Optimising Enzymatic Cross-Linking: Impact on Physicochemical and Functional Properties of Lupin Flour and Soy Protein Isolate by Teguh Santoso, Yusur Al-Shaikhli, Thao M. Ho, Mishenki Rajapakse, Thao T. Le

“…The growing demand for plant-based protein alternatives has driven interest in protein modifications to enhance their functional properties in food applications. …”
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Neurodegenerative and neuroinflammatory changes in SOD1-ALS patients receiving tofersen by Cecilia Simonini, Elisabetta Zucchi, Ilaria Martinelli, Giulia Gianferrari, Christian Lunetta, Gianni Sorarù, Francesca Trojsi, Roberta Pepe, Rachele Piras, Matteo Giacchino, Federico Banchelli, Jessica Mandrioli

“…In this multicenter study, we evaluated a cohort of 18 SOD1-ALS patients treated with tofersen, analyzing correlations between biomarkers of neurodegeneration/neuroinflammation and clinical variables indicative of disease progression. …”
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Robot-assisted adrenalectomy: Step-by-step technique and surgical outcomes at a high-volume robotic center by Federico Piramide, Carlo Andrea Bravi, Marco Paciotti, Luca Sarchi, Luigi Nocera, Adele Piro, Maria Peraire Lores, Eleonora Balestrazzi, Angelo Mottaran, Rui Farinha, Hubert Nicolas, Pieter De Backer, Frederiek D'hondt, Peter Schatteman, Ruben De Groote, Geert De Naeyer, Alexandre Mottrie

“…In order to provide a contribution to this field, we described our step-by-step technique for robotic adrenalectomy (RA) and related modifications according to the type of adrenal mass treated. …”
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Novel long noncoding lncARF mediated hyperhomocysteinemia-induced atherosclerosis via autophagy inhibition in foam cells by Ning Ding, Shengchao Ma, Qingning Chang, Lin Xie, Guizhong Li, Yinju Hao, Jiantuan Xiong, Anning Yang, Xiaoling Yang, Yideng Jiang, Huiping Zhang

“…Methods: RNA sequencing of foam cells treated with Hcy revealed a novel specific long noncoding RNA called lncARF. …”
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Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart by Rohini Dhat, Dattatray Mongad, Sivarupa Raji, Silpa Arkat, Nitish R. Mahapatra, Nishant Singhal, Sandhya L. Sitasawad

“…Global 5mC and 5hmC levels were also assessed in high glucose-treated DNMT3B knockdown H9c2 cells. Results We found the increased expression of DNMT3B, MBD2, and MeCP2 with a concomitant accumulation of 5mC and 5hmC, specifically in gene body regions of diabetic rat hearts compared to the control. …”
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Study protocol of a randomised controlled trial on SISU, a software agent providing a brief self-help intervention for adults with low psychological well-being by Harald Baumeister, Ann-Marie Küchler, David Ebert, Natalie Bauereiss, Eileen Bendig, Benjamin Erb, Lena Weger, Echo Meißner

“…In case of important protocol modifications, trial registration will be updated. This is protocol version number 1.…”
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Minimally invasive surgical treatment of female hypospadias and urethral hypermobility complicated by postcoital dysuria by O. V. Snurnitsyna, Zh. Sh. Inoyatov, M. V. Lobanov, O. Yu. Malinina, L. M. Rapoport, M. E. Enikeev

“…However, the literature does not reflect clear criteria and indications for a particular treatment method. Various modifications of the traditional urethral transposition can be accompanied by traumatic injury to the abundantly innervated paraclittoral and paraurethral zones, which provokes sexual disorders, up to anorgasmia. …”
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In vitro machine learning-based CAR T immunological synapse quality measurements correlate with patient clinical outcomes. by Alireza Naghizadeh, Wei-Chung Tsao, Jong Hyun Cho, Hongye Xu, Mohab Mohamed, Dali Li, Wei Xiong, Dimitri Metaxas, Carlos A Ramos, Dongfang Liu

“…The ML-based automated algorithm quantified CAR-T IS data correlates with the clinical responder and non-responder treated with Kappa-CAR-T cells directly from patients. …”
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Development and mechanism study of functional fermentation media for reducing alkaloid content in cigar tobacco leaves by Wanrong Hu, Li Liu, Jiabao Zhang, Quanwei Zhou, Zhongrong Jiang, Yun Jia, Qianying Zhang, Dongliang Li

“…Specifically, compared to the control group, the alkaloid content in tobacco leaves treated with the medium decreased by 9.58–19.06%. …”
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Drying kinetics and quality characteristics of ultrasound-assisted germination of quinoa grains: A study on functional properties, mineral content and bioactive compounds by Jabir Khan, Yang Li, Palwasha Gul, Qingyun Li, Kunlun Liu

“…US 40 kHz at 60 °C found rutin 22.62 µg/g, Quercetin 17.58 µg/g, while Kaempferol at 50 °C 24.51 µg/g, demonstrating a 2.5 to 4-fold increase in flavonoids and phenolic acid profiles in ultrasound pre-treated germinated quinoa grains. XRD showed no significant shifts in main peaks, although germinated samples showed intensity variations, suggesting crystallinity modifications. …”
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[Artículo traducido] ¿Es útil la clasificación CPAK (Coronal Plane Alignment of the Knee) para planificar la cirugía individualizada de artroplastia total de rodilla en la població... by O. Pujol, P. Hinarejos, A. Pons, E. Famada, A. Zumel, J. Erquicia, J. Leal-Blanquet

“…Methods: It is a cross-sectional observational study analysing radiological datasets from 121 patients with knee osteoarthritis treated with a Mako assisted TKA in three Spanish institutions. …”
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Is the coronal plane alignment of the knee (CPAK) classification useful to plan individualized total knee arthroplasty surgery for the Spanish population? A critical analysis of th... by O. Pujol, P. Hinarejos, A. Pons, E. Famada, A. Zumel, J. Erquicia, J. Leal-Blanquet

“…Methods: It is a cross-sectional observational study analysing radiological datasets from 121 patients with knee osteoarthritis treated with a Mako assisted TKA in three Spanish institutions. …”
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Phase II study of rucaparib and nivolumab in patients with leiomyosarcoma by Robert G Maki, Martina Bradic, Phillip Wong, William Tap, Vicky Makker, Sandra D’Angelo, Angela Green, Mrinal M Gounder, Evan Rosenbaum, Ciara M Kelly, Jason E Chan, Ping Chi, Mark A Dickson, Mary L Keohan, Sujana Movva, Viswatej Avutu, Martee L Hensley, Maria M Rubinstein, Ronak Shah, Kenneth Seier, Karmelina Charalambous, Seth M Cohen, Lauren B Banks, Sara Saunds, Jae-Mun Cho, Robert A Lefkowitz, Joseph Erinjeri, Li-Xuan Qin

“…Adverse events, especially due to overlapping toxicities, were frequent and often led to dose delays and modifications.…”
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Monitoring and assessment of SARS-CoV-2 evolution by V. V. Miasoiedov, P. V. Nartov, K. V. Yurko, V. M. Lesovoy, V. A. Kapustnyk, A. V. Bondarenko, M. Ye. Cherniak, V. A. Yakushchenko, V. V. Kucheriavchenko, V. S. Maslova, O. V. Bondarenko

“…Our own examination included a total of 80 nasopharyngeal swabs (at least two specimens in each case) collected from ARVI symptomatic or suspected COVID-19 patients, who were treated at the MNE KRC “Regional Clinical Infectious Diseases Hospital” from June to October 2021 and tested positive on SARS-CoV-2. …”
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Repurposing of apoptotic inducer drugs against Mycobacterium tuberculosis by Kudakwashe Nyambo, Vivette Soko, Kudzanai Ian Tapfuma, Bongani Motaung, Francis Adu-Amankwaah, Lauren Julius, Ashwil Klein, Marshall Keyster, Lucinda Baatjies, Liezel Smith, Krishna Kuben Govender, Mkhuseli Ngxande, Andre G. Loxton, Vuyo Mavumengwana

“…The integration of molecular dynamics simulations provides valuable insights into potential scaffold modifications to enhance the affinity.…”
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Red Blood Cell Exchange Apheresis in the Management of Acute Chest Syndrome: Case Study at Greater Accra Regional Hospital (Ghana)‐ Bone Marrow Transplant Unit (BMT‐Ghana) by George Awuku Asare, Coker Amin, Kate Fiador, Israel Hagbevor, Ernest Tsede, Blessing Ampofo, Benjamin Mensah

“…However, the condition relapsed and at another clinic, she was treated with i.v. paracetamol, morphine, pethidine, and i.v. fluids. …”
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Cigarette smoke modulates methylation levels of LEF1-AS1 and impedes its expression: An experimental study by Bader O. Almutairi, Ahmed Rady, Bashayer S. Aljuhani, Mikhlid H. Almutairi

“…Introduction Cigarette smoke (CS) contains carcinogenic substances and influences genetic regulation and epigenetic modifications, such as DNA methylation. It plays a role in the development of various cancers, including colon, bladder, lung cancer, and leukemia. …”
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PCOS and Inositols – Advances and Lessons We are Learning. A Narrative Review by Lentini G, Querqui A, Monti N, Bizzarri M

“…This could be done through epigenetic modifications.Keywords: (polycystic ovary syndrome), PCOS, myo-Inositol, D-chiro-inositol, insulin resistance, hyperandrogenism, aromatase…”
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Use of oxygen-ozone therapy to improve the effectiveness of antibiotic treatment on infected arthroplasty: protocol for a superiority, open-label, multicentre, randomised, parallel... by Walter Ricciardi, Fidelia Cascini, Chiara Cadeddu, Marianno Franzini, Arnaldo Andreoli, Alfonso Manzotti, Gianluigi Quaranta, Andrea Gentili

“…Introduction Surgical site infections still remain a major public health challenge and have become an increasing universal risk, especially for the implantation of orthopaedic devices.Unfortunately, the discovery and increasingly widespread use (especially the misuse) of antibiotics have led to the rapid appearance of antibiotic-resistant strains today; more and more infections are caused by microorganisms that fail to respond to conventional treatments.Oxygen-ozone therapy has been extensively used and studied for decades across various potential medical applications and has provided consistent effects with minimal side effects.This study aims to determine the superiority of oxygen-ozone therapy in combination with oral antibiotic therapy in patients with wound infections after an orthopaedic device implantation when compared with antibiotic therapy alone.Methods and analysis This is an open-label, multicentre, randomised, parallel-group study that aims to assess the efficacy and safety of oxygen-ozone therapy in combination with oral antibiotic therapy to treat infections in patients (male or female aged ≥18 years) having undergone surgery for the implant of an orthopaedic device. …”
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The Development of a Digital Patient Navigation Tool to Increase Colorectal Cancer Screening Among Federally Qualified Health Center Patients: Acceptability and Usability Testing by Leah C Savage, Luz Estefhany Soto-Cossio, Francesca Minardi, Matthew Beyrouty, Julie Schoonover, Jay Musella, Michaela Frazier, Cristina N Villagra, Jamilia R Sly, Joel Erblich, Steven H Itzkowitz, Lina H Jandorf, Neil S Calman, Ashish Atreja, Sarah J Miller

“…Next, we will test the eNav intervention in a randomized controlled trial to evaluate the efficacy of the eNav website for improving CRC screening uptake among patients treated at FQHCs.…”
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