Impact of IgG subclass on monoclonal antibody developability by Paul Cain, Lihua Huang, Yu Tang, Victor Anguiano, Yiqing Feng

“…We thus conducted a systematic study of 12 mAbs derived from three sets of unrelated variable regions, each cloned into IgG1, an IgG1 variant with diminished effector functions, IgG2, and a stabilized IgG4 variant with further reduced FcγR interaction, to evaluate the impact of IgG subclass on manufacturability and high concentration stability in a common formulation buffer matrix. …”
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Prediction of Soil Carbon Sequestration in Rangelands Regarding the Depth and Elevation of Sample Locations using Adaptive Neuro-Fuzzy Inference System (ANFIS) (Case Study: Lar Wat... by zeinab jafarian, zhila ghorbani

“…This system is based on the combination of three components: membership functions of input and output variables (fuzzification), fuzzy rules (rule base), mechanism inference (a combination of rules with fuzzy input), output characteristics, and results of the system (de-fuzzification). …”
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Organizational and Economic Factors of Health System Optimization by Oleksandr Telizhenko, Yuliia Halynska, Nataliia Baistriuchenko, Volodymyr Potseluiev, Kateryna Demchuk

“…To this aim, the factors that influence the efficiency of the organization and functioning of the medical system are identified. …”
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Sensitivity to Instruction Strategies in Motor Learning Is Predicted by Anterior–Posterior TMS Motor Thresholds by Michael L. Perrier, Kylee R. Graham, Jessica E. Vander Vaart, W. Richard Staines, Sean K. Meehan

“…Recent transcranial magnetic stimulation (TMS) studies suggest that variability in interneuron recruitment by anterior–posterior (AP) currents is linked to differences in functional connectivity between premotor and motor regions. …”
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Back-Analysis of Parameters of Jointed Surrounding Rock of Metro Station Based on Random Forest Algorithm Optimized by Cuckoo Search Algorithm by Xinping Guo, Annan Jiang, Xiang Liu

“…In this method, the mean square error between the measured displacement (stress) and the calculated displacement (stress) is taken as the objective function, and the joint parameters are taken as the decision variables. …”
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Parental acceptance of novel children's medical syringes and their influencing factors by Su Wen Luo, Peng Rui Yang

“…Furthermore, the product's function and price value significantly shape users' behavioral intentions. …”
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DeBo: Contrast enhancement for image registration using binary differential evolution and bat optimization. by Muhammad Adeel Akram, Tallha Akram, Umer Javed, Muhammad Rafiq, Mehvish Naz, Di He

“…In this study, we proposed a hybrid binary differential evolution and BAT optimization model to enhance contrast stretching by optimizing a decision variables in the transformation function. To validate its efficiency, the proposed approach is utilized as a preprocessor before feature extraction in image registration. …”
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PM21-particle stimulation augmented with cytokines enhances NK cell expansion and confers memory-like characteristics with enhanced survival by Jeremiah L. Oyer, Tayler J. Croom-Perez, Md Faqrul Hasan, Javier A. Rivera-Huertas, Sarah B. Gitto, Joanna M. Mucha, Xiang Zhu, Deborah A. Altomare, Robert Y. Igarashi, Alicja J. Copik

“…This is typically done by ex vivo stimulation with cytokines to enhance functionality or expansion for 10-14 days to increase both their activity and quantity. …”
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Steady-State Dynamical Response of a Strongly Nonlinear System with Impact and Coulomb Friction Subjected to Gaussian White Noise Excitation by Guidong Yang, Dongmei Huang, Wei Li, Meng Su

“…The Zhuravlev nonsmooth transformation of the state variables combined with the Dirac delta function is utilized to simplify the original system to one without velocity jump. …”
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Transcriptome profiling of Hyacinthus orientalis L. cultivars in floral pigmentation by Kwan-Ho Wong, Hoi-Yan Wu, Cheryl Wood-Yee Shum, Jerome Ho-Lam Hui, Pang-Chui Shaw, David Tai-Wai Lau

“…In addition, the usability of the dataset was demonstrated by the identification of differentially expressed genes, functional annotation and functional enrichment analysis. …”
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Biotinylated fusion protein-streptavidin-peroxidase complex based non-competitive magnetic immunoassay for rapid detection of organophosphorus pesticides by Ruirui Shi, Jiangke Li, Wenli Yu, Tengfei Yin, Haiyan Lin, Juan Liu, Wenyu Cui

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Antigenic characterization of the human immunodeficiency virus (HIV-1) envelope glycoprotein precursor incorporated into nanodiscs. by Kristen C Witt, Luis Castillo-Menendez, Haitao Ding, Nicole Espy, Shijian Zhang, John C Kappes, Joseph Sodroski

“…These results indicate that Env-NDs represent a potentially useful platform for investigating the structural, functional and antigenic properties of the HIV-1 Env trimer in a membrane context.…”
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Order assignment mechanism based on hierarchical decomposition and element matching by ZHANG Xinyue, LYU Weimin, WEI Dingjiang, YANG Dongsheng

“…This integrates and coordinates operational tasks, ensures no resource conflicts, and provides alternatives for responding to battlefield variables. The approach employs a planning network model to illustrate the logical interrelationships among operations. …”
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Deletion of genes linked to the C1-fixing gene cluster affects growth, by-products, and proteome of Clostridium autoethanogenum by Ugochi Jennifer Nwaokorie, Kristina Reinmets, Lorena Azevedo de Lima, Pratik Rajendra Pawar, Kurshedaktar Majibullah Shaikh, Audrey Harris, Michael Köpke, Kaspar Valgepea

“…However, our understanding of the functionalities of the genes involved in the C1-fixing gene cluster and its closely-linked genes is incomplete. …”
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Advanced microfluidic strategies for core-shell nanoparticles: the next-generation of polymeric and lipid-based drug nanocarriers by Giuseppe Nunziata, Alessandro Borroni, Filippo Rossi

“…Microfluidic technology has transformed the synthesis of core-shell nanoparticles (CSNPs), providing an unprecedented level of control over their structural and functional properties. This review critically evaluates recent advancements, highlighting the superiority of microfluidic methods over conventional batch techniques, which often suffer from variability and scalability issues. …”
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Exploring the Impact of School-Based Physical and Perceived Environments on Students’ Physical Activity During Recess: A Case Study of Four Schools in Xi’an, China by Qing Wang, Yan Wang, Lan Zhou, Yong Nan

“…The study’s results confirmed previous findings from a social–ecological perspective and provide a comprehensive assessment framework that includes the spatial organization/spatial quality of the school and the perceived variables of safety, comfort, aesthetics, accessibility and functionality. …”
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Beyond the interface: benchmarking pediatric mobile health applications for monitoring child growth using the Mobile App Rating Scale by Anggi Septia Irawan, Arie Dwi Alristina, Arie Dwi Alristina, Rizky Dzariyani Laili, Nuke Amalia, Arief Purnama Muharram, Adriana Viola Miranda, Bence Döbrössy, Edmond Girasek

“…MARS assessed applications from multiple domains, including engagement, functionality, aesthetics, and information quality. Inter-rater reliability was ensured using the Intraclass Correlation Coefficient (ICC). …”
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Optimum System Design Using Rough Interval Multi-Objective De Novo Programming by Iftikhar Hussein, Hegazy Zaher, Naglaa Ragaa Saeid, Hebaa Sayed Roshdy

“…This paper suggested a new approach for solving uncertainty of De novo programming problems (DNP) using a combination model consisting of a rough interval multi-objective programming (RIMOP) and DNP, where coefficients of decision variables of objective functions and constraints are rough intervals (RIC). …”
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Development of Speech Therapy Application for Children with Stuttering (STACS) by Janith Raj Jayaraju, Amudhu Sankar

“…Conclusion: Most parents found this prototype app easy to use, efficient in training their children, and highly functional. …”
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Bifurcations of Spatially Inhomogeneous Solutions of a Boundary Value Problem for the Generalized Kuramoto–Syvashinsky Equation by Alina V. Sekatskaya

“…In this paper, a differential partial equation with an unknown function of three variables time and two spatial variables – is considered. …”
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