Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors. by Anna Cichonska, Balaguru Ravikumar, Elina Parri, Sanna Timonen, Tapio Pahikkala, Antti Airola, Krister Wennerberg, Juho Rousu, Tero Aittokallio

“…Here, we therefore introduce and carefully test a systematic computational-experimental framework for the prediction and pre-clinical verification of drug-target interactions using a well-established kernel-based regression algorithm as the prediction model. …”
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Ultrasonic and spectroscopic investigations of molecular interactions in binary mixture of PEG-400 and DMSO at different temperatures by Dhiman Monika, Upmanyu Arun, Singh Devinder Pal, Juglan Kailash Chandra

“…In addition to it, the present system has also been examined using Fourier transform infra-red (FTIR) and UV–Vis spectroscopic techniques. …”
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DEVELOPMENT OF METHODS OF SIMULATION OF THE INTERACTION OF BIOLOGICALLY ACTIVE SUBSTANCES WITH THE ACTIVE CENTER OF ANGIOTENSIN-CONVERTING ENZYME by A. A. Glushko, A. S. Chiriapkin, V. S. Chiriapkin, A. M. Murtuzalieva, Yu. A. Polkovnikova

“…The obtained technique can be used for studying the interaction of substances, similar in structure to lisinopril with the active center of the enzyme (ACE).…”
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Wolbachia infections in Anopheles gambiae cells: transcriptomic characterization of a novel host-symbiont interaction. by Grant L Hughes, Xiaoxia Ren, Jose L Ramirez, Joyce M Sakamoto, Jason A Bailey, Anne E Jedlicka, Jason L Rasgon

“…We used Affymetrix GeneChip microarrays to investigate the effect of wAlbB and wRi infection on the transcriptome of cultured Anopheles Sua5B cells, and for a subset of genes used quantitative PCR to validate results in somatically-infected Anopheles mosquitoes. …”
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OFFSHORE SEABED PILE FOUNDATION ANALYSIS: SOIL-PILE INTERACTION AND LOAD CONDITIONS, AND DESIGN RECOMMENDATIONS by Edy Soesanto, Dicky Muslim, Evie Hadrijantie Sudjono, Cipta Endyana

“…This study begins with a comprehensive review of the analytical and numerical methods used for pile analysis. This research aims to analyze the behavior of piles in the offshore seabed environment, taking into account various factors, such as soil-pile interactions, environmental load conditions, and the design of a sturdy pile foundation. …”
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Interaction between IL-33 Gene Polymorphisms and Current Smoking with Susceptibility to Systemic Lupus Erythematosus by Xiaohua Zhu, Lin Xie, Haihong Qin, Jun Liang, Yongsheng Yang, Jinhua Xu, Tiejun Zhang

“…SNPStats (online software) was used to test the Hardy-Weinberg equilibrium in controls. …”
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Nonlinear Interactions and Dynamic Analysis of Ecosystem Resilience and Human Activities in China’s Potential Urban Agglomerations by Xinyu Wang, Shidong Ge, Yaqiong Xu, László Kollányi, Tian Bai

“…We used spatial analysis, the Optimal Parameter Geodetector (OPGD), and Multi-Scale Geographically Weighted Regression (MGWR) to examine the nonlinear spatiotemporal interaction between HAI and ER. …”
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Interactions among Cupressaceae pollen, air pollutants and meteorology in the urban and suburban areas of Beijing, China by Xiaoxin Qin, Yiyin Li, Hongxing Zhang, Wenjun Liu, Xinyi Zhao

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Biomarkers of mRNA vaccine efficacy derived from mechanistic modeling of tumor-immune interactions. by Chrysovalantis Voutouri, Lance L Munn, Triantafyllos Stylianopoulos, Rakesh K Jain

“…Using a mechanistic mathematical model, we simulated tumor growth, immune cell dynamics, and vaccine pharmacokinetics in virtual cohorts of 1,635 patients generated via Latin hypercube sampling. …”
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Coordinated Interaction Strategy of User-Side EV Charging Piles for Distribution Network Power Stability by Juan Zhan, Mei Huang, Xiaojia Sun, Zuowei Chen, Zhihan Zhang, Yang Li, Yubo Zhang, Qian Ai

“…Secondly, by combining urban transportation big data and prediction networks, high-precision inference of the spatiotemporal distribution of charging loads can be achieved. …”
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Thermodynamic studies for molecular interactions of tetraalkylammonium bromide salts in aqueous solutions: A volumetric approach by Vasim R. Shaikh, Sana R. Shaikh, Gaurav R. Gupta, Vijay M. Tangde, Kapil S. Ganorkar

“…Further, the experimental density data were used for the calculations of apparent molar volumes of solute at finite concentration (Vϕ) and apparent molar volumes of solute at infinite dilution (Vϕ0) at studied temperatures. …”
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Impact of multimorbidity and cognitive impairment on depressive symptoms in community-dwelling older adults and their interaction effects by Pengxin Dong, Haichen Wu, Yidan Chai, Ping Huang, Dongmei Huang, Lichong Lai, Jie Peng, Xiaoying Cao, Xiaoling Feng, Huiqiao Huang

“…Employing a cross-sectional design, the study collected data from 10,369 individuals aged 65 and above across 35 communities/villages in China. …”
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Correlation and path analysis of interaction between snap beans yield and its components with crop management by N. Shaban

“…Starozagorski Cher using Path- correlation coefficient of analysis. …”
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Promoting Peer Interaction and Acceptance Among Students with Special Needs Through an Experiential Learning Program by Hsiu-Ming Lin, Szu-Yin Chu, Wen-Hsuan Chang, I-Hsuan Lo, Hsin-Ting Peng

“…Background/Objectives: Inclusive education emphasizes positive interactions between students with and without special needs to foster mutual understanding and acceptance. …”
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The impact of online social interaction on urban community cohesion and group differences: evidence from China by Haibo Li, Haitao Li, Xing Zhou, Yin Kuang, Feiyue Liu

“…Methods This cross-sectional study examines urban community residents (n = 1037) across China’s eastern, central, and western regions, with proportional sampling to ensure geographic representation. Data were collected via random questionnaires. Using structural equation modeling (SEM), we empirically assess (1) the impact of online social interaction on community cohesion, (2) the underlying mechanisms, and (3) heterogeneity effects across demographic and regional subgroups. …”
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Advances in Design and Fabrication of Micro-Structured Solid Targets for High-Power Laser-Matter Interaction by Florin Jipa, Laura Ionel, Marian Zamfirescu

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Integrative causal inference illuminates gene-environment interactions linking endocrine disruptors to female infertility by Yanggang Hong, Zhuoyi Du, Jiajun Li, Yi Wang, Yirong Wang, Wanyi Shu, Qinxi Shen, Feng Chen, Sisi Li

“…We identified 4207 EDC-related genes from The Endocrine Disruption Exchange (TEDX) database and Comparative Toxicogenomics Database (CTD), and analyzed their potential causal effects on female infertility using genome-wide association data. A total of five genes showed significant associations with infertility risk, with SULT1B1, MASTL, and TTC39C linked to increased risk, and ESR1 and AKAP13 associated with a protective effect. …”
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Peculiarities in the interaction of 6He with 197Au and 206Pb at energies close to the Coulomb barrier by Yu. E. Penionzhkevich, R. A. Astabatyan, N. A. Demekhina, R. Kalpakchieva, A. A. Kulko, S. P. Lobastov, S. M. Lukyanov, E. R. Markaryan, V. A. Maslov, Yu. A. Muzychka, Yu. Ts. Oganessian, D. N. Rassadov, N. K. Skobelev, Yu. G. Sobolev, T. Zholdybaev

“…The stacked foil technique was used directly in the beam extracted from the cyclotron or in the focal plane of the magnetic spectrometer MSP-144. …”
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The Kelch 3 motif on gigaxonin mediates the interaction with NUDCD3 and regulates vimentin filament morphology by Cassandra L. Phillips, Christina So, Meredith F. Gillis, Jonathan Harrison, Chih-Hsuan Hsu, Diane Armao, Natasha T. Snider

“…Collectively, our cell biological data show the induction of an abnormal GAN-like IF phenotype in cells expressing ΔK3- and, to a lesser extent, ΔK4-gigaxonin, while our proteomic profiling links the loss of gigaxonin-NUDCD3 interactions with defective IF proteostasis.…”
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The interaction between temperature and rainfall determines the probability of tropical forest fire occurrence in Hainan Island by Xiaohua Chen, Xiaohua Chen, Qingqing Yang, Qingqing Yang, Zongzhu Chen, Jinrui Lei, Tingtian Wu, Yuanling Li, Xiaoyan Pan

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