Development and validation of an LC-MS/MS method for the simultaneous estimation of tadalafil and macitentan in rat plasma: Greenness assessment and design of experiment approach by Sravanthi Gandu, Kumaraswamy Gandla, Lalitha Repudi

“…Precision, expressed as %CV, was consistently below 15% for both intra- and inter-day variability. Drug recovery exceeded 98%, and stability tests demonstrated robustness under various conditions, with %CV values remaining under 15%. …”
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Predictors of failure in posterior short segment instrumentation for thoracolumbar burst fractures: a systematic review and meta-analysis by Parisa Javadnia, Yousef Ramazani, Mehdi Moradinazar, Nila Salimi, Soroush Moradi, Ehsan Alimohammadi

“…Both univariate and multivariate meta-regressions examined the influence of relevant variables. Funnel plots, along with Egger’s and Begg’s tests, assessed publication bias, with p-values below 0.05 indicating potential bias. …”
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HIS LEFT BUNDLE BRANCH BLOCK — PREVALENCE AND RISK FACTORS FOR ELECTRICAL AND MECHANICAL DYSSYNCHRONY by Z. I. Vozhdaeva, E. V. Sysuenkova, V. L. Glukhova, D. V. Duplyakov, S. M. Khokhlunov

“…The relation revealed, of AVD from the following variables: male gender, surface of mitral regurgitation (Smr), velocity of blood flow in early diastolic filling of the LV (E), time of isovolumic relaxation of LV. …”
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Automatic Blob Detection Method for Cancerous Lesions in Unsupervised Breast Histology Images by Vincent Majanga, Ernest Mnkandla, Zenghui Wang, Donatien Koulla Moulla

“…The early detection of cancerous lesions is a challenging task given the cancer biology and the variability in tissue characteristics, thus rendering medical image analysis tedious and time-inefficient. …”
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Multiobjective optimization of Murta (Ugni molinae Turcz) juice lactic acid fermentation with monocultures and cocultures of Lactobacillus acidophilus and Lactiplantibacillus plant... by C.J. Gomes-Lobo, R. Luna, A. Rodríguez-Machado, J.R. Pérez-Correa, W. Franco

“…Experimental validation confirmed that monocultures closely matched predicted optima, yielding higher TPC and LAB values than cocultures. While MOO and DF produced similar Pareto fronts, MOO required less computational time and generated more diverse solutions. …”
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Active Contours Connected Component Analysis Segmentation Method of Cancerous Lesions in Unsupervised Breast Histology Images by Vincent Majanga, Ernest Mnkandla, Zenghui Wang, Donatien Koulla Moulla

“…Nuclei segmentation remains a challenging problem due to cancer biology and the variability of tissue characteristics; thus, their detection in an image is a very tedious and time-consuming task. …”
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The Evolution of Match Running Performance in the Top Two Spanish Soccer Leagues: A Comparative Four-Season Study by Tomás García-Calvo, David Lobo-Triviño, Javier Raya-González, Roberto López del Campo, Ricardo Resta, Eduard Pons, José Carlos Ponce-Bordón

“…<b>Results</b>: The primary findings indicated significantly higher match running performance in First Division matches compared to Second Division matches across all variables (<i>p</i> < 0.001). Furthermore, match running performance significantly increased over the four seasons in both leagues, with notably higher values during the 2021/22 and 2022/23 seasons for all physical performance metrics (<i>p</i> < 0.001). …”
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Diagnostic Performance of a Novel Noninvasive Workup in the Setting of Dry Eye Disease by Luca Vigo, Marco Pellegrini, Federico Bernabei, Francesco Carones, Vincenzo Scorcia, Giuseppe Giannaccare

“…Continuous variables were compared between patients with DED and controls by using the Mann–Whitney U test. …”
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Under-nutrition and its associated factors among adult second-line antiretroviral treatment users in Northern Ethiopia by Seteamlak Adane Masresha, Atitegeb Abera Kidie, Getahun Fentaw Mulaw, Fentaw Wassie Feleke, Mesfin Wudu Kassaw, Tadesse Mamo Dejene, Aychew Kassie Gidafie, Fassikaw Kebede Bizuneh

“…Multiple imputation method was applied to manage variables having up to 25% missing values by using R-Version 3.6.2 software. …”
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Development of a cryptocurrency price prediction model: leveraging GRU and LSTM for Bitcoin, Litecoin and Ethereum by Ramneet Kaur, Mudita Uppal, Deepali Gupta, Sapna Juneja, Syed Yasser Arafat, Junaid Rashid, Jungeun Kim, Roobaea Alroobaea

“…Future studies should also consider additional variables, such as social media trends and trade volumes that may impact cryptocurrency pricing.…”
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Letter from editor by Carlos A. Vargas J.

“…Results of this study show how these maturity values indicate that the coal and shale extracts are marginally mature for hydrocarbon generation. …”
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When politics meets policy: a realist review of how political context shapes the impact of public health legal interventions by Yuri Lee, Jiwon Park

“…Political and social contexts are increasingly recognized as key determinants of such variability.ObjectiveThis study aimed to examine how and why public health legal interventions succeed or fail under different political circumstances, drawing on a Realist Review approach. …”
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A mathematical phase field model predicts superparamagnetic nanoparticle accelerated fusion of HeLa spheroids for field guided biofabrication by Cristian F. Rodríguez, Valentina Quezada, Paula Guzmán-Sastoque, Juan Camilo Orozco, Luis H. Reyes, Johann F. Osma, Carolina Muñoz-Camargo, Juan C. Cruz

“…Increased system complexity introduced slightly higher error variability, but the model maintained robust predictive capabilities. …”
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Assessment of ESR1, PGR, ERBB2, and MKI67 mRNA in Hormone Receptor‐Positive Early Breast Cancer: A Cross‐Sectional Study by Hamid Rezvani, Shayan Forghani, Arman Forghani, Fatemeh Mahdavi Sabet, Atieh Akbari, Sanaz Tabarestani

“…This study aimed to assess the concordance between real‐time PCR and IHC results. Methods In this study, we analyzed 178 early‐stage hormone receptor‐positive breast tumors. …”
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Effect of Rhythmic Auditory Stimulation and Nordic Walking on Arm Swing and Spatiotemporal Gait Parameters in Parkinson’s Patients: A Quasi-experimental Study by Nivruti Khanna, Kalidasan Varathan

“…Results: After analysing the data using an Independent t-test, the results for Kinovea post forward swing and Kinovea post backward swing for both the right and left sides revealed a substantial difference between the two groups. Additional variables such as Timed Up and Go (TUG), cadence, stride length and FGA indicated significant differences between groups, with p-values of 0.01, 0.03, 0.009 and 0.02, respectively. …”
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Selection of differentiated maturity genotypes of Coffea canephora by João Felipe de Brites Senra, Viviane Alexia Correia Silva, Marlon Dutra Degli Esposti, Adésio Ferreira, Idalina Sturião Milheiros, Isabela Bolari Ramos, Rosana Gomes de Oliveira, Lorran Marques Benevenute

“…The data were analyzed using the REML/BLUP methodology with the Selegen software, where the variance components and genetic values were estimated. The selection was performed using the Mulamba-Rank index. …”
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Global change drives potential niche contraction and range shift of globally threatened African vulture by Gemechis B. Mosisa, Nega Tassie, Fatuma Yesuf

“…Among the 13 bioclimatic and anthropogenic variables included in the model, four (isothermality, cropland expansion, anthropogenic biomes, and urban expansion (in order of importance)) emerged as the most influential drivers of Ruppell's vulture regional distribution. …”
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Regional features of hospitalizations and outpatient medical care among adults with established hypertension by R. N. Shepel, M. I. Kolesnokova, V. P. Lusnikov, A. V. Kontsevaya, O. M. Drapkina

“…The ratio values ranged from 1,2 in the Nizhny Novgorod region to 12,26 in the Republic of Dagestan.Conclusion. …”
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Management of Psychosis and Schizophrenia by Primary Care GPs: A Cross-Sectional Study in Spain by Jesús Sepúlveda-Muñoz, Casta Quemada González, María M. Hurtado Lara, Ángel Manuel Gutiérrez García, Celia Martí-García, José María García-Herrera Pérez-Bryan, José Miguel Morales-Asencio

“…Mental health consultancy services are valued, but collaboration with these services needs improvement. …”
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Rethinking Conservation and Restoration Strategies of Endangered and Key Medicinal Clavicarpa Plants in Yunnan‐Kweichow Plateau's Karst Areas Under Climate Change by Chao Luo, Baiyang He, Yulu Wu, Yuteng Xue, Huang Deng, Shanman Li, Xianghong Dong, Litang Lu

“…ABSTRACT The Clavicarpa species, valued for their pharmaceutical, ornamental, and economic importance, exhibit notable rarity and endemism in the Karst areas of the Yunnan‐Kweichow Plateau in China. …”
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