Computational modeling of cyclotides as antimicrobial agents against Neisseria gonorrhoeae PorB porin protein: integration of docking, immune, and molecular dynamics simulations by Muzamal Hussain, Muzamal Hussain, Nazia Kanwal, Alishba Jahangir, Nouman Ali, Nimra Hanif, Obaid Ullah

“…Current treatments rely on antibiotics, but the emergence of multi drug resistance (MDR) strains poses a significant threat to public health. This research aims to use computational modeling of cyclotides as antimicrobial agents targeting the Neisseria gonorrhoeae PorB Porin protein to inhibit its pathogenicity.MethodologyThe PorB Porin protein was retrieved from the Protein Data Bank (PDB ID: 4AUI), cleaned, and visualized using Discovery Visual Studio. …”
Get full text

Topographically driven vigorous vertical mixing supports mesoscale biological production in the Tsugaru Gyre by Hitoshi Kaneko, Takahiro Tanaka, Masahide Wakita, Ken’ichi Sasaki, Takeshi Okunishi, Yasumasa Miyazawa, Ruochao Zhang, Shoko Tatamisashi, Yoshiaki Sato, Takayuki Hashimukai, Tomokazu Chiba, Makoto Takada, Jun Yoshino

“…Abstract The Tsugaru Strait is a critical conduit linking the Sea of Japan and the Pacific Ocean and is characterized by a vigorous eastward current. Here, we use high-resolution surface current data acquired from a high-frequency radar system in conjunction with direct turbulence measurements to show that the large increase in chlorophyll-a within a hundred kilometre-scale anticyclonic gyre is driven by the intensification of turbulence, extraordinarily high diffusive nitrate fluxes and divergent flow fields limited to a very narrow area. …”
Get full text

Safety of Simultaneous Scalp and Intracranial EEG and fMRI: Evaluation of RF-Induced Heating by Hassan B. Hawsawi, Anastasia Papadaki, Vejay N. Vakharia, John S. Thornton, David W. Carmichael, Suchit Kumar, Louis Lemieux

“…We have previously demonstrated that concurrent intracranial EEG (icEEG) and fMRI data acquisitions (icEEG-fMRI) can be performed with acceptable risk in specific conditions using a head RF transmit coil. …”
Get full text

The Effect of Training Based on the SCORPIO Model on the Knowledge and Skills of Airway Management Peri-Anesthesia Induction in Undergraduate of Nursing Anesthesiology Students by Masoumeh Albooghobeish, Zinat Mohammadi, Ali Khalafi, Morteza Habibi moghadam

“…The SCORPIO model is one such method that can be used as an interactive educational station and a combination of other educational methods. …”
Get full text

Gambogenic Acid Suppresses Malignant Progression of Non-Small Cell Lung Cancer via GCH1-Mediated Ferroptosis by Menghan Wang, Jiao Liu, Wenxi Yu, Jiancang Shao, Yang Bao, Mingming Jin, Qingqing Huang, Gang Huang

“…Flow cytometry was used to detect apoptosis and the cell cycle. Proteomic analysis and LiP-SMap were used to detect the downstream target of GNA. …”
Get full text

Gendered ethnobotanical practices and their influence on livelihoods: Non-Timber Forest Product collection around Ayubia National Park by Mehwish Zaman, Asma Jabeen, Muhammad Waheed, Shiekh Marifatul Haq, Abeer Hashem, Khalid F. Almutairi, Elsayed Fathi Abd_Allah, Rainer W. Bussmann

“…The study contributes to the growing body of literature on NTFPs by providing insights into the complex interactions between socioeconomic factors and resource use, offering valuable implications for conservation and rural development strategies in the region. …”
Get full text

Efficacy and Safety of Apremilast in Oncological Patients with Moderate-to-Severe Plaque Psoriasis: A 5 years Retrospective Observational Study by Lanna C, Rivieccio A, Vultaggio M, Gaeta Shumak R, Bonacci FM, Artosi F, Borselli C, Costanza G, Bianchi L, Campione E

“…Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, has shown promise in the treatment of psoriasis and psoriatic arthritis. However, data on its use in oncological patients remain limited.Methods: This retrospective observational study evaluated the efficacy and safety of Apremilast in 79 patients with a history of cancer who were treated for psoriasis and/or psoriatic arthritis over a period of approximately five years. …”
Get full text

Association of cardiovascular health with MAFLD and mortality in overweight and obese adults and mediation by inflammation and insulin resistance by Wanjia Zhang, Menglong Zou, Junyao Liang, Dexu Zhang, Man zhou, Hui Feng, Chusen Tang, Jie Xiao, Qian Zhou, Weiqing Yang, Xiaoqin Tan, Yin Xu

“…This retrospective study used data from the National Health and Nutrition Examination Survey (NHANES, 2007–2018), including 6,885 overweight and obese individuals. …”
Get full text

Necrostatin-1 Synergizes the Pan Caspase Inhibitor to Attenuate Lung Injury Induced by Ischemia Reperfusion in Rats by Liangrong Wang, Baihui Chen, Xiangqing Xiong, Shunli Chen, Lida Jin, Meizhen Zhu

“…Upon reperfusion, expressions of receptor-interacting protein 1 (RIP1), receptor-interacting protein 3 (RIP3), and caspase-8 were measured, and the flow cytometry analysis was used to assess the cell death patterns in the lung tissue. …”
Get full text

Integrative single-cell and spatial transcriptomics uncover ELK4-mediated mechanisms in NDUFAB1+ tumor cells driving gastric cancer progression, metabolic reprogramming, and immune... by Yuwei Sun, Wenyang Nie, Zhikai Xiahou, Xiaojing Wang, Wenjia Liu, Zongkai Liu, Zhiheng Lin, Zhaidong Liu

“…CellChat was used to analyze the interactions between key cell subtypes and other cells, and the “StLearn” package was employed to investigate spatial cell communication in depth. …”
Get full text

How to Implement Digital Clinical Consultations in UK Maternity Care: the ARM@DA Realist Review by Catrin Evans, Georgia Clancy, Kerry Evans, Andrew Booth, Benash Nazmeen, Candice Sunney, Mark Clowes, Nia Wyn Jones, Stephen Timmons, Helen Spiby

“…The review had three iterative phases: (1) refining the review focus and developing initial programme theories; (2) retrieval of evidence for data extraction and analysis (using on a realist logic to identify key contexts, mechanisms and outcomes); and (3) testing and refining the programme theories. …”
Get full text

Enhancing Black Soil Fertility and Microbial Community Structure via Microbial Agents to Reduce Chemical Fertilizer Dependency: A Strategy to Boost Maize Yield by Fenglin Zhang, Nan Wang, Chenyu Zhao, Luze Yang, Xingmin Zhao, Hongjun Gao, Fugui Zhang, Hongbin Wang, Ning Huang

“…Meanwhile, the absolute quantification data of bacteria also indicated the highest bacterial abundance and diversity in MC80 samples. …”
Get full text

The PM_2.5-Bound Polycyclic Aromatic Hydrocarbon Behavior in Indoor and Outdoor Environments, Part III: Role of Environmental Settings in Elevating Indoor Concentrations... by Gordana Jovanović, Mirjana Perišić, Timea Bezdan, Svetlana Stanišić, Kristina Radusin, Aleksandar Popović, Andreja Stojić

“…For this purpose, we collected indoor and outdoor data on PM_2.5-bound PAHs, inorganic gaseous pollutants, trace metals, ions, radon, and meteorological parameters, resulting in a comprehensive dataset of 100 variables from an urban site in Belgrade, Serbia. …”
Get full text

Effectiveness of the flipped classroom versus the traditional teaching method in enhancing learning among undergraduate medical students by Dipti Mohapatra, Arati Meher, Prakash Kumar Sahoo, Tapaswini Mishra, Arati Mohanty

“…Wilcoxon and Mann-Whitney tests were used to analyse the data for statistical significance. …”
Get full text

Implementing the My Positive Health dialogue tool for children with a chronic condition: barriers and facilitators by S. de Jong-Witjes, E. E. Berkelbach van der Sprenkel, M. C. Kars, M. Huber, S. L. Nijhof, R. Nuboer, D. M. Broekhuijsen-van Henten, C. A. Lasham, E. G.A.H. van Mil, E. M. van de Putte

“…Methods We conducted a mixed-methods study involving six Dutch pediatric outpatient clinics. Quantitative data on facilitators and barriers were obtained from 18 out of 20 participating HCPs (pediatricians, nurse practitioners and physician assistants) using the Measurement Instrument for Determinants of Innovations. …”
Get full text

Broadening the <i>PHIP</i>-Associated Neurodevelopmental Phenotype by Giulia Pascolini, Giovanni Luca Scaglione, Balasubramanian Chandramouli, Daniele Castiglia, Giovanni Di Zenzo, Biagio Didona

“…We performed a clinical exome analysis on his biological sample, as well as an in silico prediction of the obtained data. At the same time, we interrogated the DeepGestalt technology powered by Face2Gene (F2G), using a frontal image of the proband, and clinically reviewed the earlier CHUJANS patients. …”
Get full text

Intestinal fibrosis associated with inflammatory bowel disease: Known and unknown by Yao Zhang, Haiming Zhuang, Kai Chen, Yizhou Zhao, Danshu Wang, Taojing Ran, Duowu Zou, Yuanyuan Ji

“…We conducted a literature review using data from PubMed up to October 2024, focusing on studies related to IBD and fibrosis. …”
Get full text

Impact of human activities and building characteristics on indoor air quality in low-income urban settlement by Fathina Izmi Nugrahanti, Mochamad Donny Koerniawan, Dewi Larasti, Agustinus Adib Abadi, Müslüm Arıcı, Surjamanto Wonorahardjo

“…Materials and methods: Particulate Matter (PM), Carbon dioxide (CO₂), airflow, temperature, and relative humidity were continuously measured using calibrated sensors in two seasons. Data on the active ventilation openings, indoor characteristics (material, volume, layout, and indoor porosity), real- time activity, and occupant’s perception were recorded through questionnaire. …”
Get full text

Guiding cultivar choice in smallholder agriculture: Identifying suitability hotspots for maturity groups of field crops by Uwe Grewer, Peter de Voil, Dilys S. MacCarthy, Daniel Rodriguez

“…However, there is a substantial lack of data-driven maturity group recommendations at a detailed spatial scale. …”
Get full text

Drought-linked resource limitations on the body condition of a large ungulate by Casey L. Brown, Ryan M. Nielson, Darren Clark, Ryan Kennedy, Kenneth Loonam, Mary M. Rowland, Michael J. Wisdom

“…Understanding how indirect effects of climate can interact with density-dependent processes has become increasingly important as variability changes resource availability for wildlife. …”
Get full text