Novel variant alters splicing of TGFB2 in family with features of Loeys-Dietz syndrome by Emily R. Gordon, Stephanie A. Felker, Stephanie A. Felker, Tanner F. Coleman, Tanner F. Coleman, Nadiya Sosonkina, Jada Pugh, Jada Pugh, Meagan E. Cochran, Meagan E. Cochran, Anna C. E. Hurst, Sara J. Cooper

“…Molecular validation of the splicing products suggests that the TGFB2 variants tested impact splicing by reducing efficiency of the canonical acceptor in favor of an alternate acceptor within the exon. …”
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Exploring Machine Learning Models for Vault Safety in ICL Implantation: A Comparative Analysis of Regression and Classification Models by Qing Zhang, Qi Li, Zhilong Yu, Ruibo Yang, Emmanuel Eric Pazo, Yue Huang, Hui Liu, Chen Zhang, Salissou Moutari, Shaozhen Zhao

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Deep learning algorithm on H&E whole slide images to characterize TP53 alterations frequency and spatial distribution in breast cancer by Chiara Frascarelli, Konstantinos Venetis, Antonio Marra, Eltjona Mane, Mariia Ivanova, Giulia Cursano, Francesca Maria Porta, Alberto Concardi, Arnaud Gerard Michel Ceol, Annarosa Farina, Carmen Criscitiello, Giuseppe Curigliano, Elena Guerini-Rocco, Nicola Fusco

“…The DL model exhibited high accuracy in tissue quantification and TP53 status prediction, outperforming traditional methods in terms of precision and efficiency. DL-based approaches offer significant promise for enhancing biomarker testing and precision oncology by reducing intra- and inter-observer variability, but further validation is required to optimize their integration into real-world clinical workflows. …”
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Optimized Dual-Battery System with Intelligent Auto-Switching for Reliable Soil Nutrient Monitoring in Remote IoT Applications by Doan Perdana, Pascal Lorenz, Bagus Aditya

“…Implementing the DLB–PAO algorithm elevates the average reliability to 91.7% over 120 h, whereas the DLB–GA algorithm achieves near-perfect reliability (99.9%) for over 170 h, exhibiting minimal variability (standard deviation: 0.9%). The integration of intelligent auto-switching mechanisms and metaheuristic optimisation algorithms demonstrates a marked enhancement in both reliability and energy efficiency for soil nutrient monitoring systems. …”
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Assessment of the Potential of Decentralized Dinance (DeFi) as an Alternative to Traditional Financial Services in the Context of the Development of the Digital Economy and Web3 by Manoilenko Oleksandr V., Kuznetsova Svitlana O., Pysakovskyi Anton O.

“…An analysis of the main characteristics of DeFi protocols, their functional capabilities, and differences from centralized financial institutions has been conducted. …”
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Research on Design and Energy-Saving Performance of Gate Rudder by Chunhui Wang, Qian Gao, Lin Li, Feng Gao, Zhiyuan Wang, Chao Wang

“…The GRS was first fully implemented on a container ship in Japan, demonstrating improved propulsion efficiency, fuel savings, and excellent performance in maneuvering, noise, and vibration reduction. …”
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FMRI insights into the neural alterations and clinical correlates in multiple sclerosis: A comprehensive overview of systematic reviews and meta-analyses by Sama Rahnemayan, Arezoo Fathalizadeh, Mehdi Behroozi, Mahnaz Talebi, Amirreza Naseri, Elham Mehdizadehfar

“…Graph theory metrics identified disrupted global efficiency and clustering in functional networks, linked to gray matter atrophy. …”
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Toward generalizable prediction of antibody thermostability using machine learning on sequence and structure features by Ameya Harmalkar, Roshan Rao, Yuxuan Richard Xie, Jonas Honer, Wibke Deisting, Jonas Anlahr, Anja Hoenig, Julia Czwikla, Eva Sienz-Widmann, Doris Rau, Austin J. Rice, Timothy P. Riley, Danqing Li, Hannah B. Catterall, Christine E. Tinberg, Jeffrey J. Gray, Kathy Y. Wei

“…In this work, we show two machine learning approaches – one with pre-trained language models (PTLM) capturing functional effects of sequence variation, and second, a supervised convolutional neural network (CNN) trained with Rosetta energetic features – to better classify thermostable scFv variants from sequence. …”
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XPolypNet: A U-Net-Based Model for Semantic Segmentation of Gastrointestinal Polyps With Explainable AI by Arjun Kumar Bose Arnob, Muhammad Mostafa Monowar, Md. Abdul Hamid, M. F. Mridha

“…The presented model was evaluated on five benchmark datasets, achieving a Dice Coefficient of 0.8378 and a Mean Intersection over Union (mIoU) of 0.8427. …”
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SVR-Optimized ANN Model for Predicting Earthquake Risk in Electrical Substations Based on Disaster Datasets in the Aceh Region, Indonesia by Elvy Sahnur Nasution, Yuwaldi Away, Syahrial, Ira Devi Sara, Andri Novandri

“…The ANN training process uses backpropagation with sigmoid and tanh activation functions. The ANN outputs are then used as input features for the SVR model, applying a Radial Basis Function (RBF) kernel to capture the non-linear relationships between variables. …”
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Validation of an interferon-gamma enzyme-linked immunosorbent spot assay to evaluate cell-mediated immunity against severe acute respiratory syndrome coronavirus 2 by Yunhwa Kim, Eun-Jeong Jang, Ji-Young Hwang, Kyung-Min Lee, Sivilay Xayaheuang, Seok-Tae Choi, Hosun Park

“…Taken together, we demonstrated that the IFN-γ ELISpot assay is feasible for evaluating SARS-CoV-2-specific cell-mediated immune function through validation based on standard operating procedures.…”
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Revealing the Immune Response of <i>Sitona callosus</i> Gyllenhal to Entomopathogenic Fungi <i>Beauveria bassiana</i> Infection Through Integrative Analyses of Transcriptomics and... by Nan Li, Xin Gu, Ming Xin, Xinpu Wang

“…Additionally, we utilized the Pearson correlation coefficient method to examine the relationships between differentially expressed immune-related genes and metabolites, revealing notably strong correlations between these two sets of variables. …”
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Network Analysis of Key Instrumental Activities of Daily Living and Cognitive Domains for Targeted Intervention in US Older Adults Without Dementia: Cross-Sectional Study by Jiaying Li, Rendong He, Erh-Chi Hsu, Junxin Li

“…Network analysis identified central and bridge variables. Nonparametric and case-dropping bootstrap methods checked network stability. …”
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Comparative study between the Patient Participation Culture Tool and the Hospital Survey on Patient Safety Culture using retrospective data from 2014 to 2021 by Ward Schrooten, Ann Van Hecke, Marlies Claesen, Evelyne Punnewaert, Simon Malfait, Kristof Eeckloo

“…Spearman’s rank correlation coefficient was employed to evaluate relationships between continuous variables represented by PACT domain and HSPSC dimensional scores among study participants.Results Data from 17 hospitals were analysed. …”
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The Effect of Season and Breed on Hypothalamic–Pituitary–Adrenal Axis Hormones, Metabolic Hormones, and Oxidative Markers in Ponies and Horses by Sarah Alison Vaughn, Margaret B. Lemons, Kelsey A. Hart

“…Linear mixed effects modeling with a random effect for animal was used to determine the effects of season and breed. Correlation coefficients were calculated for relevant variables. …”
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Identification of an additive interaction using parameter regularization and model selection in epidemiology by Chanchan Hu, Zhifeng Lin, Zhijian Hu, Shaowei Lin

“…We present two pathways to achieve this end: one is to complete the constraint by adding a regular penalty term to the model likelihood function; the other is to use model selection. Result Using simulated and real data, our proposed methods effectively identified additive interactions and proved to be applicable to real-world data. …”
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Relationship between Communication Skills and General Health in Nursing Students of Hamadan University of Medical Sciences by Roya Amini, Fariba Soleimani, Nahid Mohammadi, Tapak Leili

“…Communication skills had a significant relationship with most aspects of general health, except social function (p<0.001). There was no correlation between demographic variables and communication skills (p<0.05). …”
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Specific nature of the integrative (complex) effect of environmental factors on hazelnut cultivars in the Russian humid subtropics by T. D. Besedina, A. P. Boyko, Ts. V. Tutberidze, N. S. Kiseleva

“…The expediency of the crop’s large-scale cultivation calls for measuring the parameters of agroclimatic indicators, ranging in variability, intensity, and duration of their impact. …”
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Objective Measures of Spatial Effects in Spanish Concert Halls by Sara GIRÓN, Teófilo ZAMARRENO, Pedro BUSTAMANTE

“…The paper concludes with a discussion on the relationships of hall-average data of the five parameters with eight geometric and acoustic variables.…”
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Data-driven modeling and regression analysis on ship resistance of in-service performance by Daehyuk Kim, Shin Hyung Rhee

“…The analysis of added resistance due to waves shows significant, but sometimes inconsistent, transfer function coefficients, suggesting simpler model structures could be more effective. …”
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