Expression variation and covariation impair analog and enable binary signaling control by Kyle M Kovary, Brooks Taylor, Michael L Zhao, Mary N Teruel

“…Abstract Due to noise in the synthesis and degradation of proteins, the concentrations of individual vertebrate signaling proteins were estimated to vary with a coefficient of variation (CV) of approximately 25% between cells. …”
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Dynamics of Nepalese Stock Market Performance: An Analysis of Macro-economic, Firm-specific, Size, and Event Factors by Rajesh Gurung

“…The ARDL bounds test (F-statistic = 8.378, df = 6, I(0) = 2.88, I(1) = 2.88, α = 1%) indicates the presence of long-run interrelationships among the variables of interest. Additionally, the significant negative coefficient of the error correction term (etc. (-1) = -0.527, p < 0.01) suggests a long-run convergence towards equilibrium. …”
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Optimization Study of PVT Coupled Water Loop Heat Pump Energy Supply System by Lv Tiangang, Liu Bing, Wu Jun, Zhu Li, Hou Jingxuan

“…By employing the Hooke-Jeeves algorithm, the system's design and operation parameters were optimized with annual cost and system COP as objective functions. Design variables included PVT inclination, azimuth, area, heat pump capacity, and tank volume, while operational variables were PVT backplate temperature and tank temperature. …”
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Optimization of K-Shaped Metal Sealing Ring for Subsea Tubing Hanger Based on Response Surface Method by Huan Xie, Hongxia Zhang, Yiwei Fan, Liyuan Liu, Wei Zeng

“…To address the issue of low optimization efficiency due to the need for repeated finite element calculations during the optimization process, quadratic response surface models are established for the sealing performance indicators of the K-shaped seal ring, which were then used as the optimization objective functions to enhance the optimization efficiency. …”
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MiR-216a-3p inhibits the cytotoxicity of primary natural killer cells by Rowan Abdelbary, Rowan Abdelbary, Manon Ragheb, Manon Ragheb, Shereen A. El Sobky, Nagwa El-Badri, Nourhan Aboud, Ahmed Tawheed, Asmaa Gomaa, Mona Zidan, Ramy K. Aziz, Abd Elrahman Abouzid, Radwa Ayman Salah, Mohamed El-Kassas, Imam Waked, Ahmed Moustafa, Ahmed Moustafa, Injie Omar Fawzy, Nada El-Ekiaby, Ahmed Ihab Abdelaziz

“…IntroductionThe role of miRNAs in regulating variable molecular functions has been sought by scientists for its promising utility in regulating the immune response and, hence, in treating various diseases. …”
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Integrated analyses of copy number variations and gene expression in lung adenocarcinoma. by Tzu-Pin Lu, Liang-Chuan Lai, Mong-Hsun Tsai, Pei-Chun Chen, Chung-Ping Hsu, Jang-Ming Lee, Chuhsing Kate Hsiao, Eric Y Chuang

“…We demonstrated the reproducibility of these genes in another lung cancer study (p = 0.0034, Fisher's exact test), and showed the concordance between copy number variations and gene expression changes by elevated Pearson correlation coefficients. Pathway analysis revealed two major dysregulated functions in lung tumorigenesis: survival regulation via AKT signaling and cytoskeleton reorganization. …”
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Temporal disorientation during war: associations with work-family conflict, emotional distress, and burnout by Irene Diamant, Maor Kalfon Hakhmigari

“…Principal Component Analysis (PCA) was used to validate the factor structure of the Hebrew version of Temporal Disorientation questionnaire, Pearson correlation coefficient was used to evaluated correlations among the study variables; Hierarchical linear regression was used to model the outcome variables, emotional distress and burnout.ResultsTemporal confusion and difficulties in future orientation during wartime were significantly associated with emotional distress. …”
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Application of Optimization Algorithms in Voter Service Module Allocation by Edgar Jardón, Marcelo Romero, José-Raymundo Marcial-Romero

“…These findings align with principles of spatial justice and highlight the practical efficiency of heuristic-based solutions in administrative resource allocation. …”
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Manufacturing of Rotational Toroidal Shells in Coin Minting by Luís M. Alves, Paulo Alexandrino, Sónia Pereira

“…Through finite element modeling and experimentation, key process variables were identified, ensuring sound hollow toroidal shells with efficient rotation.…”
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Clinical diagnostic and prognostic value of homocysteine combined with hemoglobin [f (Hcy-Hb)] in cardio-renal syndrome caused by primary acute myocardial infarction by Min-Juan Zeng, Yan-Quan Liu, Ping Pang, Xiao-Jun Chen, He Huang, Rui-Na Huang, Shi-Sen Li, He-Hui Zhang, Yue Yin, Chang-Sen Wang, Jin-Da Lin, Lin Lin, Shao-Peng Chen, Li Xu, Liang-Qing Zhang

“…Conclusion The newly constructed function [f (Hcy-Hb)], integrating Hcy and Hb levels, exhibits robust diagnostic and prognostic value in CRS. …”
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Parameter Estimation for Line Impedance in Distribution Network Based on μPMU Data by Zitong ZHANG, Qun ZHOU, Yulin DIAN, Zichao GUAN, Yue YIN, Minrui LENG, Xueshan LIU

“…Moreover, through designed experiments the weight coefficients of the objective function and the size of the dataset are determined appropriately to reduce the influence of errors on the solution results such that the model can be solved with higher accuracy. …”
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Effects of Indoor Air Quality on Human Physiological Impact: A Review by Tong Nie, Guofu Zhang, Yinan Sun, Wenhao Wang, Tianai Wang, Haoyan Duan

“…Through an analysis of cardiovascular biomarkers (heart rate variability, blood pressure), respiratory parameters, and neurological indicators (electroencephalogram patterns), we identify the mechanisms linking air quality degradation to impaired physiological functioning. …”
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Test–retest reliability and validity in lower limb proprioception tests using image capture technique in healthy adults by Aisuke Takahashi, Hikaru Kawana, Katsuhiro Furukawa

“…In statistical analysis, the test–retest reliability and construct validity were evaluated using intraclass correlation coefficients (ICC) and Spearman’s rank correlation coefficients. …”
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Pavement Deterioration Modeling of the International Roughness Index Based on Fuzzy Logic Approach by Abdualmtalab Ali, Abdalrhman Milad, Hussein ALMufargi, Nur Izzi Md Yusoff

“…Various types of pavement distress, such as fatigue cracking, rutting, longitudinal cracking, block cracking, transverse cracking, patching, ravelling, and potholes, are input variables; these parameters are fuzzified into fuzzy subsets with triangular membership functions. …”
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Application of Non-Linear System Model Updating Using Feature Extraction and Parameter Effects Analysis by John F. Schultze, François M. Hemez, Scott W. Doebling, Hoon Sohn

“…This provides indicators of the statistical variation associated with parameters as well as confidence intervals on the coefficients of the resulting meta-model. Also included in this method is the investigation of linear parameter effect screening using a partial factorial variable array for simulation. …”
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Rethinking energy security in the condition of a rise in public–private partnership in energy: Fresh insights from new estimation by Le Thanh Ha

“…High energy efficiency increases the energy system's resilience by ensuring that systems with restricted funds continue functioning in the event of energy restrictions or global uncertainty.…”
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Statistical Modeling and Kinetic Studies on the Adsorption of Reactive Red 2 by a Low-Cost Adsorbent: Grape Waste-Based Activated Carbon Using Sulfuric Acid Activator-Assisted Ther... by Seyyed Alireza Mousavi, Davood Shahbazi, Arezoo Mahmoudi, Parviz Mohammadi, Tooraj Massahi

“…The efficiency of activated carbon produced from grape waste as a low-cost, nontoxic, and available adsorbent to remove Reactive Red 2 from aqueous solution has been investigated. …”
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Estimation of Fuzzy Measures Using Covariance Matrices in Gaussian Mixtures by Nishchal K. Verma

“…The mixture components of GMM provide the membership functions for the input-output fuzzy sets. By treating consequent part as a function of fuzzy measures, we derived its coefficients from the covariance matrices found directly from GMM and the defuzzified output constructed from both the premise and consequent parts of the nonadditive fuzzy rules that takes the form of Choquet integral. …”
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Regional calibration of ecosystem service valuation under climate and tourism influences: a case study in subtropical Longyan, China by Hui Li, Enhao Chen, Shenglong Lin, Liang Cheng, Guofang Zhang

“…Abstract Precise evaluation of ecosystem service value (ESV) under climate variability is essential for supporting regional ecological management. …”
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rcprd: An R package to simplify the extraction and processing of Clinical Practice Research Datalink (CPRD) data, and create analysis-ready datasets. by Alexander Pate, Rosa Parisi, Evangelos Kontopantelis, Matthew Sperrin

“…Functions are available to extract common variable types (e.g., history of a condition, or time until an event occurs, relative to an index date), and more general functions for database queries, allowing users to define their own variables for extraction. …”
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