Genome-wide identification and expression of the HB gene family during overwintering in Korla pear (Pyrus sinkiangensis) by LIU Xiaoyan, WANG Lijuan, YANG Shenghui, LUO Guanghong, ZHU Jianbo

“…In addition, differential expression patterns of these genes during the overwintering process were examined using transcriptome data. [Results] A total of 93 HB gene family members were identified in the P. sinkiangensis genome through bioinformatics approaches. …”
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A comprehensive analysis of the tryptophan metabolism-related gene signature to predict the prognosis of esophageal squamous cell carcinoma based on multi-omics by Zhengjie Wu, Zhiping Liu, Yukun Wang, Geling Teng, Xiaodong Li, Tong Lu, Fangning Hu, Shuo Wu, Guanqiang Ma, Hua Zhang

“…We aimed to explore the role and mechanism of Trp metabolism in ESCC.MethodsWe integrated single-cell RNA (scRNA) sequencing, bulk transcriptome, proteomics, and microbiome data from public databases. Tryptophan-related cell populations and their interactions were explored using the “seurat” R package at the single-cell level. …”
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Can whole genome sequencing resolve taxonomic ambiguities in fungi? The case study of Colletotrichum associated with ferns by Andrea Menicucci, Salvatore Iacono, Madalena Ramos, Madalena Ramos, Chiara Fiorenzani, Natalia Aparecida Peres, Lavern Wayne Timmer, Antonio Prodi, Riccardo Baroncelli, Riccardo Baroncelli

“…Genomic DNA was extracted and sequenced using the Illumina NovaSeq platform. High-quality genome assemblies were generated, and gene prediction was conducted using AUGUSTUS. …”
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HIV-Helminth Co-Infections and Immune Checkpoints: Implications for Cancer Risk in South Africa by Botle Precious Damane, Thanyani Victor Mulaudzi, Sayed Shakeel Kader, Pragalathan Naidoo, Zodwa Dlamini, Zilungile Lynette Mkhize-Kwitshana

“…Multiplex immune regulatory molecule assay analysis was conducted. The data were analyzed using multivariate regression analysis and adjusted for confounders (age, gender, BMI, ART, supplements, and other chronic diseases). …”
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A network toxicology and machine learning approach to investigate the mechanism of kidney injury from melamine and cyanuric acid co-exposure by Zhan Wang, Zhaokai Zhou, Zihao Zhao, Junjie Zhang, Shengli Zhang, Luping Li, Yingzhong Fan, Qi Li

“…Potential target proteins were identified using ChEMBL, STITCH, and GeneCards databases, and hub genes were screened using three machine learning algorithms: LASSO regression, Random Forest, and Molecular Complex Detection. …”
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What are the effects of teaching Evidence-Based Health Care (EBHC) at different levels of health professions education? An updated overview of systematic reviews. by Malgorzata M Bala, Tina Poklepović Peričić, Joanna Zajac, Anke Rohwer, Jitka Klugarova, Maritta Välimäki, Tella Lantta, Luca Pingani, Miloslav Klugar, Mike Clarke, Taryn Young

“…Two reviewers independently selected SRs, extracted data and evaluated quality using standardised instrument (AMSTAR2). …”
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Genomic insights into antimicrobial resistance and virulence of E. coli in central Ethiopia: a one health approach by Wagaw Sendeku Chekole, Wagaw Sendeku Chekole, Wagaw Sendeku Chekole, Lizel Potgieter, Haileeyesus Adamu, Susanna Sternberg-Lewerin, Tesfaye Sisay Tessema, Ulf Magnusson

“…A maximum likelihood SNP (single nucleotide polymorphism) tree was constructed and visualized with an interactive tree of life (IToL). Descriptive statistics were used to analyze the data. …”
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Bridging Scales: Coupling the Galactic Nucleus to the Larger Cosmic Environment by Kung-Yi Su, Priyamvada Natarajan, Hyerin Cho, Ramesh Narayan, Philip F. Hopkins, Daniel Anglés-Alcázar, Ben S. Prather

“…Coupling black hole (BH) feeding and feedback involves interactions across vast spatial and temporal scales that are computationally challenging to model. …”
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Meta-analysis on the entomological effects of differentially treated ITNs in a multi-site experimental hut study in sub-Saharan Africa by Natalie Lissenden, John Bradley, Benjamin Menze, Charles Wondji, Constant Edi, Benjamin Koudou, Raphael N’Guessan, Koama Bayili, Abdoulaye Diabaté, Njelembo Mbewe, Basiliana Emidi, Jacklin Mosha, Alphaxard Manjurano, Graham Small, Welbeck Oumbouke, Sarah Jane Moore, Derric Nimmo, Janneke Snetselaar

“…These trials were conducted on a range of net products with different AIs, across a range of geographies in Africa (East and West), vector species (Anopheles gambiae, Anopheles coluzzii, Anopheles arabiensis, and Anopheles funestus), hut designs (East and West African style) and hosts (cows and humans). The combined data from these trials were analysed in a meta-analysis, and odds ratios for the effect of the different net designs on mortality and blood-feeding were estimated using mixed effects logistic regression. …”
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Psychosocial factors associated with quality of life in cancer patients undergoing treatment: an umbrella review by Chiara Marzorati, Viktorya Voskanyan, Diana Sala, Roberto Grasso, Federico Borgogni, Ricardo Pietrobon, Iris van der Heide, Merel Engelaar, Nanne Bos, Augusto Caraceni, Norbert Couspel, Montse Ferrer, Mogens Groenvold, Stein Kaasa, Claudio Lombardo, Aude Sirven, Hugo Vachon, Alexandra Gilbert, Cinzia Brunelli, Giovanni Apolone, Gabriella Pravettoni, EUonQoL Consortium

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Governance for anti-racist AI in healthcare: integrating racism-related stress in psychiatric algorithms for Black Americans by Christopher T. Fields, Christopher T. Fields, Carmen Black, Carmen Black, Jannat K. Thind, Oluwole Jegede, Oluwole Jegede, Damla Aksen, Matthew Rosenblatt, Shervin Assari, Chyrell Bellamy, Elijah Anderson, Avram Holmes, Dustin Scheinost

“…This anti-racist approach challenges policymakers, researchers, clinicians, and AI developers to fundamentally rethink how AI is created, used, and regulated in healthcare, with profound implications for health policy, clinical practice, and patient outcomes across all medical domains.…”
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Divergent dynamics of surface water patterns and structures in Europe's coastal-zone basins by Liumeng Chen, Yongchao Liu, Jialin Li, Chao Ying, Peng Tian, Wenfei Kuang, Qiyu Huang, Tian Zheng

“…This study provides essential data for supporting biodiversity conservation, water resource management, and sustainable coastal development.…”
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An analytical approach to explore prospects and limits of nutrition-sensitive fisheries governance under climate change by Abigail Bennett, Julia G Mason, Willow Battista, Christopher M Free, Jessica A Gephart, Kristin M Kleisner, Emma D Rice, Kelly F Robinson, John Virdin

“…Anticipating the effect of governance interventions to sustain or enhance nutritional benefits from fisheries entails accounting for these multiple interacting influences. We develop an analytical approach to link available data on aquatic foods production, nutrition, distribution, and potential climate impacts to evaluate the nutrition implications of fishery management and post-harvest allocation interventions. …”
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Physical Exercise as a Therapeutic Strategy for ADHD in Children and Adolescents by Klaudia Mościszko, Joanna Kałuska, Dominika Hakało, Marta Ignatiuk-Chilkiewicz, Aleksandra Sokół, Katarzyna Nowicka, Wiktor Klimek, Maria Majewska, Tomasz Suprun, Adam Rafałowicz, Martyna Niemczuk

“…Materials and methods: A review was conducted incorporating data from PubMed and Google Scholar using keywords such as “ADHD”, “sports”, “physical activity”,“mental health”, “adolescents” and “children”.  …”
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A High-Quality Genome Resource for the Oak Wilt Pathogen Bretziella fagacearum by Karandeep Chahal, Mohit Mahey, Carmen Medina-Mora, Steven Ahrendt, Robert Riley, Anna Lipzen, Juying Yan, Emily Savage, Maxim Koriabine, Vivian Ng, Igor V. Grigoriev, Thomas C. Harrington, Eric L. Patterson, Timothy D. Miles, Monique L. Sakalidis

“…It is predicted to encode 7,554 proteins, which are annotated using RNA sequencing data from the same isolate. …”
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Proteomics of Urinary Extracellular Vesicles Highlight the Involvement of Vitronectin and the Fibrinolytic and TNF Pathways as Mechanisms Underlying Renal Fibrosis in Kidney Transp... by Marta Clos‐Sansalvador, Sergio G. Garcia, Paula Rodríguez‐Martínez, Marta Sanroque‐Muñoz, Miriam Font‐Morón, Cristina Grange, Benedetta Bussolati, Marcella Franquesa, Javier Juega, Francesc E. Borràs

“…This study aims to identify other uEV‐associated proteins linked to renal fibrosis to clarify which pathways involve VTN. uEV were isolated from 33 KTx patients and five healthy controls. uEV proteins were analysed using proximity extension assay (PEA), and data were normalized and compared using Welch's two‐sided t‐test to identify differentially expressed proteins between fibrotic (n = 31) and non‐fibrotic patients (n = 7). …”
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Drone mapping links reindeer browsing during an herbivory pulse to divergent vegetation community responses by Marcus P Spiegel, Jeffrey T Kerby, Dorothée Ehrich, Alexander Volkovitskiy, Alexandra Terekhina, Violetta Filippova, Kirill Shklyar, Natalia Sokolova, Aleksandr A Sokolov, Marc Macias-Fauria

“…Large herbivores regulate ecosystem structure and functioning across Earth’s biomes, but vegetation community responses to herbivory depend on complex interactions involving the timing and intensity of herbivory pressure and other, often abiotic, controls on vegetation. …”
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Integrated bioinformatic analysis of dysregulated microRNA‐mRNA co‐expression network in ovarian endometriosis by Yong Liu, Linyuan Fan, Lingge Jin, Chang Lu, Ting Li, Zhan Zhang, Chengmao Xie, Shenghui Li, Yudi Zhang, Jian Ren, Dan Lu

“…Material and methods Expression profiling of miRNA and mRNA in three normal endometria and five pairs of ectopic/eutopic endometria from patients with ovarian endometriosis was determined by high‐throughput sequencing techniques. The data were then integrated with the public sequencing datasets (GSE105764 and GSE105765) using a non‐biased approach and a miRNA‐mRNA co‐expression regulatory network was constructed by in‐depth bioinformatic analysis. …”
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Association between remnant cholesterol and low-density lipoprotein cholesterol discordance and type 2 diabetes or prediabetes: results from NHANES by Yijing Xin, Yimeng Wang, Yuyuan Shu, Hanyang Liang, Yanmin Yang

“…Nonlinear relationships were explored using restricted cubic splines. Mediation analysis was conducted to evaluate the direct and indirect relationships between abdominal obesity and type 2 diabetes through RC. …”
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Characteristics of shale reservoir development under the influence of sedimentary differentiation: A case study of the Cambrian Qiongzhusi Formation in the Deyang-Anyue rift trough... by Wenyi Chen, Bo Wang, Zhenxue Jiang, Dandan Wang, Hui Long, Wenlei Liu, Dadong Liu

“…This study adopts a multidisciplinary approach to investigating this issue that integrates core analysis, well-log interpretations, and geochemical data. Through systematic comparisons conducted using X-ray diffraction mineralogy, organic carbon quantification, and spontaneous imbibition experiments, we characterize the mineral assemblages, organic geochemical signatures, and pore structures found across the three structural domains of the Deyang–Anyue Rift Trough. …”
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