can be challenging due to the increasing volume of work, growing system complexity, and the need to maintain optimal performance. …”
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Unveiling Theranostics: Nanocomplex-Assisted Photodynamic Eradication of Aggressive Cancer Cells and Modulation of Tumor-Associated Macrophages by Butkute A, Kazlauske E, Mlynska A, Peciukaityte E, Karabanovas V, Rotomskis R, Steponkiene S

“…The nanocomplex accumulated efficiently and uniformly across all CRC cell lines, regardless of their aggressiveness or drug sensitivity. …”
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Comparative Genomics of Rhamnolipid Synthesis and Monoaromatic Hydrocarbon Tolerance Genes in Environmental Pseudomonas aeruginosa strains [version 2; peer review: 2 approved] by Sandro B. Martel-Torres, Camila Castillo-Vilcahuaman, ROGER A. PALOMINO HUARCAYA, Susana M. Gutiérrez Moreno, Fernando A. Merino Rafael

“…The BTEX (benzene, toluene, ethylbenzene, and xylene) are toxic hydrocarbons requiring efficient microbial degradation for bioremediation. …”
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Neutralizing monoclonal antibodies protect against human adenovirus type 55 infection in transgenic mice and tree shrews by Xinglong Liu, Zhengfeng Li, Xiao Li, Xiaoyan Zhang, Yali Zheng, Wan Su, Ying Feng, Yutong Liu, Weixuan Wu, Xikui Sun, Nana Wang, Xianmiao Ye, Zhichao Zhou, Wenkuan Liu, Jun He, Wei Wang, Linbing Qu, Rong Zhou, Ling Chen, Liqiang Feng

“…These mAbs recognized the hyper-variable-region (HVR) 1, 2, or 7 of viral hexon protein, or the fibre knob. …”
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The human gut microbiota contributes to type-2 diabetes non-resolution 5-years after Roux-en-Y gastric bypass by Jean Debédat, Tiphaine Le Roy, Lise Voland, Eugeni Belda, Rohia Alili, Solia Adriouch, Pierre Bel Lassen, Kazuyuki Kasahara, Evan Hutchison, Laurent Genser, Licia Torres, Camille Gamblin, Christine Rouault, Jean-Daniel Zucker, Nathalie Kapel, Christine Poitou, Geneviève Marcelin, Federico E. Rey, Judith Aron-Wisnewsky, Karine Clément

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Network Meta-Analysis of Factors Influencing the Carbon Sink Capacity of Urban Park Green Spaces by Yutong JI, Tianyi LIN, Lian LIU, Xiong LI

“…While habitat composition and planting strategies offer substantial localized benefits, their variability necessitates tailored interventions informed by specific ecological and social contexts. …”
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Spatial Differentiation and Correlation of Ecological Stoichiometric Characteristics of Cynodon dactylon and Soil in the Water-level Fluctuation Zone of the Three Gorges Reservoir... by XU Liwen, ZHANG Yuewei, JIAN Chen, ZHANG Yuanyuan, WANG Xiaofeng

“…However, the variability in C/N and C/P ratios in roots and stems were slightly stronger than that in leaves, suggesting that C. dactylon has evolved a strategy for maintaining stable physiological functions in leaves. 4) There were significant correlations of the nutrient contents between C. dactylon and soil, with the nitrogen supply of soil being the key factor influencing the variation of nutrient contents in C. dactylon. …”
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End-to-End Stroke Imaging Analysis Using Effective Connectivity and Interpretable Artificial Intelligence by Wojciech Ciezobka, Joan Falco-Roget, Cemal Koba, Alessandro Crimi

“…Neuroimaging data, with their rich structural and functional information, provide a fertile ground for biomarker discovery. …”
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Analisis Penerimaan Learning Management System Institut Teknologi Garut Menggunakan Technology Acceptance Model by Asri Mulyani, Dede Kurniadi, Mita Hidayani Putri

“…It is hoped that the results of this research can be used as a reference for developers to continue to optimize the functionality of the Learning Management System so that it can be used optimally. …”
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SwinDAF3D: Pyramid Swin Transformers with Deep Attentive Features for Automated Finger Joint Segmentation in 3D Ultrasound Images for Rheumatoid Arthritis Assessment by Jianwei Qiu, Grigorios M. Karageorgos, Xiaorui Peng, Soumya Ghose, Zhaoyuan Yang, Aaron Dentinger, Zhanpeng Xu, Janggun Jo, Siddarth Ragupathi, Guan Xu, Nada Abdulaziz, Girish Gandikota, Xueding Wang, David Mills

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease that can cause severe joint damage and functional impairment. Ultrasound imaging has shown promise in providing real-time assessment of synovium inflammation associated with the early stages of RA. …”
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Hierarchical GraphCut Phase Unwrapping Based on Invariance of Diffeomorphisms Framework by Xiang Gao, Xinmu Wang, Zhou Zhao, Junqi Huang, Xianfeng David Gu

“…However, the presence of noise, occlusions, and piecewise continuous phase functions induced by complex 3D surface geometry makes the inverse reconstruction of the true phase extremely challenging. …”
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