PODO447: a novel antibody to a tumor-restricted epitope on the cancer antigen podocalyxin by Blake Gilks, Martin Köbel, Diana Canals Hernaez, Michael R Hughes, Pamela Dean, Peter Bergqvist, Ismael Samudio, Ola Blixt, Katharina Wiedemeyer, Yicong Li, Chris Bond, Eric Cruz, Calvin D Roskelley, Kelly M McNagny

“…Mapping of the tumor-restricted epitope was performed using enzyme-treated human tumor cell lines and a glycan array.Results One mAb (PODO447) showed strong reactivity with a variety of Podxl+ tumor cell lines but not with normal primary human tissue including Podxl+ kidney podocytes and most vascular endothelia. …”
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Effects of an integrated social-art intervention on cognitive and psychosocial outcomes among older adults with mild cognitive impairment in nursing homes: a mixed methods study by Chenshan Huang, Yuanjiao Yan, Wilson Wai San Tam, Wenqian Sun, Yu Ye, Nafang Wang, Yanhong Shi, Ziping Zhu, Danting Chen, Lin Chen, Junyu Zhao, Rong Lin, Hong Li

“…Future research should investigate strategies for maintaining cognitive improvements and explore modifications to enhance broader clinical outcomes in this vulnerable population. …”
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Time to breast cancer recurrence and associated predictors in Public Hospitals of Addis Ababa, Central Ethiopia: a retrospective Cohort Study by Yadessa Chala, Tesfaye Techane, Bonsisa Bekele, Tesfaye Girma, Warati Fekede, Chalchisa Abdeta, Kibiru Mardasa, Tolera Abdeta, Bedada Teshome, Gashaye Atinkut, Abdinasir Wako, Mohammed Adem, Alem Deksisa

“…This study aimed to assess the time to recurrence and predictors of breast cancer among women treated in public hospitals of Addis Ababa, Ethiopia. …”
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Systems analysis and improvement to optimize opioid use disorder care quality and continuity for patients exiting jail (SAIA-MOUD) by Sarah Gimbel, Anirban Basu, Emily Callen, Abraham D. Flaxman, Omeid Heidari, Julia E. Hood, Anna Kellogg, Eli Kern, Judith I. Tsui, Ericka Turley, Kenneth Sherr

“…Medications for Opioid Use Disorder (MOUD) can effectively treat OUD. WA has prioritized improving access to MOUD, including for those in jails. …”
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Collaborative Care to Improve Quality of Life for Anxiety and Depression in Posttraumatic Epilepsy (CoCarePTE): Protocol for a Randomized Hybrid Effectiveness-Implementation Trial by Heidi M Munger Clary, Beverly M Snively, Christian Cagle, Richard Kennerly, James N Kimball, Halley B Alexander, Gretchen A Brenes, Justin B Moore, Robin A Hurley

“…The primary effectiveness analysis will compare changes in emotional quality of life scores from baseline to 6 months between the intervention and control arms using multiple linear regression modeling, adjusting for study site and using an intent-to-treat approach. ResultsEnrollment commenced in 2023, with modifications in the inclusion and exclusion made after the first 6 enrollees due to slow recruitment. …”
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tRFAla-AGC-3-M8 attenuates neuroinflammation and neuronal damage in Alzheimer’s disease via the EphA7-ERK1/2-p70S6K signaling pathway by Zihao Deng, Yudi Li, Wenjun Chi, Wanzhou Zhang, Fangming Li, Li Ling

“…BV-2 and HT22 cells were cultured and treated with Aβ25-35 at concentrations ranging from 0 µM to 40 µM. …”
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Vitamin D3 affects liver expression of pro-/anti-inflammatory cytokines and nitric oxide synthases in type 2 diabetes by Ihor Shymanskyi, Olha Lisakovska, Mykola Veliky, Olha Mezhenska, Vasyl Bilous, Andrii Siromolot, Anna Khomenko, Dmytro Labudzynskyi, Tetyana Horid’ko, Elvira Pasichna

“….), male Wistar rats were treated with/without VD (1,000 IU/kg b. w., 30 days). …”
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Entinostat in combination with nivolumab for patients with advanced cholangiocarcinoma: a phase 2 clinical trial by Elsa Hallab, Jennifer N. Durham, Rosalind Walker, Leslie Cope, Soren Charmsaz, Nicole E. Gross, Dimitrios N. Sidiropoulos, Alexei Hernandez, James Leatherman, Sarah Mitchell, Mark Yarchoan, Won Jin Ho, Nilofer S. Azad, Marina Baretti

“…However, the immunosuppressive tumor microenvironment in CCA enables immune evasion, which contributes to the limited effectiveness of immune checkpoint inhibitors (ICIs) in metastatic CCA patients. Epigenetic modifications play a critical role in cancer progression. …”
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Speciation of Potentially Carcinogenic Trace Nickel(II) Ion Levels in Human Saliva: A Sequential Metabolomics-Facilitated High-Field ¹H NMR Investigation by Kayleigh Hunwin, Georgina Page, Mark Edgar, Mohammed Bhogadia, Martin Grootveld

“…The addition of EDTA to Ni(II)-treated WMSS samples successfully reversed these resonance modifications, an observation confirming the transfer of Ni(II) from the above endogenous complexants to this exogenous chelator to form the highly stable diamagnetic octahedral [Ni(II)-EDTA] complex (K_stab = 1.0 × 10¹⁹ M⁻¹). …”
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Pharmacokinetics of Pegaspargase with a Limited Sampling Strategy for Asparaginase Activity Monitoring in Children with Acute Lymphoblastic Leukemia by Cristina Matteo, Antonella Colombini, Marta Cancelliere, Tommaso Ceruti, Ilaria Fuso Nerini, Luca Porcu, Massimo Zucchetti, Daniela Silvestri, Maria Grazia Valsecchi, Rosanna Parasole, Luciana Vinti, Nicoletta Bertorello, Daniela Onofrillo, Massimo Provenzi, Elena Chiocca, Luca Lo Nigro, Laura Rachele Bettini, Giacomo Gotti, Silvia Bungaro, Martin Schrappe, Paolo Ubezio, Carmelo Rizzari

“…<b>Methods</b>: Our study was based on 434 patients treated in Italy within the AIEOP-BFM ALL 2009 trial. …”
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Low-added sugar dietary intervention study to mitigate glucose intolerance and improve body composition in adults with cystic fibrosis: a protocol of a double-blind, randomised stu... by Priyathama Vellanki, Kirk Easley, Terryl J Hartman, Thomas R Ziegler, Puneet Sharma, Swati Zaveri, Arlene Stecenko, William R Hunt, Amy Goss, Joshua D Chandler, Tasha M Burley, Chris Driggers, Amy Ciccarella, Heather Zhou, Kristen Narlow, Tanicia Daley, Jessica Alvarez

“…All analyses will be intention-to-treat. Changes in study endpoints will be assessed with repeated-measures analysis. …”
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RZYMSKA GENEZA INSTYTUCJI ZAWIADOMIENIA DŁUŻNIKA O PRZELEWIE WIERZYTELNOŚCI. DENUNTIATIO Z C. 8,41,3 PR. A WYBRANE USTAWODAWSTWA WSPÓŁCZESNE by Piotr Ściślicki

“…There appears a risk that the debtor, unaware of the change, could still treat the assignor to be an obligee and consequently render the performance to him. …”
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Structural and functional alterations of neurons derived from sporadic Alzheimer’s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis by Raimondo Sollazzo, Domenica Donatella Li Puma, Giuseppe Aceto, Fabiola Paciello, Claudia Colussi, Maria Gabriella Vita, Guido Maria Giuffrè, Francesco Pastore, Alessia Casamassa, Jessica Rosati, Agnese Novelli, Sabrina Maietta, Francesco Danilo Tiziano, Camillo Marra, Cristian Ripoli, Claudio Grassi

“…Neurons obtained from healthy subjects treated with the inhibitor showed similar morphological changes to those observed in sAD neurons, confirming that LIMK1 activity is crucial for maintaining normal neuronal structure. …”
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Recapitulation of physiologic and pathophysiologic pulsatile CSF flow in purpose-built high-throughput hydrocephalus bioreactors by Ahmad Faryami, Adam Menkara, Shaheer Ajaz, Christopher Roberts, Ryan Jaroudi, Blake Gura, Tala Hussini, Carolyn A. Harris

“…Abstract Background Hydrocephalus, an accumulation of cerebrospinal fluid (CSF) in the ventricles of the brain, is often treated via a shunt system to divert the excess CSF to a different compartment; if left untreated, it can lead to serious complications and permanent brain damage. …”
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Acute Care Practice in the United States: The Roles of Occupational Therapy and Physical Therapy in Early Rehabilitation by Suzanne E. Holm, Kelly Nelson, Angela Patterson

“…Any patient who has or may develop impairments, activity limitations, and participation restrictions related to musculoskeletal, neuromuscular, cardiovascular, pulmonary, and integumentary systems can be treated by PT. Therefore, PTs are well-suited to promote early rehabilitation (ER) in the acute care setting. …”
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Software with artificial intelligence-derived algorithms for detecting and analysing lung nodules in CT scans: systematic review and economic evaluation by Julia Geppert, Peter Auguste, Asra Asgharzadeh, Hesam Ghiasvand, Mubarak Patel, Anna Brown, Surangi Jayakody, Emma Helm, Dan Todkill, Jason Madan, Chris Stinton, Daniel Gallacher, Sian Taylor-Phillips, Yen-Fu Chen

“…Models estimated incremental cost-effectiveness ratios, cost per correct detection of an actionable nodule, and cost per cancer detected and treated. We undertook scenario and sensitivity analyses. …”
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Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components by Marion Henderson, Anja Wittkowski, Katie Buston, Karen Crawford, Alice MacLachlan, Alex McConnachie, Emma McIntosh, Claudia-Martina Messow, Catherine Nixon, Rosaleen O’Brien, Shona Shinwell, Daniel Wight, Yiqiao Xin, Rachel Calam, Ruth Dundas, James Law, Helen Minnis, Lucy Thompson, Philip Wilson

“…Results From the 964 referrals received, 488 participants were recruited to THRIVE (marginally below the aspired 500) and completed baseline assessments. The intention-to-treat (ITT) population included 450 participants. …”
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Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms: FUTURE, a superiority RCT and economic evaluation by Mohamed Abdel-Fattah, Christopher Chapple, Suzanne Breeman, David Cooper, Helen Bell-Gorrod, Preksha Kuppanda, Karen Guerrero, Simon Dixon, Nikki Cotterill, Karen Ward, Hashim Hashim, Ash Monga, Karen Brown, Marcus Drake, Andrew Gammie, Alyaa Mostafa, Rebecca Bruce, Victoria Bell, Christine Kennedy, Suzanne Evans, Graeme MacLennan, John Norrie

“…Initial treatment includes lifestyle modifications, bladder retraining, pelvic floor exercises and pharmacological therapy. …”
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