Urinary TYROBP and HCK as genetic biomarkers for non-invasive diagnosis and therapeutic targeting in IgA nephropathy by Boji Xie, Shuting Pang, Yuli Xie, Yuli Xie, Qiuyan Tan, Shanshan Li, Mujia Jili, Mujia Jili, Yian Huang, Yian Huang, Binran Zhao, Hao Yuan, Hao Yuan, Junhao Mi, Junhao Mi, Junhao Mi, Xuesong Chen, Liangping Ruan, Hong Chen, Xiaolai Li, Boning Hu, Jing Huang, Rirong Yang, Rirong Yang, Wei Li

“…Machine learning was used to identify key differentially expressed genes, with protein expression validated by immunohistochemistry (IHC) and drug-target interactions explored via molecular docking.ResultsUrine RNA-seq analysis revealed differential expression profiles, from which TYROBP and HCK were identified as key biomarkers using machine learning. …”
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Long-term Metformin Alters Gut Microbiota and Serum Metabolome in Coronary Artery Disease Patients After Percutaneous Coronary Intervention to Improve 5-year Prognoses: A Multi-omi... by Ruilin Zhou, Qingyang Wu, Hao Qian, Liang Wang, Guangcheng Liu, Bin Zhang, Wei Wu, Shuyang Zhang

“…Multi-omics analysis was conducted using Spearman’s correlation to explore the interactions between metformin, gut microbiome, serum metabolites, and clinical prognosis. …”
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Diversity and Distribution of Fungi in the Marine Sediments of Zhanjiang Bay, China by Menghan Gao, Bihong Liu, Jianming Li, Yunyan Deng, Yulei Zhang, Ning Zhang, Feng Li, Changling Li, Xianghu Huang, Zhangxi Hu

“…The fungal molecular network exhibited primarily positive species interactions, with notable structural differences across salinity gradients. …”
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A Multifaceted Computational Approach to Identify PAD4 Inhibitors for the Treatment of Rheumatoid Arthritis (RA) by Mansour S. Alturki, Mohamed S. Gomaa, Nada Tawfeeq, Abdulaziz H. Al Khzem, Mohsina B. Shaik, Murtadha Alshaikh Jafar, Mohammad Alsamen, Hasan Al Nahab, Mohammad Al-Eid, Alhassan Almutawah, Thankhoe A. Rants’o, Khaled A. G. Ayil, Mohammed Almaghrabi

“…Methods: We utilized Maestro Schrödinger as a computational tool for preparing and docking simulations on the PAD 4 enzyme crystal structure that is retrieved from RCSB Protein Data Bank (PDB ID: 4X8G) while the docked FDA-approved medications are obtained from the Zinc 15 database. …”
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Genome-wide identification of TaeGRASs responsive to biotic stresses and functional analysis of TaeSCL6 in wheat resistance to powdery mildew by Yuanyuan Guan, Kaige Wang, Junjie Zhao, Xiangyang Miao, Xiangyang Li, Puwen Song, Haiyan Hu, Shengli Zhang, Chengwei Li

“…Nonetheless, their roles in wheat-pathogen interactions remain poorly understood. Results In this study, we used bioinformatics tools to identify and analyze wheat GRAS family genes responsive to biotic stresses and elucidated the function of TaeSCL6 within this family. …”
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SCAPAS-LungCancer—improving supportive care for patients surgically treated for non-small cell lung cancer: protocol for a prospective, longitudinal, observational and exploratory... by Wei Dai, Britt Borregaard, Zaigham Saghir, Pernille E Bidstrup, Morten Quist, Thomas Decker Christensen, Rene Horsleben Petersen, Rikke Langballe, Lin Huang, Malene Missel, Pernille Orloff Donsel, Michael Stenger, Pernille Brasch Andersen, Camilla Corvinius, Johnny Moons, Florian Fehlmann, Lisbeth Søbæk Hansen, Mai Nanna Schoenau

“…A longitudinal qualitative study, including individual interviews and ethnographic fieldwork, will be conducted to explore patients’ experiences and interactions with clinicians on symptoms and late effects. …”
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Cancer-associated fibroblast-derived fibulin-5 promotes epithelial–mesenchymal transition in diffuse-type gastric cancer via cAMP response element-binding protein pathway, showing... by Jinju Choi, Yoonjin Kwak, Miree Park, Jeong Yeon Jo, Jun Hyuk Kang, Kook Myeong-Cherl, Hang-Rae Kim, Gwanghun Kim, Seong-Ho Kong, Do-Joong Park, Hye Seung Lee, Hyuk-Joon Lee, Jung Mogg Kim, Sang Gyun Kim, Han-Kwang Yang, Ji Kon Ryu, Soo-Jeong Cho

“…Here, to identify distinct biomarkers for DGC compared with intestinal-type gastric cancer, we constructed a comprehensive large-scale signaling network using RNA-sequencing data from three genomic databases (The Cancer Genome Atlas, GSE62254 and GSE26253), developed a mathematical model and conducted simulation analyses. …”
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The Role of the Educational Programs in the Improving of Confidence in Vaccination against Pneumococcal Infection among Population by N I Briko, V A Korshunov, A Ya Mindlina, R V Polibin, A V Shamis, A G Saltykova

“…Statistical processing was performed using IBM SPSS Statistics v.20.0, data visualization – Microsoft Excel 2016. …”
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「情緒勒索量表」中文化之信效度分析 Development and Psychometric Analysis of an Emotional Blackmail Scale by 郭郡羽 Chun-Yu Kuo1, 黃子格 Zi-Ge Huang, 張仁和 Jen-Ho Chang

“…Development and Psychometric Analysis of an Emotional Blackmail Scale Emotional blackmail is a form of emotional manipulation where the blackmailer uses negative emotions such as fear, guilt, or obligation to compel the victim to comply with their demands. …”
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Local QSAR based on quantum chemistry calculations for the stability of nitrenium ions to reduce false positive outcomes from standard QSAR systems for the mutagenicity of primary... by Shigeharu Muto, Ayako Furuhama, Mika Yamamoto, Yasuteru Otagiri, Naoki Koyama, Seiji Hitaoka, Yusuke Nagato, Hirofumi Ouchi, Masahiro Ogawa, Kisako Shikano, Katsuya Yamada, Satoshi Ono, Minami Hoki, Fumiya Ishizuka, Soichiro Hagio, Chiaki Takeshita, Hisayoshi Omori, Kiyohiro Hashimoto, Satsuki Chikura, Masamitsu Honma, Kei-ichi Sugiyama, Masayuki Mishima

“…For internal PAAs, detailed Ames test data were scrutinized and final decisions were made using common evaluation criteria. …”
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The association between hepatic steatosis, vitamin D status, and insulin resistance in adolescents with obesity by Emir Tas, Amanda Flint, Ingrid Libman, Radhika Muzumdar, Xiawei Ou, David K. Williams, Elisabet Børsheim, Eva C. Diaz

“…Methods: A post-hoc analysis was performed using data from 44 adolescents participating in a 6-month observational study evaluating biomarkers of hepatosteatosis. …”
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Multi-dimensional perspectives on sustainability in domestic waste management by Y. Ismail, R. Adji, A.D. Santoso, S. Wahyono, M.A. Kholiq, T. Handayani, S.D.R. Pahri, S. Putiamini, R.A. Pratama, F. Nurfatriani, F.L. Sahwan, F. Suryanto, Prasetiyadi , R.D. Tilottama

“…This study evaluates the sustainability of domestic waste management using a multi-dimensional scaling framework, focusing on five fundamental parameters,such as environmental, economic, social interactions, technological, and regulatory sustainability. …”
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Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation by Yuya Suzuki, Takuo Emoto, Shunsuke Sato, Takeshi Yoshida, Mitsuhiko Shoda, Hiromi Endoh, Manabu Nagao, Tomoyo Hamana, Taishi Inoue, Tomohiro Hayashi, Eriko Nitta, Hiroki Konishi, Kunihiko Kiuchi, Mitsuru Takami, Kimitake Imamura, Masayuki Taniguchi, Masatoshi Inoue, Toshihiro Nakamura, Yusuke Sonoda, Hiroyuki Takahara, Kazutaka Nakasone, Kyoko Yamamoto, Kenichi Tani, Hidehiro Iwai, Yusuke Nakanishi, Shogo Yonehara, Atsushi Murakami, Ryuji Toh, Takenao Ohkawa, Tomoyuki Furuyashiki, Ryo Nitta, Tomoya Yamashita, Ken-ichi Hirata, Koji Fukuzawa

“…Therefore, we assess the single cell landscape of left atria (LA), using a combination of single cell and nucleus RNA-seq. …”
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Unveiling Wolbachia transcriptomic signature in the arboviral vector Aedes aegypti by Sebastián Mejías, Sebastián Mejías, Natalia E. Jiménez, Natalia E. Jiménez, Natalia E. Jiménez, Carlos Conca, Carlos Conca, J. Cristian Salgado, J. Cristian Salgado, Ziomara P. Gerdtzen, Ziomara P. Gerdtzen, Ziomara P. Gerdtzen, Ziomara P. Gerdtzen

“…By identifying differences between Wolbachia-infected and uninfected A. aegypti, previous transcriptomic studies proposed a wide range of symbiotic interactions, but a systematic identification of consistent effects across datasets is still missing.MethodsTo identify A. aegypti genes and functions consistently affected by Wolbachia, we performed differential expression and functional enrichment analysis on published transcriptomic datasets, followed by a meta-analysis of the obtained p-values using the maxP method. …”
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Synergistic Network Pharmacology: Preclinical Validation and Clinical Safety in Acute Ischemic Stroke by Ana I. Casas, Cristian Nogales, Rebecca D. Szepanowski, Mahmoud H. Elbatreek, Elisa Anastasi, Sepideh Sadegh, James Skelton, Benedikt Frank, Anil Wipat, Jan Baumbach, Christoph Kleinschnitz, Harald H. H. W. Schmidt

“…For preclinical validation, we used C57/Bl6 mice and humanized NOX5–knock‐in mice because NOX5 is not present in the mouse genome despite playing a key role in early stroke. …”
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Comparison of porous and non-porous biochar for trimethoprim removal: Quantifying uncertainty in sorption and thermodynamic parameters over different pH and temperature by Nguyen Thi Phuong Thao, Pham Thi Le Na, Ky-Phuong-Ha Huynh, Bao-Trong Dang

“…The biochar was characterized by yield, point of zero charge, scanning electron microscopy with energy-dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, X-ray diffraction, and N2 adsorption-desorption isotherms. The experimental data were statistically interpreted using the pseudo-second-order, modified intraparticle diffusion, and Langmuir isotherm model. …”
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Virtual human retina: Simulating neural signalling, degeneration, and responses to electrical stimulation by Keith Ly, Michael L. Italiano, Mohit N. Shivdasani, David Tsai, Jia-Yi Zhang, Chunhui Jiang, Nigel H. Lovell, Socrates Dokos, Tianruo Guo

“…The model is constructed using electrophysiology, immunohistology, and optical coherence tomography imaging data from healthy and degenerate human retinas. …”
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A multi-country comparison between mobile phone surveys and face-to-face household surveys to estimate the prevalence of non-communicable diseases behavioural risk factors in low-... by Gulam Muhammed Al Kibria, Saifuddin Ahmed, Dustin G Gibson, Kennedy Lishimpi, Jones K Masiye, Daksha Shah, Melanie Cowan, Wilbroad Mutale, Namasiku Siyumbwa, Julián A Fernández-Niño, Champika Wickramasinghe, Leanne Riley, Stacy Davlin, Rachael Phadnis, Romina Costa Beltrán, Juan Carlos Zevallos Lopez, Juan Vásconez, Hicham El Berri, Samir Mounach, Mangla Gomare, Gulnar Khan, Niraj Dave, Udara Perera

“…MPS sampling frames were generated by random digit dialling, while data collection was done by interactive voice response and SMS. …”
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Gymnadenia conopsea orchid: a systematic review by Jing-Yi Wu, Jing-Yi Wu, Ruo-Nan Tang, Ruo-Nan Tang, Jia-Wen Wang, Jia-Wen Wang, Wan-Ying Chen, Wan-Ying Chen, Xing Liu, Ji-Wen Wang, Mei-Ya Li, Fu-Sheng Jiang, Fu-Sheng Jiang

“…., a medicinally significant orchid used for millennia in China, is systematically reviewed regarding its botany, resources, ethnomedicinal applications, phytochemistry, pharmacology, and propagation strategies to advance therapeutic utilization and conservation.MethodsUsing keywords such as “G. conopsea,” “phytochemistry,” “propagation and breeding,” “bioactive compounds,” “immunomodulatory effects,” and “neuroprotective potential,” we systematically searched literature related to G. conopsea plants from databases including Web of Science, SciFinder, PubMed, ACS Publications, CNKI, Wanfang Data, Google Scholar, and Baidu Scholar.ResultsA total of 1,074 papers were retrieved and 133 full-text articles were ultimately selected and comprehensively reviewed. …”
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The Mediating Role of Depression in the Relationship Between Perceived Injustice and Pain Intensity Among Fibromyalgia Patients by Raev S, Aloush V, Gilam G, Elkana O

“…Statistical methods were used to analyze how these factors interact.Our findings showed that people who felt a higher sense of injustice were more likely to experience symptoms of depression. …”
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