Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells by Xiaofei Wei, Lin Shen, Chang Liu, Cheng Zhang, Min Tao, Jian Li, Xicheng Wang, Ting He, Fei Dai, Changsong Qi, Mingyang Ma, Yanping Ding, Xinan Lu, Dongqun Liu

“…An antigen-sensitive and long-lasting CAR-T cell targeting GUCY2C was investigated in this study.Methods Using constructed tumor cell lines with various GUCY2C expression densities, we screened out an antigen-sensitive single chain variable fragment (scFv) that enabled CAR-T cells to efficiently eradicate the GUCY2C lowly expressed tumor cells. …”
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Application of multi-objective neural network algorithm in industrial polymerization reactors for reducing energy cost and maximising productivity by Fakhrony Sholahudin Rohman, Sharifah Rafidah Wan Alwi, Dinie Muhammad, Ashraf Azmi, Zainuddin Abd Manan, Jeng Shiun Lim, Hong An Er, Siti Nor Azreen Ahmad Termizi

“…Optimization on an industrial scale is a complex task that involves fine-tuning the performance of large-scale systems and applications to make them more efficient and effective. This process can be challenging due to the increasing volume of work, growing system complexity, and the need to maintain optimal performance. …”
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The human gut microbiota contributes to type-2 diabetes non-resolution 5-years after Roux-en-Y gastric bypass by Jean Debédat, Tiphaine Le Roy, Lise Voland, Eugeni Belda, Rohia Alili, Solia Adriouch, Pierre Bel Lassen, Kazuyuki Kasahara, Evan Hutchison, Laurent Genser, Licia Torres, Camille Gamblin, Christine Rouault, Jean-Daniel Zucker, Nathalie Kapel, Christine Poitou, Geneviève Marcelin, Federico E. Rey, Judith Aron-Wisnewsky, Karine Clément

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ITER NBI operational window and power availability constraints due to shine-through losses by P. Vincenzi, M. Schneider, P. Veltri, J.F. Artaud, A. Loarte, S. Nicolici, C. Poggi, A.R. Polevoi, A. Snicker

“…We then present a new heuristic formula which permits the calculation of the ST fraction and the minimum plasma density that permits ITER NBI operations as a function of global variables. This allows for establishing operational limits for Hydrogen and Deuterium NBI in Hydrogen, Deuterium, and Deuterium–Tritium plasmas. …”
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AngleCam: Predicting the temporal variation of leaf angle distributions from image series with deep learning by Teja Kattenborn, Ronny Richter, Claudia Guimarães‐Steinicke, Hannes Feilhauer, Christian Wirth

“…The plausibility of the predicted leaf angle time series was underlined by its close relationship with environmental variables related to transpiration. The evaluations confirm that AngleCam is a robust and efficient method to track leaf angles under field conditions. …”
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Supply chain management and optimization in transportation logistics by Saoussen Krichen

“…SCM can also be seen as the process of optimizing a set of decisions that generate cost-effective solutions which provide efficient plans for acting on numerous levels while considering all decision-making standpoints. …”
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Human saliva exerts strong type-dependent effects on adenovirus infectivity by Erwan Sallard, Wenli Zhang, Nikita Chilakamarri, Setareh Farzanehkari, Setareh Farzanehkari, Inga Marte Charlott Seuthe, Anja Ehrhardt, Malik Aydin, Malik Aydin

“…All human Ads used were replication-competent and expressed a GLN cassette containing a green-fluorescent protein, nano-luciferase, and neomycin resistance. Loss-of-function experiments were conducted by immunoprecipitation or enzymatic digestion of specific saliva components to decipher related mechanisms.ResultsTemporal and inter-individual variability in saliva samples were observed, validating the use of a saliva pool to represent the population. …”
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Optimal selection of satellite XCO₂ images for urban CO₂ emission monitoring by A. Danjou, G. Broquet, A. Schuh, F.-M. Bréon, T. Lauvaux, T. Lauvaux

“…Despite such efficient filtering, the accuracy of the estimates corresponding to the former group of images varies widely from city to city.…”
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Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition by Mie K. Jakobsen, Sofie Traynor, Aaraby Y. Nielsen, Christina Dahl, Mette Staehr, Simon T. Jakobsen, Maria S. Madsen, Rasmus Siersbaek, Mikkel G. Terp, Josefine B. Jensen, Christina B. Pedersen, Anup Shrestha, Jonathan R. Brewer, Pascal H. G. Duijf, Odd L. Gammelgaard, Henrik J. Ditzel, Alexei F. Kirkin, Per Guldberg, Morten F. Gjerstorff

“…Results We show that breast cancer tumors and cell cultures exhibit a highly heterogenous response to DNA methyltransferase inhibitors, persisting even under high drug concentrations and efficient DNA methyltransferase depletion. The observed variability in response to DNA methyltransferase inhibitors was independent of cancer-associated aberrations and clonal genetic diversity. …”
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The Relationship Between Supply Environment, Supply Chain Integration and Performance Considering Opportunistic Behaviors by Abbas َAsadi, safanaz Heidari

“…Then, inferential statistics are employed to explain the relationships between variables and generalize the results to the society. …”
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Immunological Avalanches in Renal Immune Diseases by Davide Viggiano, Pietro Iulianiello, Antonio Mancini, Candida Iacuzzo, Luca Apicella, Renata Angela Di Pietro, Sarah Hamzeh, Giovanna Cacciola, Eugenio Lippiello, Andrea Gigliotti, Carmine Secondulfo, Giancarlo Bilancio, Giuseppe Gigliotti

“…Additionally, biological age calculations provide valuable prognostic information, while proteinuria measurements offer efficient sampling for system dynamics assessment. …”
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Manufacturing of Rotational Toroidal Shells in Coin Minting by Luís M. Alves, Paulo Alexandrino, Sónia Pereira

“…Through finite element modeling and experimentation, key process variables were identified, ensuring sound hollow toroidal shells with efficient rotation.…”
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Machine learning-based model for acute asthma exacerbation detection using routine blood parameters by Youpeng Chen, Junquan Sun, Yabang Chen, Enzhong Li, Jiancai Lu, Huanhua Tang, Yifei Xie, Jiana Zhang, Lesi Peng, Haojie Wu, Zhangkai J. Cheng, Baoqing Sun

“…Background: Acute asthma exacerbations (AAEs) are a leading cause of asthma-related morbidity and mortality, especially in resource-limited settings where pulmonary function tests are unavailable or when patients are unable to cooperate with testing. …”
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Influence of structural surface roughness on the strength of layered fill bodies based on PFC2D by Jinxing WANG, Zongsheng HU, Huazhe JIAO, Xiaolin YANG, Qi ZHANG, Xiaohui LIU, Ping XU, Junqiang XU, Xun CHEN

“…The cracks form as large macroscopic fractures in the vertical direction, indicating that as the interface roughness increases, the quality of the bonding surface improves, leading to more efficient usage of the overall mechanical properties of the specimens. …”
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rcprd: An R package to simplify the extraction and processing of Clinical Practice Research Datalink (CPRD) data, and create analysis-ready datasets. by Alexander Pate, Rosa Parisi, Evangelos Kontopantelis, Matthew Sperrin

“…Functions are available to extract common variable types (e.g., history of a condition, or time until an event occurs, relative to an index date), and more general functions for database queries, allowing users to define their own variables for extraction. …”
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Development of data-driven machine learning models and their potential role in predicting dengue outbreak by Bushra Mazhar, Nazish Mazhar Ali, Farkhanda Manzoor, Muhammad Kamran Khan, Muhammad Nasir, Muhammad Ramzan

“…This involves gathering data on various climatic factors, including temperature, rainfall, relative humidity, and wind speed, along with monthly records of dengue cases. The study functions as an efficient warning system, enabling the anticipation of dengue outbreaks. …”
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Two Weighted Fuzzy Goal Programming Methods to Solve Multiobjective Goal Programming Problem by Mousumi Gupta, Debasish Bhattacharjee

“…Here, the relative weights represent the relative importance of the objective functions. The proposed methods involve one additional goal constraint by introducing only underdeviation variables to the fuzzy operator λ (resp., 1-λ), which is more efficient than some well-known existing methods such as those proposed by Zimmermann, Hannan, Tiwari, and Mohamed. …”
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Predicting the Permeability of Pervious Concrete Based on the Beetle Antennae Search Algorithm and Random Forest Model by Jiandong Huang, Tianhong Duan, Yi Zhang, Jiandong Liu, Jia Zhang, Yawei Lei

“…The results showed that the hyperparameters of RF can be tuned by the BAS efficiently; the BAS can combine the conventional RF algorithm to construct the evolved model to predict the permeability of pervious concrete; the cement/aggregate ratio was the most significant variable to determine the permeability, followed by the coarse aggregate proportions.…”
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Study of the possibility of controlling the production of low-molecular-weight heparin preparations by domestic test systems (review) by A. L. Berkovsky, E. V. Sergeeva, A. V. Suvorov

“…The data on the wide clinical use of low-molecular-weight heparin (LMWH) preparations are presented, necessitating the need for efficient and high-quality production of appropriate pharmaceuticals. …”
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An enhanced buck-boost converter for photovoltaic diagnosis application: Accurate MPP tracker and I-V tracer by Yassine Chouay, Mohammed Ouassaid

“…In normal operation, the converter is controlled by neural network (NN) controller to efficiently extract maximum power point (MPP). However, in the event of a system failure, the converter automatically transitions to variable load mode to capture different points on the current-voltage (I-V) curve. …”
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