Cancer-associated fibroblast-derived fibulin-5 promotes epithelial–mesenchymal transition in diffuse-type gastric cancer via cAMP response element-binding protein pathway, showing... by Jinju Choi, Yoonjin Kwak, Miree Park, Jeong Yeon Jo, Jun Hyuk Kang, Kook Myeong-Cherl, Hang-Rae Kim, Gwanghun Kim, Seong-Ho Kong, Do-Joong Park, Hye Seung Lee, Hyuk-Joon Lee, Jung Mogg Kim, Sang Gyun Kim, Han-Kwang Yang, Ji Kon Ryu, Soo-Jeong Cho

“…Here, to identify distinct biomarkers for DGC compared with intestinal-type gastric cancer, we constructed a comprehensive large-scale signaling network using RNA-sequencing data from three genomic databases (The Cancer Genome Atlas, GSE62254 and GSE26253), developed a mathematical model and conducted simulation analyses. …”
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The potential impact of policies and structural interventions in reducing cardiovascular disease and mortality: a systematic review of simulation-based studies by Olalekan A Uthman, Rachel Court, Seun Anjorin, Jodie Enderby, Lena Al-Khudairy, Chidozie Nduka, Hema Mistry, G J Melendez-Torres, Sian Taylor-Phillips, Aileen Clarke

“…Future work and limitations There is significant heterogeneity in simulation models, making comparisons of output data impossible. While policy interventions typically include a variety of strategies, none of the models considered possible interrelationships between multiple policies or potential interactions. …”
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Anti-atherosclerotic effect of lipid/cholesterol-cyclodextrin inclusion complexes similar to free cyclodextrins in ApoE-/- mice fed a high-fat diet by Yuanfang Li, Yuan Zhang, Mengyi Lan, Zhilu Fan, Tingting Gong, Langtao Xu, Tong Rong, Kun Wang, Huaying Wang, Meiying Ao, Yong Chen

“…The results reveal that both cholesterol- and lipids-HPβCD inclusion complexes significantly reversed blood lipid increase and plaque formation, implying that similar to free cyclodextrins drug-cyclodextrin inclusion complexes potentially also have anti-atherosclerotic efficacy. The data provide strong evidence for the notion and guideline that drug-cyclodextrin inclusion complexes are potentially a dual-use drug and the possibility of using drug-cyclodextrin inclusion complexes instead of free cyclodextrins for the treatment of atherosclerosis or ASCVDs. …”
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Formulating outputs from a mixed-methods study of access to general practice: a series of collaborative stakeholder workshops by Helen Atherton, Toto Gronlund, Abi Eccles, Carol Bryce, Angela Martin, Catherine Pope

“…Methods We held three sequential interactive workshops. These covered (1) early findings of the study, (2) what evidence-based resources attendees use and (3) what resources they would like to see produced. …”
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The Role of the Educational Programs in the Improving of Confidence in Vaccination against Pneumococcal Infection among Population by N I Briko, V A Korshunov, A Ya Mindlina, R V Polibin, A V Shamis, A G Saltykova

“…Statistical processing was performed using IBM SPSS Statistics v.20.0, data visualization – Microsoft Excel 2016. …”
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Local QSAR based on quantum chemistry calculations for the stability of nitrenium ions to reduce false positive outcomes from standard QSAR systems for the mutagenicity of primary... by Shigeharu Muto, Ayako Furuhama, Mika Yamamoto, Yasuteru Otagiri, Naoki Koyama, Seiji Hitaoka, Yusuke Nagato, Hirofumi Ouchi, Masahiro Ogawa, Kisako Shikano, Katsuya Yamada, Satoshi Ono, Minami Hoki, Fumiya Ishizuka, Soichiro Hagio, Chiaki Takeshita, Hisayoshi Omori, Kiyohiro Hashimoto, Satsuki Chikura, Masamitsu Honma, Kei-ichi Sugiyama, Masayuki Mishima

“…For internal PAAs, detailed Ames test data were scrutinized and final decisions were made using common evaluation criteria. …”
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The association between hepatic steatosis, vitamin D status, and insulin resistance in adolescents with obesity by Emir Tas, Amanda Flint, Ingrid Libman, Radhika Muzumdar, Xiawei Ou, David K. Williams, Elisabet Børsheim, Eva C. Diaz

“…Methods: A post-hoc analysis was performed using data from 44 adolescents participating in a 6-month observational study evaluating biomarkers of hepatosteatosis. …”
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Multi-dimensional perspectives on sustainability in domestic waste management by Y. Ismail, R. Adji, A.D. Santoso, S. Wahyono, M.A. Kholiq, T. Handayani, S.D.R. Pahri, S. Putiamini, R.A. Pratama, F. Nurfatriani, F.L. Sahwan, F. Suryanto, Prasetiyadi , R.D. Tilottama

“…This study evaluates the sustainability of domestic waste management using a multi-dimensional scaling framework, focusing on five fundamental parameters,such as environmental, economic, social interactions, technological, and regulatory sustainability. …”
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Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation by Yuya Suzuki, Takuo Emoto, Shunsuke Sato, Takeshi Yoshida, Mitsuhiko Shoda, Hiromi Endoh, Manabu Nagao, Tomoyo Hamana, Taishi Inoue, Tomohiro Hayashi, Eriko Nitta, Hiroki Konishi, Kunihiko Kiuchi, Mitsuru Takami, Kimitake Imamura, Masayuki Taniguchi, Masatoshi Inoue, Toshihiro Nakamura, Yusuke Sonoda, Hiroyuki Takahara, Kazutaka Nakasone, Kyoko Yamamoto, Kenichi Tani, Hidehiro Iwai, Yusuke Nakanishi, Shogo Yonehara, Atsushi Murakami, Ryuji Toh, Takenao Ohkawa, Tomoyuki Furuyashiki, Ryo Nitta, Tomoya Yamashita, Ken-ichi Hirata, Koji Fukuzawa

“…Therefore, we assess the single cell landscape of left atria (LA), using a combination of single cell and nucleus RNA-seq. …”
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Unveiling Wolbachia transcriptomic signature in the arboviral vector Aedes aegypti by Sebastián Mejías, Sebastián Mejías, Natalia E. Jiménez, Natalia E. Jiménez, Natalia E. Jiménez, Carlos Conca, Carlos Conca, J. Cristian Salgado, J. Cristian Salgado, Ziomara P. Gerdtzen, Ziomara P. Gerdtzen, Ziomara P. Gerdtzen, Ziomara P. Gerdtzen

“…By identifying differences between Wolbachia-infected and uninfected A. aegypti, previous transcriptomic studies proposed a wide range of symbiotic interactions, but a systematic identification of consistent effects across datasets is still missing.MethodsTo identify A. aegypti genes and functions consistently affected by Wolbachia, we performed differential expression and functional enrichment analysis on published transcriptomic datasets, followed by a meta-analysis of the obtained p-values using the maxP method. …”
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Synergistic Network Pharmacology: Preclinical Validation and Clinical Safety in Acute Ischemic Stroke by Ana I. Casas, Cristian Nogales, Rebecca D. Szepanowski, Mahmoud H. Elbatreek, Elisa Anastasi, Sepideh Sadegh, James Skelton, Benedikt Frank, Anil Wipat, Jan Baumbach, Christoph Kleinschnitz, Harald H. H. W. Schmidt

“…For preclinical validation, we used C57/Bl6 mice and humanized NOX5–knock‐in mice because NOX5 is not present in the mouse genome despite playing a key role in early stroke. …”
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Comparison of porous and non-porous biochar for trimethoprim removal: Quantifying uncertainty in sorption and thermodynamic parameters over different pH and temperature by Nguyen Thi Phuong Thao, Pham Thi Le Na, Ky-Phuong-Ha Huynh, Bao-Trong Dang

“…The biochar was characterized by yield, point of zero charge, scanning electron microscopy with energy-dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, X-ray diffraction, and N2 adsorption-desorption isotherms. The experimental data were statistically interpreted using the pseudo-second-order, modified intraparticle diffusion, and Langmuir isotherm model. …”
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Virtual human retina: Simulating neural signalling, degeneration, and responses to electrical stimulation by Keith Ly, Michael L. Italiano, Mohit N. Shivdasani, David Tsai, Jia-Yi Zhang, Chunhui Jiang, Nigel H. Lovell, Socrates Dokos, Tianruo Guo

“…The model is constructed using electrophysiology, immunohistology, and optical coherence tomography imaging data from healthy and degenerate human retinas. …”
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A multi-country comparison between mobile phone surveys and face-to-face household surveys to estimate the prevalence of non-communicable diseases behavioural risk factors in low-... by Gulam Muhammed Al Kibria, Saifuddin Ahmed, Dustin G Gibson, Kennedy Lishimpi, Jones K Masiye, Daksha Shah, Melanie Cowan, Wilbroad Mutale, Namasiku Siyumbwa, Julián A Fernández-Niño, Champika Wickramasinghe, Leanne Riley, Stacy Davlin, Rachael Phadnis, Romina Costa Beltrán, Juan Carlos Zevallos Lopez, Juan Vásconez, Hicham El Berri, Samir Mounach, Mangla Gomare, Gulnar Khan, Niraj Dave, Udara Perera

“…MPS sampling frames were generated by random digit dialling, while data collection was done by interactive voice response and SMS. …”
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Gymnadenia conopsea orchid: a systematic review by Jing-Yi Wu, Jing-Yi Wu, Ruo-Nan Tang, Ruo-Nan Tang, Jia-Wen Wang, Jia-Wen Wang, Wan-Ying Chen, Wan-Ying Chen, Xing Liu, Ji-Wen Wang, Mei-Ya Li, Fu-Sheng Jiang, Fu-Sheng Jiang

“…., a medicinally significant orchid used for millennia in China, is systematically reviewed regarding its botany, resources, ethnomedicinal applications, phytochemistry, pharmacology, and propagation strategies to advance therapeutic utilization and conservation.MethodsUsing keywords such as “G. conopsea,” “phytochemistry,” “propagation and breeding,” “bioactive compounds,” “immunomodulatory effects,” and “neuroprotective potential,” we systematically searched literature related to G. conopsea plants from databases including Web of Science, SciFinder, PubMed, ACS Publications, CNKI, Wanfang Data, Google Scholar, and Baidu Scholar.ResultsA total of 1,074 papers were retrieved and 133 full-text articles were ultimately selected and comprehensively reviewed. …”
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The Mediating Role of Depression in the Relationship Between Perceived Injustice and Pain Intensity Among Fibromyalgia Patients by Raev S, Aloush V, Gilam G, Elkana O

“…Statistical methods were used to analyze how these factors interact.Our findings showed that people who felt a higher sense of injustice were more likely to experience symptoms of depression. …”
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USP14 inhibition by degrasyn induces YAP1 degradation and suppresses the progression of radioresistant esophageal cancer by Fang Yuan, Juan Xu, Lingmei Xuan, Chan Deng, Wei Wang, Rong Yang

“…We also used transplantation tumor mouse model to investigate the course of the cancer cell growth. …”
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Investigating patient engagement associations between a postdischarge texting programme and patient experience, readmission and revisit rates outcomes by Farzan Sasangohar, Claudia García, Roberta L Schwartz, Courtenay Bruce, Theresa Pinn-Kirkland, Adam Meyers, Emmanuel Javaluyas, John Osborn, Sayali Kelkar, Lindsey Bruchhaus, Kristen McLaury, Katherine Sauceda, Karen Carr, Lee Ann Arabie, Terrell Williams, Gail Vozzella, Tariq Nisar

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Assessing the quality of care in primary health care facilities in all municipalities in Kosovo 2016–2023 by Astrid M. Knoblauch, Astrid M. Knoblauch, Sarah Rajkumar, Sarah Rajkumar, Robert Canavan, Robert Canavan, Qamile Ramadani, Ariana Bytyçi Katanolli, Shegë Bahtiri, Debra Stevenson, Debra Stevenson, Debra Stevenson, Merita Stavileci Mustafa, Nicu Fota, Nicu Fota, Nicu Fota, Jana Gerold, Jana Gerold

“…Three quality of care studies were conducted with the aim of measuring progress in PHC and NCD management.MethodsThree facility-based, cross-sectional studies were conducted in 2016, 2018 and 2023 across 12, 20, and 38 selected municipalities in Kosovo, respectively. Data were collected on PHC infrastructure, provider-patient interactions, and patient outcomes using standardized assessments, observational tools, and exit interviews.ResultsThe overall infrastructure score improved from 56% in 2016 to 68% in 2023. …”
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Metabolic profiling of Perilla leaves of different colors: insights into metabolite variation and bioactive compound distribution by Senouwa Segla Koffi Dossou, Qianchun Deng, Feng Li, Lei Wang, Nanjun Jiang, Habtamu Kefale, Rong Zhou, Donghua Li, Meilian Tan, Linhai Wang

“…Furthermore, they offer valuable data for a comprehensive use of Perilla leaves and exploring gene-metabolites interactions in Perilla leaves.…”
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