Human saliva exerts strong type-dependent effects on adenovirus infectivity by Erwan Sallard, Wenli Zhang, Nikita Chilakamarri, Setareh Farzanehkari, Setareh Farzanehkari, Inga Marte Charlott Seuthe, Anja Ehrhardt, Malik Aydin, Malik Aydin

“…All human Ads used were replication-competent and expressed a GLN cassette containing a green-fluorescent protein, nano-luciferase, and neomycin resistance. Loss-of-function experiments were conducted by immunoprecipitation or enzymatic digestion of specific saliva components to decipher related mechanisms.ResultsTemporal and inter-individual variability in saliva samples were observed, validating the use of a saliva pool to represent the population. …”
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Heat generation/absorption and bioconvective swirling stagnation point flow impact of magnetized Maxwell nanofluid by a stretchable rotating disk by Arfan Shahzad, Muhammad Imran, Madeeha Tahir, Shan Ali Khan, Nehad Ali Shah

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Health-related quality of life and associated factors among patients with stroke at tertiary level hospitals in Ethiopia. by Ashenafi Zemed, Kalkidan Nigussie Chala, Getachew Azeze Eriku, Andualem Yalew Aschalew

“…A generalized linear model with a gamma distribution and log-link function was used to investigate potential predictors, and variables with a P value of <0.05 were considered statistically significant.…”
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Influence of the Milling Cutter Drill on Implant Placement Accuracy in Partially Guided Surgery: An In Vitro Experimental Study by Ana Raquel Ferreira, Catarina Mendes Fonseca, André Correia, Patrícia Fonseca

“…Implant positions were virtually planned with coDiagnostiX^® (version 10.9) software and executed with or without the use of the milling cutter drill. …”
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HIV-associated neurocognitive disorders in Africa: challenges, peculiarities, and future directions by Tobi Olajide, Evelyn Ogungbemi, Gideon Olajide, Deborah Ogundijo, Oluwanifemi Osakuade, Favour Moshood

“…Evidence from Africa emphasizes the variability in the prevalence of neurocognitive impairment among people living with HIV. …”
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Achieving high precision and productivity in laser machining of Ti6Al4V alloy: A comprehensive study using a n-predictor polynomial regression model and PSO algorithm by Avinash Chetry, Sandesh Sanjeev Phalke, Arup Nandy

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Pancreatic satellite cells derived galectin-1 increase the progression and less survival of pancreatic ductal adenocarcinoma. by Dong Tang, Jingqiu Zhang, Zhongxu Yuan, Jun Gao, Sen Wang, Nianyuan Ye, Ping Li, Sujun Gao, Yi Miao, Daorong Wang, Kuirong Jiang

“…<h4>Background</h4>Galectin-1, a member of carbohydrate-binding proteins with a polyvalent function on tumor progression, was found strongly expressed in pancreatic satellite cells (PSCs), which partner in crime with cancer cells and promote the development of pancreatic ductal adenocarcinoma (PDAC). …”
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Enhancing the Efficacy and Safety of Methotrexate Treatment: A Focus on Drug Interactions (Review) by S. A. Doktorova, Yu. Yu. Grabovetskaya, M. Stefanov, V. V. Rafalskiy

“…The toxicity of MTX may be increased by the concomitant administration of medicinal products that exhibit haematotoxicity and affect renal function (impair the elimination of medicines). When co-administering MTX and medicines having clinically significant DDIs described in the literature, healthcare providers should consider the risk factors for each individual patient. …”
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The Potential of Lactic Acid Bacteria and Dairy By-Products in Controlling <i>Campylobacter jejuni</i> in Poultry by Naga Pavan Kumar Reddy Jonnagiri, Gintare Zakariene, Naila Nawaz, Ausra Gabinaitiene, Artūras Stimbirys

“…., lactoferrin), reduces <i>C. jejuni</i> viability, decreasing the food product contamination on the carcass for a short time by 40%. LAB antimicrobial function becomes more effective when used with acid whey, although specific farm-related variables require additional optimization. …”
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Aging-related changes in neuromuscular control strategies and their influence on postural stability by Scott J. Mongold, Christian Georgiev, Thomas Legrand, Esranur Yildiran Carlak, Antonella Iannotta, Pierre Cabaraux, Gilles Naeije, Marc Vander Ghinst, Mathieu Bourguignon

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Reducing syndemics of non-communicable chronic diseases in Mayan Indigenous population through community-based participatory research: a mixed-methods study protocol by Maarten M H Lahr, Erik Buskens, Adalberto Loyola-Sanchez, Ingris Peláez-Ballestas, Alfonso Gastelum Strozzi, Emilio Motte-García, Cinthya Cadena-Trejo, María Fernanda Ramírez-Flores, María Victoria Fernandez-Garcia, Karen G Castillo-Hernandez, Kenia Nayrobi López-Herrera

“…We will follow four phases of the CBPR: (1) situational analysis, through community censuses and semistructured interviews to understand the prevalence of NCDs and the syndemics in these communities; (2) co-construction of the elements of a SCM based on the health priorities identified by researchers, community members and healthcare workers; (3) implementation of this SCM and (4) evaluation of the SCM through (1) statistical analyses involving the construction of a syndemic index through stepwise logistic regression of the normalised and standardised key clinical, social and economic variables; interval and ratio variables will be normalised by their z-score and categorical variables will be one-hot encoded; similarity and social networks analysis with clustering to identify syndemic subpopulations; and cost-effectiveness and cost-utility analyses using Markov modelling and (2) narrative and thematic qualitative analysis of the SCM’s implementation and impact on community members’ health, function and quality of life.Ethics and dissemination Research ethics boards of participant institutions approved this research protocol. …”
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Insect seedling herbivory is influenced by multiple factors, but the plant apparency theory is more supported than other hypotheses – A case study in a subtropical forest by Baozhu Yuan, Bo Wang

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Adaptive trial for the treatment of depressive symptoms associated with concussion using accelerated intermittent theta burst stimulation (ADEPT): rationale, design and methods by Lindsay M. Oberman, Adriana I. Penafiel, Rachel Dieterich, Cuong T. Phan, Yi-Yu Chou, Dzung L. Pham, Maheen M. Adamson, Maheen M. Adamson, Christopher E. Hines, Zeynab Rezaee, Zhi-De Deng, Hemant Pal, Sarah H. Lisanby, Sarah H. Lisanby, David L. Brody, David L. Brody

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Factors affecting the design of the management dashboard framework with an emphasis on the components of human resources productivity by Hassan Barmaki, Farshad Faezy Razi, Ehtesham Rashidi

“…Using productivity as a standard is useful for calculating efficiency, and can guide efforts to allocate resources optimally. …”
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Supply chain management and optimization in transportation logistics by Saoussen Krichen

“…SCM can also be seen as the process of optimizing a set of decisions that generate cost-effective solutions which provide efficient plans for acting on numerous levels while considering all decision-making standpoints. …”
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Developments in the study of the role of lactate metabolism in the genesis and progression of thyroid cancer by Lei Shi, Lei Shi, Lei Shi, Xuyang Zhong, Jiafeng Liu, Yong Ying, Zibing Liao, Jin Liu, Liwen Zhao, Jianing Zhong, Jianing Zhong, Xiangtai Zeng, Xiangtai Zeng

“…We systematically dissect the multifaceted regulatory circuits governing lactate metabolism by integrating three pivotal dimensions: (i) canonical signaling cascades; (ii) tumor-microenvironmental variables, most notably hypoxia and acidosis; and (iii) the emerging epigenetic paradigm of lactylation, which dynamically reprograms the catalytic efficiency of rate-limiting enzymes and reshapes the transcriptional landscape of metabolic genes, thereby precisely coordinating lactate homeostasis. …”
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Comparative Evaluation of Vibratory Physiotherapy Methods in the Early Period after Cardiac Surgery by А. А. Eremenko, T. P. Zyulyaeva, D. V., Ryabova, А. P. Аlferova

“…Mechanical respiratory therapy procedures led to significant improvement in gas exchange variables, as evidenced by an increase in SpO2 in Groups 1 and 2 (p = 0.000009 and 0.000001, respectively) and a decrease in the proportion of patients with impaired oxygenating lung function (SpO2 below 92%) by 11 and 12 times, respectively (p &lt; 0.01). …”
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Good Governance and Seigniorage in a Selected OPEC Countries and Iran by ALI Rashid Shamkhal, Kambiz Paykarjou, beitollah Akbari Moghaddam

“…Good governance has several positive effects on government revenues and efficiency. While the use of seigniorage may initially appear as a natural right of governments, if it leads to a faster growth rate of money compared to economic growth, it can result in inflation and impose inflationary taxes. …”
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The Role of the Gut Microbiome in Exercise-Induced Inflammation and Recovery: A Narrative Review by Stanisław Dudek, Weronika Koziak, Aleksandra Bętkowska, Agata Kornacka, Kamila Szostak, Rafał Tomaka, Michalina Makieła, Wojciech Dudek, Anna Byra

“…While moderate exercise enhances immune function and microbial diversity, excessive training can lead to gut dysbiosis, increased intestinal permeability, and chronic inflammation. …”
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Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition by Mie K. Jakobsen, Sofie Traynor, Aaraby Y. Nielsen, Christina Dahl, Mette Staehr, Simon T. Jakobsen, Maria S. Madsen, Rasmus Siersbaek, Mikkel G. Terp, Josefine B. Jensen, Christina B. Pedersen, Anup Shrestha, Jonathan R. Brewer, Pascal H. G. Duijf, Odd L. Gammelgaard, Henrik J. Ditzel, Alexei F. Kirkin, Per Guldberg, Morten F. Gjerstorff

“…Results We show that breast cancer tumors and cell cultures exhibit a highly heterogenous response to DNA methyltransferase inhibitors, persisting even under high drug concentrations and efficient DNA methyltransferase depletion. The observed variability in response to DNA methyltransferase inhibitors was independent of cancer-associated aberrations and clonal genetic diversity. …”
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