The pediatric surgeon's perspective on the liver hanging maneuver: a case report and literature review by Francesca Gigola, Kejd Bici, Antonino Morabito, Antonino Morabito, Chiara Grimaldi

“…No complications or mortality related to surgery were observed.DiscussionResults demonstrate that with appropriate modifications, the HM is a safe and effective technique in children, offering advantages in minimizing bleeding while improving surgical efficiency.…”
Get full text

Terahertz photoneuromodulation of lateral orbitofrontal cortex neurons ameliorates stress-induced depression and cognitive impairment by Yuanyuan He, Jing Ma, Yun Yu, Junkai Yin, Ge Gao, Yifang Yuan, Hao Ruan, Xueqing Yan, Zihua Song, Chao Chang

“…Mild THz photoneuromodulation circumvents the need for exogenous agents or genetic modifications, mitigating potential risks while precisely modulating neurotransmitter levels and neuronal excitability to alleviate depression-like behaviors. …”
Get full text

Process standardization and characterization of Mozzarella cheese made from blend of homogenized milk and unhomogenized milk by Patel Harsh, Jana Atanu, Ankit Bihola, Shaikh Adil, Parmar Satish

“…To avail the benefits accrued from milk homogenization, a standardized protocol of Mozzarella cheesemaking adopting direct acidification method employing lactic acid was developed using a blend of homogenized and unhomogenized milk (1:1 w/w). The key modifications adopted in the cheesemaking protocol involved (a) use of calcium chloride at 0.015% and 0.035% (w/w) for milk homogenized at 1.96 + 0.98 MPa (P1) and 2.94 + 0.98 MPa (P2) pressures respectively, involving use of milk blend; (b) raising the final cooking temperatures to 46°C and 48°C; maintaining whey acidity at 0.40% and 0.42% lactic acid during whey drainage as “stretch point’’; molding water temperatures of 84°C and 80°C for plasticizing the cheese curds obtained from milk blends containing homogenized milk treated at the two pressures (P1, P2) respectively; and (c) incorporating 0.125% (w/w) blend of trisodium citrate and disodium phosphate emulsifying salts into the cheese curd prior to plasticizing treatment. …”
Get full text

ABA-induced alternative splicing drives transcriptomic reprogramming for drought tolerance in barley by Anna Collin, Hubert Matkowski, Ewa Sybilska, Asmarany Biantari, Oliwia Król, Agata Daszkowska-Golec

“…Transcriptomic analysis revealed that ABA pre-treatment primed plants for faster activation of stress-responsive pathways, with enhanced expression of genes related to chromatin modifications, RNA metabolism, and ABA signaling during drought. …”
Get full text

Treatment of Pediatric Acute Lymphoblastic Leukemia in India as per modified BFM 95 protocol with Minimal Residual Disease monitoring by Dhwanee Thakkar, K. Upasana, D. S. Udayakumar, Neha Rastogi, Ritu Chadha, Sunisha Arora, Bhawna Jha, Anjali Yadav, Shalini Goel, Renu Saxena, Satya Prakash Yadav

“…Here we report improved outcomes of pediatric ALL from India.Methods: We analyzed outcomes of children with ALL treated at our center between 2016 and 2021. They were treated as per the modified BFM 95 protocol with Minimal Residual Disease (MRD) monitoring by flow cytometry (FCM).Results: We diagnosed and managed 68 patients, 57 being Precursor B (Pre B) cell ALL and the rest of T cell ALL. …”
Get full text

Valosin-containing protein (VCP), a component of tumor-derived extracellular vesicles, impairs the barrier integrity of brain microvascular endothelial cells by Ramon Handerson Gomes Teles, Nicolas Jones Villarinho, Ana Sayuri Yamagata, Camila Tamy Hiroki, Murilo Camargo de Oliveira, Gisela Ramos Terçarioli, Ruy Gastaldoni Jaeger, Patrick Meybohm, Malgorzata Burek, Vanessa Morais Freitas

“…From these cells, small and large extracellular vesicles were harvested to treat hCMEC/D3 cells, an immortalized cell line from the human brain microvasculature. …”
Get full text

Involvement of Histone Lysine Methylation in p21 Gene Expression in Rat Kidney In Vivo and Rat Mesangial Cells In Vitro under Diabetic Conditions by Xiangjun Li, Chaoyuan Li, Xiaoxia Li, Peihe Cui, Qifeng Li, Qiaoyan Guo, Hongbo Han, Shujun Liu, Guangdong Sun

“…Recently, posttranscriptional modifications (PTMs) have uncovered novel molecular mechanisms involved in DN. …”
Get full text

Analysis of apoptotic cells using Beadlyte® suspension arrays by Paul W. Rhyne, Jason D. Scull, Lynn M. Stiles, Dominic P. Eisinger

“…Cells grown in 96-well plates were treated with anisomycin for up to 7 h, washed, and lysed in their respective wells. …”
Get full text

Oncological Management of Adrenocortical Carcinoma: An Update and Critical Review by Nicholas P. Rowell

“…Patients of borderline performance status may be treated with various modifications of this regime. …”
Get full text

2024 FDA TIDES (Peptides and Oligonucleotides) Harvest by Othman Al Musaimi, Danah AlShaer, Beatriz G. de la Torre, Fernando Albericio

“…Furthermore, novel modifications to the ribose moiety in oligonucleotides, such as the 3′-amino substitution in imetelstat, enhance their stability. …”
Get full text

Optimization of difficult endodontic treatment with nickel-titanium files in martensitic and austenitic phase by D. A. Ostanina, Yu. A. Mitronin, D. V. Anisimova, A. V. Mitronin

“…A different degree of the surface damage of the instruments was revealed, depending on the number of treated root canals. The safest and most effective endodontic system for the mechanical preparation of curved root canals is the Race EVO.…”
Get full text

Targeted photodynamic therapy as potential treatment modality for the eradication of colon cancer and colon cancer stem cells by Natasha Hodgkinson, Cherie A Kruger, Heidi Abrahamse

“…Colorectal cancer is commonly treated by tumour resection, as chemotherapy and radiation have proven to be less effective, especially if the tumour has metastasized. …”
Get full text

Characteristics and management of follicular events and contact dermatitis in patients using tapinarof cream for the treatment of atopic dermatitis or plaque psoriasis by Linda Stein Gold, Matthew J. Bruno, G. Michael Lewitt, Adelaide A. Hebert

“…Purpose: Provide insights into the incidence, pre­sentation and management of follicular events and contact dermatitis in patients with plaque psoriasis or atopic dermatitis (AD) treated with tapinarof cream 1%.Materials and methods: Key clinical trial publications for tapinarof were reviewed and augmented with the authors’ opinions based on real-world clinical experience.Results: In the PSOARING and ADORING trials, discontinuation rates due to follicular events and contact dermatitis were low and most patients did not require dose modifications or treatment interruptions. …”
Get full text

Hepatic and Renal Toxicity Induced by TiO2 Nanoparticles in Rats: A Morphological and Metabonomic Study by Xavier Valentini, Pascaline Rugira, Annica Frau, Vanessa Tagliatti, Raphaël Conotte, Sophie Laurent, Jean-Marie Colet, Denis Nonclercq

“…The metabonomic approach allowed us to detect modifications in urine samples already detectable after 4 days in animals treated at the lowest dose. …”
Get full text

Design, Synthesis, and Evaluation of 1-Benzylpiperidine and 1-Benzoylpiperidine Derivatives as Dual-Target Inhibitors of Acetylcholinesterase and Serotonin Transporter for Alzheime... by Juan Pablo González-Gutiérrez, Damián Castillo-Ríos, Víctor Ríos-Campos, Ignacio Alejandro González-Gutiérrez, Dánae Flores Melivilu, Emilio Hormazábal Uribe, Felipe Moraga-Nicolás, Kerim Segura, Valentina Hernández, Amaury Farías-Cea, Hernán Armando Pessoa-Mahana, Miguel Iván Reyes-Parada, Patricio Iturriaga-Vásquez

“…AChE inhibitors are principal drugs prescribed to alleviate symptoms in AD patients, while up to 50% of these individuals also suffer from depression, frequently treated with selective serotonin reuptake inhibitors (SSRIs). …”
Get full text

Oxidative Toxicity in Neurodegenerative Diseases: Role of Mitochondrial Dysfunction and Therapeutic Strategies by Katie Facecchia, Lee-Anne Fochesato, Sidhartha D. Ray, Sidney J. Stohs, Siyaram Pandey

“…However, increased oxidative stress results in oxidative modifications in lipid, protein, and nucleic acids, leading to mitochondrial dysfunction and cell death. …”
Get full text

The cardioprotective effect of whey protein against thioacetamide-induced toxicity through its antioxidant, anti-inflammatory, and anti-apoptotic effects in male albino rats by Zakiah Nasser Almohawes, Hanan A. Okail, Wafa A. Al-Megrin, Manal F. El-Khadragy, Mona A. Ibrahim, Ayah S. Fathalla, Doaa Soliman, Sherif R. Mohamed

“…It has been linked to oxidative stress, inflammation, apoptosis, fibrosis, and epigenetic modifications. Whey protein (WP) provides an abundant supply of essential and non-essential amino acids that are vital for the human body. …”
Get full text

Case report: HSV lymphadenitis in immunocompromised patient with CLL by Talal Al-Assil, Shane Handelsman, Faisal Ansari, Ellen Flatley, Ellen Flatley, Steven Stone, Steven Stone, Steven Stone, Mohammad Omaira, Mohammad Omaira, Mohammad Omaira

“…He was diagnosed with Rai Stage I CLL with del6q, without TP53 mutation, and treated with 6 cycles of fludarabine, cyclophosphamide, and rituximab (FCR) 6 years prior. …”
Get full text

Leucocalocybe mongolica Fungus Enhances Rice Growth by Reshaping Root Metabolism, and Hormone-Associated Pathways by Mingzheng Duan, Ming Tao, Fuhan Wei, Honggao Liu, Sirui Han, Jieming Feng, Qiuyue Ran, Xiande Duan, Zhifang He, Shunqiang Yang, Muhammad Junaid Rao

“…KEGG pathway analysis highlighted modifications in nitrogen metabolism (24 genes), photosynthesis (41 genes), hormone signaling and tillering (222 genes), and cell wall and amino acids biosynthesis (365 genes). …”
Get full text

Management of Refractory Noninsulinoma Pancreatogenous Hypoglycemia Syndrome with Gastric Bypass Reversal: A Case Report and Review of the Literature by Bhavana B. Rao, Benjamin Click, George Eid, Ronald A. Codario

“…We report a case that was successfully treated with RYGB reversal. Case Report. A 58-year-old male with history of RYGB nine months earlier for morbid obesity presented for evaluation of postprandial, hypoglycemic seizures. …”
Get full text