Cohort profile: the open, prospective Community-Based chronic Care Lesotho (ComBaCaL) cohort – design, baseline chronic disease risk factors and hypertension and diabetes care casc... by Matthias Briel, Thilo Burkard, Ravi Gupta, Frédérique Chammartin, Alain Amstutz, Thabo Ishmael Lejone, Eleonora Seelig, Irene Ayakaka, Mosa Tlahali, Matumaole Bane, Makhebe Khomolishoele, Tristan Lee, Niklaus Daniel Labhardt, Felix Gerber, Giuliana Sanchez-Samaniego, Thesar Tahirsylaj, Fabian Raeber, Mamakhala Chitja, Malebona Mathulise, Thuso Kabi, Mosoetsi Mokaeane, Malehloa Maphenchane, Manthabiseng Molulela, Mota Mota, Sesale Masike, Retselisitsoe Makabateng, Mamoronts’ane Sematle, Lebohang Sao, Sejojo Phaaroe, Malitaba Litaba, Madavida Mphunyane, Dave Brian Basler, Kevin Kindler, Pauline Grimm

“…It serves as a platform for implementing nested trials using the Trials within Cohorts (TwiCs) design to assess community-based chronic care interventions. …”
Get full text

The effects of microencapsulated hot chili pepper on the blood metabolites and physiological parameters of dairy cows by Mónica Madrigal-Valverde, Marcus Vínicius Galvão Loiola, José Esler Freitas Junior, Murilo Ramos Santiago, Lara Lôbo Dantas, Artur Azevedo Menezes, Sandro Percário, Everton Luiz Pompeu Varela, Eduardo Costa, Endrigo Adonis Braga de Araujo, Rodrigo Freitas Bittencourt

“…Physiological measurements, including body condition score, heart rate, respiratory frequency, and urine pH, were also assessed weekly. Data were statistically analyzed using mixed-model procedures with repeated measures over time. …”
Get full text

Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway by Kyonghwan Choe, Muhammad Ali, Roy Lardenoije, Renzo J.M. Riemens, Ehsan Pishva, Horst Bickel, Siegfried Weyerer, Per Hoffmann, Michael Pentzek, Steffi Riedel-Heller, Birgitt Wiese, Martin Scherer, Michael Wagner, Diego Mastroeni, Paul D. Coleman, Alfredo Ramirez, Inez H.G.B. Ramakers, Frans R.J. Verhey, Bart P.F. Rutten, Gunter Kenis, Daniel L.A. van den Hove

“…Functional interactions between genes and identification of common phenotype-specific positive and negative elementary circuits were conducted using computational modeling, i.e. gene regulatory network (GRN) and network perturbational analysis. …”
Get full text

The KNAT3a1-WND2A/3A module positively regulates fiber secondary cell wall biosynthesis in Populus tomentosa by Kuan Sun, Di Fan, Yingying Peng, Chang Liu, Lingfei Kong, Ting Lan, Xianqiang Wang, Dan Li, Chaofeng Li, Keming Luo

“…Taken together, these data suggest that the KNAT3a1-WND2A/3A module positively regulates fiber development of the secondary xylem in poplar via the WND2A/3A-mediated hierarchical regulatory network, and supplies useful information for fiber SCW formation. …”
Get full text

Multi-dimensional Exposure Characteristics and Health Benefits Differentiation of Green Spaces within Community Life Circle by Hailin HONG, Qing CHANG

“…A total of 1,116 residents from 36 neighborhoods are examined using multi-source data, involving green space metrics, health outcomes survey, and demographic and socioeconomic indicators. …”
Get full text

Non-adherence to medication and its associations among type 2 diabetes patients following up with health coaches in primary healthcare centers, Makkah city, KSA by Ahmad Salah Alkathiri, Renad Turki Alghamdi, Abeer Ahmad Alamri, Haneen Hassan Alhazmi, Sarah Badr Alsharif, Sahab Muqbil Alharbi, Muath Aldomini, Baraa Sami Quronfulah, Mohamed O. Nour, Mohamed Osman Elamin, Abdullah Khalid Alafif, Saud Hasan Surbaya, Osama M. Hayat Noor

“…Methodology A cross-sectional study was conducted among 327 T2DM adult patients. Data on socio-demographic characteristics, clinical, medication-related, and psychological factors, barriers to adherence, and communication difficulties were collected by health coaches at all 24 PHCCs in Makkah City using a structured interview questionnaire. …”
Get full text

Safety and Immunogenicity of a rAd35-EnvA Prototype HIV-1 Vaccine in Combination with rAd5-EnvA in Healthy Adults (VRC 012). by Michelle C Crank, Eleanor M P Wilson, Laura Novik, Mary E Enama, Cynthia S Hendel, Wenjuan Gu, Martha C Nason, Robert T Bailer, Gary J Nabel, Adrian B McDermott, John R Mascola, Richard A Koup, Julie E Ledgerwood, Barney S Graham, VRC012 Study Team

“…The humoral and cellular immunogenicity data reported here may inform future vaccine and study design.…”
Get full text

Design, Construction, and Evaluation of a Spatial Depth Measurement System for Subsoiler in Sugarcane Fields by N. Loveimi, A. Azizi, A. Kaab, A. Neisi

“…Furthermore, by integrating recorded depth data with geospatial information, it becomes possible to generate detailed maps illustrating depth variations across the field. …”
Get full text

Identification and validation of a KRAS-macrophage-associated gene signature as prognostic biomarkers and potential therapeutic targets in melanoma by Beichen Cai, Beichen Cai, Beichen Cai, Qian Lin, Qian Lin, Qian Lin, Ruonan Ke, Ruonan Ke, Ruonan Ke, Jiaqi Yu, Jiaqi Yu, Jiaqi Yu, Lu Chen, Lu Chen, Xuejun Ni, Xuejun Ni, Hekun Liu, Xiuying Shan, Xiuying Shan, Biao Wang, Biao Wang, Biao Wang

“…The prognostic value of the KMPAG signature was assessed through its correlation with clinical outcomes, immune cell infiltration patterns, response to therapy, drug sensitivity, and miRNA-gene regulatory interactions. Cell-cell communication within the SKCM microenvironment was explored using the “CellChat” tool. …”
Get full text

Associations of long-term exposure to fine particle and its components with ischemic stroke: A cohort study in China by Lisha Xu, Yexiang Sun, Xinhan Zhang, Jingjing Hu, Jie Qiu, Yonghao Wu, Zongming Yang, Yixing Wang, Zihan Li, Jiayun Zhang, Ping Cheng, Dandan Xu, Zhijian Chen, Hongbo Lin, Liming Shui, Zhiqin Jiang, Mengling Tang, Mingjuan Jin, Xiaofeng Wang, Kun Chen, Jianbing Wang

Get full text

Niches and Interspecific Association of Dominant Sciaenidae Species in the Offshore Waters of Southern Zhejiang Province by Yahui YUAN, Shiyu WANG, Chunxia GAO, Jing ZHAO, Qingzhu HUANG

“…To comprehensively investigate the ecological niche characteristics and interspecific interactions of Sciaenidae species in the offshore waters of southern Zhejiang Province, this study used data from four quarterly fishery resource surveys conducted from May 2020 to January 2021. …”
Get full text

Outpatient Virtual Care Among People Living With and Beyond Cancer From Culturally and Linguistically Diverse Backgrounds in Australia: A Protocol for a Realist Evaluation by Prince Peprah, Sagda Osman, Rebecca Mitchell, Ashfaq Chauhan, Ramya Walsan, Maryam Sina, Bronwyn Newman, Nadine El‐Kabbout, Jan Mumford, Emilie Francis‐Auton, Elizabeth Manias, Virginia Mumford, Kate Churruca, Michelle Moscova, Natalie Taylor, Craig Nelson, Alexander Cardenas, Robyn Clay‐Williams, Jeffrey Braithwaite, Reema Harrison

“…ABSTRACT Background Virtual care is increasingly being used to deliver outpatient cancer services, yet people from culturally and linguistically diverse (CALD) backgrounds can experience inequities in accessing these services. …”
Get full text

The comprehensive transcriptomic atlas of porcine immune tissues and the peripheral blood mononuclear cell (PBMC) immune dynamics reveal core immune genes by Qingyao Zhao, Jiahao Wang, Fuping Ma, Quanzhen Chen, Huatao Liu, Jinyan Yang, Siqian Chen, Yongjie Tang, Siyuan Mi, Lulu Wang, Xini Wang, Guohong Liu, Kai Xing, Ying Yu, Chuduan Wang

“…With the development of genomics technology, the combination of transcriptome, genetic variation, immune response, and QTL mapping data to illustrate the interactions between pathogen and host immune system, will be an effective tool for identification of disease resistance genes in pigs. …”
Get full text

Three Fast-spinning Medium-sized Hilda Asteroids Uncovered by TESS by Nóra Takács, Csaba Kiss, Róbert Szakáts, Emese Plachy, Csilla E. Kalup, Gyula M. Szabó, László Molnár, Krisztián Sárneczky, Róbert Szabó, Attila Bódi, András Pál

“…In this Letter, we report on the identification of three fast-rotating Hilda asteroids with spin periods in the 3.2–3.7 hr range using data from the Transiting Exoplanet Survey Satellite. …”
Get full text

Caveolin 1 in bovine liver is associated with fatty acid–induced lipid accumulation and the endoplasmic reticulum unfolded protein response: Role in fatty liver development by Ming Li, Bichen Zhao, Jingyi Wang, Huijing Zhang, Yue Yang, Shihao Song, Androniki Psifidi, Wenda Wu, Juan J. Loor, Chuang Xu

“…Overexpressing CAV1 reversed TM-induced increases in mRNA and protein associated with ER stress and de novo fatty acid synthesis. Furthermore, use of hepatocytes transfected with pc-CAV1 for 48 h and subjected to co-immunoprecipitation revealed that CAV1 interacts with IRE1α and ATF6. …”
Get full text

Evaluating Digital Rehabilitation Outcomes in Chronic Musculoskeletal Conditions Across Non-Obesity, Obesity, and Severe Obesity by Pereira AP, Janela D, Areias AC, Molinos M, Tong X, Bento V, Yanamadala V, Cohen SP, Correia FD, Costa F

“…Depending on the clinical outcomes, latent basis growth analysis and logistic regression were used.Results: Completion rates were high across all groups (77.5– 85.6%), although slightly lower in the obesity groups. …”
Get full text

THROMBOTIC AND BLEEDING RISK FACTORS IN ESSENTIAL THROMBOCYTHEMIA by A. A. Zhernyakova, I. S. Martynkevich, V. A. Shuvaev, L. B. Polushkina, M. S. Fominykh, V. Yu. Udal’eva, I. I. Zotova, D. I. Shiсhbabaeva, S. V. Voloshin, S. S. Бессмельцев, A. V. Chechetkin, K. M. Abdulkadyrov

“…Outpatient’s charts of 240 ET patients, who had been diagnosed with ET at our institution according to WHO 2008 criteria. The following data were assessed: complete blood count, bone marrow biopsy results, bone marrow cytogenetic, the restriction fragment length polymorphism (RFLP) results used for JAK2V617F detection, in case of JAK2V617F-negative status the PCR-RFLP results (MPL detection) and the direct sequencing results (CALR detection). …”
Get full text

Seasonal distribution and nature reserve planning of Indo-Pacific humpback dolphins in the Pearl River estuary from South China Sea by Xikai Tang, Dingyu Luo, Xian Sun, Bin Sun, Lang Guo, Hongri Wang, Nuoyan Huang, Zhiwei Liu, Yifei Liu, Nan Wang, Yuping Wu

“…This study provides a seasonal evaluation of habitat suitability and distribution for PRE humpback dolphins using five years of boat-based field survey data from 2019 to 2023. …”
Get full text

Effects of antagonistic network-targeted tDCS on brain co-activation patterns depends on the networks’ electric field: a simultaneous tDCS-fMRI study by Hechun Li, Hongru Shi, Sisi Jiang, Changyue Hou, Haonan Pei, Hanxi Wu, María Luisa Bringas Vega, Gang Yao, Dezhong Yao, Cheng Luo

“…Individual electric field (EF) strength was simulated using individual head model. Six recurring brain patterns (co-activation patterns, CAPs) were identified. …”
Get full text

Long-term exposure to fine particulate matter components with obesity in children and adolescents in China: The age-sex disparities and key effect modifiers by Jinling Wang, Xinyi Li, Guannan Bai, Rachel Huxley, Kejia Hu, Jinna Yuan, Xuelian Zhou, Xiaochi Zhang, Ke Huang, Guanping Dong, Wei Wu, Bingyan Cao, Rongxiu Zheng, Chunlin Wang, Haiyan Wei, Yan Liang, Hui Yao, Feihong Luo, Pin Li, Zhe Su, Ruimin Chen, Shaoke Chen, Jingsi Luo, Hongwei Du, Mireguli. Maimaiti, Jianwei Zhang, Yu Yang, Min Zhu, Qi Zhao, Junfen Fu

Get full text