Seq2scFv: a toolkit for the comprehensive analysis of display libraries from long-read sequencing platforms by Marianne Bachmann Salvy, Luca Santuari, Emanuel Schmid-Siegert, Nikolaos Lykoskoufis, Ioannis Xenarios, Bulak Arpat

“…With its versatile and standalone functionality, we anticipate that the implementation of Seq2scFv tools in antibody discovery pipelines will efficiently expedite the full characterization of display libraries and potentially facilitate the identification of high-affinity antibody candidates.…”
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Optimal Design of Interior Permanent Magnet Synchronous Motor Considering Various Sources of Uncertainty by Giacomo Guidotti, Dario Barri, Federico Soresini, Massimiliano Gobbi

“…The method incorporates an innovative use of the neural network-based variance estimation (NNVE) technique to efficiently calculate the standard deviation of the objective functions. …”
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TheraVision: Engineering platform technology for the development of oncolytic viruses based on herpes simplex virus type 1 by Christina Funk, Nadja Uhlig, Zsolt Ruzsics, Florentin Baur, Matthias Peindl, Sarah Nietzer, Karina Epting, Gabriele Vacun, Gudrun Dandekar, Catherine Botteron, Christian Werno, Thomas Grunwald, Susanne M. Bailer

“…Viruses are able to efficiently penetrate cells, multiply, and eventually kill infected cells, release tumor antigens, and activate the immune system. …”
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La biodiversidad y los servicios ecosistémicos en sistemas agroecológicos. Una revisión by Wendy Mercedes Ramírez-Suárez, Jorge Carlos López-Chouza, María de los Ángeles Flores-Acosta, Saray Sánchez-Cárdenas, Pedro Lázaro Rodríguez-Morejón

“…There is a strong interrelationship between the functioning of biodiversity and the development of ecosystem processes that will subsequently form the basis of production, based on the richness and spatial and temporal variability of species, their performance in the complexity of ecosystems and the maintenance of ecosystem services at different scales.…”
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A transient homotypic interaction model for the influenza A virus NS1 protein effector domain. by Philip S Kerry, Juan Ayllon, Margaret A Taylor, Claudia Hass, Andrew Lewis, Adolfo García-Sastre, Richard E Randall, Benjamin G Hale, Rupert J Russell

“…While RBD dimerization seems functionally conserved, two possible apo ED dimers have been proposed (helix-helix and strand-strand). …”
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Changes in AXL and/or MITF melanoma subpopulations in patients receiving immunotherapy by M. Willemsen, J. Bulgarelli, S.K. Chauhan, R.R. Lereim, D. Angeli, G. Grisendi, G. Krebbers, I. Davidson, J.A. Kyte, M. Guidoboni, R.M. Luiten, W.J. Bakker

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A Robust Multi-Objective Evolutionary Framework for Artificial Island Construction Scheduling Under Dynamic Constraints by Tianju Zheng, Liping Sun, Mingwei Li, Guangyao Yuan, Shuqi Li

“…MACEMGA combines cooperative coevolution, adaptive dynamic weighting, dynamic penalty functions, and advanced genetic operators to navigate the solution space efficiently and identify Pareto optimal schedules. …”
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Nitrogen deposition favors later leaf senescence in woody species by Jian Wang, Xiaoyue Wang, Josep Peñuelas, Hao Hua, Chaoyang Wu

“…Changes in climate conditions and nitrogen deposition levels jointly controlled the direction of date of foliar senescence trends (advance or delay). The spatial variability of nitrogen deposition effects can be related to plant traits (e.g., nitrogen resorption and use efficiencies), climatic conditions, and soil properties. …”
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Ectopic expression of vaccinia virus E3 and K3 cannot rescue ectromelia virus replication in rabbit RK13 cells. by Erin S Hand, Sherry L Haller, Chen Peng, Stefan Rothenburg, Adam R Hersperger

“…In this study, we observed that ectromelia virus (ECTV) does not replicate efficiently in cultured rabbit RK13 cells. Conversely, vaccinia virus (VACV) replicates well in these cells. …”
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Importance of ice algae versus phytoplankton in the diet of megabenthic organisms under contrasting sea ice conditions (Canadian Arctic): a dual biochemical approach (SIA and HBIs) by Thibaud Combaz, Thibaud Combaz, Ursula Witte, Thomas A. Brown, Philippe Archambault

“…Overall, organisms responded rapidly and efficiently to this pulse of fresh organic matter but trends in resource utilisation (quality and quantity) were observed based on feeding strategy. …”
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ClimKern v1.2: a new Python package and kernel repository for calculating radiative feedbacks by T. P. Janoski, T. P. Janoski, T. P. Janoski, T. P. Janoski, T. P. Janoski, I. Mitevski, R. J. Kramer, M. Previdi, L. M. Polvani, L. M. Polvani, L. M. Polvani

“…The radiative kernel method is commonly used to efficiently compute individual climate feedbacks from climate model or reanalysis output. …”
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Tranexamic acid impairs plasmin generation on human mesenchymal stem cells and derived membrane microvesicles, halting pericellular proteolysis by Ramy Abou Rjeily, Christina Mrad, Fatiha Z. El-Ghazouani, Florence Toti, Audrey Cras, Audrey Cras, Eduardo Angles-Cano

“…Our findings provide the first demonstration that TXA efficiently inhibits MSC-driven plasmin generation by competitively blocking plasminogen binding to the uPA•uPAR complex at the cell plasma membrane.DiscussionWe propose that plasmin formation on MSCs may be involved in pathological processes such as endometrial hemorrhage (metrorrhagia and Post-Partum Hemorrhage), autoimmune and ischaemic diseases, as well as cancer. …”
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Phenotypic screen of early-developing larvae of the blood fluke, schistosoma mansoni, using RNA interference. by M M Mourão, Nathalie Dinguirard, Glória R Franco, Timothy P Yoshino

“…Although RNAi holds great promise as a functional genomics tool for larval schistosomes, our finding of potential off-target or nonspecific effects of some dsRNA treatments and variable efficiencies in specific gene knockdown indicate a critical need for gene-specific testing and optimization as an essential part of experimental design, execution and data interpretation.…”
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Unveiling Theranostics: Nanocomplex-Assisted Photodynamic Eradication of Aggressive Cancer Cells and Modulation of Tumor-Associated Macrophages by Butkute A, Kazlauske E, Mlynska A, Peciukaityte E, Karabanovas V, Rotomskis R, Steponkiene S

“…The nanocomplex accumulated efficiently and uniformly across all CRC cell lines, regardless of their aggressiveness or drug sensitivity. …”
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Neutralizing monoclonal antibodies protect against human adenovirus type 55 infection in transgenic mice and tree shrews by Xinglong Liu, Zhengfeng Li, Xiao Li, Xiaoyan Zhang, Yali Zheng, Wan Su, Ying Feng, Yutong Liu, Weixuan Wu, Xikui Sun, Nana Wang, Xianmiao Ye, Zhichao Zhou, Wenkuan Liu, Jun He, Wei Wang, Linbing Qu, Rong Zhou, Ling Chen, Liqiang Feng

“…These mAbs recognized the hyper-variable-region (HVR) 1, 2, or 7 of viral hexon protein, or the fibre knob. …”
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Spatial Differentiation and Correlation of Ecological Stoichiometric Characteristics of Cynodon dactylon and Soil in the Water-level Fluctuation Zone of the Three Gorges Reservoir... by XU Liwen, ZHANG Yuewei, JIAN Chen, ZHANG Yuanyuan, WANG Xiaofeng

“…However, the variability in C/N and C/P ratios in roots and stems were slightly stronger than that in leaves, suggesting that C. dactylon has evolved a strategy for maintaining stable physiological functions in leaves. 4) There were significant correlations of the nutrient contents between C. dactylon and soil, with the nitrogen supply of soil being the key factor influencing the variation of nutrient contents in C. dactylon. …”
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Hierarchical GraphCut Phase Unwrapping Based on Invariance of Diffeomorphisms Framework by Xiang Gao, Xinmu Wang, Zhou Zhao, Junqi Huang, Xianfeng David Gu

“…The resulting label maps are fused via majority voting to efficiently and robustly estimate the unwrapped phase count <inline-formula><tex-math notation="LaTeX">$k$</tex-math></inline-formula> at each pixel, using an odd number of votes to break ties. …”
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