Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition by Mie K. Jakobsen, Sofie Traynor, Aaraby Y. Nielsen, Christina Dahl, Mette Staehr, Simon T. Jakobsen, Maria S. Madsen, Rasmus Siersbaek, Mikkel G. Terp, Josefine B. Jensen, Christina B. Pedersen, Anup Shrestha, Jonathan R. Brewer, Pascal H. G. Duijf, Odd L. Gammelgaard, Henrik J. Ditzel, Alexei F. Kirkin, Per Guldberg, Morten F. Gjerstorff

“…Results We show that breast cancer tumors and cell cultures exhibit a highly heterogenous response to DNA methyltransferase inhibitors, persisting even under high drug concentrations and efficient DNA methyltransferase depletion. The observed variability in response to DNA methyltransferase inhibitors was independent of cancer-associated aberrations and clonal genetic diversity. …”
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Evaluation of the efficacy of hydrated sodium calcium aluminosilicate at mitigating the negative impact of aflatoxicosis on nutrient digestibility and other production- and health-... by Ahmed Ali Saleh, Rashed A. Alhotan, Mohammed A.A. Al-Badwi, Elsayed Osman Hussein, Livio Galosi, Giuseppe Crescenzo, Mahmoud Alagawany, Walied Abdo, Sara Mahmoud Omar, Claudia Zizzadoro

“…Importantly, not all types of aluminosilicates have the same decontaminating efficiency; thus, a full characterization of the protective properties of each single material would assist in selecting the most appropriate binder. …”
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AngleCam: Predicting the temporal variation of leaf angle distributions from image series with deep learning by Teja Kattenborn, Ronny Richter, Claudia Guimarães‐Steinicke, Hannes Feilhauer, Christian Wirth

“…The plausibility of the predicted leaf angle time series was underlined by its close relationship with environmental variables related to transpiration. The evaluations confirm that AngleCam is a robust and efficient method to track leaf angles under field conditions. …”
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A differential diagnostic model based on immunological evaluation and routine laboratory tests: distinguishing multiple myeloma from other disorders with aberrant immunoglobulin el... by Manning Li, Sixun Jia, Han Wu, Chunyi Shou, Xiaolu Song, Ye Peng, Huafang Wang, Ying Wang, Xiangmin Tong, Yirui Chen

“…Laboratory indicators, including complete blood count, biochemistry, coagulation function, and immunoglobulin markers, were collected. …”
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New Patient PROMIS Scores of Patients Presenting with Low Back Pain Predict Time to Elective Spine Surgery by Justin E. Kung, Chase Gauthier, Yianni Bakaes, Michael Spitnale, Richard A. Bidwell, David G. Edelman, Heidi C. Ventresca, J. Benjamin Jackson, Shari Cui, Gregory Grabowski

“…A chart review was conducted to collect sociodemographic variables, clinic visit details, and PROMIS domain scores (PF [Physical Function], PI [Pain Interference], Depression, and Global Health―Physical and Global Health―Mental). …”
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Optimizing the Construction Supply Chain Network Considering the Flow of Materials, Equipment, Manpower, Drawings and Technical Documents by Seyed Saeid Helli, Hadi Mokhtari, Saeed Dehnavi

“…All indices, parameters, decision variables, objective functions and constraints have been introduced and presented in the proposed model. …”
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‘‘Practices and factors affecting on-site medical equipment maintenance at Wau Teaching Hospital, South Sudan’’ by Natale Massimino Ucin, Manassé Nimpagaritse, Shital Mahindra Maru, Mulatedzi Makhado, Shiferaw Mitiku Tebeka

“…Abstract Background of the study Along with developments in the clinical domain, medical equipment is becoming more sophisticated, and it needs to function at peak efficiency. In this case, hospitals should priorities the prompt and effective maintenance of life-saving equipment. …”
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Effect of Central Motor and Neuromuscular Impairments on Front Crawl Body Roll Characteristics of Para Swimmers by Yu-Hsien Lee, Dawn Nicola O’Dowd, Luke Hogarth, Brendan Burkett, Carl Payton

“…CMNI swimmers were divided into three upper-limb [mild (n = 9), moderate (n = 9), severe (n = 9)] and three lower-limb function subgroups [bilateral (n = 2), unilateral (n = 6), without kick (n = 19)] based on their Froude efficiency (a measure of how effectively upper limbs contribute to propulsion) and the number of lower limbs actively kicking during trials, respectively. …”
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Immunological Avalanches in Renal Immune Diseases by Davide Viggiano, Pietro Iulianiello, Antonio Mancini, Candida Iacuzzo, Luca Apicella, Renata Angela Di Pietro, Sarah Hamzeh, Giovanna Cacciola, Eugenio Lippiello, Andrea Gigliotti, Carmine Secondulfo, Giancarlo Bilancio, Giuseppe Gigliotti

“…Additionally, biological age calculations provide valuable prognostic information, while proteinuria measurements offer efficient sampling for system dynamics assessment. …”
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Investigating the relationship between the monetary policy shock through the exchange rate channel on the management quality index in the banking system: by examining the productiv... by Farhad Sharifi Bagha, Jafar Haqiqat, Zahra Karimi Takanloo

“…During this time, the number of changes in the target variables by the variables themselves decreases and the changes in the variables caused by the shock of the exchange rate channel increase. …”
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Neural Network-Based Design of a Buck Zero-Voltage-Switching Quasi-Resonant DC–DC Converter by Nikolay Hinov, Bogdan Gilev

“…The converter is a piecewise linear system mathematically described by Kirchhoff’s laws and represented through switching functions. In this way, a mathematical model is used to generate data on the behavior of the state variables obtained under various design parameters. …”
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Clinical Outcome Prediction Model in Tetralogy of Fallot Without Pulmonary Valve Replacement Using Contraction Fraction From the SCOUT‐TOF Registry by Mark A. Fogel, Jennifer A. Faerber, Abdullah Mahmood, Keerthi Reddy, Xuemei Zhang, Elizabeth Goldmuntz, Matthew A. Harris, David Biko, Sara Partington, Stephen Paridon, Michael Mcbride, Victor Ferrari, Kevin K. Whitehead, Laura Mercer‐Rosa

“…Conclusions In rTOF, RV contraction fraction, a novel biomarker of ventricular efficiency, may be used to possibly improve risk stratification. …”
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Coordination of technology of railway operation of the Republic of Tajikistan and organization of railways in international traffic by P. N. Pulatov

“…Proposed classification of technological restrictions and controlled variables in the performance of transport takes into account methods for changing external conditions for the functioning of the railway landfill and methods for increasing internal efficiency of its operation. …”
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Machine learning-based model for acute asthma exacerbation detection using routine blood parameters by Youpeng Chen, Junquan Sun, Yabang Chen, Enzhong Li, Jiancai Lu, Huanhua Tang, Yifei Xie, Jiana Zhang, Lesi Peng, Haojie Wu, Zhangkai J. Cheng, Baoqing Sun

“…Background: Acute asthma exacerbations (AAEs) are a leading cause of asthma-related morbidity and mortality, especially in resource-limited settings where pulmonary function tests are unavailable or when patients are unable to cooperate with testing. …”
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Hemodynamic homeostasis disequilibrium in critical illness by Jie Wang, Xiaoting Wang, Dawei Liu, Hui Lian, Guangjian Wang, Zewen Tong, Qingyu Deng, Qirui Guo, Qian Zhang, Yangong Chao, Wanhong Yin

“…Over millions of years, the circulatory system evolved from primitive forms into a highly specialized network capable of overcoming time-distance constraints and enhancing diffusion efficiency. This structural advancement laid the physiological foundation for the regulation of hemodynamics and systemic homeostasis. …”
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Framework for extracting multi-objective operation rules for cascade reservoirs based on causal features and physical mechanisms by Donglin Gu, Baowei Yan, Jianbo Chang, Yixuan Zou, Dongxu Yang, Mingbo Sun, Xiaoyu Diao

“…To reduce high dimensionality, Convergent Cross Mapping (CCM) quantifies causal relationships between features and decision variables. Moreover, embedding physical constraints into the model’s loss function further enhances interpretability. …”
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Modeling the contribution of micronekton diel vertical migrations to carbon export in the mesopelagic zone by H. Thibault, F. Ménard, J. Abitbol-Spangaro, J.-C. Poggiale, S. Martini

“…The functional approach highlighted the importance of size and taxonomy, particularly regarding fishes, crustaceans, and cephalopods as key factors controlling the efficiency of carbon transport. …”
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Energy factors affecting environmental pollution for sustainable development goals: The case of India by Vu Ngoc Xuan

“…The study used data from the World Bank from 2000 to 2023; the methodology adopted includes vector autoregression modeling, Granger causality tests, cointegration analysis, impulse response functions, and variance decomposition. These econometric techniques were selected due to their ability to capture dynamic relationships, determine causality, and identify long-term equilibrium among the variables. …”
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Non-Iterative Estimation of Multiscale Geographically and Temporally Weighted Regression Model by Ya-Di Dai, Hui-Guo Zhang

“…Simulation experiments are conducted to evaluate the performance of the proposed non-iterative method compared to traditional methods and the backfitting-based approach in terms of coefficient estimation accuracy and computational efficiency. The results demonstrate that the non-iterative estimation method for MGTWR significantly enhances computational efficiency while effectively capturing the scale effects of spatiotemporal variation in the regression coefficient functions for each predictor.…”
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Assessment of Outcomes of the Modified Stoppa Approach in the Treatment of Acetabular Fractures: A Retrospective Cohort Study by Nurgeldi Manap, Nagmet Mursalov, Mukhtar Abilmazhinov

“…Exclusion criteria: other operative approaches to pelvic bones and patients under 18 years of age. 21 patients underwent surgery with the use of modified Stoppa approach (group A) and 10 surgeries were performed using the ilioinguinal approach (group B). Efficiency was evaluated by comparison of duration of surgical procedures, amount of blood lossbetween groups, size of skin incision, quality of reduction and functional outcomes. …”
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