Novel variant alters splicing of TGFB2 in family with features of Loeys-Dietz syndrome by Emily R. Gordon, Stephanie A. Felker, Stephanie A. Felker, Tanner F. Coleman, Tanner F. Coleman, Nadiya Sosonkina, Jada Pugh, Jada Pugh, Meagan E. Cochran, Meagan E. Cochran, Anna C. E. Hurst, Sara J. Cooper

“…Molecular validation of the splicing products suggests that the TGFB2 variants tested impact splicing by reducing efficiency of the canonical acceptor in favor of an alternate acceptor within the exon. …”
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Integrated transportation system planning with gravitational search algorithm approach based on fuzzy mutant controller by Alireza Hosseinzadeh Kashani, Seyed Ahmad Shayannia, Mohammad Mehdi Movahedi, Soheila Sardar

“…The efficiency of the gravity search algorithm and the mutated gravity search algorithm is better in functions F4, F7, F11, F21. …”
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Deep learning algorithm on H&E whole slide images to characterize TP53 alterations frequency and spatial distribution in breast cancer by Chiara Frascarelli, Konstantinos Venetis, Antonio Marra, Eltjona Mane, Mariia Ivanova, Giulia Cursano, Francesca Maria Porta, Alberto Concardi, Arnaud Gerard Michel Ceol, Annarosa Farina, Carmen Criscitiello, Giuseppe Curigliano, Elena Guerini-Rocco, Nicola Fusco

“…The DL model exhibited high accuracy in tissue quantification and TP53 status prediction, outperforming traditional methods in terms of precision and efficiency. DL-based approaches offer significant promise for enhancing biomarker testing and precision oncology by reducing intra- and inter-observer variability, but further validation is required to optimize their integration into real-world clinical workflows. …”
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Optimized Dual-Battery System with Intelligent Auto-Switching for Reliable Soil Nutrient Monitoring in Remote IoT Applications by Doan Perdana, Pascal Lorenz, Bagus Aditya

“…Implementing the DLB–PAO algorithm elevates the average reliability to 91.7% over 120 h, whereas the DLB–GA algorithm achieves near-perfect reliability (99.9%) for over 170 h, exhibiting minimal variability (standard deviation: 0.9%). The integration of intelligent auto-switching mechanisms and metaheuristic optimisation algorithms demonstrates a marked enhancement in both reliability and energy efficiency for soil nutrient monitoring systems. …”
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Expanding a Health Technology Solution to Address Therapist Challenges in Implementing Homework With Adult Clients: Mixed Methods Study by Brian E Bunnell, Kaitlyn R Schuler, Julia Ivanova, Lea Flynn, Janelle F Barrera, Jasmine Niazi, Dylan Turner, Brandon M Welch

“… BackgroundHomework is implemented with variable effectiveness in real-world therapy settings, indicating a need for innovative solutions to homework challenges. …”
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Impact of IgG subclass on monoclonal antibody developability by Paul Cain, Lihua Huang, Yu Tang, Victor Anguiano, Yiqing Feng

“…We thus conducted a systematic study of 12 mAbs derived from three sets of unrelated variable regions, each cloned into IgG1, an IgG1 variant with diminished effector functions, IgG2, and a stabilized IgG4 variant with further reduced FcγR interaction, to evaluate the impact of IgG subclass on manufacturability and high concentration stability in a common formulation buffer matrix. …”
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FMRI insights into the neural alterations and clinical correlates in multiple sclerosis: A comprehensive overview of systematic reviews and meta-analyses by Sama Rahnemayan, Arezoo Fathalizadeh, Mehdi Behroozi, Mahnaz Talebi, Amirreza Naseri, Elham Mehdizadehfar

“…Graph theory metrics identified disrupted global efficiency and clustering in functional networks, linked to gray matter atrophy. …”
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XPolypNet: A U-Net-Based Model for Semantic Segmentation of Gastrointestinal Polyps With Explainable AI by Arjun Kumar Bose Arnob, Muhammad Mostafa Monowar, Md. Abdul Hamid, M. F. Mridha

“…The presented model was evaluated on five benchmark datasets, achieving a Dice Coefficient of 0.8378 and a Mean Intersection over Union (mIoU) of 0.8427. …”
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Modeling and Regulation of Dynamic Temperature for Layer Houses Under Combined Positive- and Negative-Pressure Ventilation by Lihua Li, Min Li, Yao Yu, Yuchen Jia, Zhengkai Qian, Zongkui Xie

“…Additionally, a temperature control method for a layer house is designed using a variable universe fuzzy PID control algorithm (VFPID). …”
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Validation of an interferon-gamma enzyme-linked immunosorbent spot assay to evaluate cell-mediated immunity against severe acute respiratory syndrome coronavirus 2 by Yunhwa Kim, Eun-Jeong Jang, Ji-Young Hwang, Kyung-Min Lee, Sivilay Xayaheuang, Seok-Tae Choi, Hosun Park

“…Taken together, we demonstrated that the IFN-γ ELISpot assay is feasible for evaluating SARS-CoV-2-specific cell-mediated immune function through validation based on standard operating procedures.…”
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Deletion of genes linked to the C1-fixing gene cluster affects growth, by-products, and proteome of Clostridium autoethanogenum by Ugochi Jennifer Nwaokorie, Kristina Reinmets, Lorena Azevedo de Lima, Pratik Rajendra Pawar, Kurshedaktar Majibullah Shaikh, Audrey Harris, Michael Köpke, Kaspar Valgepea

“…However, our understanding of the functionalities of the genes involved in the C1-fixing gene cluster and its closely-linked genes is incomplete. …”
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Application of Post-Occupancy Evaluation in the Design of Collegiatae Educational Space: (Case study: Faculty of Arts and Architecture, Islamic Azad University-Tehran South Branch) by Reza Naghdbishi, Zeinab Gohari

“…This analysis identified the relationship between research variables and evaluated their impact on the design. …”
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Specific nature of the integrative (complex) effect of environmental factors on hazelnut cultivars in the Russian humid subtropics by T. D. Besedina, A. P. Boyko, Ts. V. Tutberidze, N. S. Kiseleva

“…The expediency of the crop’s large-scale cultivation calls for measuring the parameters of agroclimatic indicators, ranging in variability, intensity, and duration of their impact. …”
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Data-driven modeling and regression analysis on ship resistance of in-service performance by Daehyuk Kim, Shin Hyung Rhee

“…The analysis of added resistance due to waves shows significant, but sometimes inconsistent, transfer function coefficients, suggesting simpler model structures could be more effective. …”
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Automatic detection of optic canal fractures and recognition and segmentation of anatomical structures in the orbital apex based on artificial intelligence by Yu-Lin Li, Yu-Hao Li, Mu-Yang Wei, Guang-Yu Li

“…Timely and accurate diagnosis and treatment are crucial for preserving visual function. However, diagnosing OCF can be challenging for inexperienced clinicians due to atypical OCF changes in imaging studies and variability in optic canal anatomy. …”
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How to personalise ventilation of infants with congenital diaphragmatic hernia? A simulation study by Barbara Stankiewicz, Magdalena Mierzewska-Schmidt, Krzysztof J. Pałko, Marek Darowski, Maciej Kozarski

“…The T1/T2 and CW/CL correlated with defect size (gamma coefficient: 1; P < 0.05), duration of mechanical ventilation and hospitalization (Spearmen’s coefficient: 0.99; P < 0.01). …”
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Which Metrics Can I Monitor? Test-Retest Reliability of Countermovement Jump and Countermovement Rebound Jump Force-Time Metrics in Youth Soccer Players In-Season by Andrew Badby, Paul Comfort, Nicholas Ripley, Matthew Cuthbert, Francisco Robles-Palazón, Peter Mundy, John McMahon

“…Objective measures provide the most effective means of monitoring the magnitude and time course of changes in neuromuscular function (NMF) resulting from physical activity if measurements are repeatable (reliability). …”
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A comprehensive assessment of physical image quality of five different scanners for head CT imaging as clinically used at a single hospital centre-A phantom study. by Patrizio Barca, Fabio Paolicchi, Giacomo Aringhieri, Federica Palmas, Daniela Marfisi, Maria Evelina Fantacci, Davide Caramella, Marco Giannelli

“…CT image quality for each scanner/acquisition protocol was assessed through noise level, noise power spectrum (NPS), contrast-to-noise ratio (CNR), modulation transfer function (MTF), low contrast detectability (LCD) and non-uniformity index analyses. …”
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Same data, different results? Machine learning approaches in bioacoustics by Kaja Wierucka, Derek Murphy, Stuart K. Watson, Nikola Falk, Claudia Fichtel, Julian León, Stephan T. Leu, Peter M. Kappeler, Elodie F. Briefer, Marta B. Manser, Nikhil Phaniraj, Marina Scheumann, Judith M. Burkart

“…We investigated the impact of using different feature extraction (spectro‐temporal measurements, linear and Mel‐frequency cepstral coefficients (MFCC), as well as highly comparative time‐series analysis) and classification methods (discriminant function analysis, neural networks, random forests (RF), and support vector machines) on the consistency of caller identity classification accuracy across 16 mammalian datasets. …”
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MANAGING FRAUD IN CONTEMPORARY BUSINESS ENVIRONMENT, THE ROLE OF INFORMATION SECURITY MANAGEMENT: A STUDY OF QUOTED DEPOSIT MONEY BANKS (DMBs) IN NIGERIA by Onajero Kensington OHWO

“…Cronbach’s alpha reliability coefficients for the constructs ranged from 0.864 to 0.952. …”