Study on numerical simulation of rock breaking by PDC wear teeth cutting by Maosheng CAI, Hongbo WANG, Chunjiang ZHANG, Sai LI, Shuting CHENG

“…Considering the fluctuation of cutting efficiency and load, the front angle should be controlled at 15°−20° as far as possible, which is beneficial to prolong the service life of the cutting teeth. …”
Get full text

The agricultural plastic paradox: Feeding more, harming more? by Kai Wang, Xuejun Liu, David R. Chadwick, Changrong Yan, Michaela Reay, Tida Ge, Fan Ding, Jingkuan Wang, Ruimin Qi, Mouliang Xiao, Rui Jiang, Yanling Chen, Ji Ma, Charlotte Lloyd, Richard P. Evershed, Yongming Luo, Yongguan Zhu, Fusuo Zhang, Davey L. Jones

Get full text

Deep learning algorithm on H&E whole slide images to characterize TP53 alterations frequency and spatial distribution in breast cancer by Chiara Frascarelli, Konstantinos Venetis, Antonio Marra, Eltjona Mane, Mariia Ivanova, Giulia Cursano, Francesca Maria Porta, Alberto Concardi, Arnaud Gerard Michel Ceol, Annarosa Farina, Carmen Criscitiello, Giuseppe Curigliano, Elena Guerini-Rocco, Nicola Fusco

“…The DL model exhibited high accuracy in tissue quantification and TP53 status prediction, outperforming traditional methods in terms of precision and efficiency. DL-based approaches offer significant promise for enhancing biomarker testing and precision oncology by reducing intra- and inter-observer variability, but further validation is required to optimize their integration into real-world clinical workflows. …”
Get full text

Light-activated decellularized extracellular matrix-based bioinks for enhanced mechanical integrity by Minji Kim, Dayoon Kang, Hohyeon Han, Jinah Jang

“…The advent of photocrosslinking technologies marks a paradigm shift, with light-activated functional groups such as methacrylates, thiol-enes, and phenols substantially improving the gelation efficiency, mechanical properties, and spatial fidelity of the printed constructs. …”
Get full text

Mobile machine design through dynamic load simulation on their drive units by S. A. Partko, L. M. Groshev, A. N. Sirotenko

“…The root cause for the occurrence of vibration effects is the profile irregularity of the mobile machine path, and the variability of physicomechanical characteristics of the soil. …”
Get full text

Comparison of river and drinking water quality of infiltration intakes based on statistical colour data by Yalaletdinova Alina, Malkova Maria, Vozhdaeva Margarita, Serebryakov Pavel, Kantor Evgeny

“…The construction of cross-correlation functions on the average monthly values of the indicator for the whole observation period and in the model year showed that there is a relationship between the colour of river water and drinking water. …”
Get full text

Intelligent Field Sensor Station for Monitoring Agrophysical Parameters and Phenotyping in Precision Agriculture System by S. A. Vasilyev, S. Ye. Limonov, S. A. Mishin

“…(Results and discussion) The intelligent field sensor station successfully demonstrated its efficiency, confirming both its functionality and reliability in simultaneous data collection. …”
Get full text

Observational partitioning of water and CO₂ fluxes at National Ecological Observatory Network (NEON) sites: a 5-year dataset of soil and plant components for spatial... by E. Zahn, E. Bou-Zeid

“…<p>Long-term time series of transpiration, evaporation, plant net photosynthesis, and soil respiration are essential for addressing numerous research questions related to ecosystem functioning. However, quantifying these fluxes is challenging due to the lack of reliable and direct measurement techniques, which has left gaps in the understanding of their temporal cycles and spatial variability. …”
Get full text

Artificial intelligence Defect Detection Robustness inReal-time Non-Destructive Testing of Metal Surfaces by Chaoyu Dong, Jovian Sanjaya Putra, Andrew A. Malcolm

“…Their structural integrity, durability, and functionality depend heavily on their quality, making surface inspection a vital process. …”
Get full text

Genome-wide association study of blood vitamin D metabolites and bone remodelling markers in pigs by Dipanwita Paul, Michael Oster, Siriluck Ponsuksili, Klaus Wimmers, Henry Reyer

“…Hence, mineral utilization efficiency might be indirectly improved which remains to be empirically demonstrated through further research.…”
Get full text

Phenotypic screen of early-developing larvae of the blood fluke, schistosoma mansoni, using RNA interference. by M M Mourão, Nathalie Dinguirard, Glória R Franco, Timothy P Yoshino

“…Although RNAi holds great promise as a functional genomics tool for larval schistosomes, our finding of potential off-target or nonspecific effects of some dsRNA treatments and variable efficiencies in specific gene knockdown indicate a critical need for gene-specific testing and optimization as an essential part of experimental design, execution and data interpretation.…”
Get full text

Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…[xv] The center they present to and the variable evaluative criteria the center uses may discount an individual’s claim to a fair opportunity to access a scarce resource. …”
Get full text

Development of smart samplers and their comparison to dried serum spots for the analysis of growth hormone releasing hormone analogs using LCHRMS/MS by Christina Johannsen, Anna Kha Tu Nguyen, Sasha Shabani, Inger Oulie, Siri Dørum, Yvette Dehnes, Leon Reubsaet, Trine Grønhaug Halvorsen

“…Smart samplers combine sampling and sample preparation in one tool; in this study smart samplers were developed using divinyl sulfone functionalized paper to immobilize antibodies for selective analyte capture. …”
Get full text

Systematic Evaluation of Isolation Techniques and Freeze‐Thaw Effects on Plasma Extracellular Vesicle Heterogeneity and Subpopulation Profiling by Xueqi Li, Xiangyu Li, Lingjun Tong, Liqiao Hu, Yanfen Hong, Ruoyu Zhou, Zonghong Li, Ming Dong, Junjie Hou, Tao Xu, Wen Zhong

“…However, standardizing blood‐derived EV isolation remains challenging due to the heterogeneity of EV populations and variability among isolation techniques. In this study, we systematically evaluated three distinct EV isolation methods, including asymmetrical flow field‐flow fractionation (AF4), size‐exclusion chromatography (SEC) and automated centrifugal microfluidic disc system combined with functionalized membranes (Exo‐CMDS), to compare their efficiency in isolating EVs from both freshly frozen and freeze‐thawed plasma samples. …”
Get full text

Tranexamic acid impairs plasmin generation on human mesenchymal stem cells and derived membrane microvesicles, halting pericellular proteolysis by Ramy Abou Rjeily, Christina Mrad, Fatiha Z. El-Ghazouani, Florence Toti, Audrey Cras, Audrey Cras, Eduardo Angles-Cano

“…Cells thus obtained were seeded in multi-well plates and treated with different concentrations of plasminogen and pro-urokinase in the presence or absence of variable amounts of tranexamic acid. We measured MVs formation and phenotypical changes occurring on MSCs. …”
Get full text

Reference Intervals for Echocardiography Parameters of Children Living in the Arkhangelsk Region and a Digital Application for Their Assessment by Aleksey A Karyakin, Igor’ S. Chub, Ol’ga E. Karyakina, Andrey M. Grjibovski, Aleksey V. Artemov, Ul’yana R. Zakharchenko

“…Reference intervals of echocardiography parameters were determined using body surface area as the dependent variable. The values were automatically calculated in our digital application that allows one to increase the accuracy and efficiency of interpretation of cardiac ultrasound parameters. …”
Get full text

Structural network topologies are associated with deep brain stimulation outcomes in Meige syndrome by Bin Liu, Zhiqi Mao, Xinyuan Yan, Hang Yang, Junpeng Xu, Zhebin Feng, Yanyang Zhang, Xinguang Yu

“…However, the DBS efficacy varies across MS patients and the factors contributing to the variable responses remain enigmatic. We aim to explain the difference in DBS efficacy from a network perspective. …”
Get full text

Optimized Dual-Battery System with Intelligent Auto-Switching for Reliable Soil Nutrient Monitoring in Remote IoT Applications by Doan Perdana, Pascal Lorenz, Bagus Aditya

“…Implementing the DLB–PAO algorithm elevates the average reliability to 91.7% over 120 h, whereas the DLB–GA algorithm achieves near-perfect reliability (99.9%) for over 170 h, exhibiting minimal variability (standard deviation: 0.9%). The integration of intelligent auto-switching mechanisms and metaheuristic optimisation algorithms demonstrates a marked enhancement in both reliability and energy efficiency for soil nutrient monitoring systems. …”
Get full text

Expanding a Health Technology Solution to Address Therapist Challenges in Implementing Homework With Adult Clients: Mixed Methods Study by Brian E Bunnell, Kaitlyn R Schuler, Julia Ivanova, Lea Flynn, Janelle F Barrera, Jasmine Niazi, Dylan Turner, Brandon M Welch

“… BackgroundHomework is implemented with variable effectiveness in real-world therapy settings, indicating a need for innovative solutions to homework challenges. …”
Get full text

Impact of IgG subclass on monoclonal antibody developability by Paul Cain, Lihua Huang, Yu Tang, Victor Anguiano, Yiqing Feng

“…We thus conducted a systematic study of 12 mAbs derived from three sets of unrelated variable regions, each cloned into IgG1, an IgG1 variant with diminished effector functions, IgG2, and a stabilized IgG4 variant with further reduced FcγR interaction, to evaluate the impact of IgG subclass on manufacturability and high concentration stability in a common formulation buffer matrix. …”
Get full text