Dynamic time warping network analysis of posttraumatic stress symptoms in Japanese first responders by Florentine H. S. van der Does, Masato Kitano, Masanori Nagamine, Taku Saito, Nic J. A. van der Wee, Toshinori Chiba, Naoki Edo, Eric Vermetten, Erik J. Giltay

“…DTW, a statistical technique for identifying patterns in time-series data, was employed to model undirected and directed (temporal) symptom networks.Results: The sample consisted of 10211 personnel [97.8% male, mean age 36.7 (SD = 7.5)]. …”
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Sacubitril Does Not Exert Proarrhythmic Effects in Combination with Different Antiarrhythmic Drugs by Christian Ellermann, Carlo Mengel, Julian Wolfes, Felix K. Wegner, Benjamin Rath, Julia Köbe, Lars Eckardt, Gerrit Frommeyer

“…<b>Methods and results:</b> A total of 25 rabbit hearts were perfused using a Langendorff setup. Following baseline data collection, hearts were treated with mexiletine (25 µM, 13 hearts) or d,l-sotalol (100 µM, 12 hearts). …”
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Immunological profiling in type 2 diabetes mellitus and type 2 diabetic kidney disease: insights from single-cell LacNAc sequencing by Mengyun Xiao, Zigan Xu, Xiaohui Zhu, Jing Chen, Ru Wang, Yaxuan Wang, Xiang Gao, Shaodong Luan, Xiaoyan Pu

“…In vitro cultures of primary human neutrophils under high glucose and high glucose plus serum from patients with T2DKD were used to assess NET formation via myeloperoxidase (MPO) detection. …”
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Attenuated sex-related DNA methylation differences in cancer highlight the magnitude bias mediating existing disparities by Jiaqi Zhou, Miao Li, Yu Chen, Shangzi Wang, Danke Wang, Chen Suo, Xingdong Chen

“…Abstract Background DNA methylation (DNAm) influences both sex differences and cancer development, yet the mechanisms connecting these factors remain unclear. Methods Utilizing data from The Cancer Genome Atlas, we conducted a comprehensive analysis of sex-related DNAm effects in nine non-reproductive cancers, compared to paired normal adjacent tissues (NATs), and validated the results using independent datasets. …”
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RAD51 expression and prognostic impact in patients with stomach adenocarcinoma by Baiyu Jian, Hao Zhang, Li Fan, Yang Li, Nan Wu, Ningning Wang, Lingmin Li, Xueyan Li, Pengling Ge, Yingcai Niu, Jicheng Liu

“…Methods In this study, RAD51 mRNA expression in STAD patients was assessed using the UALCAN and GEPIA databases. The diagnostic value of RAD51 was evaluated by analyzing the ROC curve (data from the The Cancer Genome Atlas (TCGA) database). …”
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Integrative analysis of m6A-SNPs and single-cell RNA sequencing reveals key drivers of endocrine combined with CDK4/6 inhibitor therapy resistance in ER+ breast cancer by Ruijie Ming, Ruijie Ming, Han Zhang, Huan Wu, Fangbiao Zhan, Fangbiao Zhan, Xiaoping Huang, Xiaoping Huang, Huawen Liu, Huawen Liu

“…This study explores the role of N6-methyladenosine (m6A) modifications, influenced by m6A-SNPs, in shaping therapy resistance, utilizing single-cell RNA sequencing to delineate the underlying molecular mechanisms.MethodsWe integrated genome-wide association study data with single-cell transcriptomic profiles from ER+ breast cancer patients, focusing on differences between resistant and sensitive responses to CDK4/6 inhibitors. m6A-SNPs were identified and analyzed for their impact on gene expression and interactions with RNA-binding proteins, with a particular focus on their roles within key cellular pathways.ResultsThe study identified crucial m6A-SNPs associated with therapy resistance. …”
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The Influence of Planting Method and Short-Term Organic Amendments on Rhizosphere Microbial Communities in Paddies: Preliminary Results by Ziqi Liu, Zhiqiang Tang, Lili Wang, Li Wen, Yi Liang, Changhua Wang, Hui Wang

“…RDA ordination plots were used to examine the interactions between soil bacterial communities and soil physicochemical properties; planting techniques and organic additions had different effects on soil bacterial communities. …”
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Diffusion of Hydrogen Isotopes in Zirconium Alloys by Long WANG, Zhi-hao HONG, You-zhi WANG, Zi-kai LIU, Xiao-qian ZHANG, Tian-guang ZHANG, Long ZHANG

“…The diffusion coefficient, a key parameter for evaluating the risks associated with hydrogen isotope diffusion, is typically measured using gas-driven permeation and electrochemical hydrogen permeation testing methods, as introduced in this study. …”
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This is not a coaltown: what makes a coal community a ‘coal community’? by Brian Capobianco, Jeffrey B Jacquet, Kathryn Finneran

“…In analyzing interview data with fifty coal employees, local leaders and town residents from across four coal communities across southeast Ohio and northern West Virginia at varying stages of coal transition, this article uses concepts from postmodern social theory to illustrate the nature of how the meanings and identity of coal towns persist even after there is no longer coal. …”
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LAMA4+ CD90+ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8+ T cell senescence by Jianlei Zhang, Zhihui Li, Qiong Zhang, Wen Ma, Weina Fan, Jing Dong, Jingjie Tian, Hongfan Liao, Junzhe Guo, Yabing Cao, Jiang Yin, Guopei Zheng, Nan Li

“…Here, we integrated single-cell RNA sequencing and spatial transcriptomic data of pan-liver cancers to characterize the different subtypes of cancer-associated fibroblasts (CAFs). siRNA transfection was used for knockdown the expression of LAMA4. …”
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Unveiling host-genetic drivers of caecal microbial communities in chickens through genome-wide association studies by Ankit Hinsu, Xiaoxia Dai, Christos Dadousis, Christos Dadousis, Melanie Hay, Bruno Fosso, Matteo Crotta, Ramesh Pandit, Javier Guitian, Fiona Tomley, Prakash Koringa, Chaitanya Joshi, Chaitanya Joshi, Damer Blake, Androniki Psifidi

“…Whole-genome sequencing data were then used to further investigate candidate regions around significantly associated variants from the high-density DNA array. …”
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Multi-level Hierarchical Structure Analysis of Influencing Factors of Coal Mine Managers' Blame Avoidance Behavior by Li Wang, Wenyi Zeng, Ziyan Jing, Yonghui Xu, Jiang Li

“…Methods: Based on the semi-structured interviews and questionnaire surveys (20 middle-level managers in coal mines), this paper used the Grounded Theory and Nvivo Software qualitative research methodology to open, spindle, and selectively encode the interview data. …”
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Indole-3-propionic acid promotes hepatic stellate cells inactivation by Mariana Ilha, Ratika Sehgal, Johanna Matilainen, Kirsi Rilla, Dorota Kaminska, Shrey Gandhi, Ville Männistö, Charlotte Ling, Stefano Romeo, Päivi Pajukanta, Eija Pirinen, Kirsi A. Virtanen, Kirsi H. Pietiläinen, Maija Vaittinen, Jussi Pihlajamäki

“…Circulating IPA levels were measured using LC–MS, liver transcriptomics with total RNA-sequencing and DNA methylation with Infinium HumanMethylation450 BeadChip. …”
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Hadron Identification Prospects with Granular Calorimeters by Andrea De Vita, Abhishek, Max Aehle, Muhammad Awais, Alessandro Breccia, Riccardo Carroccio, Long Chen, Tommaso Dorigo, Nicolas R. Gauger, Ralf Keidel, Jan Kieseler, Enrico Lupi, Federico Nardi, Xuan Tung Nguyen, Fredrik Sandin, Kylian Schmidt, Pietro Vischia, Joseph Willmore

“…In this work we consider the problem of determining the identity of hadrons at high energies based on the topology of their energy depositions in dense matter, along with the time of the interactions. Using GEANT4 simulations of a homogeneous lead tungstate calorimeter with high transverse and longitudinal segmentation, we investigated the discrimination of protons, positive pions, and positive kaons at 100 GeV. …”
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Search for Slow Bars in Two Barred Galaxies with Nuclear Structures: NGC 6951 and NGC 7716 by Yun Hee Lee, Ho Seong Hwang, Virginia Cuomo, Myeong-Gu Park, Taehyun Kim, Narae Hwang, Hong Bae Ann, Woong-Tae Kim, Hyun-Jeong Kim, Ji Yeon Seok, Jeong Hwan Lee, Yeon-Ho Choi

“…We also find hints of a rapidly rotating oval structure within the primary bar, although it is not clearly seen in the imaging data. In contrast, the primary bar in NGC 7716 is too weak to be classified as a barred galaxy, while its nuclear disk and nuclear bar are unusually large, possibly due to tidal interactions or the weakness of the primary bar. …”
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Parenting interventions to promote early child development in the first three years of life: A global systematic review and meta-analysis. by Joshua Jeong, Emily E Franchett, Clariana V Ramos de Oliveira, Karima Rehmani, Aisha K Yousafzai

“…Parenting outcomes included parenting knowledge, parenting practices, parent-child interactions, and parental depressive symptoms. We calculated intervention effect sizes as the standardized mean difference (SMD) and estimated pooled effect sizes for each outcome separately using robust variance estimation meta-analytic approaches. …”
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An Approach to, and Tool for, Predicting the Time Course of an Infectious Disease Outbreak as a Function of Behavioral Interventions by Abebe HT, Siraj A, Berhane K, Siraj D, Van Breukelen GJ

“…To demonstrate the application of our interactive program and discuss user decision-making, we provide an example using key parameters from recent studies. …”
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Impact of a pain education program for people with spinal cord injury who experience neuropathic pain by Nicholas P. Cherup, Kimberly D. Anderson, Marlon L. Wong, Gabriel E. Fernandez, Linda E. Robayo, Kathryn Roach, Roberta Vastano, Eva Widerstrom-Noga, Eva Widerstrom-Noga

“…Despite the availability of various treatments, many report inadequate pain relief, and various side effects.ObjectiveThe primary purpose of the current study was to explore participants’ perspectives on a brief, four-week virtual pain education program and second to evaluate any effects on pain and psychosocial factors.MethodsThis study included 36 participants with SCI who experienced moderate to severe neuropathic pain and explored their perspectives on the pain program using qualitative interviews and evaluated a small set of self-reported pain outcomes.ResultsThe analysis and coding of the qualitative interview data resulted in two primary overarching themes: Benefits of pain education and Content and delivery of pain education. …”
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Acceptability and adherence to a Mediterranean diet in the postnatal period to prevent type 2 diabetes in women with gestational diabetes in the UK: a protocol for a single-arm fea... by Doris Lanz, Julie Dodds, Graham Hitman, Elena Pizzo, Shakila Thangaratinam, Angeliki Bolou, Zoe Drymoussi, Francisco Jose Gonzalez Carreras, Maria del Carmen Pardo Llorente, Amy Thomas, James Heighway, Anita Sanghi, Angela Harden, Teresa Pérez, Mohammed SB Huda, Anita Mehay, Frances Austin

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Genome-wide analyses identify circAQR, a circular RNA suppressing proliferation but promoting migration and invasion in thyroid cancer by Tianjiao Zhou, Zheng Li, Weijun Huang, Enhui Zhou, Yumeng Jiang, Yueqing Bai, Chen Xu, Wen Lu, Kaiming Su, Chuan Xu, Hongliang Yi

“…Circular RNAs (circRNAs) have emerged as critical regulators of tumor biology; however, their roles in thyroid cancer progression remain poorly understood. Using RNA sequencing data from clinical and GEO-derived samples, we identified 111,971 circRNAs, including 13,399 novel thyroid cancer-specific circRNAs. …”
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