Comparative chromato-mass spectrometric study of tinctures based on Echinacea purpurea (L.) Moench by Y. I. Kornievskiy, D. Yu. Skoryna, V. H. Korniievska, N. V. Kandybei

“…An urgent problem today is the spread of secondary immunodeficiencies associated with increased stress, urbanization, and negative changes in the environment that lead to impaired immune function. Herbal remedies are milder, less likely to become addictive and have side effects, and are long-lasting. …”
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Abstract 020: Undulating Flow Velocities as an Induced Test of Autoregulation After Thrombectomy for Acute Ischemic Stroke by Aya Mikkawi, Qasem N Alshaer, Mahmoud Mohammaden, Diogo Haussen, Aaron Anderson

“…This case is unique since it provides an induced test of autoregulation and compares pre‐ and post‐EVT autoregulatory function. Prior reports did not use any stressors to test for autoregulation. …”
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A Comprehensive Performance Evaluation Method Based on Dynamic Weight Analytic Hierarchy Process for In-Loop Automatic Emergency Braking System in Intelligent Connected Vehicles by Dongying Liu, Wanyou Huang, Ruixia Chu, Yanyan Fan, Wenjun Fu, Xiangchen Tang, Zhenyu Li, Xiaoyue Jin, Hongtao Zhang, Yan Wang

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Alternative splicing induces sample-level variation in gene–gene correlations by Yihao Lu, Brandon L. Pierce, Pei Wang, Fan Yang, Lin S. Chen

“…By analyzing gene–gene co-expression variation within functional pathways accounting for splicing, we characterized the patterns of the “hub” genes with isoform-specific regulatory effects on multiple other genes. …”
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Common bean pan-genome reveals abundant variation patterns and relationships of stress response genes and pathways by Xu Wang, Ming Yan, Shanshan Cui, Fang Li, Qingqing Zhao, Qingnan Wang, Bin Jiang, Yixin Huang, Yang Sun, Xiangdong Kong

“…Core and shell genes may be co-expressed in all samples and may have functional complementarity to maintain the stability of plant growth. …”
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Multi-omics identification of a polyamine metabolism related signature for hepatocellular carcinoma and revealing tumor microenvironment characteristics by Yuexi Yu, Huiru Liu, Kaipeng Liu, Meiqi Zhao, Yiyan Zhang, Runci Jiang, Fengmei Wang

“…Further analysis revealed significant differences in clinical features, biological functions, mutation profiles, and immune cell infiltration between high-risk and low-risk groups. …”
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WRF-ELM v1.0: a regional climate model to study land–atmosphere interactions over heterogeneous land use regions by H. Huang, Y. Qian, G. Bisht, J. Wang, T. Chakraborty, D. Hao, J. Li, T. Thurber, B. Singh, Z. Yang, Y. Liu, P. Xue, P. Xue, W. J. Sacks, E. Coon, R. Hetland

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Cognitive impact and brain structural changes in long COVID patients: a cross-sectional MRI study two years post infection in a cohort from Argentina by Sol A. Cataldo, Andrea Micciulli, Laura Margulis, Melina Cibeyra, Sabrina Defeo, Silvina G. Horovitz, Analía Martino, Raul Melano, Milagros Mena, Francisco Parisi, Diego Santoro, Florencia Sarmiento, Martin A. Belzunce

“…Abstract Objective Long COVID is a condition characterised by persistent symptoms after a SARS-CoV-2 infection, with neurological manifestations being particularly frequent. …”
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Transcriptome analysis to decipher the molecular underpinnings of response to treatment in systemic lupus erythematosus by Dimitrios T Boumpas, Antonis Fanouriakis, George Bertsias, Dionysis Nikolopoulos, Aggelos Banos, Anastasia Filia, Antigone Pieta, Sofia Flouda, Katerina Chavatza, Panagiotis Garantziotis, Spyridon Katechis, Noemin Kapsala, George Sentis, Georgia Savina Moysidou, Nikos Malissovas

“…We identified differentially expressed genes and co-expressed transcript modules.Results Achieving response, irrespective of treatment, was accompanied by downregulation of B cell immunity-related and complement activation-related signatures. …”
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Assessment of Terrestrial Carbon Sinks in China Simulated by Multiple Vegetation Models by Weiyi Xu, Jing Liu, Longgao Chen, Suchen Ying

“…The impact of climate change is variable, and the carbon sink effect engendered by CO₂ fertilization is negated by the adverse influence of land use change. …”
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Imidacloprid decreases energy production in the hemolymph and fat body of western honeybees even though, in sublethal doses, it increased the values of six of the nine compounds in... by Jerzy Paleolog, Jerzy Wilde, Marek Gancarz, Aneta Strachecka

“…The concentrations of the strongly correlated NADH2, ATP and acetyl-CoA decreased both in IM-200 and IM-5, whereas the levels of the other compounds decreased in IM-200 but increased in IM-5.…”
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Pulmonary vein isolation does not alter cardiovascular afferent autonomic reflexes in atrial fibrillation by Varun Malik, Adrian D. Elliott, Gijo Thomas, Bradley Pitman, John L. Fitzgerald, Glenn D. Young, Leonard F. Arnolda, Dennis H. Lau, Prashanthan Sanders

“…Mean age was 64 ± 3 years (78% male); BMI 28 ± 1 kg/m2; LA size 37 ± 2 mL/m2; and left ventricular function 65 ± 3%. Despite alterations in heart rate variability (HRV), there was no difference in IHR, Valsalva, or LBNP responses pre‐ versus post‐PVI. …”
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IGF2BP3 promotes autophagy-mediated TNBC metastasis via m6A-dependent, cap-independent c-Met translation by Zi-Wen Wang, Yi-Han Li, Meng-Yuan Cai, Xu Zhang, Ruo-Xi Xu, Hai-Yan Yang, Yu-Zhou Huang, Liang Shi, Ji-Fu Wei, Qiang Ding

“…Methylated RNA immunoprecipitation sequencing, luciferase assays and co-immunoprecipitation mass spectrometry showed that IGF2BP3 promoted mRNA translation initiation in an N6-methyladenosine (m6A)-dependent manner. …”
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Life cycle greenhouse gas emissions of diesel oil and zero-emission trucks: Systematic review of status and perspectives by Gaia Gentilucci, Antonella Accardo, Ezio Spessa

“…Quantitatively, the analysis highlights a significant variability of the carbon footprint results, ranging between 431–1780 tons CO2eq for diesel ICEVs, 175–1626 tons CO2eq for battery electric vehicles, 366–2944 tons CO2eq for fuel cell electric vehicles. …”
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Una mirada al origen y las propiedades de los suelos magnésicos en el Valle del Cauca-Colombia by Garcia O. A., Malagón C. D., Madero E

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ELM‐Wet: Inclusion of a Wet‐Landunit With Sub‐Grid Representation of Eco‐Hydrological Patches and Hydrological Forcing Improves Methane Emission Estimations in the E3SM Land Model... by Theresia Yazbeck, Gil Bohrer, Madeline E. Scyphers, Justine E. C. Missik, Oleksandr Shchehlov, Eric J. Ward, Sergio L. Merino, Robert Bordelon, Diana Taj, Jorge A. Villa, Kelly Wrighton, Qing Zhu, William J. Riley

“…Our results show that ELM‐Wet reduces the model's CH4 emission root mean squared error by up to 33% and is able to represent inter‐daily CO2 and CH4 flux variability across the wetland's eco‐hydrological patches, including during periods of extreme dry or wet conditions.…”
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An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy by Keke Ma, Jie Wang, Min Jiang, Juanhua He, Fangyang Li, Dan Lu, Chao Su, Yan Chai, Wenjing Jin, Yu Chen, Catherine W.H. Zhang, Xiaopeng Ma, Hui Tan, George F. Gao, Shuguang Tan

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Self-silencing adenovirus enables precise infectious titration of recombinant adeno-associated viral vectors by Chloé Fustinoni, Xiang Liu, Zhi Chen, Ryan Cawood, Weimin Valenti, Maria I. Patrício, Weiheng Su

“…The industry standard method for rAAV titration is the 50% tissue culture infectious dose (TCID50) assay using HeLa-based cell lines that stably encode the rep and cap genes from AAV serotype 2. Co-infection with wild-type (WT) adenoviruses provides the helper functions for expression of these genes, and the use of quantitative PCR (qPCR)/droplet digital PCR (ddPCR) serves as the endpoint method for the detection of infectious events. …”
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An integrated machine learning model of transcriptomic genes in multi-center chronic obstructive pulmonary disease reveals the causal role of TIMP4 in airway epithelial cell by Erkang Yi, Haiqing Li, Yu Liu, Qingyang Li, Chengshu Xie, Ruining Sun, Fan Wu, Zhishan Deng, Kunning Zhou, Hairong Wang, Xinru Ran, Yumin Zhou, Pixin Ran

“…Gene expression in specific cell types was analyzed, and Mendelian randomization was used to confirm associations between candidate genes and lung function/COPD. Preliminary in vitro functional validation was performed on prioritized core candidate genes. …”
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Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection. by Matthias Hoffmann, Nikos Pantazis, Genevieve E Martin, Stephen Hickling, Jacob Hurst, Jodi Meyerowitz, Christian B Willberg, Nicola Robinson, Helen Brown, Martin Fisher, Sabine Kinloch, Abdel Babiker, Jonathan Weber, Nneka Nwokolo, Julie Fox, Sarah Fidler, Rodney Phillips, John Frater, SPARTAC and CHERUB Investigators

“…Expression of PD-1, Tim-3, Lag-3 and CD38 on CD8 T cells from the closest pre-therapy time-point to seroconversion was measured by flow cytometry, and correlated with surrogate markers of HIV-1 disease (HIV-1 plasma viral load (pVL) and CD4 T cell count) and the trial endpoint (time to CD4 count <350 cells/μl or initiation of antiretroviral therapy). To explore the functional significance of these markers, co-expression of Eomes, T-bet and CD39 was assessed. …”
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