Polygenic Risk Scores for Personalized Cardiovascular Pharmacogenomics―A Scoping Review by Aaryan Dwivedi, Jobanjit S. Phulka, Peyman Namdarimoghaddam, Zachary Laksman

“…Our findings showed that PRS is most robustly validated in lipid-lowering therapies, especially statins, where studies reported that individuals with higher PRSs derived the greatest reduction in lipids while on statins. …”
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An Interpretable Model for Salinity Inversion Assessment of the South Bank of the Yellow River Based on Optuna Hyperparameter Optimization and XGBoost by Xia Liu, Yu Hu, Xiang Li, Ruiqi Du, Youzhen Xiang, Fucang Zhang

“…Correlation analysis and continuous variable projection were employed to identify key inversion factors. …”
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Risk Stratification after Biochemical Failure following Curative Treatment of Locally Advanced Prostate Cancer: Data from the TROG 96.01 Trial by Allison Steigler, James W. Denham, David S. Lamb, Nigel A. Spry, David Joseph, John Matthews, Chris Atkinson, Sandra Turner, John North, David Christie, Keen-Hun Tai, Chris Wynne

“…Survival following biochemical failure is highly variable. Using a randomized trial dataset, we sought to define a risk stratification scheme in men with locally advanced prostate cancer (LAPC). …”
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Characterization of Virulence Factors, Cellular Stress Response, and Antifungal Susceptibility Testing of <i>Trichosporon</i> spp. Isolated from Northeast Brazilian Patients by Márcia Gabriele de Souza Jimenez, Matheus Firmino de Azevedo, Elaine Cristina Francisco, Ana Maria de Andrade Oliveira Boczar, Ana Carolina Barbosa Padovan, Eveline Pipolo Milan, Walicyranison Plinio da Silva Rocha, Guilherme Maranhão Chaves

“…The antifungal susceptibility profiling was determined. The most prevalent strains belonged to the recently described species <i>T. austroamericanum</i>, with 17 isolates. …”
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Summary measures in non-inferiority clinical trials with a time-to-event outcome: an empirical comparison of power by S. D. Lana Broer, Ian R. White, Tim P. Morris, Isabelle R. Weir, Marta Fiocco, Matteo Quartagno

“…Sub-group analyses consistently showed similar results. Results were more variable when converting margins under an exponential distribution, highlighting the importance of correct margin conversion. …”
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The current status of nano-hydrogel preparations for osteochondral repair: Systematic Review by Abebe Feyissa Amhare, Abebe Feyissa Amhare, Lichun Qiao, Huan Deng, Jinyan Lin, Jun Wang, Wei Wang, Jing Han

“…Studies varied in scaffold design, bioactive integration, and fabrication techniques. Most nano-hydrogels demonstrated high biocompatibility, tunable degradation, and enhanced tissue integration. …”
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Diagnostic Accuracy of Pre-Biopsy MRI and CT Features for Predicting Vertebral Biopsy Yield in Suspected Vertebral Discitis Osteomyelitis: A Retrospective Single-Center Study by Amirmasoud Negarestani, Andrew Pasion, Caleb Bhatnagar, Zuhaib Khokhar, Ashima Kundu, Samantha Diulus, Jorge P. Parada, Emad Allam

“…However, biopsy yields are variable, and guidance on patient selection remains limited. …”
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Efficacy of an acoustic hailing device as an avian dispersal tool by Peter E. Schlichting, Amanda E. Holland, James C. Beasley, Albert L. Bryan, Robert A. Kennamer, Travis L. DeVault, Bradley F. Blackwell, Olin E. Rhodes Jr.

“…Our study design included experimental trials with timed‐interval counts of birds directly before and after AHD treatment. For most species, counts of birds associated with treatment periods (use of AHD) and control periods (no use of AHD) occurred on different days. …”
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<i>Streptococcus agalactiae</i> Infection in Wild Trahira (<i>Hoplias malabaricus</i>) and Farmed Arapaima (<i>Arapaima gigas</i>) in Brazil: An Interspecies Transmission in Aquati... by Carlos Augusto Gomes Leal, Rafael Gariglio Clark Xavier, Guilherme Alves de Queiroz, Tarcísio Martins França Silva, Júnia Pacheco Teixeira, Flávia Figueira Aburjaile, Guilherme Campos Tavares

“…Since floating cages are one of the most common culture systems used in the country, the close contact between farmed tilapia and native fish species presents a risk concerning the transmission of this pathogen. …”
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Comparative analysis of key aroma compounds in air-frying roasted pork from five species by Lin Li, Pingping Huang, Rujie Yang, Jingyu Li, Yuping Zhang, Junke Li, Jianjun Li, Jianmei Zhang, Nigel P. Brunton, Huan Liu, Xiangru Wei

“…Among the species, Tibetan and Min pigs were found to be the most suitable for roasting, with Min pigs showing particular promise.…”
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Patient Satisfaction Following Top Surgery: A RealSelf Analysis Using Advanced Natural Language Processing by Leonardo Alaniz, MD, MBA, Avril Stulginski, BS, Jenny Ventura, BS, Arman Ghafari, BS, Hoyune Esther Cho, MD, MS, Medha Vallurupalli, BA, Justin Cordero, BS, Sierra Willens, BS, Jagmeet Arora, BS, Cathy J. Tang, MD, MS

“…Outcomes are highly variable and operator-dependent, with limited research evaluating them from the patient’s perspective. …”
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Regulatory mechanism and prognostic value of sex hormone pathways connected with metabolism and immune signaling in clear cell renal cell carcinoma by Xinyu Geng, Jiahao Shan, Yu Dai, Ziwei Liu, Simin Min, Shuo Zhao, Zhengyuan Zhang, Kai Shi, Duobing Zhang, Tuo Ji, Baoyuan Chang

“…Abstract Clear cell renal cell carcinoma (ccRCC) represents a major subtype of kidney cancer with variable prognosis. A comprehensive understanding of sex hormone-related pathways could potentially refine the prediction of patient outcomes in ccRCC. …”
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Mathematical model of on-demand route formation for public transport based on individual passenger requests in low-density population area by Svetlana S. Titova, Andrey V. Ostroukh

“…Various route optimization algorithms were investigated, and the most suitable method was selected for solving the stated problem. …”
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Impact of SARS-CoV-2 pandemic on sexually transmitted infections and treatment outcomes at a healthcare facility in Ile-Ife, Nigeria by A. Ajani, F. Olanrewaju, M. Oripelaye, A. Enitan, O. Olasode

“…OBJECTIVE: The SARS-CoV-2 pandemic had a variable impact on sexually transmitted infections (STIs) in different regions of the world. …”
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Modeling the compressive strength of concrete at different curing regimes using machine learning by Kennedy C. Onyelowe, Ahmed M. Ebid, Rosa Belén Ramos Jiménez, Angel Geovanny Lozano Guamán, Diego Ramiro Ñacato Estrella, Juan Carlos Cayán Martínez, Eduardo Francisco García Cabezas, Paul Awoyera

“…The relative importance values for each input parameter were studied.The results indicated that (Age) has the most influence than the regular concrete components; C, W, FAg, CAg in the mixes then the additives; FA,mSi, nAl, nSi, and PL. …”
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Cardiopulmonary resuscitation in obese patients: A scoping review by Julie Considine, Keith Couper, Robert Greif, Gene Yong-Kwang Ong, Michael A. Smyth, Kee Chong Ng, Tracy Kidd, Theresa Mariero Olasveengen, Janet Bray

“…In adults there were variable results in neurological outcome, survival to hospital discharge, longer term survival (months to years), and ROSC. …”
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Status and perceptions of ChatGPT utilization among medical students: a survey-based study by Na Hu, Xiao Qin Jiang, Yi Da Wang, Yan Ming Kang, Zhen Xia, Hao Hui Chen, Sai Nan Duan, Dong Xu Chen

“…Conclusion Our research showed that while most medical students perceived ChatGPT as a valuable tool for academic study and research, they remained cautious about its potential risks, particularly regarding misinformation and plagiarism concerns. …”
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Widespread 3′UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites by Nejc Haberman, Holly Digby, Rupert Faraway, Rebecca Cheung, Anob M. Chakrabarti, Andrew M. Jobbins, Callum Parr, Kayoko Yasuzawa, Takeya Kasukawa, Chi Wai Yip, Masaki Kato, Hazuki Takahashi, Piero Carninci, Santiago Vernia, Jernej Ule, Christopher R. Sibley, Aida Martinez-Sanchez, Boris Lenhard

“…High-resolution imaging and long-read sequencing analysis validate several 3′UTR-derived RNAs, showcase their variable abundance and show that they may not co-localise with the parental mRNAs. …”
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Digital Image Processing Applied in the Deformation Analysis of Hip Prosthesis: Multivariate Regression Analysis by Jorge Ramos-Frutos, Israel Miguel-Andres, Diego Oliva, Marco Perez-Cisneros, Teresa Alonso-Rasgado, Colin G. Bailey, Jose Francisco del Valle-Mojica

“…Total Hip Arthroplasty (THA) is one of the most performed surgical procedures to treat osteoarthritis of the hip joint or other skeletal disorders, such as Developmental Dysplasia of the Hip (DDH) or malformations. …”
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Children with chronic-refractory autoimmune cytopenias: a single center experience by Tuba Hilkay Karapınar, Ersin Töret, Sultan Aydın Köker, Erkin Serdaroğlu, Salih Gözmen, Ferah Genel, Yılmaz Ay, Nesrin Gülez, Yeşim Oymak, Ersin Durgun, Canan Vergin

“…A total of 13 patients (56.5%) had single-lineage and 10 (46.5%) had multilineage cytopenias. The most frequent single-lineage cytopenia was thrombocytopenia, followed by anemia. …”
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