Pharmacoeconomic analysis of using cyclin-dependent kinase 4 and 6 inhibitors in the first line treatment of HR-positive HER2-negative advanced breast cancer by N. A. Avxentyev, E. V. Lubennikova, M. Yu. Frolov

“…All patients who can be treated with palbociclib or ribociclib were considered.Results. …”
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Osteoporosis Awareness and Effecting Factors: A Descriptive Cross-Sectional Study by Oğuzhan Gökalp, Çiğdem Kaya, Yılmaz Kaya

“…The prevalence of osteoporosis has increased because of demographic changes and lifestyle modifications. Osteoporotic fractures are associated with a previous fragility fracture. …”
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Astrocytes phenomics as new druggable targets in healthy aging and Alzheimer’s disease progression by Daniele Lana, Filippo Ugolini, Ludovica Iovino, Selene Attorre, Maria Grazia Giovannini

“…In this review, we report and discuss the recent literature on the phenomic differences of astrocytes in health and their modifications in disease conditions, focusing mainly on the hippocampus, a region involved in learning and memory encoding, in the age-related memory impairments, and in Alzheimer’s disease (AD) dementia. …”
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Investigation into the pharmacodynamics and pharmacokinetics of recombinant human interferon alfa-2b vaginal suppository following process optimization in chinese rhesus macaque by Xueyan Zhang, Baisong Zhou, Yihan Gong, Yulin Liu

“…Abstract Recombinant human interferon Alfa-2b vaginal suppository is a gynecological preparation mainly made of interferon, commonly used to treat diseases related to viral infections such as cervical erosion. …”
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Bar Dislocation after Pectus Excavatum Repair: A Systematic Review of Risk Factors, Stabilization Techniques, and Management Strategies by H Shafeeq Ahmed, Sneha Reddy Pulkurthi, Akhil Fravis Dias, Bethineedi Lakshmi Deepak, Prekshitha Mohan R

“…While surgical modifications and stabilization techniques aim to reduce risks, bar displacement persists as a critical concern. …”

Octoploid blueberry development for drought tolerance: A combined approach of in vitro polyploidization and somatic organogenesis by Alejandra Araujo Heraldez, Susana Valdez Peñuelas, Gabriela Jarpa-Tauler, Aparna Banerjee, Kattia Núñez-Montero, Patricio Arce-Johnson, Jesús L. Romero-Romero

“…To achieve this purpose, blueberry microcuttings were treated with colchicine (0.02%) for six hours for 2, 4, 6 and 8 consecutive days and induced to form shoots in vitro with Zeatin (1 mg·L−1). …”
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Insights of cellular and molecular changes in sugarcane response to oxidative signaling by Lucas Felipe Silva, Kellya F. M. Barreto, Helaine Cristiane Silva, Iara Dantas de Souza, Carlos H. S. G. Meneses, Adriana F. Uchôa, Katia C. Scortecci

“…In this study, two-month-old sugarcane plants were treated with varying concentrations of H2O2 to investigate how this molecule acts as a signal at the cellular, biochemical, and proteomic levels. …”
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Anti-EGFR re-challenge with chemotherapy in RAS wild-type advanced colorectal cancer (A-REPEAT study): efficacy and correlations with tissue and plasma genotyping by J. Sgouros, A. Eliades, K. Papadopoulou, N. Korfiatis, D. Papamichael, E. Fountzilas, E. Tsolaki, A. Achilleos, K. Tsangaras, C. Loizides, G. Oikonomopoulos, T. Makatsoris, E. Kypri, M. Ioannides, G. Koumbaris, G. Fountzilas, P.C. Patsalis, G. Pentheroudakis

“…The objective RR in the intention-to-treat population was 13%, and the disease control rate (DCR) was 52%. …”
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Semaglutide and laparoscopic sleeve gastrectomy in an adolescent with congenital adrenal hyperplasia due to 21-hydroxylase: a case report by Alaina P. Vidmar, Linus Kaiser, Matthew J. Martin, Stuart Abel, Aimee G. Kim, Madeleine Weitzner, Cynthia E. Muñoz, Lynda K. Fisher, Mimi S. Kim, Kamran Samakar

“…Subsequently, he was treated with semaglutide, achieving an 11% body mass index reduction. …”
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A multicentre randomised feasibility STUdy evaluating the impact of a prognostic model for Management of BLunt chest wall trauma patients: STUMBL Trial by Ceri Battle, Richard Body, Hayley A Hutchings, Fiona Elizabeth Lecky, Timothy Driscoll, James Gagg, Claire O’Neill, Sam Groves, Sally Jones, Zoe Abbott, Phillip A Evans

“…Minor methodological modifications will be made for the full trial.Trial registration number ISRCTN95571506; Post-results.…”
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Tear Ferning Test and Pathological Effects on Ocular Surface before and after Topical Cyclosporine in Vernal Keratoconjunctivitis Patients by Marcella Nebbioso, Marta Sacchetti, Guia Bianchi, Anna Maria Zicari, Marzia Duse, Paola Del Regno, Alessandro Lambiase

“…Purpose.To evaluate the role of the lacrimal mucous component in VKC patients and compare tear ferning test (TFT) modifications, MUC5AC levels in tears, and density of conjunctival goblet cells to clinical characteristics before and after treatment with cyclosporine A (CY) in eye drops. …”
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Preclinical Efficacy and Proteomic Prediction of Molecular Targets for s-cal14.1b and s-cal14.2b Conotoxins with Antitumor Capacity in Xenografts of Malignant Pleural Mesothelioma by Angélica Luna-Nophal, Fernando Díaz-Castillo, Vanessa Izquierdo-Sánchez, Jesús B. Velázquez-Fernández, Mario Orozco-Morales, Luis Lara-Mejía, Johana Bernáldez-Sarabia, Noemí Sánchez-Campos, Oscar Arrieta, José Díaz-Chávez, Jorge-Ismael Castañeda-Sánchez, Alexei-Fedorovish Licea-Navarro, Saé Muñiz-Hernández

“…Proteomics analysis of 3D cultures treated with conotoxins was performed to examine changes in expression or abundance. …”
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Lung‐delivered IL‐10 mitigates Lung inflammation induced by repeated endotoxin exposures in male mice by Aaron D. Schwab, Todd A. Wyatt, Oliver W. Schanze, Amy J. Nelson, Angela M. Gleason, Michael J. Duryee, Deanna D. Mosley, Geoffrey M. Thiele, Ted R. Mikuls, Jill A. Poole

“…C57BL/6 mice were intratracheally instilled with LPS (10 μg) and treated with IL‐10 (1 μg) or vehicle control for 3 days. …”
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Electronic Measurement-based care (eMBC) for perinatal depression and anxiety: a pilot randomized controlled trial by Neda Askari, Renu Gupta, Neesha Hussain-Shamsy, Lucy C. Barker, Trevor Champagne, Raymond W. Lam, Katie Bishop, Jenna Pirmohamed, Maria Michalowska, Vishva Shah, Hailey Katzman, Ashna Jalan, Anushika Shanmuganathan, Vivienne Wang, Simone N. Vigod

“…Abstract Background As few as 20% of perinatal patients with depression or anxiety are treated to remission. Measurement-based care (MBC) improves patient outcomes but has not been evaluated for perinatal mental illness. …”
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Decoding dynamic landslide hazard processes for a massive refugee camp in Bangladesh by Dewan Mohammad Enamul Haque, Ritu Roy, Sumya Tasnim, Shamima Ferdousi Sifa, Suniti Karunatillake, A.S.M. Maksud Kamal, Juan M. Lorenzo

“…We produced multi-temporal inventories to represent conditions before (2018 and prior) and after (2021 and prior) the establishment of refugee settlements. Anthropogenic modifications, such as distance from roads, land-use/NDVI changes, and rainfall, are treated as dynamic factors, while other factors are considered static predisposing conditions. …”
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Antidepressant-like effect of Entada Africana Guill. & Perr. (Fabaceae) in mice: Involvement of monoamine neurotransmitters, cortisol, BDNF, and oxidative stress by M.Y. Bebeji, A.H. Yaro, A.R. Abubakar, M.H. Ahmad, A.B. Nazifi, A.A.E. Ahmed

“…Background: Entada Africana is used to treat various disease conditions including stomach ache, cataract, liver disease, epilepsy and depression. …”
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Case Report: Solitary adrenal metastasis from esophageal adenocarcinoma by Riddhi Machchhar, Ahmed Dawood Al Mahrizi, Fatima Mossolem, Mariam Abdeen, Ujjwala Jain, Jyotibala Jain, Prashant Desai

“…Complications from esophageal adenocarcinoma and its treatment can significantly impact the patient’s quality of life and prognosis.Case presentationOur patient was treated with systemic therapy and, although he initially had a complete response, he later experienced local disease progression along with the development of additional metastatic sites. …”
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The Modulation of Fibrosis in Vocal Fold Repair: A Study on c-Met Agonistic Antibodies and Hepatocyte Growth in Animal Studies by Hyun-Il Shin, Hyunsu Choi, Jae-Kyun Jung, Choung-Soo Kim

“…The right vocal folds were injured and treated with HGF or c-Met agonistic antibody injections. …”
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Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation. by Dan Su, Xuting Wang, Michelle R Campbell, Lingyun Song, Alexias Safi, Gregory E Crawford, Douglas A Bell

“…To elucidate how p53RE sequences and local chromatin context interact to affect p53 binding and gene transactivation, we mapped genome-wide binding localizations of p53 and H3K4me3 in untreated and doxorubicin (DXR)-treated human lymphoblastoid cells. We examined the relationships among p53 occupancy, gene expression, H3K4me3, chromatin accessibility (DNase 1 hypersensitivity, DHS), ENCODE chromatin states, p53RE sequence, and evolutionary conservation. …”
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The Influence of Performance Therapy with Statins on Androgen Balance in Patients with Stable Angina in Combination with Type 2 Diabetes Mellitus by Kapustуnska O.

“…To investigate the status of androgen support in patients with stable angina pectoris (SAP) in combination with type 2 diabetes mellitus (DM) and its modifications under the influence of statin treatment. …”
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