Synthesis of Novel Benzothiazole–Profen Hybrid Amides as Potential NSAID Candidates by Iliyan Ivanov, Stanimir Manolov, Dimitar Bojilov, Yordan Stremski, Gabriel Marc, Stela Statkova-Abeghe, Smaranda Oniga, Ovidiu Oniga, Paraskev Nedialkov

“…The compounds were characterized using techniques such as ¹H- and ¹³C-NMR, FT-IR spectrometry, and high-resolution mass spectrometry (HRMS), with detailed HRMS analysis conducted for each molecule. …”
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Development of a tertiary lymphoid structure-based prognostic model for breast cancer: integrating single-cell sequencing and machine learning to enhance patient outcomes by Xiaonan Zhang, Li Li, Xiaoyu Shi, Yunxia Zhao, Zhaogen Cai, Ni Ni, Di Yang, Zixin Meng, Xu Gao, Li Huang, Tao Wang

“…Using single-cell RNA sequencing and machine learning algorithms, we identified critical TLS-associated genes and developed a TLS-based predictive model. …”
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Comprehensive gene expression analysis of organoid-derived healthy human colonic epithelium and cancer cell line stimulated with live probiotic bacteria by Akira Sen, Atsuki Imai, Eiji Miyauchi, Kota Yanagisawa, Tsukasa Oda, Fuki Sasaki, Shintaro Uchida, Takuhisa Okada, Takehiko Yokobori, Hiroshi Saeki, Toshitaka Odamaki, Nobuo Sasaki

“…In vitro host cell modeling and bacterial interactions at the anaerobic interphase have elucidated the crosstalk molecular basis. …”
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A risk prediction system for depression in middle-aged and older adults grounded in machine learning and visualization technology: a cohort study by Jinsong Du, Jinsong Du, Jinsong Du, Xinru Tao, Le Zhu, Wenhao Qi, Xiaoqiang Min, Xiaoqiang Min, Hongyan Deng, Shujie Wei, Xiaoyan Zhang, Xiao Chang

“…This study innovatively proposed a visual risk prediction system for depressive symptoms and depression in middle-aged and older adults, rooted in machine learning and visualization technologies.MethodsUsing cohort data from the China Health and Retirement Longitudinal Study (CHARLS), involving 8,839 middle-aged and older adult participants, the study developed predictive models based on eight machine learning algorithms, primarily including LightGBM, XGBoost, and AdaBoost. …”
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Building a Hand-Curated ceRNET for Endometrial Cancer, Striving for Clinical as Well as Medicolegal Soundness: A Systematic Review by Roberto Piergentili, Stefano Sechi, Lina De Paola, Simona Zaami, Enrico Marinelli

“…<b>Methods:</b> In this systematic review, we collected all available data from PubMed about experimentally verified (by luciferase assay) regulatory axes in endometrial cancer (EC), excluding works not using this test; <b>Results:</b> This search allowed the selection of 172 bibliographic sources, and manually building a series of ceRNETs of variable complexity showed the known axes and the deduced intersections. …”
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MiR-6721-5p as a natural regulator of Meta-VCL is upregulated in the serum of patients with coronary artery disease by Akram Gholipour, Ali Zahedmehr, Maedeh Arabian, Farshad Shakerian, Majid Maleki, Maziar Oveisee, Mahshid Malakootian

“…Cell-based ectopic expression analysis and a dual-luciferase assay were used to examine the interactions between miRNAs and meta-VCL. …”
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Unveiling the perceptions of medical and allied health students towards cadaveric dissection and virtual resources in anatomy education: a cross sectional study by Rana Elbeshbeishy, Rasha Salama, BK Manjunatha Goud, Rasha Babiker, Malay Jhancy, Nour Hamed, Farah Oraby, Tarig Merghani

“…A convenience sampling method was used. The questionnaire assessed sociodemographic data, attitudes toward cadaveric dissection, its significance in practical learning, comparisons with digital resources, and its role in professional development. …”
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Theoretical Insights into the Chemical Bonding, Electronic Structure, and Spectroscopic Properties of the Lanarkite Pb₂SO₅ Structure by Guilherme S. L. Fabris, Mateus M. Ferrer, Claudio R. R. Almeida, Carlos A. Paskocimas, Julio R. Sambrano, Felipe A. La Porta

“…A comprehensive investigation of the chemical bonding, electronic structure, and spectroscopic properties of the lanarkite-type Pb₂SO₅ (PSO) structure was conducted, for the first time, using density functional theory simulations. Thus, different functionals, PBE, PBE0, PBESOL, PBESOL0, BLYP, WC1LYP, and B3LYP, were used, and their results were compared to predict their fundamental properties accurately. …”
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Analysis of the dynamics of environmental movements in France; Emphasizing the concept of ecological citizenship by maryam yari estahbanati, Bahare Sazmand

“…Introduction and objectives: This article examines how environmental movements in France interact with their global counterparts and emphasizes the importance of cross-border cooperation and shared responsibility in addressing environmental challenges. …”
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Changes of endogenous hormone concentrations and transcriptome analysis during the healing process of greenwood grafting in grape by DENG Jiayi, WEI Jiayan, CHEN Aisai, HE Fei, YU Keji, WANG Jun

“…[Methods] The stion combinations of Tiangong Liren/Beta, Tiangong Moyu/Beta and Shine Muscat/Beta were used as materials and were collected at 1, 4, 7, 10 and 13 days after grafting (DAG), respectively. …”
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ZAR1 and ZAR2 orchestrate the dynamics of maternal mRNA polyadenylation during mouse oocyte development by Yu-Ke Wu, Ruibao Su, Zhi-Yan Jiang, Yun-Wen Wu, Yan Rong, Shu-Yan Ji, Jingwen Liu, Zhuoyue Niu, Zhiyi Li, Yuanchao Xue, Falong Lu, Heng-Yu Fan

“…Combined analyses using total RNA-seq, LACE-seq, PAIso-seq2, and immunoprecipitation-mass spectrometry reveals that ZAR1 may target the 3’-untranslated regions of maternal transcripts, regulates their stability in germinal vesicle stage oocytes, and interacts with other proteins to control the polyadenylation of mRNAs. …”
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The role of Cultural Socialization and Contextual Factors on the Subjective Well-Being of Immigrant Adolescent Girls at the Beginning and End of Adolescence: A life course perspect... by Elaheh Hejazi, Ahmad Baseri, Zahra Naghsh, simin ebrahimi

“…A sample of 500 girls were selected using multi-stage random sampling method. The Life Satisfaction Questionnaire (Diener et al., 1985), which includes five questions, was used to measure the cognitive dimension of subjective well-being (original study r = 0.84). …”
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The effect of 12 weeks of HIIT and curcumin consumption on oxidative indices in obese men with type-2 diabetes mellitus by Hasan Naghizadeh, Faeze Heydari

“…Sampling was performed in two stages, pre-test and post-test to measure the plasma concentrations of paraoxonase-1, superoxide dismutase, glutathione peroxidase and malondialdehyde. Data were analyzed using Shapiro-Wilk, one-way analysis of variance and two-way covariance method. …”
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From reality to virtuality: Unveiling Gen Z's purchasing behavior through virtual influencers in the metaverse by Tri-Quan Dang, Tan-Minh Nguyen, Phuc-Thien Tran, Tien-Thao Cong Phan, Thach-Bao Huynh, Luan-Thanh Nguyen

“…The data were analyzed using a mixed-method approach, incorporating fuzzy-set Qualitative Comparative Analysis (fsQCA), Partial Least Squares Structural Equation Modeling (PLS-SEM), and Artificial Neural Networks (ANN techniques). …”
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Multimodal gradients unify local and global cortical organization by Yezhou Wang, Nicole Eichert, Casey Paquola, Raul Rodriguez-Cruces, Jordan DeKraker, Jessica Royer, Donna Gift Cabalo, Hans Auer, Alexander Ngo, Ilana R. Leppert, Christine L. Tardif, David A. Rudko, Robert Leech, Katrin Amunts, Sofie L. Valk, Jonathan Smallwood, Alan C. Evans, Boris C. Bernhardt

“…Here, we present an approach to integrate inter- and intra-areal similarities of microstructure, structural connectivity, and functional interactions. Using high-field in-vivo 7 tesla (7 T) Magnetic Resonance Imaging (MRI) data and a probabilistic post-mortem atlas of cortical cytoarchitecture, we derive multimodal gradients that capture cortex-wide organization. …”
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Predicting cellular responses to complex perturbations in high‐throughput screens by Mohammad Lotfollahi, Anna Klimovskaia Susmelj, Carlo De Donno, Leon Hetzel, Yuge Ji, Ignacio L Ibarra, Sanjay R Srivatsan, Mohsen Naghipourfar, Riza M Daza, Beth Martin, Jay Shendure, Jose L McFaline‐Figueroa, Pierre Boyeau, F Alexander Wolf, Nafissa Yakubova, Stephan Günnemann, Cole Trapnell, David Lopez‐Paz, Fabian J Theis

“…CPA learns to in silico predict transcriptional perturbation response at the single‐cell level for unseen dosages, cell types, time points, and species. Using newly generated single‐cell drug combination data, we validate that CPA can predict unseen drug combinations while outperforming baseline models. …”
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Giant extrachromosomal element “Inocle” potentially expands the adaptive capacity of the human oral microbiome by Yuya Kiguchi, Nagisa Hamamoto, Yukie Kashima, Lucky R. Runtuwene, Aya Ishizaka, Yuta Kuze, Tomohiro Enokida, Nobukazu Tanaka, Makoto Tahara, Shun-Ichiro Kageyama, Takao Fujisawa, Riu Yamashita, Akinori Kanai, Josef S. B. Tuda, Taketoshi Mizutani, Yutaka Suzuki

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LLMonFHIR by Paul Schmiedmayer, PhD, Adrit Rao, Philipp Zagar, MS, Lauren Aalami, MS, Vishnu Ravi, MD, Aydin Zahedivash, MD, MBA, Dong-han Yao, MD, Arash Fereydooni, MD, Oliver Aalami, MD

“…Methods: We present LLMonFHIR, an open-source mobile application that uses large language models (LLMs) to allow users to “interact” with their health records at any degree of complexity, in various languages, and with bidirectional text-to-speech functionality. …”
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Summer soil moisture-convective precipitation coupling in Northern China at different timescales by Hongwei Yang, Zesu Yang, Hang He

“…Land-atmosphere coupling plays an important role in regional precipitation and climate change, but the coupling characteristics at different time scales remain controversial. This study uses ERA5 reanalysis data from 1970 to 2023 to examine how soil moisture impacts precipitation at different timescales. …”
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Rare disease narratives on social media: A content analysis by Hannah J. Park, Cassidy J. Scott, Hadley Stevens Smith, Monica H. Wojcik

“…Two authors independently coded videos for content matter and conducted thematic analysis using a mixed deductive-inductive approach. The demographic characteristics of the content and names of specific rare conditions were documented when available, as were the characteristics of the videos themselves. …”
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