GPATCH3, a splicing regulator that facilitates tumor immune evasion via the modulation of ATPase activity of DHX15 by Tingrong Ren, Gaigai Wei, Gaigai Wei, Jingjing Yi, Jingjing Yi, Yuqi Zhang, Haiping Zhao, Nana Wu, Huiling Zhang, Zhihan Guo, Yihan Wang, Jiating Kuang, Zhaoying Sheng, Duanwu Zhang

“…In vitro and in vivo models, including GPATCH3-depleted cell lines and mouse xenografts, were used to assess its roles in tumor progression. Immune infiltration patterns were analyzed using TIMER2.0 based on TCGA transcriptomic data.ResultsGPATCH3 interacts with the RNA helicase DHX15 and enhances its ATPase activity, promoting proper spliceosome disassembly. …”
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One Health Surveillance for SARS-CoV-2 in Non-Human Primates and Small Mammals in Minas Gerais, Brazil by Pedro Augusto Almeida-Souza, Thamires Gabriele Macedo Silva, Gabriele Barbosa Penha, Thaynara de Jesus Teixeira, Ramon Oliveira-Silva, Iago Alves Celestino, Maria Eduarda Gonçalves-dos-Santos, Cirilo Henrique de Oliveira, Alice dos Santos Nunes Ferreira, Emerson Márcio Gusmão, Vinícius de Oliveira Ottone, Danilo Simonini-Teixeira, Fabrício Souza Campos, Paulo Michel Roehe, Leonardo Camilo de Oliveira, Mauro Martins Teixeira, Filipe Vieira Santos de Abreu, Danilo Bretas de Oliveira

“…By providing baseline data on SARS-CoV-2 dynamics in wildlife, we emphasize the need for ongoing ecological and epidemiological surveillance to assess potential spillover events and their implications for biodiversity and public health in Brazil.…”
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A Novel Digital Intervention to Facilitate Diabetes Self-Management Among People with Schizophrenia and Related Disorders: Development and Acceptability Testing of SMART by Arnautovska U, Ritchie G, Soole R, Menon A, Korman N, Milton A, Varnfield M, Kelly JT, Jansen PM, Baker A, Ireland D, Russell AW, Chapman J, Mulligan K, Hirani SP, Vitangcol KJ, McKeon G, Siskind D

“…Barriers to usability included lack of mobile/internet data, precluding the ability to reply to text messages, and a preference for more hyperlinks and additional interactive features.Conclusion: The comprehensive co-design process resulted in the development of a novel digital intervention for prevention and self-management of T2D tailored to unique needs and preferences of people with SSD. …”
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Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway by Weijie Ni, Yajie Zhao, Jinxin Shen, Qing Yin, Yao Wang, Zuolin Li, Taotao Tang, Yi Wen, Yilin Zhang, Wei Jiang, Liangyunzi Jiang, Jinxuan Wei, Weihua Gan, Aiqing Zhang, Xiaoyu Zhou, Bin Wang, Bi-Cheng Liu, Yuanyuan Ji

“…Dunnett’s multiple comparison and t-test were used to analyze the data. Results:. Compared with the control mice, miR-26a expression was significantly downregulated in both the kidney and the heart after Ang-II infusion. …”
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First-Episode Psychosis incidence pre-, during, and post-COVID-19 pandemic: a six-year natural quasi-experimental study in South LondonResearch in context by Andrea Quattrone, Eleni Petkari, Edoardo Spinazzola, Perry B.M. Leung, Zhikun Li, Robert Stewart, Diego Quattrone, Marta Di Forti, Robin M. Murray, Mariana Pinto da Costa

“…We hypothesised that FEP rates rose during the pandemic and subsequently returned to pre-pandemic levels. Methods: Using the Clinical Record Interactive Search (CRIS) system, we screened individuals referred for FEP to Early Intervention Services for Psychosis (EISs) of the South London and Maudsley NHS Foundation Trust (SLaM) from 1 March 2018 to 29 February 2024. …”
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Network analysis in depressed adolescents with suicidal ideation: the role of depression, anxiety, and childhood abuse by Ziyang Huang, Ziyang Huang, Ziyang Huang, Liya A, Liya A, Liya A, Liya A, Kewen Yan, Kewen Yan, Kewen Yan, Hailiang Ran, Yusan Che, Runxu Yang, Runxu Yang, Runxu Yang, Linling Jiang, Linling Jiang, Linling Jiang, Rui Xiao, Rui Xiao, Rushuang Zeng, Rushuang Zeng, Rushuang Zeng, Tong Li, Tong Li, Tong Li, Yiling Xie, Yiling Xie, Yiling Xie, Yuanyuan Xiao, Jin Lu, Jin Lu, Jin Lu

“…Employing symptom network analysis, this study investigates the interactions among depressive symptoms, anxiety, and childhood abuse in adolescents diagnosed with major depressive disorder (MDD) and suicidal ideation.MethodsWe analyzed data from 733 Chinese adolescents diagnosed with MDD (mean age = 14.81 years). …”
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The influence of absorbing aerosols on the morning PBL growth dynamic in the EDMF-AERO modeling framework by G. M. Florczyk, K. M. Markowicz

“…<p>Using the novel PBL evolution model EDMF-AERO and the dataset collected during a measurement campaign at the Swider Geophysical Observatory in 2014, we studied morning PBL dynamics under high pollution. …”
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Causal relationships between four types of lipids and breast cancer risk with potential mediators: evidence from Mendelian randomization study and bioinformatics analysis by Xu-Chu Li, Bangqi Wang, Yu Tang

“…The expression of ZC3HC1 was further explored using the TIMER, GEPIA2 and HPA database. Finally, enrichment analyses of Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and protein–protein interactions (PPI) network analysis were conducted on ZC3HC1 and its related genes. …”
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Validity and network structure of the Nomophobia Questionnaire in Peruvian medical students by Peter Garcia-Portocarrero, Deysi A. Saldaña-Amaya, Brayan Miranda-Chavez, Javier A. Flores-Cohaila, Cesar Copaja-Corzo

“…Methods: An observational cross-sectional study was conducted with 3139 medical students from 38 schools in Peru, using the Spanish-adapted NMP-Q. Data were collected through an online survey, promoted via social media and direct contacts. …”
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Single-Cell and Single-Nuclei transcriptomics profiling reveals dynamic cellular features in tumor-related adipose microenvironment of breast cancer patients with high BMI by Xiaoxiao Hu, Fang Jia, Lili Li, Wuzhen Chen, Leyi Zhang, Jun Pan, Sangsang Zhu, Zhen Wang, Jian Huang

“…Materials and methods: We unveiled a comprehensive cell atlas by employing single-cell (N = 27) and single-nuclei (N = 6) transcriptomics to address dynamic changes of immune and stromal cell components within WAT in high BMI population. Bulk RNA-seq data sets were used for validation. Results: Characteristics of adipose-infiltrating tissue-resident macrophages (PVMs), APOD+γδ T cells, and mature FKBP5+ adipocytes in breast cancer women with high BMI were revealed, in terms of transcriptional genes, metabolism features, developmental trajectories and gene set enrichment analysis (GSEA). …”
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Bringing it all together: science priorities for improved understanding of Earth system change and to support international climate policy by C. G. Jones, F. Adloff, B. B. B. Booth, P. M. Cox, V. Eyring, V. Eyring, P. Friedlingstein, P. Friedlingstein, K. Frieler, H. T. Hewitt, H. A. Jeffery, S. Joussaume, T. Koenigk, T. Koenigk, B. N. Lawrence, E. O'Rourke, M. J. Roberts, B. M. Sanderson, R. Séférian, S. Somot, P. L. Vidale, D. van Vuuren, D. van Vuuren, M. Acosta, M. Bentsen, M. Bentsen, R. Bernardello, R. Betts, R. Betts, E. Blockley, J. Boé, T. Bracegirdle, P. Braconnot, V. Brovkin, C. Buontempo, F. Doblas-Reyes, F. Doblas-Reyes, M. Donat, I. Epicoco, I. Epicoco, P. Falloon, P. Falloon, S. Fiore, T. Frölicher, T. Frölicher, N. S. Fučkar, N. S. Fučkar, M. J. Gidden, H. F. Goessling, R. G. Graversen, S. Gualdi, J. M. Gutiérrez, T. Ilyina, T. Ilyina, T. Ilyina, D. Jacob, C. D. Jones, C. D. Jones, M. Juckes, M. Juckes, E. Kendon, E. Kendon, E. Kjellström, R. Knutti, J. Lowe, J. Lowe, M. Mizielinski, P. Nassisi, M. Obersteiner, P. Regnier, R. Roehrig, D. Salas y Mélia, C.-F. Schleussner, M. Schulz, E. Scoccimarro, L. Terray, H. Thiemann, R. A. Wood, S. Yang, S. Zaehle

“…Regional downscaling and impact models should use forcing data from these simulations, so impact and regional climate projections cover a more complete range of potential responses to a warming overshoot. …”
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Remodeling of the chromatin landscape in peripheral blood cells in patients with severe Delta COVID-19 by Vasiliy E. Akimov, Dmitriy I. Tychinin, Olga A. Antonova, Abusaid M. Shaymardanov, Maria D. Voronina, Kseniia A. Deinichenko, Oleg D. Fateev, Vladimir S. Yudin, Sergey M. Yudin, Vladimir E. Mukhin, Svetlana V. Romanova, Aleksandra I. Nekrasova, Anastasia S. Zhdanova, Anastasia V. Tsypkina, Ivan S. Vladimirov, Antonida V. Makhotenko, Anton A. Keskinov, Sergey A. Kraevoy, Ekaterina A. Snigir, Dmitry V. Svetlichnyy, Veronika I. Skvortsova

“…Moreover, cases with the Delta variant were accompanied by a specific monocyte subtype discovered using scATAC-seq data. Our analysis showed that immune cells of individuals with severe Delta COVID-19 underwent significant remodeling of the chromatin accessibility landscape and development of the proinflammatory expression pattern. …”
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Strontium isoscapes for provenance, mobility and migration: the way forward by Maximilian J. Spies, Amanda Alblas, Stanley H. Ambrose, Sarah Barakat, Ramiro Barberena, Clément Bataille, Gabriel J. Bowen, Kate Britton, Hayley Cawthra, Roger Diamond, Anthony Dosseto, Jane A. Evans, Erich Fisher, Kerryn Gray, Phoebe Heddell-Stevens, Emily Holt, Hannah F. James, Anneke Janzen, Mael Le Corré, Petrus le Roux, Julia Lee-Thorp, Alexander Mackay, Patricia J. McNeill, Janet Montgomery, Bedone Mugabe, Vicky M. Oelze, Michèle Pfab, Michael P. Richards, Celeste T. Samec, Francisca Santana-Sagredo, Alejandro Serna, Chris Stantis, Christophe Snoeck, Brian Stewart, Cameron Stuurman, Damon Tarrant, Adam G. West, Christine Winter-Schuh, Judith Sealy

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In vitro and in silico investigations of Propolis-derived phytochemicals as potential inhibitors of Plasmodium falciparum by Dhrubo Ahmed Khan, Md. Nazmul Hasan, Rachasak Boonhok, Suthinee Sungkanu, Yutatirat Singhaboot, Afsana Amin Shorna, Anamul Hasan, Kesinee Chotivanich, Polrat Wilairatana, Abolghasem Siyadatpanah, Roghayeh Norouzi, Imran Sama-ae, Watcharapong Mitsuwan, Alok K. Paul, Maria de Lourdes Pereira, Shanmuga S. Sundar, Tooba Mahboob, Christophe Wiart, Ryan V. Labana, Siriphorn Chimplee, Veeranoot Nissapatorn

“…Molecular docking and 100-ns molecular dynamic (MD) simulations were performed to evaluate the binding affinity and stability of selected compounds (tectochrysin and galangin) against PfLDH in both holo (Protein Data Bank [PDB] ID: 1LDG) and apo (PDB ID: 2X8L) forms. …”
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Decoding Cellular Landscapes: Unravelling Periodontitis and Periapical Periodontitis at the Single-Cell Frontier by Yuan Li, Jun Wang, Yu Zhang, Dengke Li, Wuyang Zhang, Xuebing Li, Bolun Zhang, Kaijin Hu, Jianfei Yan, Yang Xue

“…Objective: Elucidate differences in key gene expression and cellular heterogeneity in alveolar bone between periodontitis (PD) and periapical periodontitis (PP) by analysing single-cell RNA sequencing data. Methods: Single-cell RNA sequencing datasets for PD (GSE171213) and PP (GSE181688) were obtained from the Gene Expression Omnibus and analysed. …”
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Impact of environmental pollution on human health: Investigating the role of Polycyclic Aromatic Hydrocarbons in pediatric osteosarcoma by Mingxian Xu, Yu Xu, Yaping Huang, Jixiang Shi, Lifeng Yin, Jian Tu, Junqiang Yin, Changye Zou

“…A total of 1617 candidate PAH-associated molecular targets were retrieved from bioinformatics databases (PubChem, STITCH, GeneCards, DisGeNET), and core targets were identified using STRING and Cytoscape network analyses. Molecular docking was conducted to assess interactions between selected targets and two major PAH compounds, naphthalene (NAP) and benzo[a]pyrene (BaP). …”
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Vitamin K‐dependent gamma‐carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGF... by Zheng Wu, Qing Ye, Shan Zhang, Li‐Peng Hu, Xiao‐Qi Wang, Lin‐Li Yao, Lei Zhu, Shu‐Yu Xiao, Zong‐Hao Duan, Xue‐Li Zhang, Shu‐Heng Jiang, Zhi‐Gang Zhang, De‐Jun Liu, Dong‐Xue Li, Xiao‐Mei Yang

“…Methods Analysis of pancreatic ductal adenocarcinoma (PDAC) datasets, including transcription profiles, clinical data, and tissue microarrays, was conducted to evaluate PRRG1 expression and its clinical relevance. …”
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Seroprevalence and Risk Factors for Toxoplasma gondii Infection in People Living with HIV: A Cross-Sectional Study from Maputo Central Hospital, Mozambique by Manuel L, Comia IR, Miambo RD, Sousa IM, Cuboia N, Carimo A, Massuanganhe SJ, Buene TP, Banze LR, Paraque BP, Nhancupe N, Schooley RT, Santos-Gomes GM, Noormahomed EV, Benson CA

“…Sociodemographic and clinical data, such as age, sex, WHO HIV/AIDS stage, and CD4+ T-cell count, were collected. …”
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The influence of H. pylori infection in HER2-positive gastric cancer cell lines: insights from Wnt/β-catenin pathway by Valli De Re, Mariateresa Casarotto, Giulia Brisotto, Stefania Zanussi, Mariangela De Zorzi, Ombretta Repetto, Elena Muraro, Paola Spessotto, Paolo Baldo, Vito Racanelli, Marco Vincenzo Lenti, Marco Vincenzo Lenti, Marino Venerito, Matteo Fassan, Matteo Fassan, Agostino Steffan, Stefano Realdon, Renato Cannizzaro, Renato Cannizzaro

“…HER2, PD-L1 and PD-L2 protein levels were assessed in all cell lines using multicolor flow cytometry (FACS) before and after HV-HP exposure.ResultsOur data revealed that HV-HP infection reduced MSH6 mRNA expression, which is indicative of impaired DNA repair, and up-regulated PDCD1LG2, suggesting enhanced immunosuppression. …”
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Assessment of grassland carrying capacity drivers and evaluation of pasture-livestock balance: A case study of Xinjiang, China by Guangyu Wang, Yaoming Li, Lianlian Fan, Xuexi Ma, Yuanye Liang, Tingting Hui, Wenbo Zhang, Wei Li, Jiefei Mao

“…Additionally, we incorporated livestock data to evaluate the overgrazing conditions of the grassland ecosystem. …”
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