IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody. by Simone I Richardson, Bronwen E Lambson, Andrew R Crowley, Arman Bashirova, Cathrine Scheepers, Nigel Garrett, Salim Abdool Karim, Nonhlanhla N Mkhize, Mary Carrington, Margaret E Ackerman, Penny L Moore, Lynn Morris

“…By exchanging hinge regions between subclass variants, we showed that hinge length modulated both neutralization potency and Fc function. This study showed that co-operation between the variable and natural IgG3 constant regions enhanced the polyfunctionality of antibodies, indicating the value of leveraging genetic variation which could be exploited for passive immunity.…”
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Effects of blood pump flow and arteriovenous fistula blood flow rate on blood pressure and cardiac function in maintenance hemodialysis patients by PU Jian, LIN Ju, ZHANG Jun-feng, SHEN Yan, QIU Ling, LIU Xiao-bin

“…Multiple linear regression models were used to analyze the correlation of variables with blood pressure and cardiac function parameters. …”
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Evaluation of Autoconversion Representation in E3SMv2 Using an Ensemble of Large‐Eddy Simulations of Low‐Level Warm Clouds by Mikhail Ovchinnikov, Po‐Lun Ma, Colleen M. Kaul, Kyle G. Pressel, Meng Huang, Jacob Shpund, Shuaiqi Tang

“…The agreement, however, comes from a combination of an underestimated E3SM‐tuned local Au rate and an overestimated subgrid cloud variability enhancement factor. The latter bias is traced to neglecting the horizontal variability of nc and its co‐variability with qc in parameterizing the grid‐mean Au.…”
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The importance of the tortoise tick Hyalomma aegyptium as a carrier of bacterial agents on a wide range by Matej Kautman, Branka Bilbija, Markéta Nováková, Emil Tkadlec, Ivo Papoušek, Peter Mikulíček, David Jandzik, Hossein Javanbakht, Ghoulem Tiar, Pavel Široký

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A vascular endothelial cell, neuron, and microglia tri-culture model to study hypertension-related depression by Hongxia Zhao, Hongxia Zhao, Lingge Huang, Jian Liu, Min Feng, Yeqian Liu, Hong Li, Shan Gong, Chunming Chen, Shuiqing Zeng, Weiqiong Ren

“…Vascular endothelial function and inflammatory levels were assessed using fluorescent probes and enzyme-linked immunosorbent assays. …”
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Effects of pH/<i>p</i>CO₂ fluctuations on photosynthesis and fatty acid composition of two marine diatoms, with reference to consequences of coastal acidification by Y. Shang, J. Qiu, Y. Weng, X. Wang, D. Zhang, Y. Zhou, J. Xu, J. Xu, F. Li, F. Li

“…<p>Coastal waters are impacted by a range of natural and anthropogenic factors, which superimpose on effects of increasing atmospheric CO<span class="inline-formula">₂</span>, resulting in dynamically changing seawater carbonate chemistry. …”
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Long Term Effects of Farming System on Soil Water Content and Dry Soil Layer in Deep Loess Profile of Loess Tableland in China by Li-ping CHENG, Wen-zhao LIU

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Advancing Chrononutrition for Cardiometabolic Health: A 2023 National Heart, Lung, and Blood Institute Workshop Report by Hassan S. Dashti, Erica C. Jansen, Faris M. Zuraikat, Shilpy Dixit, Marishka Brown, Aaron Laposky, Josiane L. Broussard, Matthew P. Butler, Seth A. Creasy, Cibele A. Crispim, Christopher M. Depner, Karyn A. Esser, Marta Garaulet, Erin C. Hanlon, Nour Makarem, Emily N. C. Manoogian, Courtney M. Peterson, Frank A. J. L. Scheer, Kenneth P. Wright, David C. Goff, Charlotte A. Pratt, Karen L. Gamble, Marie‐Pierre St‐Onge

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Synergistic effect of biochar and post-thermophilic stage application of supplemental Tithonia diversifolia on compost nutrient dynamics by Felix Matheri, Collins Musafiri, David Bautze, Chloé Durot, Milka Kiboi

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Correlation Between Modified Functional Reach Test and Medio-Lateral Center of Pressure in Paraplegic Individuals With Motor-Complete Spinal Cord Injury by Valeska Gatica-Rojas, Juan Claudio López-Monardez, Ricardo Cartes-Velásquez

“…No studies have explored which mFRT reach directions correlate with the center of pressure (CoP) variables in patients with motor-complete SCI (mcSCI). …”
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Targeting CD16A on NK cells and GPC3 in hepatocellular carcinoma: development and functional validation of a therapeutic bispecific antibody by Liu Chen, Yuankui Zhu, Mingqian Feng, Mingqian Feng, Dianbao Zuo, Guoping Chen, Kangkang Ji, Kangkang Ji

“…Functional validation included binding kinetics (ELISA, flow cytometry, and fluorescence co-localization analysis), in vitro cytotoxicity assays (luciferase-based killing), and in vivo efficacy studies in Huh7 xenograft models. …”
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Exposure-response functions of the correlated environmental exposures green space, noise, and air pollution for quantifying mortality burden in health impact assessment by Xuan Chen, Ulrike Gehring, Georgia M.C. Dyer, Kees de Hoogh, Sasha Khomenko, Haneen Khreis, Natalie Mueller, Roel Vermeulen, Harry Williams, Belen Zapata-Diomedi, Mark Nieuwenhuijsen, Gerard Hoek

“…The studies show substantial variability in exposure levels and correlations between exposures. …”
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Sensitivity Analysis of Numerical Coherency Model for Rock Sites by Dongyeon Lee, Yonghee Lee, Hak-Sung Kim, Jeong-Seon Park, Duhee Park

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A genome-wide association study identifies new loci associated with response to SARS-CoV-2 mRNA-1273 vaccine in a cohort of healthy healthcare workers by Antonio José Cabrera-Serrano, Antonio José Cabrera-Serrano, Lucía Ruiz-Durán, Lucía Ruiz-Durán, Juan Francisco Gutiérrez-Bautista, Juan Francisco Gutiérrez-Bautista, Juan Francisco Gutiérrez-Bautista, Juan Francisco Gutiérrez-Bautista, María Carretero-Fernández, María Carretero-Fernández, Rob ter Horst, Rob ter Horst, Rob ter Horst, Yang Li, Yang Li, Fernando Jesús Reyes-Zurita, Francisco José García-Verdejo, Francisco José García-Verdejo, Mihai G. Netea, Mihai G. Netea, Pedro Sánchez-Rovira, Pedro Sánchez-Rovira, Miguel Ángel López-Nevot, Miguel Ángel López-Nevot, Miguel Ángel López-Nevot, Antonio Sampedro, Antonio Sampedro, Juan Sainz, Juan Sainz, Juan Sainz, Juan Sainz

“…The identification of genetic variants could inform future strategies to enhance vaccine efficacy and provide a deeper understanding of individual variability in vaccine responses, especially for COVID-19 and other viral infections.…”
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SARS-CoV-2 Infection and Adverse Maternal and Perinatal Outcomes: Time-to-Event Analysis of a Hospital-Based Cohort Study of Pregnant Women in Rio de Janeiro, Brazil by Michelle Brendolin, Mayumi Duarte Wakimoto, Raquel de Vasconcellos Carvalhaes de Oliveira, Larissa Rangel Mageste, Karin Nielsen-Saines, Patricia Brasil

“…Survival functions were estimated by the Kaplan–Meier method, and the Cox proportional hazards model was employed to interpret the effects of SARS-CoV-2 infection on time to adverse maternal and perinatal outcomes, adjusted for vaccination, comorbidity, and gestational trimester. …”
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Observational partitioning of water and CO₂ fluxes at National Ecological Observatory Network (NEON) sites: a 5-year dataset of soil and plant components for spatial... by E. Zahn, E. Bou-Zeid

“…Overall, we observed good agreement across most methods for ET components, increasing confidence in these estimates. Partitioning of CO<span class="inline-formula">₂</span> components, on the other hand, was found to be less robust and more dependent on prior knowledge of water use efficiency. …”
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Stability of a colloidal system based on avocado (Persea americana Mill. cv. Hass) and others: Effect of process and composition by Eliana María Estrada Mesa, Misael Cortés Rodríguez, Guillermo Antonio Correa Londono

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Impaired physical function in relation to later-life exposure to ambient fine particulate matter and ozone among Chinese middle-aged and older adults by Yuxi Tan, Qianqian Xiang, Yalin Zhang, Jiajun Shen, Minjin Peng, Xiaojie Sun, Ting Cai, Yunquan Zhang

“…Stratified analyses for co-pollutants indicated weakened effects of PM2.5 and O3 at higher co-pollutant levels (PM2.5: −0.448 [−0.522, −0.373]; O3: −0.796 [−1.070, −0.522]) than at lower levels (PM2.5: −0.608 [−0.708, −0.507]; O3: −1.293 [−1.612, −0.974]). …”
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In-depth immunochemical characterization of the serum antibody response using a dual-titration microspot assay by Ágnes Kovács, Ágnes Kovács, Zoltán Hérincs, Krisztián Papp, Jakub Zbigniew Kaczmarek, Daniel Nyberg Larsen, Daniel Nyberg Larsen, Pernille Stage, László Bereczki, Eszter Ujhelyi, Tamás Pfeil, Tamás Pfeil, József Prechl

“…Both titration curves were simultaneously fitted using an algorithm based on the generalized logistic function and adapted for analyzing biochemical variables of binding. …”
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Heterotypic spheroids as a strategy for 3D culture of cryopreserved primary human hepatocytes in stirred-tank systems by Francisca Arez, Lena Preiss, Isabella Ramella Gal, Sofia P. Rebelo, Lassina Badolo, Catarina Brito, Thomas Spangenberg, Paula M. Alves

“…Primary human hepatocytes (PHHs) are the preferred cell source to address liver function. Despite originating from the native tissue, one of the bottlenecks when using primary material is the donor-to-donor variability. …”
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