A Novel Digital Intervention to Facilitate Diabetes Self-Management Among People with Schizophrenia and Related Disorders: Development and Acceptability Testing of SMART by Arnautovska U, Ritchie G, Soole R, Menon A, Korman N, Milton A, Varnfield M, Kelly JT, Jansen PM, Baker A, Ireland D, Russell AW, Chapman J, Mulligan K, Hirani SP, Vitangcol KJ, McKeon G, Siskind D

“…Barriers to usability included lack of mobile/internet data, precluding the ability to reply to text messages, and a preference for more hyperlinks and additional interactive features.Conclusion: The comprehensive co-design process resulted in the development of a novel digital intervention for prevention and self-management of T2D tailored to unique needs and preferences of people with SSD. …”
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Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway by Weijie Ni, Yajie Zhao, Jinxin Shen, Qing Yin, Yao Wang, Zuolin Li, Taotao Tang, Yi Wen, Yilin Zhang, Wei Jiang, Liangyunzi Jiang, Jinxuan Wei, Weihua Gan, Aiqing Zhang, Xiaoyu Zhou, Bin Wang, Bi-Cheng Liu, Yuanyuan Ji

“…Dunnett’s multiple comparison and t-test were used to analyze the data. Results:. Compared with the control mice, miR-26a expression was significantly downregulated in both the kidney and the heart after Ang-II infusion. …”
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First-Episode Psychosis incidence pre-, during, and post-COVID-19 pandemic: a six-year natural quasi-experimental study in South LondonResearch in context by Andrea Quattrone, Eleni Petkari, Edoardo Spinazzola, Perry B.M. Leung, Zhikun Li, Robert Stewart, Diego Quattrone, Marta Di Forti, Robin M. Murray, Mariana Pinto da Costa

“…We hypothesised that FEP rates rose during the pandemic and subsequently returned to pre-pandemic levels. Methods: Using the Clinical Record Interactive Search (CRIS) system, we screened individuals referred for FEP to Early Intervention Services for Psychosis (EISs) of the South London and Maudsley NHS Foundation Trust (SLaM) from 1 March 2018 to 29 February 2024. …”
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Network analysis in depressed adolescents with suicidal ideation: the role of depression, anxiety, and childhood abuse by Ziyang Huang, Ziyang Huang, Ziyang Huang, Liya A, Liya A, Liya A, Liya A, Kewen Yan, Kewen Yan, Kewen Yan, Hailiang Ran, Yusan Che, Runxu Yang, Runxu Yang, Runxu Yang, Linling Jiang, Linling Jiang, Linling Jiang, Rui Xiao, Rui Xiao, Rushuang Zeng, Rushuang Zeng, Rushuang Zeng, Tong Li, Tong Li, Tong Li, Yiling Xie, Yiling Xie, Yiling Xie, Yuanyuan Xiao, Jin Lu, Jin Lu, Jin Lu

“…Employing symptom network analysis, this study investigates the interactions among depressive symptoms, anxiety, and childhood abuse in adolescents diagnosed with major depressive disorder (MDD) and suicidal ideation.MethodsWe analyzed data from 733 Chinese adolescents diagnosed with MDD (mean age = 14.81 years). …”
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The influence of absorbing aerosols on the morning PBL growth dynamic in the EDMF-AERO modeling framework by G. M. Florczyk, K. M. Markowicz

“…<p>Using the novel PBL evolution model EDMF-AERO and the dataset collected during a measurement campaign at the Swider Geophysical Observatory in 2014, we studied morning PBL dynamics under high pollution. …”
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Causal relationships between four types of lipids and breast cancer risk with potential mediators: evidence from Mendelian randomization study and bioinformatics analysis by Xu-Chu Li, Bangqi Wang, Yu Tang

“…The expression of ZC3HC1 was further explored using the TIMER, GEPIA2 and HPA database. Finally, enrichment analyses of Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and protein–protein interactions (PPI) network analysis were conducted on ZC3HC1 and its related genes. …”
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Validity and network structure of the Nomophobia Questionnaire in Peruvian medical students by Peter Garcia-Portocarrero, Deysi A. Saldaña-Amaya, Brayan Miranda-Chavez, Javier A. Flores-Cohaila, Cesar Copaja-Corzo

“…Methods: An observational cross-sectional study was conducted with 3139 medical students from 38 schools in Peru, using the Spanish-adapted NMP-Q. Data were collected through an online survey, promoted via social media and direct contacts. …”
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Single-Cell and Single-Nuclei transcriptomics profiling reveals dynamic cellular features in tumor-related adipose microenvironment of breast cancer patients with high BMI by Xiaoxiao Hu, Fang Jia, Lili Li, Wuzhen Chen, Leyi Zhang, Jun Pan, Sangsang Zhu, Zhen Wang, Jian Huang

“…Materials and methods: We unveiled a comprehensive cell atlas by employing single-cell (N = 27) and single-nuclei (N = 6) transcriptomics to address dynamic changes of immune and stromal cell components within WAT in high BMI population. Bulk RNA-seq data sets were used for validation. Results: Characteristics of adipose-infiltrating tissue-resident macrophages (PVMs), APOD+γδ T cells, and mature FKBP5+ adipocytes in breast cancer women with high BMI were revealed, in terms of transcriptional genes, metabolism features, developmental trajectories and gene set enrichment analysis (GSEA). …”
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Remodeling of the chromatin landscape in peripheral blood cells in patients with severe Delta COVID-19 by Vasiliy E. Akimov, Dmitriy I. Tychinin, Olga A. Antonova, Abusaid M. Shaymardanov, Maria D. Voronina, Kseniia A. Deinichenko, Oleg D. Fateev, Vladimir S. Yudin, Sergey M. Yudin, Vladimir E. Mukhin, Svetlana V. Romanova, Aleksandra I. Nekrasova, Anastasia S. Zhdanova, Anastasia V. Tsypkina, Ivan S. Vladimirov, Antonida V. Makhotenko, Anton A. Keskinov, Sergey A. Kraevoy, Ekaterina A. Snigir, Dmitry V. Svetlichnyy, Veronika I. Skvortsova

“…Moreover, cases with the Delta variant were accompanied by a specific monocyte subtype discovered using scATAC-seq data. Our analysis showed that immune cells of individuals with severe Delta COVID-19 underwent significant remodeling of the chromatin accessibility landscape and development of the proinflammatory expression pattern. …”
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In vitro and in silico investigations of Propolis-derived phytochemicals as potential inhibitors of Plasmodium falciparum by Dhrubo Ahmed Khan, Md. Nazmul Hasan, Rachasak Boonhok, Suthinee Sungkanu, Yutatirat Singhaboot, Afsana Amin Shorna, Anamul Hasan, Kesinee Chotivanich, Polrat Wilairatana, Abolghasem Siyadatpanah, Roghayeh Norouzi, Imran Sama-ae, Watcharapong Mitsuwan, Alok K. Paul, Maria de Lourdes Pereira, Shanmuga S. Sundar, Tooba Mahboob, Christophe Wiart, Ryan V. Labana, Siriphorn Chimplee, Veeranoot Nissapatorn

“…Materials and Methods: The anti-Plasmodium activity of ethanol-extracted Propolis was assessed against P. falciparum NF54 using the SYBR Green I fluorescence assay. Gas chromatography-mass spectrometry (GC-MS) analysis identified major phytochemicals in the most active extract. …”
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Decoding Cellular Landscapes: Unravelling Periodontitis and Periapical Periodontitis at the Single-Cell Frontier by Yuan Li, Jun Wang, Yu Zhang, Dengke Li, Wuyang Zhang, Xuebing Li, Bolun Zhang, Kaijin Hu, Jianfei Yan, Yang Xue

“…Cell types were annotated using SingleR, and key cell types were further analysed for their proportions, intercellular communication, and gene expression patterns. …”
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Impact of environmental pollution on human health: Investigating the role of Polycyclic Aromatic Hydrocarbons in pediatric osteosarcoma by Mingxian Xu, Yu Xu, Yaping Huang, Jixiang Shi, Lifeng Yin, Jian Tu, Junqiang Yin, Changye Zou

“…A total of 1617 candidate PAH-associated molecular targets were retrieved from bioinformatics databases (PubChem, STITCH, GeneCards, DisGeNET), and core targets were identified using STRING and Cytoscape network analyses. Molecular docking was conducted to assess interactions between selected targets and two major PAH compounds, naphthalene (NAP) and benzo[a]pyrene (BaP). …”
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Vitamin K‐dependent gamma‐carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGF... by Zheng Wu, Qing Ye, Shan Zhang, Li‐Peng Hu, Xiao‐Qi Wang, Lin‐Li Yao, Lei Zhu, Shu‐Yu Xiao, Zong‐Hao Duan, Xue‐Li Zhang, Shu‐Heng Jiang, Zhi‐Gang Zhang, De‐Jun Liu, Dong‐Xue Li, Xiao‐Mei Yang

“…Methods Analysis of pancreatic ductal adenocarcinoma (PDAC) datasets, including transcription profiles, clinical data, and tissue microarrays, was conducted to evaluate PRRG1 expression and its clinical relevance. …”
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Seroprevalence and Risk Factors for Toxoplasma gondii Infection in People Living with HIV: A Cross-Sectional Study from Maputo Central Hospital, Mozambique by Manuel L, Comia IR, Miambo RD, Sousa IM, Cuboia N, Carimo A, Massuanganhe SJ, Buene TP, Banze LR, Paraque BP, Nhancupe N, Schooley RT, Santos-Gomes GM, Noormahomed EV, Benson CA

“…NPD disorders were assessed using the International Classification of Diseases criteria. …”
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The influence of H. pylori infection in HER2-positive gastric cancer cell lines: insights from Wnt/β-catenin pathway by Valli De Re, Mariateresa Casarotto, Giulia Brisotto, Stefania Zanussi, Mariangela De Zorzi, Ombretta Repetto, Elena Muraro, Paola Spessotto, Paolo Baldo, Vito Racanelli, Marco Vincenzo Lenti, Marco Vincenzo Lenti, Marino Venerito, Matteo Fassan, Matteo Fassan, Agostino Steffan, Stefano Realdon, Renato Cannizzaro, Renato Cannizzaro

“…HER2, PD-L1 and PD-L2 protein levels were assessed in all cell lines using multicolor flow cytometry (FACS) before and after HV-HP exposure.ResultsOur data revealed that HV-HP infection reduced MSH6 mRNA expression, which is indicative of impaired DNA repair, and up-regulated PDCD1LG2, suggesting enhanced immunosuppression. …”
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Hemoglobin state-flux: A finite-state model representation of the hemoglobin signal for evaluation of the resting state and the influence of disease. by Randall L Barbour, Harry L Graber, San-Lian S Barbour

“…Notable features of the methodology include access to this information solely from measures acquired in the resting state, and analysis of these by treating the various components of the hemoglobin (Hb) signal as a co-varying interacting system.<h4>Approach</h4>The principal data-transform kernel projects Hb state-space trajectories onto a coordinate system that constitutes a finite-state representation of covariations among the principal elements of the Hb signal (i.e., its oxygenated (ΔoxyHb) and deoxygenated (ΔdeoxyHb) forms and the associated dependent quantities: total hemoglobin (ΔtotalHb = ΔoxyHb + ΔdeoxyHb), hemoglobin oxygen saturation (ΔHbO2Sat = 100Δ(oxyHb/totalHb)), and tissue-hemoglobin oxygen exchange (ΔHbO2Exc = ΔdeoxyHb-ΔoxyHb)). …”
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Cohort profile: the open, prospective Community-Based chronic Care Lesotho (ComBaCaL) cohort – design, baseline chronic disease risk factors and hypertension and diabetes care casc... by Matthias Briel, Thilo Burkard, Ravi Gupta, Frédérique Chammartin, Alain Amstutz, Thabo Ishmael Lejone, Eleonora Seelig, Irene Ayakaka, Mosa Tlahali, Matumaole Bane, Makhebe Khomolishoele, Tristan Lee, Niklaus Daniel Labhardt, Felix Gerber, Giuliana Sanchez-Samaniego, Thesar Tahirsylaj, Fabian Raeber, Mamakhala Chitja, Malebona Mathulise, Thuso Kabi, Mosoetsi Mokaeane, Malehloa Maphenchane, Manthabiseng Molulela, Mota Mota, Sesale Masike, Retselisitsoe Makabateng, Mamoronts’ane Sematle, Lebohang Sao, Sejojo Phaaroe, Malitaba Litaba, Madavida Mphunyane, Dave Brian Basler, Kevin Kindler, Pauline Grimm

“…It serves as a platform for implementing nested trials using the Trials within Cohorts (TwiCs) design to assess community-based chronic care interventions. …”
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The effects of microencapsulated hot chili pepper on the blood metabolites and physiological parameters of dairy cows by Mónica Madrigal-Valverde, Marcus Vínicius Galvão Loiola, José Esler Freitas Junior, Murilo Ramos Santiago, Lara Lôbo Dantas, Artur Azevedo Menezes, Sandro Percário, Everton Luiz Pompeu Varela, Eduardo Costa, Endrigo Adonis Braga de Araujo, Rodrigo Freitas Bittencourt

“…Physiological measurements, including body condition score, heart rate, respiratory frequency, and urine pH, were also assessed weekly. Data were statistically analyzed using mixed-model procedures with repeated measures over time. …”
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Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway by Kyonghwan Choe, Muhammad Ali, Roy Lardenoije, Renzo J.M. Riemens, Ehsan Pishva, Horst Bickel, Siegfried Weyerer, Per Hoffmann, Michael Pentzek, Steffi Riedel-Heller, Birgitt Wiese, Martin Scherer, Michael Wagner, Diego Mastroeni, Paul D. Coleman, Alfredo Ramirez, Inez H.G.B. Ramakers, Frans R.J. Verhey, Bart P.F. Rutten, Gunter Kenis, Daniel L.A. van den Hove

“…Functional interactions between genes and identification of common phenotype-specific positive and negative elementary circuits were conducted using computational modeling, i.e. gene regulatory network (GRN) and network perturbational analysis. …”
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The KNAT3a1-WND2A/3A module positively regulates fiber secondary cell wall biosynthesis in Populus tomentosa by Kuan Sun, Di Fan, Yingying Peng, Chang Liu, Lingfei Kong, Ting Lan, Xianqiang Wang, Dan Li, Chaofeng Li, Keming Luo

“…Taken together, these data suggest that the KNAT3a1-WND2A/3A module positively regulates fiber development of the secondary xylem in poplar via the WND2A/3A-mediated hierarchical regulatory network, and supplies useful information for fiber SCW formation. …”
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