Unraveling novel variants in the NF1 gene and investigating potential therapeutic strategies by Jianmei Huang, Ke Yang, Yaoping Wang, Xinrui Ma, Wenke Yang, Xiaodong Huo, Jie Bai, Hongjie Zhu, Jinming Wang, Yibing Lv, Shixiu Liao

“…A retrospective analysis of 49 clinical trials over the past 20 years revealed that NF1 therapies predominantly target neurofibromin’s GTPase function. Gene therapies aiming to restore neurofibromin by transducing the truncated NF1-GRD gene have been developed but faced pre-clinical challenges, including cloning capacity, transduction efficiency, and immunogenicity caused by gene delivery. …”
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Performance Analysis of Reconfigurable Intelligent Surface-Assisted Underwater Wireless Optical Communication Systems by Qi Zhang, Dian-Wu Yue, Xian-Ying Xu

“…In the RIS-assisted UWOC systems with intensity modulation and direct detection (IM-DD), we apply the approximate distribution of the sum of Gamma-Gamma random variables to derive the probability density function (PDF) of the instantaneous received signal-to-noise ratio (SNR) for the first time. …”
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The accuracy of a simple, low-cost GPS data logger/receiver to study outdoor human walking in view of health and clinical studies. by Bénédicte Noury-Desvaux, Pierre Abraham, Guillaume Mahé, Thomas Sauvaget, Georges Leftheriotis, Alexis Le Faucheur

“…<h4>Introduction</h4>Accurate and objective measurements of physical activity and lower-extremity function are important in health and disease monitoring, particularly given the current epidemic of chronic diseases and their related functional impairment.…”
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Association between TSH Values and GFR Levels in Euthyroid Cases with Metabolic Syndrome by H. Keskin, K. Cadirci, K. Gungor, T. Karaaslan, T. Usta, A. Ozkeskin, A. Musayeva, F. Yesildal, F. Isman, H. Y. Zengin

“…Partial correlation coefficients were calculated to investigate the relationship between the eGFR values and several other numerical variables while controlling for age and BMI in addition to the adjusted gender effect. …”
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Time-Jerk Optimal Robotic Trajectory Planning Under Jerk and Continuity Constraints via Convex Optimization by Chen Qian, Jianjun Yao, Yikun Zhang

“…Additionally, the objective function is improved to optimize both time and joint jerk simultaneously. …”
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A New Optimization Approach for Maximizing the Photovoltaic Panel Power Based on Genetic Algorithm and Lagrange Multiplier Algorithm by Mahdi M. M. El-Arini, Ahmed M. Othman, Ahmed Fathy

“…The technique which is based on objective function represents the output power of the PV panel and constraints, equality and inequality. …”
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A Three-Block Inexact Heterogeneous Alternating Direction Method of Multipliers for Elliptic PDE-Constrained Optimization Problems with a Control Gradient Penalty Term by Xiaotong Chen, Tongtong Wang, Xiaoliang Song

“…In some practical applications, it is necessary to smooth the control variables and suppress their large fluctuations, especially at the boundary. …”
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Optimization of fermentation conditions for enhanced acetylcholine and biomass production of Lactiplantibacillus plantarum AM2 using the Taguchi approach by Walid A. Lotfy, Amira M. Ali, Heba M. Abdou, Khaled M. Ghanem

“…Abstract This study aimed to optimize the fermentation conditions and medium composition for maximum acetylcholine (ACh) and biomass production by Lactiplantibacillus plantarum AM2 using the Taguchi array design, which enables efficient identification of influential variables through minimal experimental runs. …”
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Binary composite crossover genetic algorithm for locating critical slip surface by Wei Qin, Jiancheng Zhao

“…A reasonable combination of parameters for the binary composite crossover (BCC) operator in the RGA-BCC is determined through six benchmark function experiments. On this basis, the stability of five soil slopes from the literature was analysed using the RGA-BCC in combination with the Morgenstern and Price method, and the results obtained were compared with those in the published literature to demonstrate that the RGA-BCC is able to efficiently determine the CSSs of slopes and their minimum factors of safety. …”
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Optimization of Aerodynamic Design of a Winged UAV Through Genetic Algorithms and Large Eddy Simulation by Mohammad Javad Ebrahimi, Mahmoud Pasandidehfard, Ali Esmaeili, Mohammad Hossein Moghimi Esfandabadi

“…Optimization was conducted for six variables in a single stage, with 25 tests performed. …”
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Optimal tuning of multi-PID controller using improved CMOCSO algorithm by Ying Hu, Xiongyan Liu, Hao Chen

“…In this model, the parameters are designated as decision variables, the performance index serves as the objective function, and the stability constraints of the system are incorporated. …”
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Performance Investigation of Coated Carbide Tools in Milling Procedures by Paschalis Charalampous

“…The optimization of the manufacturing conditions in milling processes composes a crucial task for enhancing machining efficiency and extending the tool’s lifespan. This study presents an investigation of the cutting tool’s performance under varying machining parameters via the generation of an experimental dataset that was obtained through laboratory-controlled milling operations. …”
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Decentralized queue control with delay shifting in edge-IoT using reinforcement learning by Viacheslav Kovtun

“…Analytical expressions for key QoS indicators (delay, variability, loss, energy consumption) as functions of the shift parameter are derived, and a multi-factor reward function is constructed. …”
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Phenotypic screen of early-developing larvae of the blood fluke, schistosoma mansoni, using RNA interference. by M M Mourão, Nathalie Dinguirard, Glória R Franco, Timothy P Yoshino

“…Although RNAi holds great promise as a functional genomics tool for larval schistosomes, our finding of potential off-target or nonspecific effects of some dsRNA treatments and variable efficiencies in specific gene knockdown indicate a critical need for gene-specific testing and optimization as an essential part of experimental design, execution and data interpretation.…”
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Analysis of value-based healthcare (VBHC) framework by incremental cost-effectiveness of surgical and therapeutic interventions: a retrospective study at tertiary private health gr... by Mona Khamis, Zainab Almoosa, Marie Santos, Engineer Diaa Kamal, Suhail Yaghmor, Muhammad Daniyal, Abbas Al Mutair

“…Additionally, ICER values were positively associated with better functional outcomes in MS and stroke patients, with mobility (b = 1.027, p = 0.003) and activity (b = 1.768, p < 0.001). …”
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A Low-Complexity Direction-of-Arrival Estimation Algorithm for Noncircular Signals via Subspace Rotation Technique by Wei Wang, Ming Zhang, Bobin Yao, Tongxing Zheng, Xiaojiao Fan

“…Then, utilizing the separation of variables and the orthogonality between the reduced-dimension noise subspace and the space spanned by the columns of the extended manifold matrix, a new one-dimensional spectral search function is derived to estimate DoAs. …”
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Elucidating Genotypic Variation in Quinoa via Multidimensional Agronomic, Physiological, and Biochemical Assessments by Samreen Nazeer, Muhammad Zubair Akram

“…The results revealed that significant variation was observed across all measured parameters, highlighting the diverse adaptive strategies and functional capacities among the tested genotypes. More specifically, genotypes Q4, Q11, Q15, and Q126 demonstrated superior agronomic potential and canopy-level physiological efficiencies, including high biomass accumulation, low infrared canopy temperatures and sustained NDVI values. …”
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EEGUnity: Open-Source Tool in Facilitating Unified EEG Datasets Toward Large-Scale EEG Model by Chengxuan Qin, Rui Yang, Wenlong You, Zhige Chen, Longsheng Zhu, Mengjie Huang, Zidong Wang

“…To tackle the challenges, this paper introduces EEGUnity, an open-source tool that incorporates modules of "EEG Parser", "Correction", "Batch Processing", and "Large Language Model Boost". Leveraging the functionality of such modules, EEGUnity facilitates the efficient management of multiple EEG datasets, such as intelligent data structure inference, data cleaning, and data unification. …”
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Crisis Communication About the Maui Wildfires on TikTok: Content Analysis of Engagement With Maui Wildfire–Related Posts Over 1 Year by Jim P Stimpson, Aditi Srivastava, Ketan Tamirisa, Joseph Keaweʻaimoku Kaholokula, Alexander N Ortega

“…Using TikTok’s search functionality, we identified and reviewed public posts that contained relevant hashtags. …”
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Natural Diversity of <i>Crataegus monogyna</i> Jacq. in Northeastern Türkiye Encompassing Morphological, Biochemical, and Molecular Features by Bora Erkek, Mehmet Yaman, Ahmet Sümbül, Serap Demirel, Fatih Demirel, Ömer Faruk Coşkun, Ahmet Say, Barış Eren, Adnan Aydin, Ayten Eroglu

“…The Jaccard similarity coefficient ranged from 0.04 (M9 and M16) to 0.63 (M17 and M3), indicating substantial genetic variability. …”
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