Optimization of PLGA-Doxorubicin Hybrid Nanoparticles using Design of Experiments: Synthesis, Characterization, and Applications by Adina TURCU-STIOLICA, Andrei BITA, Maria Viorica CIOCILTEU

“…The encapsulation efficiency of doxorubicin in PLGA nanoparticles was determined using spectrophotometric methods. …”
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Development of a cyclone separator for particulate matter control in fique bag production: A case study at Empaques del Cauca S.A. by Johana Astudillo Gutierrez, Jhon Alexander Guerrero Narvaez, Diego Andres Campo Ceballos, Javier Andres Muñoz Chaves

“…Both materials effectively eject zero particles per second into the air and collect the particles in the collector condenser with variable velocity profiles. In the case of the stainless-steel design, a marginal increase in particle collection is observed at specific velocity profiles, highlighting its overall efficiency. …”
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Deterministic Calculation Method for Continuous-energy Neutron Transport Equation in No-resonance Energy-range by LIU Haopo, LI Yunzhao, WU Hongchun, CAO Liangzhi

“…In order to eliminate the multi-group approximation in the deterministic method, a method for calculating neutron transport equation in the non-resonant energy region based on function expansion was proposed. Initially, the non-resonant energy region was subdivided into segments, and within each segment, orthogonal polynomials serve as base functions for expanding the neutron flux density, which realized the processing of single energy independent variable in the neutron flight and absorption process, as well as the handling of double energy independent variable in the neutron scattering process. …”

Exploring the optimal lower blood pressure boundary during endovascular thrombectomy in patients with large vessel occlusion by Yu-Ming Chang, Chun-Min Wang, Kang-Po Lee, Po-Chun Shen, Po-Yu Lin, Chi-Hung Liu, Sheng-Hsiang Lin, Chih-Hung Chen, Meng-Tsang Hsieh, Pi-Shan Sung

“…No significant relationship was observed between DBP and functional outcomes. Patients with higher periprocedural SBP coefficient variance exhibited a decreased rate of good functional outcomes at 3 months (aOR, 0.42, 95% CI, 0.18–0.96). …”
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Discriminative Validity and Reliability of the Single-Leg Squat and Single-Leg Landing Frontal Plane Kinematics in Individuals with Lower Limb Functional Deficits by Jean Marlon Machado, Marcelo Peduzzi de Castro, Amandda de Souza, Carlos Alberto Atherinos Pierri, Francisco Xavier de Araujo, Heiliane de Brito Fontana, Caroline Ruschel

“…It is necessary to identify variables and tests with adequate reliability and with the capability to discriminate individuals with and without lower limb functional deficits. …”
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Sinusoidal regression model for assessment of mudflows dynamics by B. A. Ashabokov, A. A. Tashilova, L. A. Kesheva, N. V. Teunova

“…The article shows that the use of the sinusoidal regression function makes it possible to identify the cyclicity of time series, which will help in assessing the dynamics of mudflows taking into account long-term changes in climate variables. …”
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Unveiling the ecological dominance of button mangrove (Conocarpus erectus L.) through microstructural and functional traits modifications across heterogenic environmental condition... by Ummar Iqbal, Akkasha Azam, Khawaja Shafique Ahmad, Sahar Mumtaz, Ansar Mehmood, Nargis Naz, Zartasha Usman, Hina Abbas, Muhammad Akram

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Neural correlates of subjective cognitive decline in Alzheimer’s disease: a systematic review of structural and functional brain changes for early diagnosis and intervention by Giulia Marafioti, Laura Culicetto, Desirèe Latella, Angela Marra, Angelo Quartarone, Viviana Lo Buono

“…Dynamic functional connectivity studies report reduced brain activity efficiency, while graph theory analyses show decreased network integration. …”
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Dynamic brain-heart-gut coupling during sleep: a continuous physiological signal analysis by Guojing Wang, Guojing Wang, Guojing Wang, Hongyun Liu, Hongyun Liu, Shijing Wu, Shijing Wu, Xiaohua Yu, Xiaohua Yu, Weidong Wang, Weidong Wang

“…However, current research on gut function primarily focuses on gut microbiota, with a lack of systematic investigation into the macroscopic dynamic changes of gut function. …”
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Research of Parameterization and Optimization of Shaped-profile and Size of Circular Arc Rotor Pair for Roots Pump by Li Yulong, Zhang Chenhe, Ran Guangze

“…Then,from pitch circle radius and shape coefficient as two design variables,the minimum wrapping cube space volume of rotor pair as an objective function,the upper limit of the shape coefficient and rounded-value of center distance and the diameter ratio of the rotor and other as constraint functions. …”
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Research Progress of Intelligent Evaluation and Virtual Reality Based Training in Upper Limb Rehabilitation afrer Stroke by XIE Qiurong, LIN Wanqi, ZHANG Qi, SHENG Bo, ZHANG Yanxin, HUANG Jia

“…Automated assessment of upper extremity motor function based on machine learning algorithms with markerless sensing techniques has focused on the Fugl-Meyer assessment of upper extremity (FMA-UE), Brunnstrom stages, and Wolf motor function test (WMFT) scales and has been proved with high-scoring accuracy and time efficiency. …”
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Genetically surface-modified Escherichia coli outer membrane vesicles targeting MUC1 antigen in cancer cells by Sedthawut Laotee, Wanatchaporn Arunmanee

“…In conclusion, this rapid and efficient bio-ligation system facilitates the display of functional scFv on OMV surfaces, offering a promising approach for targeted delivery to MUC1-expressing cancer cells.…”
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Exploring the potentials of mango-orange leaf extract as an inhibitor on carbon steel in an acidic medium: Optimization, kinetics, and thermodynamics by Elijah Emeteveke Aghogho, Prosper Eguono Ovuoraye, Innocent Oseribho Oboh, Oluwafemi Osarhiemen Olayebi

“…The effects of optimized variables on corrosion inhibition were examined. The result confirmed optimum inhibition efficiency of 96 % corresponding to MOEx concentration, temperature, and time of 450 ppm, 30 0C, and 3 h recorded at an optimum acid concentration of 1.3 M of H2SO4. …”
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Novel active-feedback device improves sleep quality in insomnia disorder: a randomized placebo-controlled trial by Antonia Ypsilanti, Maan van de Werken, Anna Robson, Petra Examilioti, Lambros Lazuras, Lambros Lazuras

“…ObjectivesInsomnia disorder is a public health challenge associated with impaired cognitive functioning, reduced quality of life, and adverse mental health outcomes. …”
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qBiCo: a method to assess global DNA conversion performance in epigenetics via single-copy genes and repetitive elements by Faidra Karkala, Roy B. Simons, Floor Claessens, Vivian Kalamara, Manfred Kayser, Athina Vidaki

“…Depending on the starting DNA quantity, bisulfite-converted DNA recoveries ranged from 8.5 to 100%, conversion efficiencies from 78 to 99.9%, while certain kits highly fragment DNA, demonstrating large variability in their performance. …”
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The effect of early childhood stature on later cognitive functions in Indonesian adolescents: comparation using the National growth reference and the WHO growth standard by Annang Giri Moelyo, Aman B. Pulungan, Mei Neni Sitaresmi, Madarina Julia

“…In adolescence, cognitive function were assessed. An analysis was performed to assess the associations between variables. …”
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Exposure-response functions of the correlated environmental exposures green space, noise, and air pollution for quantifying mortality burden in health impact assessment by Xuan Chen, Ulrike Gehring, Georgia M.C. Dyer, Kees de Hoogh, Sasha Khomenko, Haneen Khreis, Natalie Mueller, Roel Vermeulen, Harry Williams, Belen Zapata-Diomedi, Mark Nieuwenhuijsen, Gerard Hoek

“…The studies show substantial variability in exposure levels and correlations between exposures. …”
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The association between TNF-receptors (TNFR1 and TNFR2) and mortality as well as kidney function decline in patients with chronic kidney disease by Per Wändell, Tobias Feldreich, Anders Larsson, Philip A. Kalra, Johan Ärnlöv, Toralph Ruge, Axel C. Carlsson

“…Differences in eGFR decline in relation to plasma TNFR1 and TNFR2 were estimated by both linear and logistic regression models, with regression coefficients and odds ratios (ORs). Results: Univariate models showed significant associations between TNFR1 (n = 985) and TNFR2 (n = 988) and all-cause mortality based on 7424 person-years at risk, but in the fully adjusted models with continuous variables significant only for TNFR2 HR 1.17 (1.03–1.34), but with a borderline value for TNFR1 HR 1.15 (1.00–1.31). …”
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Different whole body HIIT protocols do not promote different muscle thickness and functional adaptations among healthy physically active subjects by Alexandre L. Evangelista, Júlio B. B. de Camargo, Roberta L. Rica, Luiz Carlos Carnevali Júnior, Gregg S. Mallett, Valentina Bullo, Marco Bergamin, Stefano Gobbo, Danilo S. Bocalini

“…Morphological (ultrasound-derived muscle thickness of the vastus lateralis [MTVL]) and general fitness (muscle endurance and maximal oxygen consumption) assessments were performed at pre- and post-intervention moments.ResultsBoth training protocols elicited significant improvements in all dependent variables (p < 0.05), with no significant between-group differences.ConclusionRegardless of the training configuration, both WB-HIIT programs serve as time-efficient strategies to induce changes in muscle thickness of the vastus lateralis and functional adaptations in healthy, physically active young individuals.…”
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MULTI-OBJECTIVE OPTIMIZATION DESIGN FOR CUTTING MECHANISM OF ROADHEADER BASED ON IMPROVED GENETIC ALGORITHM by MAO Jun, PAN DeWen, XIE Miao, ZHENG GuangHui

“…The comprehensive performance of cutting mechanism of roadheader is decided by cutting dust,quantity of pick consumption,specific density consumption,load fluctuation and production efficiency. This paper takes motion parameters and structure parameters of cutting mechanism for design variables and optimizes multi-objective function of comprehensive performance of cutting mechanism based on the improved genetic algorithm. …”
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