Molecular and spatial analysis of tertiary lymphoid structures in Sjogren’s syndrome by Saba Nayar, Jason D. Turner, Saba Asam, Eanna Fennell, Matthew Pugh, Serena Colafrancesco, Onorina Berardicurti, Charlotte G. Smith, Joe Flint, Ana Teodosio, Valentina Iannizzotto, David H. Gardner, Joel van Roon, Ilya Korsunsky, Dawn Howdle, Roche Fibroblast Network Consortium, Andreas P. Frei, Kara G. Lassen, Simon J. Bowman, Wan-Fai Ng, Adam P. Croft, Andrew Filer, Benjamin A. Fisher, Christopher D. Buckley, Francesca Barone

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Immersive Virtual Reality and AI (Generative Pretrained Transformer) to Enhance Student Preparedness for Objective Structured Clinical Examinations: Mixed Methods Study by Shaniff Esmail, Brendan Concannon

“…The VR used artificial intelligence in the form of a generative pretrained transformer to generate responses from virtual patients as students interacted with them in natural language. …”
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Influence of Sociodemographic Factors on Level Stress and Coping Strategies of Nurses and Midwives Caring for Newborns with Lethal Defects by Katarzyna Anna Urbańska, Beata Naworska, Agnieszka Drosdzol-Cop

“…A stratified random sampling method was employed to ensure representation from various professional backgrounds. Data analysis was conducted using descriptive statistics, chi-square tests, Spearman’s correlation, and Cohen’s d coefficient, with statistical significance set at <i>p</i> < 0.05. …”
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Incorporating science communication and bicultural knowledge in teaching a blended volcanology course by B. Kennedy, K. Engel, J. Davidson, S. Tapuke, D. Hikuroa, T. Martin, P. Zaka

“…</p> <p>We compare the skill-focused courses with baseline data from 2021, gathered during an initial iteration of the course that included interactive volcanology lectures and an online Iceland virtual field trip component. …”
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Network analysis of the relationships between voice behavior and team psychological safety climate among Chinese nurses by Miaoji Lu, Ruinan Xia, Rui Wang, Xiaofang Zou

“…Methods From April to June 2022, clinical nurses were recruited from five cities in Guangdong Province, China using convenience sampling. Data were collected using validated scales, including the Voice Behavior Scale and Team Psychological Safety Climate Scale. …”
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Political economy analysis of health financing reforms in times of crisis: findings from three case studies in south-east Asia by Sophie Witter, Maria Paola Bertone, Sushil Baral, Ghanshyam Gautam, Saugat K. C. Pratap, Aungsumalee Pholpark, Nurmala Selly Saputri, Arif Budi Darmawan, Nina Toyamah, Rizki Fillaili, Valeria de Oliveira Cruz, Susan Sparkes

“…In this article, we examine recent health financing reforms in Nepal, Thailand and Indonesia, using a political economy lens. The objective is to understand whether and how crises can be utilised to progress UHC and to analyse the strategies used by reformers to benefit from potential windows of opportunity. …”
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Tumor-associated bacteria activate PRDX1-driven glycolysis to promote immune evasion and PD-1 antibody resistance in hepatocellular carcinoma by Heng Zhang, Xi Lan, Liquan Cai, Xunfeng Gao, Feng Gao, Dan Yu, Jinlong Zhang, Jinhui Zhang, Qinwen Tai

“…This study investigates the mechanisms by which bacterial infection reshapes tumor metabolism to undermine the efficacy of anti-PD-1 therapy.MethodsWe conducted 16S rRNA gene sequencing on 29 HCC clinical samples and integrated the data with single-cell RNA sequencing of 12,487 cells to map microbial, metabolic, and immune interactions within the tumor microenvironment. …”
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Drought-induced shifts in cowpea rhizoplane bacterial communities across different vegetative and reproductive stages by Durga P.M. Chinthalapudi, Nisarga Kodadinne Narayana, Sujan Poudel, John P. Brooks, Shankar Ganapathi Shanmugam, Raju Bheemanahalli

“…Further, integration of amplicon metagenomics and physiological data showed that drought significantly altered rhizoplane bacterial communities in cowpea, with distinct genotype-specific responses. …”
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A Multispecies Atmospheric Escape Model with Excited Hydrogen and Helium: Application to HD209458b by Anna Ruth Taylor, Tommi T. Koskinen, Luca Argenti, Nicholas Lewis, Chenliang Huang, Anthony Arfaux, Panayotis Lavvas

“…Atmospheric escape shapes exoplanet evolution and star–planet interactions, with He I 10830 Å absorption serving as a key tracer of mass loss in hot gas giants. …”
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Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy by Rebecca F. Slykerman, Naomi Davies, Klara Vlckova, Kenneth J. O'Riordan, Shalome A. Bassett, James Dekker, Harriët Schellekens, Niall P. Hyland, Gerard Clarke, Elaine Patterson

“…Expediting the transition from positive preclinical data to proven benefits in humans includes interpreting the promises and pitfalls of animal behavioural assays, as well as navigating mechanism‐informed decision making to select the right microbe(s) for the job. …”
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Mapping the rare disease paediatric clinical trial availabilities in Europe by Eva Degraeuwe, Eva Degraeuwe, Mark A. Turner, Ricardo M. Fernandes, Ann Raes, Ann Raes, Ann Raes, Johan Vande Walle, Johan Vande Walle, Franz Schaefer, Franz Schaefer

“…Site analyses were done at country and setting levels. Heatmaps and an interactive matrix tool were developed using RStudio (v2023.12.0).ResultsThe highest overlap between ERN and c4c networks is found in the Netherlands, Belgium, Sweden, Denmark, and the Czech Republic, indicating strong integration in these regions, while Nordic (Sweden and Denmark), Eastern, and Southern European countries show varying levels of overlap. …”
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Ultrasonographic evaluation of testicular and Pampiniform plexus characteristics in young bulls under different microclimatic conditions in a tropical environment by Joedson Dantas Gonçalves, Alexandre Rossetto Garcia, Rubens Paes de Arruda, José Ricardo Macedo Pezzopane, Felipe Tonato, Alda Juliana Castro de Sousa, Lívia Ferreira Pinho, Veronica Schinaider do Amaral Pereira, Gabriel Brun Vergani, Maria Emilia Franco Oliveira

“…Testicular biometric measurements, B-mode ultrasound assessments (echogenicity and heterogeneity of the testicular parenchyma and mediastinum), color Doppler (blood perfusion of the testicular parenchyma and pampiniform plexus), spectral Doppler of the supratesticular artery (pulsatility and resistance index), and blood collection from the jugular to determine testosterone concentration were performed monthly. Data were analyzed using the PROC MIXED procedure of SAS (p < 0.05), and possible interactions between production systems and animal age are presented. …”
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Vitamin D receptor gene polymorphism in oral cancer as a function of tobacco consumption: an evidence based systematic review and meta-analysis by Tribikram Debata, Amrita Swain, Amrita Swain, Soumya Ranjan Jena, Soumya Ranjan Jena, Surya Narayan Das, Niranjan Mishra, Luna Samanta, Luna Samanta

“…The meta-analysis highlights interactions between genetic polymorphisms, smoking, aging, and oral health risks. …”
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Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells by Nan Huang, Zhiwei Liu, Jiabei Zhu, Zhongqi Cui, Yuguang Li, Yongchun Yu, Fenyong Sun, Qiuhui Pan, Qingyuan Yang

“…To our knowledge, the biological roles of sirtuin 6 in esophageal cancer cells have still been underestimated. In the study, data from quantitative reverse transcriptase polymerase chain reaction–based assays and immunohistochemical assays revealed that sirtuin 6 was remarkably overexpressed in esophageal squamous tumor tissues. …”
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The Inhibitory Effect and Adsorption Properties of Testagen Peptide on Copper Surfaces in Saline Environments: An Experimental and Computational Study by Aurelian Dobriţescu, Adriana Samide, Nicoleta Cioateră, Oana Camelia Mic, Cătălina Ionescu, Irina Dăbuleanu, Cristian Tigae, Cezar Ionuţ Spînu, Bogdan Oprea

“…The tetrapeptide synthesized from the amino acids lysine (Lys), glutamic acid (Glu), aspartic acid (Asp), and glycine (Gly), named as H-Lys-Glu-Asp-Gly-OH, achieved an inhibition efficiency of around 86% calculated from electrochemical measurements, making KEDG a promising new copper corrosion inhibitor. The experimental data were best fitted to the Freundlich adsorption isotherm. …”
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Association between sleep disorders and myopia in Shanghai adolescents: a cross-sectional survey conducted among junior school students by Xiaoya Yin, Xuelai Wang, Zhe Zhang, Yani Zhai, Xinyi Zhou, Linlin Yuan, Shuman Li, Zhengzhong Wang, Lijing Sun, Chunyan Luo

“…A generalized additive model was used to analyze the relationship between SE and sleep disorder. …”
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Comprehensive insights into the disease burden linked to air pollution exposure across U.S. states: findings from the 2021 Global Burden of Disease Study by Kaibin Lin, Junxian Quan, Jiafen Liao, Jiafen Liao, Yiyue Chen, Yiyue Chen, Bing Zhou, Bing Zhou, Xi Xu

“…Disease burdens were assessed for chronic obstructive pulmonary disease (COPD), diabetes mellitus, ischemic heart disease (IHD), lower respiratory infections, stroke, and lung cancer. Data were standardized to the GBD reference population for comparability over time.ResultsFrom 1990 to 2021, PM2.5-attributable mortality declined by 80.5%, with IHD deaths falling by 70.6% (79,684–23,433 deaths) and associated DALYs by 71.2%. …”
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Participant experiences in HIV cure-directed trial with an extended analytical treatment interruption in Philadelphia, United States by Andrea Bilger, Eion Plenn, Frances K. Barg, Katharine A. Rendle, William B. Carter, Andrea Lamour-Harrington, Nora Jones, Beth Peterson, John A. Sauceda, Pablo Tebas, Karam Mounzer, David Metzger, Luis J. Montaner, Karine Dubé

“…Methods From April to November 2022, we conducted post-ATI in-depth interviews with BEAT2 clinical trial (NCT03588715) participants who stopped ART while receiving an immunotherapy regimen. We used conventional content analysis to code the data. …”
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Inflammation mediates the association between hyperuricemia and stroke mortality: a cohort study by Yiwen He, Yiwen He, Jun You, Jun You, Zhenjie Fan, Zhenjie Fan, Zhiyong Wang, Zhiyong Wang, Min Qian, Min Qian

“…Cox proportional hazards regression models were used to evaluate the impact of hyperuricemia on all-cause and cardiovascular mortality among stroke patients. …”
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Single-cell transcriptomics analysis reveals that the tumor-infiltrating B cells determine the indolent fate of papillary thyroid carcinoma by Chunmei Li, Pei Wang, Zhizhong Dong, Weihan Cao, Yanjun Su, Jianming Zhang, Shuyan Zhao, Zhiyuan Wang, Zi Lei, Li Shi, Ruochuan Cheng, Wen Liu

“…Findings were validated in an additional 25 tumors using cell co-culture, migration assays, immunofluorescence staining, flow cytometry, and analysis of data from The Cancer Genome Atlas (TCGA). …”
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