Formulation development and evaluation, in silico PBPK modeling and in vivo pharmacodynamic studies of clozapine matrix type transdermal patches by Abdul Qadir, Syed Umer Jan, Muhammad Harris Shoaib, Muhammad Sikandar, Rabia Ismail Yousuf, Fatima Ramzan Ali, Fahad Siddiqui, Abdul Jabbar Magsi, Ghulam Mustafa, Muhammad Talha Saleem, Shafi Mohammad, Mohammad Younis, Muhammad Arsalan

“…Abstract Clozapine is a potent serotonin receptor antagonist and commonly used for the treatment of Schizophrenia. The study aimed to develop and optimize the transdermal matrix patch of clozapine. …”
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Severity Degrees of Syntropic Stable Arterial Hypotension in the Cirrhotic Patients and Their Dependence on the Daily Blood Pressure Monitoring and Liver Damage Class by C.G. Child... by Abrahamovych M., Farmaha M., Abrahamovych O., Fayura O., Drobinska N.

“…The disorders of the circadian rhythm and blood pressure variability were also found in the patients of the experimental group. …”
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Factors associated with uptake and acceptability of cervical cancer screening among female sex workers in Northeastern Uganda: A cross-sectional study. by Ronald Opito, Emmanuel Tiyo Ayikobua, Hellen Akurut, Susan Alwedo, Saadick Mugerwa Ssentongo, Walter Drake Erabu, Lazarus Oucul, Musa Kirya, Lameck Lumu Bukenya, Elly Ekwamu, Abraham Ignatius Oluka, Samuel Kabwigu, Emmanuel Othieno, Amos Deogratius Mwaka

“…Modified Poisson regression model with a robust variance estimator was used to determine association between the outcome variables and selected independent variables including demographic characteristics. …”
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Growth Differentiation Factor 15 Predicts Cardiovascular Events in Peripheral Artery Disease by Ben Li, Farah Shaikh, Houssam Younes, Batool Abuhalimeh, Abdelrahman Zamzam, Rawand Abdin, Mohammad Qadura

“…The model’s primary evaluation metric was the F1 score, a validated measurement of the harmonic mean of the precision and recall values of the prediction model. Secondary model performance metrics included precision, recall, positive likelihood ratio (LR+), and negative likelihood ratio (LR-). …”
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Optimal surgery sequence in the treatment of degenerative hip-spine syndrome: a propensity score-based inverse probability of treatment weighting analysis by Yiming Fan, Yi Huang, Tianhao Wang, Qi Wang, Han yu, Chao Xue, Guoquan Zheng, Yan Wang

“…After conducting IPTW, all baseline data variables had P-values greater than 0.50, indicating that the baseline characteristics between the two groups were comparable. …”
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Development and Validation of a Dynamic Real-Time Risk Prediction Model for Intensive Care Units Patients Based on Longitudinal Irregular Data: Multicenter Retrospective Study by Zhuo Zheng, Jiawei Luo, Yingchao Zhu, Lei Du, Lan Lan, Xiaobo Zhou, Xiaoyan Yang, Shixin Huang

“…However, existing models are often limited by their inability to handle irregular sampling and missing values, and many lack rigorous external validation across institutions. …”
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Estudio piloto sobre las respuestas motrices y psicológicas de jugadores y entrenadores durante la competición a la propuesta de reglas para mini-balonmano playa (Pilot study on p... by Juan Antonio Sánchez-Sáez, Juan Pablo Morillo-Baro, José Miguel Sánchez Malia, Daniel Lara Cobos, Jose Luis Arias-Estero

“…Cuantitativamente, las variables dependientes fueron motrices y psicológicas. …”
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Long‐Term Impact of Physical Activity on Mortality in Adults With Multimorbidity: A 12‐Year Cohort Longitudinal Study From the Survey on Health, Ageing and Retirement in Europe by Nicola Veronese, Francesco Saverio Ragusa, André Hajek, Brendon Stubbs, Lee Smith, Mario Barbagallo, Ligia Juliana Dominguez, Luigi Fontana, Pinar Soysal, Shaun Sabico, Nasser M. Al‐Daghri

“…Cox's regression analysis, adjusted for potential confounders, was used to assess the association between PA level and mortality. p‐values were calculated using the Jonckheere–Terpstra test for continuous variables and the Mantel–Haenszel Chi‐square test for categorical variables, stratified by PA level. …”
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Measuring and estimation of suspended sediment variation using sediment rating curve approach in Mereg River by Sohila Aghabeigi Amin, Heidar Mirzaei

“…Therefore, recognizing the variability of rivers is essential to manage water resources and environmental issues. …”
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Assessment of satisfaction level of community-based health insurance and associated factors among households in Akaki Kality subcity, Addis Ababa, Ethiopia: a cross-sectional study... by Kedir Hussein Abegaz, Trhas Tadesse Berhe, Alachew Wondie Tamrat, Habtewold Mulat, Natinael Muluneh, Getachew Weldeyohanes Tedla

“…Bivariate logistic regression was applied to assess the association with p values <0.25. Those variables which showed significant association were included in multivariate analysis. …”
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Exploring Enamel Hypoplasia and Metabolic Impacts on Dental Structures in Chronic Kidney Disease: A Systematic Review and Meta-Analysis by Sadaf Ambreen, Amna Farrukh, Muhammad Mustafa, Ashar Hussain, Irum Naz, Fatima Ali

“…The inclusion criteria included human subjects with CKD who were reporting measurable values of enamel hypoplasia, tooth wear, or biomarkers in saliva. …”
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New equations to estimate 24-h urinary creatinine excretion by Gabriela Callo-Quinte, Jorge Leonid Aching Samatelo, Romildo Luiz Monteiro Andrade, Jose Geraldo Mill

“…Abstract We aimed to develop and validate prediction equations to estimate the 24-h creatinine excretion in Brazilian adults. …”
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Relationship between Levels of Interleukin-6 and Tumour Necrosis Factor Alpha and Khorana Scores of Newly Diagnosed Ambulatory Cancer Patients by Angela Ogechukwu Ugwu, Sunday Ocheni, Emmanuel Onyebuchi Ugwu, Peter Chienye Ekwueme, Ifeoma Clara Ajuba, Augustine Nwakuche Duru, Chiemelie Raluchukwu Onwasigwe, Umar Garba Kangiwa, Chukwudi Simon Anigbo

“…Conclusion: Inflammatory biomarkers are elevated in ambulatory CNACP and their values are significantly related with Khorana scores. …”
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Evaluating handgrip strength and functional tests as indicators of gait speed in older females by Valentina Muollo, Samuel D’Emanuele, Laura Ghiotto, Doriana Rudi, Federico Schena, Cantor Tarperi

“…This cross-sectional study aims to investigate the associations between HGS and common functional tests and to determine the optimal cut-off values for these tests in assessing GS.Methods142 community-dwelling older females aged 60–80 years old (mean age: 75 ± 6 years) were evaluated with HGS, the 30-second arm curl (30 s-AC), 30-second chair stand (30 s-CS), the Short Physical Performance Battery (SPPB), and the 8-foot Up & Go (8-UG) test. …”
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Calcium metabolism, arterial stiffness and 24-hour blood pressure monitoring data in postmenopausal women with magnesium deficiency, hypertension, and heart failure by D. E. Maylyan, V. V. Kolomiets

“…Aim. To assess the calcium metabolism, arterial stiffness and 24-hour blood pressure (BP) monitoring data in postmenopausal women with magnesium deficiency, hypertension, and heart failure with preserved ejection fraction (HFpEF)Material and methods. …”
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Sedative protocols for the restraint of coatis (Nasua nasua) for management and monitoring by M. Marangoni, V. E. Mamgue, A. G. Felichak, M. T. Lemes, A. L. R. Marques, M. S. P. Bellucci, C. M. Parola, P. H. Braz

“…In this context, ensuring an effective sedation method is critical. This study aimed to compare the effects of two sedation protocols (dexmedetomidine-ketamine and tiletamine-zolazepam) in coatis, assessing their efficacy and safety. …”
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Análise do desempenho reprodutivo e do uso de energia elétrica em instalações climatizadas de cachaços Analysis of reproductive performance and use of electrical energy in the accl... by Luiz A. Rossi, Nina M. Velloso, Marcelo T. de Lima, Juliana Sarubbi, Luciano H. S. Vieira

“…The results showed that animals in Group A remained in a comfortable environmental conditions though there was no improvement in the mean values of seminal volume and sperm concentration. …”
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Assessment of right ventricular endocardial fibroelastosis in fetuses with critical pulmonary stenosis and pulmonary atresia with intact ventricular septum by Yue Wang, Gang Luo, Yi Sun, Taotao Chen, Silin Pan

“…The associations among EFE severity, anatomic variables, and late-gestational circulatory outcomes were analysed.ResultsEighty-one patients with RV EFE were identified. …”
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Predictors of failure in posterior short segment instrumentation for thoracolumbar burst fractures: a systematic review and meta-analysis by Parisa Javadnia, Yousef Ramazani, Mehdi Moradinazar, Nila Salimi, Soroush Moradi, Ehsan Alimohammadi

“…Both univariate and multivariate meta-regressions examined the influence of relevant variables. Funnel plots, along with Egger’s and Begg’s tests, assessed publication bias, with p-values below 0.05 indicating potential bias. …”
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Construction and validation of a chemokine-related gene signature associated with prognosis, clinical significance, and immune microenvironment characteristics in cervical cancer by Tianjiao Huang, Renshuang Cao, Cong Gao, Jie Luo, Zhiyu Zhou, Kun Ma

“…Multivariate Cox regression confirmed the signature’s independence from conventional clinical variables (P < 0.05). The nomogram demonstrated robust predictive accuracy, with 1-, 3-, and 5-year survival AUC values of 0.805, 0.729, and 0.710, respectively. …”
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