Defective i6A37 modification of mitochondrial and cytosolic tRNAs results from pathogenic mutations in TRIT1 and its substrate tRNA. by John W Yarham, Tek N Lamichhane, Angela Pyle, Sandy Mattijssen, Enrico Baruffini, Francesco Bruni, Claudia Donnini, Alex Vassilev, Langping He, Emma L Blakely, Helen Griffin, Mauro Santibanez-Koref, Laurence A Bindoff, Ileana Ferrero, Patrick F Chinnery, Robert McFarland, Richard J Maraia, Robert W Taylor

“…Identifying the genetic basis for mitochondrial diseases is technically challenging given the size of the mitochondrial proteome and the heterogeneity of disease presentations. Using next-generation exome sequencing, we identified in a patient with severe combined mitochondrial respiratory chain defects and corresponding perturbation in mitochondrial protein synthesis, a homozygous p.Arg323Gln mutation in TRIT1. …”
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Medidas eletrencefalográficas durante a aprendizagem de tarefa motora sob efeito do bromazepam Electroencephalography measures in motor skill learning and effects of bromazepam by Victor Hugo Bastos, Dionis Machado, Marlo Cunha, Claudio Elidio Portella, Maurício Cagy, Vernon Furtado, Roberto Piedade, Pedro Ribeiro

“…In the comportamental analysis was noticed blocks as main effect to behavioral variables (time and mistakes in the task). Electrophysiological data showed significants interactions to: laterally/condition/moment; laterally/condition; laterally/moment; condition/moment; condition/site.…”
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Unlocking the therapeutic potential of unexplored phytocompounds as hepatoprotective agents through integration of network pharmacology and in-silico analysis by Pranali A. Jadhav, Asha B. Thomas, Mohsin K. Pathan, Somdatta Y. Chaudhari, Ravindra D. Wavhale, Sohan S. Chitlange

“…The Gene Ontology, Kyoto Encyclopedia of Genes and Genome data were compiled and enrichment analysis was performed using the DAVID database. …”
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Genetics of ovulatory dysfunction and infertility: a scoping review and gene ontology analysis by Erin E. DiPietro, Erin E. DiPietro, Sara M. Sarasua, Casey S. Hopkins, Satishkumar Ranganathan Ganakammal, Luigi Boccuto, Joshua Hurwitz

“…The findings from this review, specifically the list of ODRI genes, can be used for targeted gene panel development in assisted reproductive technology to improve clinical testing and diagnosis, as well as in developing individualized treatment strategies for ODRI patients.…”
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Plankton food-webs: to what extent can they be simplified? by Domenico D'Alelio, Marina Montresor, Maria Grazia Mazzocchi, Francesca Margiotta, Diana Sarno, Maurizio Ribeira d'Alcalà

“…We performed an extensive review of the plankton literature to provide a compilation of data suitable for implementing food-web models including plankton trophic processes at high taxonomic resolution. …”
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Program Diorama Kearsipan Sebagai Sarana Literasi Budaya Pemustaka Di Aceh by Niswana Almadania, Nurhayati Ali Hasan, T. Mulkan Safri, Abdul Manan, Mukhtaruddin Mukhtaruddin

“…This study employs a qualitative research method using interviews, observations, and documentation techniques. …”
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Targeting NLRC4 for potential therapeutic strategies in lung adenocarcinoma by Xue Xu, Meng-Yu Zhang, Jia-Qi Fan, Guo-Dong Li, Jun-Yi Li, Xiao Chen

“…Methods In this study, ARGs were sourced from the Human Autophagy Database (HADb), with gene expression data retrieved from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. …”
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Interpersonal and intrapersonal leadership competencies: an interpretative phenomenological analysis on effective leadership strategies by Marion Koreen Andrea Aquino, Alicia Mae Bumacod, Arizzandra Gerriz Calapine, Jan Marie Therese Yaco, Margarett Luz Dimailig, Avon Pearl Amores, Joseph Francisco

“…Purposive sampling was used to select five Filipino organizational leaders from diverse industries. …”
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SIRT5 prevents mitochondrial dysfunction and cardiac hypertrophy induced by RIP140 by Liying Liang, Yi Huang, Qiujuan Wang, Ye Hong, Honghui Zhen, Yanfang Chen

“…Cellular oxygen consumption and ATP production were investigated using assay kits. All data are from at least three independent experiments.Results: The expression of SIRT5 was down-regulated in NRCMs and hearts treated with Ang II. …”
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Determining the factors associated with suicidal thoughts in outpatients referred to a specialized psychiatric facility by Alireza Haji Seyed Javadi, Adeleh Askari Diarjani, Ali Akbar Shafikhani

“…Demographic and clinical data were collected and analyzed using appropriate statistical methods. …”
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Spatial association characteristics and evolutionary mechanisms of water pollution in China: A network structure dependence perspective by Ning Zhang, Hongjie Liu, Hongji Dong, Zhijie Cao, Ruoxin Zhan

“…Under conditions of homophily in environmental regulation, heterophily in technological innovation, water use structure, population density, industrial structure, and digital infrastructure level, as well as geographic proximity, the long-term stable development of GWF spatial associations and the deepening of positive spatial interactions of resource elements through mechanisms such as market regulation are essential to advancing cross-regional collaborative water pollution governance.…”
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General anesthesia in dental treatments: where and how? by Tuba Çatak, Şeref Nur Mutlu, Ali Özgül Saltalı, Yasemin Derya Fidancıoğlu

“…The objective of the present research was to gather the opinions of anesthesiologists and dentists regarding the prompt treatment of dental patients requiring GA in institutions that offer optimal conditions for patient safety. Methods Data were collected using a 28-item questionnaire developed by the researchers based on a literature review and interviews with both dentists and anesthesiologists involved in dental procedures under GA. …”
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Evaluation of Quality and Some Agronomic Traits of Bread Wheat (Triticum aestivum L.) Lines and Cultivars under Kahramanmaraş Ecological Conditions by İlker YÜCE, Tuğba BAŞKONUŞ, Tevrican DOKUYUCU, Aydın AKKAYA, Hüseyin GÜNGÖR, Ziya DUMLUPINAR

“…Bread wheat genotypes varied significantly for all investigated traits in terms of the year, genotype, and year x genotype interactions. Based on average data, the investigated traits were determined as; plant height (PH) 90.86 cm, spike length (SL) 9.40 cm, spikelet number (SN) 18.90, grain number per spike (GNS) 56.22, grain weight per spike (GWP) 1.95 g, thousand kernel weight (TKW) 34.90 g, grain yield (GY) 654.54 kg/da, test weight (TW) 76.17 kg/hl, protein ratio (PO) 12.28%, wet gluten (WG) 34.16% and Zeleny sedimentation (ZS) 33.87 ml. …”

Predictive value of preclinical models for CAR-T cell therapy clinical trials: a systematic review and meta-analysis by Sebastian Kobold, Carsten Marr, David Andreu-Sanz, Lisa Gregor, Emanuele Carlini, Daniele Scarcella

“…Background Experimental mouse models are indispensable for the preclinical development of cancer immunotherapies, whereby complex interactions in the tumor microenvironment can be somewhat replicated. …”
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Deciphering microbial and metabolic influences in gastrointestinal diseases-unveiling their roles in gastric cancer, colorectal cancer, and inflammatory bowel disease by Daryll Philip, Rebecca Hodgkiss, Swarnima Kollampallath Radhakrishnan, Akshat Sinha, Animesh Acharjee

“…Abstract Introduction Gastrointestinal disorders (GIDs) affect nearly 40% of the global population, with gut microbiome-metabolome interactions playing a crucial role in gastric cancer (GC), colorectal cancer (CRC), and inflammatory bowel disease (IBD). …”
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Assessment of Personalized Exercise Prescriptions Issued by ChatGPT 4.0 and Intelligent Health Promotion Systems for Patients with Hypertension Comorbidities Based on the Transtheo... by Xu Y, Liu Q, Pang J, Zeng C, Ma X, Li P, Ma L, Huang J, Xie H

“…The performance of intelligent tools such as ChatGPT 4.0 and Intelligent Health Promotion Systems (IHPS) in issuing exercise prescriptions for patients with hypertension comorbidities remains to be verified.Patients and Methods: After collecting patient information through IHPS hardware and questionnaire systems, the data were input into the software terminals of ChatGPT 4.0 and IHPS according to the five stages of the Transtheoretical Model, resulting in exercise prescriptions. …”
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Exploring the relationship between sleep characteristics and cardiovascular biomarkers among adults aged 46–85 years measured in the Doetinchem cohort study by Laura W. Samson, Hanneke Wijnhoven, W. M. Monique Verschuren, H. Susan J. Picavet

“…Abstract We examined the associations between sleep characteristics and cardiovascular biomarkers among middle-aged and older adults from the general population and explored interactions by age and sex. Cross-sectional data from wave 6 (2013–2017) of the Doetinchem Cohort Study were used, including 3,437 adults aged 46–85 years. …”
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Artificial intelligence as a virtual coach in a cognitive behavioural intervention for perfectionism in young people: A randomised feasibility trial by Catherine Johnson, Sarah J. Egan, Per Carlbring, Roz Shafran, Tracey D. Wade

“…GSH-AI participants were given suggested questions to ask AI for guidance in completing the intervention. Data were collected at baseline, 4- and 8-weeks post-randomisation. …”
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The Role of Organizational Culture and Emotional Intelligence: Enhancing Healthcare Professionals’ Job Satisfaction by Vasiliki Georgousopoulou, Maria Amanatidou, Pinelopi Vlotinou, Eleni Lahana, Anna Tsiakiri, Ioannis Koutelekos, Eleni Koutra, Georgios Manomenidis

“…<b>Methods</b>: A descriptive cross-sectional study was conducted among 338 nurses working in secondary and tertiary hospitals in Greece. Data were collected using the Organizational Culture Assessment Instrument (OCAI), Wong and Law Emotional Intelligence Scale (WLEIS), and Job Satisfaction Survey (JSS). …”
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A quantitative analysis of the factors that influence clinical blood demand in the Suzhou area by Shuhong Xie, Mingyuan Wang, Longhai Tang, Yiming Jin, Yan Cao, Wei Gao, Yu Yan, Qi Xiao, Weibin Yan

“…From March to April 2023, 422 experts in transfusion medicine were surveyed using the Delphi method, and the data were analyzed via exploratory and confirmatory factor analyses (EFA/CFA) to construct a hierarchical structural model. …”
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