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A versatile genetic toolkit for engineering Wickerhamomyces ciferrii for tetraacetyl phytosphingosine production
Published 2025-04-01“…To demonstrate the functional application of this toolkit, we overexpressed a phosphorylation-insensitive mutant of acetyl-CoA carboxylase (ACC1S26A-S1161A), resulting in a 2.4-fold increase in TAPS production. …”
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Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy
Published 2025-01-01“…Abstract α-Klotho (KLA) is a type-1 membranous protein that can associate with fibroblast growth factor receptor (FGFR) to form co-receptor for FGF23. The ectodomain of unassociated KLA is shed as soluble KLA (sKLA) to exert FGFR/FGF23-independent pleiotropic functions. …”
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An evaluation of stress in medical students at a South African university
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Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli.
Published 2007-07-01“…In a bladder cell culture system, beta1 and alpha3 integrin receptors co-localize with invading type 1-piliated bacteria and F-actin. …”
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Body Temperature Differences Between Green And Brown Grasshoppers Do Not Result From Thermal Physiology or Thermal Preferences
Published 2025-03-01“…ABSTRACT Colour polymorphisms correspond to the co‐occurrence of several distinct colour morphs that vary in hue and/or brightness, independently of sex, age or any other state‐dependent modifiers. …”
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Association between aging and ectopic fat depositions in abdominal viscera
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Protein epigenetic scores and overall mortality in the longitudinal Swedish Adoption/Twin Study of Aging (SATSA)
Published 2025-03-01“…Abstract Introduction DNA methylation (DNAm) has a functional role in gene regulation, and it has been used to estimate various human characteristics. …”
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Divergent altitudinal patterns of arbuscular and ectomycorrhizal fungal communities in a mid-subtropical mountain ecosystem
Published 2025-04-01“…Among the examined factors, soil properties emerged as the predominant driver of altitudinal variations in ecosystem multifunctionality, followed by AMF communities and climatic variables. These findings provide critical insights into the ecological functions and environmental adaptations of mycorrhizal fungi, advancing our understanding of their responses to environmental changes in mountain ecosystems and informing evidence-based conservation strategies.…”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials
Published 2023-03-01“…A requirement for simultaneous allograft co-listing can safeguard the interests of vulnerable potential subjects. …”
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Binding patterns of glycine receptor autoantibodies are related to clinical syndromes
Published 2025-07-01“…Even if variations between labeled areas and cell layers were rather patient-specific than group-specific, functionality of the labeled areas aligned with the patients’ impaired functions. …”
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Bioprinting for drug screening: A path toward reducing animal testing or redefining preclinical research?
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Characterization and clustering of intra-day physical activity patterns using accelerometry among sexual and gender minority adults
Published 2025-07-01“…., clusters) of daily PA trajectories among sexual and gender minority (SGM; lesbian, gay, bisexual, transgender, queer) adults using functional latent block models (FLBMs), a co-clustering technique that simultaneously accounts for variation at the individual- and day-level. …”
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