Ultrasonographic evaluation of testicular and Pampiniform plexus characteristics in young bulls under different microclimatic conditions in a tropical environment by Joedson Dantas Gonçalves, Alexandre Rossetto Garcia, Rubens Paes de Arruda, José Ricardo Macedo Pezzopane, Felipe Tonato, Alda Juliana Castro de Sousa, Lívia Ferreira Pinho, Veronica Schinaider do Amaral Pereira, Gabriel Brun Vergani, Maria Emilia Franco Oliveira

“…Testicular biometric measurements, B-mode ultrasound assessments (echogenicity and heterogeneity of the testicular parenchyma and mediastinum), color Doppler (blood perfusion of the testicular parenchyma and pampiniform plexus), spectral Doppler of the supratesticular artery (pulsatility and resistance index), and blood collection from the jugular to determine testosterone concentration were performed monthly. Data were analyzed using the PROC MIXED procedure of SAS (p < 0.05), and possible interactions between production systems and animal age are presented. …”
Get full text

Vitamin D receptor gene polymorphism in oral cancer as a function of tobacco consumption: an evidence based systematic review and meta-analysis by Tribikram Debata, Amrita Swain, Amrita Swain, Soumya Ranjan Jena, Soumya Ranjan Jena, Surya Narayan Das, Niranjan Mishra, Luna Samanta, Luna Samanta

“…The meta-analysis highlights interactions between genetic polymorphisms, smoking, aging, and oral health risks. …”
Get full text

Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells by Nan Huang, Zhiwei Liu, Jiabei Zhu, Zhongqi Cui, Yuguang Li, Yongchun Yu, Fenyong Sun, Qiuhui Pan, Qingyuan Yang

“…To our knowledge, the biological roles of sirtuin 6 in esophageal cancer cells have still been underestimated. In the study, data from quantitative reverse transcriptase polymerase chain reaction–based assays and immunohistochemical assays revealed that sirtuin 6 was remarkably overexpressed in esophageal squamous tumor tissues. …”
Get full text

The Inhibitory Effect and Adsorption Properties of Testagen Peptide on Copper Surfaces in Saline Environments: An Experimental and Computational Study by Aurelian Dobriţescu, Adriana Samide, Nicoleta Cioateră, Oana Camelia Mic, Cătălina Ionescu, Irina Dăbuleanu, Cristian Tigae, Cezar Ionuţ Spînu, Bogdan Oprea

“…The tetrapeptide synthesized from the amino acids lysine (Lys), glutamic acid (Glu), aspartic acid (Asp), and glycine (Gly), named as H-Lys-Glu-Asp-Gly-OH, achieved an inhibition efficiency of around 86% calculated from electrochemical measurements, making KEDG a promising new copper corrosion inhibitor. The experimental data were best fitted to the Freundlich adsorption isotherm. …”
Get full text

Association between sleep disorders and myopia in Shanghai adolescents: a cross-sectional survey conducted among junior school students by Xiaoya Yin, Xuelai Wang, Zhe Zhang, Yani Zhai, Xinyi Zhou, Linlin Yuan, Shuman Li, Zhengzhong Wang, Lijing Sun, Chunyan Luo

“…A generalized additive model was used to analyze the relationship between SE and sleep disorder. …”
Get full text

Comprehensive insights into the disease burden linked to air pollution exposure across U.S. states: findings from the 2021 Global Burden of Disease Study by Kaibin Lin, Junxian Quan, Jiafen Liao, Jiafen Liao, Yiyue Chen, Yiyue Chen, Bing Zhou, Bing Zhou, Xi Xu

“…Disease burdens were assessed for chronic obstructive pulmonary disease (COPD), diabetes mellitus, ischemic heart disease (IHD), lower respiratory infections, stroke, and lung cancer. Data were standardized to the GBD reference population for comparability over time.ResultsFrom 1990 to 2021, PM2.5-attributable mortality declined by 80.5%, with IHD deaths falling by 70.6% (79,684–23,433 deaths) and associated DALYs by 71.2%. …”
Get full text

Participant experiences in HIV cure-directed trial with an extended analytical treatment interruption in Philadelphia, United States by Andrea Bilger, Eion Plenn, Frances K. Barg, Katharine A. Rendle, William B. Carter, Andrea Lamour-Harrington, Nora Jones, Beth Peterson, John A. Sauceda, Pablo Tebas, Karam Mounzer, David Metzger, Luis J. Montaner, Karine Dubé

“…Methods From April to November 2022, we conducted post-ATI in-depth interviews with BEAT2 clinical trial (NCT03588715) participants who stopped ART while receiving an immunotherapy regimen. We used conventional content analysis to code the data. …”
Get full text

Inflammation mediates the association between hyperuricemia and stroke mortality: a cohort study by Yiwen He, Yiwen He, Jun You, Jun You, Zhenjie Fan, Zhenjie Fan, Zhiyong Wang, Zhiyong Wang, Min Qian, Min Qian

“…Cox proportional hazards regression models were used to evaluate the impact of hyperuricemia on all-cause and cardiovascular mortality among stroke patients. …”
Get full text

Single-cell transcriptomics analysis reveals that the tumor-infiltrating B cells determine the indolent fate of papillary thyroid carcinoma by Chunmei Li, Pei Wang, Zhizhong Dong, Weihan Cao, Yanjun Su, Jianming Zhang, Shuyan Zhao, Zhiyuan Wang, Zi Lei, Li Shi, Ruochuan Cheng, Wen Liu

“…Findings were validated in an additional 25 tumors using cell co-culture, migration assays, immunofluorescence staining, flow cytometry, and analysis of data from The Cancer Genome Atlas (TCGA). …”
Get full text

Repurposing of compound libraries yields new inhibitors of NDM-1 metallo-β-lactamase with diverse zinc-binding moieties by Vid Kavaš, Philip Hinchliffe, Maša Zorman, Alen Krajnc, Matic Proj, Majda Golob, Martina Hrast Rambaher, James Spencer, Stanislav Gobec

“…These data identify promising scaffolds for the further development of potent MBL inhibitors and show the utility of repurposing chemical libraries to target clinically important enzymes.…”
Get full text

AI-powered machine learning models for monitoring and optimization of biodrying process by Abhisit Bhatsada, Panida Payomthip, Tanik Itsarathorn, Ye Nyi Nyi Lwin, Eka Wahyanti, Sirintornthep Towprayoon, Suthum Patumsawad, Chart Chiemchaisri, Komsilp Wangyao

“…However, the nonlinear and dynamic interactions between influencing factors governing biodrying remain challenging to predict using traditional statistical and kinetic models. …”
Get full text

Metagenome Analysis Identified Novel Microbial Diversity of Sandy Soils Surrounded by Natural Lakes and Artificial Water Points in King Salman Bin Abdulaziz Royal Natural Reserve,... by Yahya S. Al-Awthan, Rashid Mir, Fuad A. Alatawi, Abdulaziz S. Alatawi, Fahad M. Almutairi, Tamer Khafaga, Wael M. Shohdi, Amal M. Fakhry, Basmah M. Alharbi

“…In addition, genomic DNA was extracted from the collected soil samples, and 16S rRNA sequencing was conducted using high-throughput Illumina technology. Several computational analysis tools were used for gene prediction and taxonomic classification of the microbial groups. …”
Get full text

Serotype-specific host proteome remodeling in human foreskin fibroblasts during lytic HSV-1 and HSV-2 infection by Xiaohong Pan, Jiaxin Xie, Zhidan Zhang, Xiaomei Guo, Jixiong Li, Di Lin, Ying Qian, Jingwen Xu, Yunzhang Hu, Jiandong Shi

“…This study presents a comparative proteomic analysis of human foreskin fibroblast (HFF-1) cells during lytic HSV-1 and HSV-2 infections to elucidate host–pathogen interactions driving differential virulence. Using data-independent acquisition mass spectrometry (DIA-MS), we identified 280 and 219 differentially expressed proteins (DEPs) in HSV-1- and HSV-2-infected cells, respectively. …”
Get full text

Akkermansia muciniphila upregulates genes involved in maintaining the intestinal barrier function via ADP-heptose-dependent activation of the ALPK1/TIFA pathway by Camille Martin-Gallausiaux, Diego Garcia-Weber, Amandine Lashermes, Pierre Larraufie, Ludovica Marinelli, Veronica Teixeira, Alice Rolland, Fabienne Béguet-Crespel, Vincent Brochard, Timothé Quatremare, Alexandre Jamet, Joël Doré, Scott D. Gray-Owen, Hervé M. Blottière, Cécile Arrieumerlou, Nicolas Lapaque

“…Here, we seek for novel MAMP-PRR interactions involved in the beneficial effect of the commensal bacterium Akkermansia muciniphila on intestinal homeostasis. …”
Get full text

Systematic Search for Blue Hypervelocity Stars from LAMOST Survey by Yongkang Sun, Yang Huang, Jifeng Liu, Haozhu Fu, Huawei Zhang, Yinbi Li, Cuihua Du, Jianrong Shi, Xiao Kong

“…To expand this sample with the second-phase LAMOST survey that started in 2018, we conducted a systematic search for early-type HVSs using the LAMOST Data Release 10. We identified 125 early-type high-velocity candidates with total velocities exceeding 300 km s ^−1 . …”
Get full text

Characteristics of the gut virome in patients with premalignant colorectal adenoma by Pan Zhang, Xiaofeng Tuo, Jiong Jiang, Yue Zhang, Juhui Zhao, Chengzhao Deng, Gang Zhao, Yan Cheng, Lingqin Song, Yan Yang, Ruochun Guo, Huan Zhang, Hongli Zhao, Shiyang Ma, Lu Li, Haitao Shi

“…Methods Based on the Metagenomic Gut Virus catalogue (MGV) containing 54,118 non-redundant gut viral genomes, this study characterized the virome composition and diversity using publicly available metagenomic sequencing data from 419 individuals with premalignant colorectal adenoma and 552 healthy controls. …”
Get full text

Super-enhancer-hijacking RBBP7 potentiates metastasis and stemness of breast cancer via recruiting NuRD complex subunit LSD1 by Yuanyin Xi, Ruoding Wang, Man Qu, Qinwen Pan, Minghao Wang, Xiang Ai, Zihan Sun, Chao Zhang, Peng Tang, Jun Jiang, Ying Hu

“…Methods The bioinformatic analysis was used to assess the clinical significance of RBBP7 in BCa. …”
Get full text

Lipid-Metabolism-Related Gene Signature Predicts Prognosis and Immune Microenvironment Alterations in Endometrial Cancer by Zhangxin Wu, Yufei Nie, Deshui Kong, Lixiang Xue, Tianhui He, Kuaile Zhang, Jie Zhang, Chunliang Shang, Hongyan Guo

“…Tumor immune infiltration patterns were evaluated using single-sample Gene Set Enrichment Analysis (ssGSEA), Estimation of Stromal and Immune Cells in Malignant Tumors using Expression Data (ESTIMATE), and Tumor Immune Dysfunction and Exclusion (TIDE) algorithms. …”
Get full text

Antitumor Assessment of Liposomal Beta-Carotene with Tamoxifen Against Breast Carcinoma Cell Line: An In Vitro Study by Marim H. Elsayed, Medhat W. Shafaa, Mohga S. Abdalla, Manal F. El-Khadragy, Ahmed E. Abdel Moneim, Shimaa S. Ramadan

“…The present study was designed to characterize the interactions between lecithin liposomes, a model membrane, and either β-carotene or tamoxifen. …”
Get full text

Non‐differential gut microbes contribute to hypertension and its severity through co‐abundances: A multi‐regional prospective cohort study by Lu Liu, Qianyi Zhou, Tianbao Xu, Qiufeng Deng, Yuhao Sun, Jingxiang Fu, Muxuan Chen, Xiaojiao Chen, Zhenchao Ma, Quanbin Dong, Beining Ma, Yuwen Jiao, Yan Zhou, Tingting Wu, Huayiyang Zou, Jing Shi, Yifeng Wang, Yanhui Sheng, Liming Tang, Chao Zheng, Wei Wu, Wenjun Ma, Wei Sun, Shixian Hu, Hongwei Zhou, Yan He, Xiangqing Kong, Lianmin Chen

“…Using gut microbiome data from the Guangdong Gut Microbiome Project, which includes 2355 hypertensive and 4644 non‐hypertensive participants across 14 regions, we identified replicable hypertension‐related microbial interactions. …”
Get full text