Development of an Agrobacterium tumefaciens-mediated transformation system for somatic embryos and transcriptome analysis of LcMYB1’s inhibitory effect on somatic embryogenesis in... by Yaqi Qin, Bo Zhang, Xueliang Luo, Shiqian Wang, Jiaxin Fu, Zhike Zhang, Yonghua Qin, Jietang Zhao, Guibing Hu

Get full text

Model supports asymmetric regulation across the intercellular junction for collective cell polarization. by Katherine Levandosky, Calina Copos

“…Symmetry breaking, which is ubiquitous in biological cells, functionally enables directed cell movement and organized embryogenesis. …”
Get full text

The DOE E3SM version 2.1: overview and assessment of the impacts of parameterized ocean submesoscales by K. M. Smith, A. M. Barthel, L. M. Conlon, L. P. Van Roekel, A. Bartoletti, J.-C. Golaz, C. Zhang, C. B. Begeman, J. J. Benedict, G. Bisht, Y. Feng, W. Hannah, B. E. Harrop, N. Jeffery, W. Lin, P.-L. Ma, M. E. Maltrud, M. R. Petersen, B. Singh, Q. Tang, T. Tesfa, J. D. Wolfe, S. Xie, X. Zheng, K. Balaguru, O. Garuba, P. Gleckler, A. Hu, J. Lee, B. Moore-Maley, A. C. Ordoñez

Get full text

Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial by Jess Kerr-Gaffney, Zohra Zenasni, Kimberley Goldsmith, Nahel Yaziji, Huajie Jin, Alessandro Colasanti, John Geddes, David Kessler, R Hamish McAllister-Williams, Allan H Young, Alvaro Barrera, Lindsey Marwood, Rachael W Taylor, Helena Tee, Anthony J Cleare

“…The QIDS-SR outcome was analysed using a linear mixed model with weekly scores as the dependent variable, and treatment allocation, randomisation stratification variables, time and time by treatment interaction terms as explanatory variables, using an area under the curve (AUC) approach. …”
Get full text

From rings to regions: modeling and mapping climate-driven timber production zones for Cyclocarya paliurus by integrating niche models and growth traits by Zijie Zhang, Zijie Zhang, Zhengyang Ye, Xulan Shang, Xulan Shang, Wanxia Yang, Wanxia Yang, Tongli Wang, Shengzuo Fang, Shengzuo Fang

Get full text

Acupuncture-moxibustion for chemotherapy-induced peripheral neuropathy: A systematic review and network meta-analysis by Yan LI, Shuang LIU, Hai-fa QIAO

Get full text

In vivo therapeutic effect of combination treatment with metformin and Scutellaria baicalensis on maintaining bile acid homeostasis. by Kyungsun Han, Shambhunath Bose, Jing-Hua Wang, Soo-Kyoung Lim, Young-Won Chin, Young-Mi Kim, Han-Seok Choi, Hojun Kim

“…Although there were no significant changes in BSH-active gut microbiota due to high variability, functional prediction with 16S sequences showed increased primary and secondary bile acid biosynthesis in the combination treatment group. …”
Get full text

Altitudinal patterns of bacterial communities across soil layers in the alpine meadows of the Qinghai-Tibet Plateau by Zhiyuan Chen, Yeteng Xu, Xinyue Wang, Tong Ma, Yang Liu, Xiang Qin, Wei Zhang, Tuo Chen, Guangxiu Liu, Binglin Zhang

“…Microorganisms in the soils of alpine meadows on the Qinghai-Tibet Plateau are pivotal in sustaining ecosystem functionality and stability. The community structure and functional composition of these microbes exhibit pronounced altitudinal variations; however, specific distribution patterns across different soil layers remain inadequately elucidated within alpine meadow ecosystems. …”
Get full text

A Preliminary Investigation into Heavy Metal Tolerance in <i>Pseudomonas</i> Isolates: Does the Isolation Site Have an Effect? by Alessandro De Santis, Antonio Bevilacqua, Angela Racioppo, Barbara Speranza, Maria Rosaria Corbo, Clelia Altieri, Milena Sinigaglia

“…A subset of isolates showed co-tolerance to elevated temperatures and heavy metals. …”
Get full text

Spatial-temporal Evolution and Driving Factors of Ecological Environment Quality in Weihe River Basin Based on Remote Sensing Ecological Index by Wu Mengyue, Li Yu

Get full text

Analysis of mRNA Pentatricopeptide Repeat Domain 1 as a prospective oncogene in clear cell renal cell carcinoma that accelerates tumor cells proliferation and invasion via the Akt/... by Zhongbao Zhou, Yulong Li, Yumeng Chai, Yong Zhang, Pu Yan

“…WGCNA discovered a significant relationship between PTCD1 and IARS2, LRPPRC, MT-ND2, MT-CO1, MT-CO2, MT-CYB, MT-ATP6, and MT-ND4. Furthermore, PTCD1 expression levels was closely associated with immune infiltrating, immunological checkpoint, EMT, immunotherapy responsiveness, and anti-tumor medication sensitivities. …”
Get full text

Properties and anti-fungal activity of liquid by-products from softwood bark carbonization by Mariem Zouari, Faksawat Poohphajai, Kristine Meile, Marica Mikuljan, Rene Herrera Diaz

Get full text

Randomized single-dose crossover comparative bioavailability study of two novel oral cannabidiol (CBD) formulations in healthy volunteers under fed conditions, compared to a standa... by Mehmet Nevzat Pisak, Edibe Bereket, Aydin Erenmemisoglu

“…No clinically significant changes in liver function tests or other laboratory values were observed. …”
Get full text

Physiological attunement and flourishing: understanding the influence of relationships on health by Marco A. Vinhosa Bastos, Danilo Faria Braz, Ana Laura Manzan Porto, Khadija S. da Silva Cordeiro, Renata Boschi Portella, Douglas Alan Granger

“…BackgroundFlourishing can be defined as the experience of life going well, a combination of feeling good and functioning effectively. High-quality relationships are essential to flourishing and long-term health. …”
Get full text

Field Investigation of Thermal Comfort and Indoor Air Quality Analysis Using a Multi-Zone Approach in a Tropical Hypermarket by Kathleen Jo Lin Teh, Halim Razali, Chin Haw Lim

“…Environmental parameters were monitored using a network of IoT-enabled sensors across five functional zones during actual operations. Thermal indices (PMV, PPD) and IAQ metrics (CO₂, TVOC, PM2.5, PM10) were analysed and benchmarked against ASHRAE 55 standards to assess spatial variations and occupant exposure. …”
Get full text

Ref-1 redox activity modulates canonical Wnt signaling in endothelial cells by Gabriella D. Hartman, Kamakshi Sishtla, Eyram K. Kpenu, Mahmut Mijit, Anbukkarasi Muniyandi, Ha-Neul Jo, Harald J. Junge, Aaron Shaw, Daniela Bischof, Sheng Liu, Jun Wan, Mark R. Kelley, Timothy W. Corson

“…Previous studies demonstrate that targeting the redox-mediated transcriptional regulatory function of APE1/Ref-1 reduces pathological neovascularization. …”
Get full text

Clinical characterization of Collagen XII‐related disease caused by biallelic COL12A1 variants by Riley M. McCarty, Dimah Saade, Pinki Munot, Chamindra G. Laverty, Hailey Pinz, Yaqun Zou, Meghan McAnally, Pomi Yun, Cuixia Tian, Ying Hu, Lucy Feng, Rahul Phadke, Sophia Ceulemans, Pilar Magoulas, Andrew J. Skalsky, Jennifer R. Friedman, Stephen R. Braddock, Sarah B. Neuhaus, Denise M. Malicki, Matthew N. Bainbridge, Shareef Nahas, David P. Dimmock, Stephen F. Kingsmore, Timothy E. Lotze, A. Reghan Foley, Francesco Muntoni, Volker Straub, Sandra Donkervoort, Carsten G. Bönnemann

“…Results All patients presented with a consistent constellation of congenital onset clinical features: hypotonia, dysmorphic features, most notably gingival hypertrophy, prominent distal joint hyperlaxity, with co‐occurring contractures of large joints, and variable muscle involvement, evident both clinically and on muscle imaging. …”
Get full text

Environmental impact assessment of maize cultivation system considering different irrigation methods by Filippo Vigo, Michele Zoli, Daniela Lovarelli, Jacopo Bacenetti

“…Climate change was found to range from 116.66 kg CO2 eq./t of ear maize for flood irrigation to 207.42 kg CO2 eq.…”
Get full text

Veterans Traumatic Brain Injuries and Neurosurgical Challenges: A Narrative Review by Ali Mortezaei, Negin Safari, Hediye Gholamshahi, Kimia Kazemzadeh, Abbas Tafakhori

“…Managing TBIs in veterans presents neurosurgical challenges such as timely diagnosis and intervention, tailored treatment approaches due to injury variability (blast vs. blunt trauma), and co‐occurring conditions like PTSD and depression. …”
Get full text

Computer-aided recognition of polish vowels in continuous speech by Wiktor JASSEM, Danuta GEMBIAK, Andrzej DYCZKOWSKI

“…Vowels pronounced by male voices in typical Polish sentences were the object of the recognition. Vowel formants as variable time functions were measured from the spectrograms. …”
Get full text