The cross-sectional association between cardiometabolic index and abdominal aortic calcification in U.S. adults: evidence from NHANES 2013–2014 by Jiawei Peng, Jijun Wu, Xitu Luo, Chengyu Yang, Shian Wu, Wenjun Liu, Wenjun Liu, Yuanhao Feng

“…This cross-sectional study aimed to investigate the association between CMI and AAC.MethodsA cross-sectional study was conducted using data from the 2013 to 2014 National Health and Nutrition Examination Survey (NHANES) to explore the relationship between CMI and AAC. …”
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Emodin promotes GSK-3β-mediated PD-L1 proteasomal degradation and enhances anti-tumor immunity in hepatocellular carcinoma by Xuemei Yang, Weiguang Chen, Haitao Sun, Weicong Chen, Wei Xu, Chunyu He, Yang Liu, Ying Kuang, Yanhao Ma, Binglian Zhong, Chaojie Li, Guohuan Li, Qingfeng Du, Songqi He

“…Abstract Background Programmed death-ligand 1 (PD-L1), a prominent immune checkpoint, interacts with programmed death protein-1 (PD-1) on cytotoxic T cells within tumors and promotes immune evasion. …”
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A social media listening study of patients’ experiences relating to metabolic dysfunction-associated steatotic liver disease: The LISTEN-MASLD study by Jeffrey V. Lazarus, William Alazawi, Ron Basuroy, Laurent Castera, Dmitry Estulin, Yiannoula Koulla, Preethy Prasad, Manuel Romero-Gomez, Hirokazu Takahashi, Vincent Wai-Sun Wong, Jörn M. Schattenberg

“…Introduction and Objectives: Patients increasingly use social media to share and access health-related information and experiences. …”
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Patterns of intestinal parasite prevalence in brown bears (Ursus arctos) revealed by a 3-year survey on the Shiretoko peninsula, Hokkaido, Japan by Mizuki Moriyoshi, Naoki Hayashi, Nariaki Nonaka, Ryo Nakao, Masami Yamanaka, Toshio Tsubota, Michito Shimozuru

“…From June 2022 to November 2024, 334 fecal samples were collected from the Shiretoko Peninsula, Hokkaido, Japan, and examined for parasites using the centrifugal flotation technique. Fecal DNA analysis and data from a long-term field monitoring survey led to the identification of 49 individuals, which were further classified based on sex and age. …”
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The dynamics of the gut microbiota in prediabetes during a four-year follow-up among European patients—an IMI-DIRECT prospective study by Liwei Lyu, Yong Fan, Josef Korbinian Vogt, Marc Clos-Garcia, Amelie Bonnefond, Helle Krogh Pedersen, Avirup Dutta, Robert Koivula, Sapna Sharma, Kristine Højgaard Allin, Caroline Brorsson, Henna Cederberg, Elizaveta Chabanova, Federico De Masi, Emmanouil Dermitzakis, Petra J. Elders, Marieke T. Blom, Monika Hollander, Rebeca Eriksen, Ian Forgie, Gary Frost, Giuseppe N. Giordano, Harald Grallert, Mark Haid, Tue Haldor Hansen, Bernd Jablonka, Tarja Kokkola, Anubha Mahajan, Andrea Mari, Timothy J. McDonald, Petra B. Musholt, Imre Pavo, Cornelia Prehn, Martin Ridderstråle, Hartmut Ruetten, Leen M.‘t Hart, Jochen M. Schwenk, Evelina Stankevic, Henrik S. Thomsen, Jagadish Vangipurapu, Henrik Vestergaard, Ana Viñuela, Mark Walker, Torben Hansen, Allan Linneberg, Henrik Bjørn Nielsen, Søren Brunak, Mark I. McCarthy, Philippe Froguel, Jerzy Adamski, Paul W. Franks, Marku Laakso, Joline W. J. Beulens, Ewan Pearson, Oluf Pedersen

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應用智慧型家教系統於國小學童閱讀策略 教學之學習歷程研究 A Study on the Learning Process of Applying an Autotutoring System to Teach Reading Strategies to Elementary School Children... by 陳茹玲 Ju-Ling Chen, 曾厚強 Hou-Chiang Tseng, 連啟舜 Chi-Shun Lien, 蔡旻穎 Min-Ying Tsai, 宋曜廷 Yao-Ting Sung

“…Verbal data indicated that, although students attempted to use comprehension monitoring to support understanding, the frequency was low. …”
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Epidemiology of Overweight and Obesity in Early Childhood in China and Associated Factors by Li H, Xiang W, Yi Y, Huang X, Luo H, Cai Y, Liu L, Li H, Huang Y, Luo Q, Fan L, Lin Q

“…Data on potential risk factors for childhood overweight/obesity were obtained through questionnaires. …”
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Public Attitudes Towards Free-Ranging Dogs (Canis familiaris) and Management Methods in Qazvin Province, Iran by Ehsan Moqanaki, Navid Gholikhani, Atie Taktehrani

“…We analysed the resulting data using a qualitative social science approach and fitted a generalized linear mixed model to quantify village-level determinants of complaints. …”
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Muscular and Renal Safety of Ticagrelor with High-Intensity Statins: Retrospective Cohort Findings by Alshammari AS, Shalwala AA, Alnuhait MA, Alhazmi AY, Fagieha RE, Hallabi NB, Alandijani EA, Aloufi MA, Alharbi MS, Alzahrani RS, Elkholy EM, Elrggal ME, Alotaibi AS

“…However, recent pharmacodynamic studies and case reports suggest potential drug-drug interactions that may increase the risk of adverse events, particularly muscular and renal complications. …”
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Pre-challenge gut microbial signature predicts RhCMV/SIV vaccine efficacy in rhesus macaques by Hayden N. Brochu, Elise Smith, Sangmi Jeong, Michelle Carlson, Scott G. Hansen, Jennifer Tisoncik-Go, Lynn Law, Louis J. Picker, Michael Gale, Xinxia Peng

“…Despite vaccination group differences, by using newly developed compositional data analysis techniques, we identified a common gut microbial signature predictive of vaccine protection outcome across the three vaccination groups. …”
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From transition management towards just transition and place-based governance. Τhe case of Western Macedonia in Greece by Lefteris Topaloglou, Lefteris Ioannidis

“…The validity of the research findings is strengthened by using multiple sources of evidence and data triangulation. …”
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Addictive behaviour of adolescents and young men in the education system: Review of psychological and pedagogical research by S. A. Minyurova, O. V. Kruzhkova, I. V. Vorobyeva, A. I. Matveeva

“…The practical significance is due to the potential possibilities of using the data obtained to organise effective prophylactic work for preventing the development of addictive behaviour among students within the framework of the educational process in an educational organisation, taking into account international experience and psychological and pedagogical basis.…”
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Multiomics integration analysis identifies tumor cell-derived MIF as a therapeutic target and potentiates anti-PD-1 therapy in osteosarcoma by Yan Liao, Hao Yao, Weidong Chen, Yutong Zou, Ji Fang, Jiongfeng Zhang, Zehao Guo, Jian Tu, Junkai Chen, Zijun Huo, Lili Wen, Xianbiao Xie

“…Single-cell RNA sequencing was used to explore cell-to-cell interactions within the tumor microenvironment. …”
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Urinary TYROBP and HCK as genetic biomarkers for non-invasive diagnosis and therapeutic targeting in IgA nephropathy by Boji Xie, Shuting Pang, Yuli Xie, Yuli Xie, Qiuyan Tan, Shanshan Li, Mujia Jili, Mujia Jili, Yian Huang, Yian Huang, Binran Zhao, Hao Yuan, Hao Yuan, Junhao Mi, Junhao Mi, Junhao Mi, Xuesong Chen, Liangping Ruan, Hong Chen, Xiaolai Li, Boning Hu, Jing Huang, Rirong Yang, Rirong Yang, Wei Li

“…Machine learning was used to identify key differentially expressed genes, with protein expression validated by immunohistochemistry (IHC) and drug-target interactions explored via molecular docking.ResultsUrine RNA-seq analysis revealed differential expression profiles, from which TYROBP and HCK were identified as key biomarkers using machine learning. …”
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Long-term Metformin Alters Gut Microbiota and Serum Metabolome in Coronary Artery Disease Patients After Percutaneous Coronary Intervention to Improve 5-year Prognoses: A Multi-omi... by Ruilin Zhou, Qingyang Wu, Hao Qian, Liang Wang, Guangcheng Liu, Bin Zhang, Wei Wu, Shuyang Zhang

“…Multi-omics analysis was conducted using Spearman’s correlation to explore the interactions between metformin, gut microbiome, serum metabolites, and clinical prognosis. …”
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Diversity and Distribution of Fungi in the Marine Sediments of Zhanjiang Bay, China by Menghan Gao, Bihong Liu, Jianming Li, Yunyan Deng, Yulei Zhang, Ning Zhang, Feng Li, Changling Li, Xianghu Huang, Zhangxi Hu

“…The fungal molecular network exhibited primarily positive species interactions, with notable structural differences across salinity gradients. …”
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A Multifaceted Computational Approach to Identify PAD4 Inhibitors for the Treatment of Rheumatoid Arthritis (RA) by Mansour S. Alturki, Mohamed S. Gomaa, Nada Tawfeeq, Abdulaziz H. Al Khzem, Mohsina B. Shaik, Murtadha Alshaikh Jafar, Mohammad Alsamen, Hasan Al Nahab, Mohammad Al-Eid, Alhassan Almutawah, Thankhoe A. Rants’o, Khaled A. G. Ayil, Mohammed Almaghrabi

“…Methods: We utilized Maestro Schrödinger as a computational tool for preparing and docking simulations on the PAD 4 enzyme crystal structure that is retrieved from RCSB Protein Data Bank (PDB ID: 4X8G) while the docked FDA-approved medications are obtained from the Zinc 15 database. …”
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Genome-wide identification of TaeGRASs responsive to biotic stresses and functional analysis of TaeSCL6 in wheat resistance to powdery mildew by Yuanyuan Guan, Kaige Wang, Junjie Zhao, Xiangyang Miao, Xiangyang Li, Puwen Song, Haiyan Hu, Shengli Zhang, Chengwei Li

“…Nonetheless, their roles in wheat-pathogen interactions remain poorly understood. Results In this study, we used bioinformatics tools to identify and analyze wheat GRAS family genes responsive to biotic stresses and elucidated the function of TaeSCL6 within this family. …”
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SCAPAS-LungCancer—improving supportive care for patients surgically treated for non-small cell lung cancer: protocol for a prospective, longitudinal, observational and exploratory... by Wei Dai, Britt Borregaard, Zaigham Saghir, Pernille E Bidstrup, Morten Quist, Thomas Decker Christensen, Rene Horsleben Petersen, Rikke Langballe, Lin Huang, Malene Missel, Pernille Orloff Donsel, Michael Stenger, Pernille Brasch Andersen, Camilla Corvinius, Johnny Moons, Florian Fehlmann, Lisbeth Søbæk Hansen, Mai Nanna Schoenau

“…A longitudinal qualitative study, including individual interviews and ethnographic fieldwork, will be conducted to explore patients’ experiences and interactions with clinicians on symptoms and late effects. …”
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Close encounters between infants and household members measured through wearable proximity sensors. by Laura Ozella, Francesco Gesualdo, Michele Tizzoni, Caterina Rizzo, Elisabetta Pandolfi, Ilaria Campagna, Alberto Eugenio Tozzi, Ciro Cattuto

“…Here, we report on the use of wearable proximity sensors based on RFID technology to measure face-to-face proximity between family members within 16 households with infants younger than 6 months for 2-5 consecutive days of data collection. …”
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