Impact of IgG subclass on monoclonal antibody developability by Paul Cain, Lihua Huang, Yu Tang, Victor Anguiano, Yiqing Feng

“…We thus conducted a systematic study of 12 mAbs derived from three sets of unrelated variable regions, each cloned into IgG1, an IgG1 variant with diminished effector functions, IgG2, and a stabilized IgG4 variant with further reduced FcγR interaction, to evaluate the impact of IgG subclass on manufacturability and high concentration stability in a common formulation buffer matrix. …”
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XPolypNet: A U-Net-Based Model for Semantic Segmentation of Gastrointestinal Polyps With Explainable AI by Arjun Kumar Bose Arnob, Muhammad Mostafa Monowar, Md. Abdul Hamid, M. F. Mridha

“…The presented model was evaluated on five benchmark datasets, achieving a Dice Coefficient of 0.8378 and a Mean Intersection over Union (mIoU) of 0.8427. …”
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SVR-Optimized ANN Model for Predicting Earthquake Risk in Electrical Substations Based on Disaster Datasets in the Aceh Region, Indonesia by Elvy Sahnur Nasution, Yuwaldi Away, Syahrial, Ira Devi Sara, Andri Novandri

“…The ANN training process uses backpropagation with sigmoid and tanh activation functions. The ANN outputs are then used as input features for the SVR model, applying a Radial Basis Function (RBF) kernel to capture the non-linear relationships between variables. …”
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Validation of an interferon-gamma enzyme-linked immunosorbent spot assay to evaluate cell-mediated immunity against severe acute respiratory syndrome coronavirus 2 by Yunhwa Kim, Eun-Jeong Jang, Ji-Young Hwang, Kyung-Min Lee, Sivilay Xayaheuang, Seok-Tae Choi, Hosun Park

“…Taken together, we demonstrated that the IFN-γ ELISpot assay is feasible for evaluating SARS-CoV-2-specific cell-mediated immune function through validation based on standard operating procedures.…”
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Organizational and Economic Factors of Health System Optimization by Oleksandr Telizhenko, Yuliia Halynska, Nataliia Baistriuchenko, Volodymyr Potseluiev, Kateryna Demchuk

“…To this aim, the factors that influence the efficiency of the organization and functioning of the medical system are identified. …”
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Sensitivity to Instruction Strategies in Motor Learning Is Predicted by Anterior–Posterior TMS Motor Thresholds by Michael L. Perrier, Kylee R. Graham, Jessica E. Vander Vaart, W. Richard Staines, Sean K. Meehan

“…Recent transcranial magnetic stimulation (TMS) studies suggest that variability in interneuron recruitment by anterior–posterior (AP) currents is linked to differences in functional connectivity between premotor and motor regions. …”
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Back-Analysis of Parameters of Jointed Surrounding Rock of Metro Station Based on Random Forest Algorithm Optimized by Cuckoo Search Algorithm by Xinping Guo, Annan Jiang, Xiang Liu

“…In this method, the mean square error between the measured displacement (stress) and the calculated displacement (stress) is taken as the objective function, and the joint parameters are taken as the decision variables. …”
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Parental acceptance of novel children's medical syringes and their influencing factors by Su Wen Luo, Peng Rui Yang

“…Furthermore, the product's function and price value significantly shape users' behavioral intentions. …”
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DeBo: Contrast enhancement for image registration using binary differential evolution and bat optimization. by Muhammad Adeel Akram, Tallha Akram, Umer Javed, Muhammad Rafiq, Mehvish Naz, Di He

“…In this study, we proposed a hybrid binary differential evolution and BAT optimization model to enhance contrast stretching by optimizing a decision variables in the transformation function. To validate its efficiency, the proposed approach is utilized as a preprocessor before feature extraction in image registration. …”
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Revealing the Immune Response of <i>Sitona callosus</i> Gyllenhal to Entomopathogenic Fungi <i>Beauveria bassiana</i> Infection Through Integrative Analyses of Transcriptomics and... by Nan Li, Xin Gu, Ming Xin, Xinpu Wang

“…Additionally, we utilized the Pearson correlation coefficient method to examine the relationships between differentially expressed immune-related genes and metabolites, revealing notably strong correlations between these two sets of variables. …”
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Network Analysis of Key Instrumental Activities of Daily Living and Cognitive Domains for Targeted Intervention in US Older Adults Without Dementia: Cross-Sectional Study by Jiaying Li, Rendong He, Erh-Chi Hsu, Junxin Li

“…Network analysis identified central and bridge variables. Nonparametric and case-dropping bootstrap methods checked network stability. …”
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Comparative study between the Patient Participation Culture Tool and the Hospital Survey on Patient Safety Culture using retrospective data from 2014 to 2021 by Ward Schrooten, Ann Van Hecke, Marlies Claesen, Evelyne Punnewaert, Simon Malfait, Kristof Eeckloo

“…Spearman’s rank correlation coefficient was employed to evaluate relationships between continuous variables represented by PACT domain and HSPSC dimensional scores among study participants.Results Data from 17 hospitals were analysed. …”
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The Effect of Season and Breed on Hypothalamic–Pituitary–Adrenal Axis Hormones, Metabolic Hormones, and Oxidative Markers in Ponies and Horses by Sarah Alison Vaughn, Margaret B. Lemons, Kelsey A. Hart

“…Linear mixed effects modeling with a random effect for animal was used to determine the effects of season and breed. Correlation coefficients were calculated for relevant variables. …”
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Identification of an additive interaction using parameter regularization and model selection in epidemiology by Chanchan Hu, Zhifeng Lin, Zhijian Hu, Shaowei Lin

“…We present two pathways to achieve this end: one is to complete the constraint by adding a regular penalty term to the model likelihood function; the other is to use model selection. Result Using simulated and real data, our proposed methods effectively identified additive interactions and proved to be applicable to real-world data. …”
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Relationship between Communication Skills and General Health in Nursing Students of Hamadan University of Medical Sciences by Roya Amini, Fariba Soleimani, Nahid Mohammadi, Tapak Leili

“…Communication skills had a significant relationship with most aspects of general health, except social function (p<0.001). There was no correlation between demographic variables and communication skills (p<0.05). …”
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Specific nature of the integrative (complex) effect of environmental factors on hazelnut cultivars in the Russian humid subtropics by T. D. Besedina, A. P. Boyko, Ts. V. Tutberidze, N. S. Kiseleva

“…The expediency of the crop’s large-scale cultivation calls for measuring the parameters of agroclimatic indicators, ranging in variability, intensity, and duration of their impact. …”
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Objective Measures of Spatial Effects in Spanish Concert Halls by Sara GIRÓN, Teófilo ZAMARRENO, Pedro BUSTAMANTE

“…The paper concludes with a discussion on the relationships of hall-average data of the five parameters with eight geometric and acoustic variables.…”
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Data-driven modeling and regression analysis on ship resistance of in-service performance by Daehyuk Kim, Shin Hyung Rhee

“…The analysis of added resistance due to waves shows significant, but sometimes inconsistent, transfer function coefficients, suggesting simpler model structures could be more effective. …”
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Automatic detection of optic canal fractures and recognition and segmentation of anatomical structures in the orbital apex based on artificial intelligence by Yu-Lin Li, Yu-Hao Li, Mu-Yang Wei, Guang-Yu Li

“…Timely and accurate diagnosis and treatment are crucial for preserving visual function. However, diagnosing OCF can be challenging for inexperienced clinicians due to atypical OCF changes in imaging studies and variability in optic canal anatomy. …”
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RELATIONSHIP BETWEEN PRIVATE DOMESTIC INVESTMENT AND ECONOMIC GROWTH IN NIGERIA (1986-2018): AUTO-REGRESSIVE DISTRIBUTED LAG APPROACH by Isiaka Kareem JIMBA, Rosemary Bukola AJALA

“…The study incorporated other investment measures like foreign direct investment and public investment into the model, while inflation and exchange rate were taken as control variables. Secondary data was sourced from CBN statistical bulletin of various editions and was estimated using autoregressive distributed lag bound test and its coefficients. …”
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