COMPARATIVE ESTIMATION OF THE STATE OF THE CAPILLARY NETWORK OF THE MUCOUS MEMBRANE OF UNDERDENTURE SPACE AND SPEED OF THE ATROPHY OF ALVEOLAR PROCESS WITH PROSTHETICS MADE FROM DI... by V.G. Shuturminskiy

“…As for the patients of Group 5, with dentures made on our technology, treated in a glow discharge plasma, the level of atrophy was 3 months. 0.65 mm, and after 1 year - 0.88 mm, which is only 35.9% of the level of atrophy of acrylic dentures. …”
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Association of 5α-reductase inhibitor prescription with immunotherapy efficacy in metastatic renal cell carcinoma: a multicenter retrospective analysis by Lin Yang, Hai Huang, Qiong Wang, Peng Wu, Ke Chen, Weijia Li, Bisheng Cheng, Jilin Wu, Jianghua Yang, WenTai Shangguan, Wenxue Huang, Cunzhen Ma, Zhuohang Li, Boyuan Sun

“…Single-cell RNA sequencing analysis revealed that 5-ARI treated patients exhibited a reduced presence of regulatory T cells and CD8 T-cell exhaustion (CD8 Tex), and lower programmed cell death protein-1 expression in CD8 Tex cells, suggesting an immunologically favorable modification of the tumor.Conclusion A history of 5-ARI use is associated with improved responses to ICI therapy in mRCC, potentially through AR-related modulation of CD8+ T-cell activity and favorable alterations in the immune microenvironment. …”
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AuNRs-PPARγmAb Induce Targeted Adipocyte Apoptosis Through Photothermal Effects for Effective Localized Fat Reduction by Hu Y, Xiao K, Chen Z, Ou S, Sima C, Wang H, Zhang J, Zhang Z, Li X

“…Differentiated adipocytes and obese mice were treated with AuNRs-PPARγmAb and exposed to 808nm near-infrared (NIR) laser irradiation to evaluate fat reduction effects and biocompatibility.Results: The PPARγmAb modification did not significantly affect the optical properties of AuNRs but greatly increased their retention in adipocytes. …”
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Telehealth Support From Cardiologists to Primary Care Physicians in Heart Failure Treatment: Mixed Methods Feasibility Study of the Brazilian Heart Insufficiency With Telemedicine... by Leonardo Graever, Priscila Cordeiro Mafra, Vinicius Klein Figueira, Vanessa Navega Miler, Júlia dos Santos Lima Sobreiro, Gabriel Pesce de Castro da Silva, Aurora Felice Castro Issa, Leonardo Cançado Monteiro Savassi, Mariana Borges Dias, Marcelo Machado Melo, Viviane Belidio Pinheiro da Fonseca, Isabel Cristina Pacheco da Nóbrega, Maria Kátia Gomes, Laís Pimenta Ribeiro dos Santos, José Roberto Lapa e Silva, Anne Froelich, Helena Dominguez

“…ObjectiveThis study aimed to assess the feasibility of telehealth support provided by cardiologists for treating patients with heart failure to primary care physicians from public primary care practices in Rio de Janeiro, Brazil. …”
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Multi-omics analysis reveals Jianpi formula-derived bioactive peptide-YG-22 potentially inhibited colorectal cancer via regulating epigenetic reprogram and signal pathway regulatio... by Jun Wang, Jun Wang, Lijuan Zhu, Yuanyuan Li, Mingming Ding, Xiyu Wang, Bo Xiong, Hongyu Chen, Lisheng Chang, Wenli Chen, Bo Han, Jun Lu, Qin Shi

“…IntroductionColorectal cancer (CRC) is a prevalent malignancy worldwide, often treated with chemotherapy despite its limitations, including adverse effects and resistance. …”
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Radiotherapy and MVA-MUC1-IL-2 vaccine act synergistically for inducing specific immunity to MUC-1 tumor antigen by Philippe Slos, Gilda G. Hillman, Lyndsey A. Reich, Shoshana E. Rothstein, Lisa M. Abernathy, Matthew D. Fountain, Kali Hankerd, Christopher K. Yunker, Joseph T. Rakowski, Eric Quemeneur

“…Background We previously demonstrated that tumor irradiation potentiates cancer vaccines using genetic modification of tumor cells in murine tumor models. To investigate whether tumor irradiation augments the immune response to MUC1 tumor antigen, we have tested the efficacy of tumor irradiation combined with an MVA-MUC1-IL2 cancer vaccine (Transgene TG4010) for murine renal adenocarcinoma (Renca) cells transfected with MUC1.Methods Established subcutaneous Renca-MUC1 tumors were treated with 8 Gy radiation on day 11 and peritumoral injections of MVA-MUC1-IL2 vector on day 12 and 17, or using a reverse sequence of vaccine followed by radiation. …”
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Artrosis de rodilla asociada a deformidad extraarticular tratada mediante prótesis total de rodilla y osteotomía correctora de forma simultánea by L. Arbeloa-Gutierrez, A. Arenas-Miquelez, J. de Pablos

“…In terms of imaging, we determined the apex and angulation of the EAD as well as the modification of the mechanical parameters post-treatment. …”
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Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology by Yuyan Zhou, Xinyue Wang, Xiaorong Tian, Deyu Zhang, Hanxiao Cui, Wei Du, Zhenghui Yang, Jiayu Li, Wanshun Li, Jiaheng Xu, Ying Duanmu, Ting Yu, Fengping Cai, Wenhao Li, Zhendong Jin, Wencheng Wu, Haojie Huang

“…Finally, the review highlights recent advances in applying cell membrane-coated nanoparticles (CMC-NPs) for treating tumors, ischemic stroke, and inflammatory diseases.…”
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Y Reverse: Modified technique in challenging airway management by Gaetana Messina, Giovanni Natale, Davide Gerardo Pica, Giuseppe Vicario, Noemi Maria Giorgiano, Rosa Mirra, Vincenzo Di Filippo, Beatrice Leonardi, Francesca Capasso, Francesco Panini D'Alba, Riccardo Vinciguerra, Alessia Caputo, Maria Antonietta Puca, Mario Pirozzi, Ciro Balbo, Sara Di Lorenzo, Stefano Farese, Giovanni Liguori, Giovanni Vicidomini, Giovanni Messina, Alfonso Fiorelli, Fortunato Ciardiello, Morena Fasano

“…These difficulties guided us to develop a modification of the classic technique that addresses some of the challenges during positioning. …”
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Deletion of PPARα in mouse brown adipocytes increases their De Novo Lipogenesis by Pierre-Louis Batrow, Sylvie Caspar-Bauguil, Nathalie Rochet, Nadine Gautier, Anne-Sophie Rousseau, Marielle Maret, Samah Rekima, Etienne Mouisel, Emmanuel Van Obberghen, Christian H. Roux, Hervé Guillou, Catherine Postic, Christian Wolfrum, Dominique Langin, Ez-Zoubir Amri, Isabelle Mothe-Satney

“…Moreover, lipid profiles in phospholipids were different, suggesting a modification in the membrane content with an increase of palmitoleate. …”
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Single intravenous administration of oncolytic adenovirus TILT-123 results in systemic tumor transduction and immune response in patients with advanced solid tumors by Elise Jirovec, Dafne C. A. Quixabeira, James H. A. Clubb, Santeri A. Pakola, Tatiana Kudling, Victor Arias, Lyna Haybout, Katriina Jalkanen, Tuomo Alanko, Tine Monberg, Amir Khammari, Brigitte Dreno, Inge Marie Svane, Matthew S. Block, Daniel A. Adamo, Johanna Mäenpää, Claudia Kistler, Suvi Sorsa, Otto Hemminki, Anna Kanerva, João M. Santos, Victor Cervera-Carrascon, Akseli Hemminki

“…Results Across all three trials (TUNIMO, TUNINTIL, and PROTA), 52 total patients were treated with i.v. TILT-123. Overall, TILT-123 was found to be well-tolerated, with no dose-limiting toxicities observed. …”
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Effects of aerobic or resistance exercise during neoadjuvant chemotherapy on tumor response and therapy completion in women with breast cancer: The randomized controlled BENEFIT tr... by Martina E. Schmidt, Siri Goldschmidt, Charlotte Kreutz, Jana Müller, Andreas Schneeweiss, Anne M. May, Friederike Rosenberger, Joachim Wiskemann, Karen Steindorf

“…Background: The potential of exercise as a concurrent therapy for actively treated primary tumors has been suggested by emerging preclinical and observational studies. …”
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Engineered extracellular vesicles with sequential cell recruitment and osteogenic functions to effectively promote senescent bone repair by Lei Qi, Jing Wang, Jinge Yan, Weidong Jiang, Weiwen Ge, Xin Fang, Xudong Wang, Steve GF Shen, Lu Liu, Lei Zhang

“…To combine the advantages of Apt19s and miR-376b-5p, dual engineered extracellular vesicles (Apt-376b-EV) comprising both Apt19s and miR-376b-5p modifications were constructed. To further validate its function, Gelatin methacryloyl (GelMA) hydrogel was used as a carrier to construct the Apt-376b-EV@GelMA delivery system. …”
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Unified ELM suppression on KSTAR and DIII-D via adaptive feedback control strategies by R. Shousha, S.K. Kim, K.G. Erickson, S.H. Hahn, A.O. Nelson, N.C. Logan, S.M. Yang, Q.M. Hu, R. Wilcox, J.-K. Park, C. Paz-Soldan, A. Battey, M.W. Kim, G. Shin, W.H. Ko, Y.M. Jeon, J.H. Lee, J. Jang, D.C. Seo, J. Abbate, A. Rothstein, E. Kolemen

“…This paper reports on the extension of our amplitude-based resonant magnetic perturbation (RMP) edge localized mode (ELM) controller to support phasing control (relative toroidal phases of RMP waveforms between rows of coils), multiple toroidal mode numbers, and new ‘jump’ and ‘probing’ strategies, all deployed on KSTAR and DIII-D. By treating the control algorithm as device-independent and adjusting only the real-time interfaces to sensors and power supplies, we have confirmed that the same finite state machine—based feedback logic can be ported between machines with minor modifications. …”
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EUFOREA meeting on defining disease states in allergic rhinitis: towards a unified language in AR by G. K. Scadding, D. M. Conti, D. M. Conti, S. Scheire, V. Backer, M. Blaiss, L. O. Cardell, L. O. Cardell, W. De Yun, A. K. Ellis, W. Fokkens, A. T. Fox, T. Gilbert Kruz, S. Halken, P. W. Hellings, P. W. Hellings, P. W. Hellings, V. Hox, L. Kalogjera, S. Lau, S. Marinho, M. McDonald, R. Mösges, R. Mösges, J. Mullol, S. Nasser, R. Pawankar, D. Price, D. Price, D. Ryan, G. Scadding, P. Smith, M. Sosa Kostrábová, M. Vazquez-Ortiz, U. Wahn, L. Zhang, P. Gevaert

“…This paper presents a consensus on revised AR definitions, including control, severe allergic rhinoconjunctivitis (SARC), refractory severe allergic rhinoconjunctivitis (R-SARC), remission, resolution, improvement, exacerbation, treatable traits (TTs), treat to target, relapse, progression, disease modification, and prevention.…”
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Frequency of hyperkalemia during optimization of guideline-directed medical therapy in ambulatory patients with HFrEF by Genaro H. Mendoza-Zavala, Gibran Reynoso-Hernandez, Edith L. Posada-Martinez, Miguel Sandoval-Jimenez, Jairo I. A. Alejo-Arcos, Kassandra Rios-Felix, Eileen Amaro-Balderas, Marisol Gomez-Lopez, Sonia C. Juarez-Comboni, Luis F. Tejado-Gallegos, Emerson Joachin-Sanchez, Luis Olmos-Dominguez, Moises Aceves-Garcia, Marco J. Olalde-Roman, Marissa A. Silva-Garcia, Eduardo Almeida-Gutierrez, Cristina Revilla-Monsalve, Adolfo Chavez-Mendoza, Jose A. Cigarroa-Lopez, Jonathan S. Chávez-Iñiguez, Jose A. Magaña-Serrano, Juan B. Ivey-Miranda

“…The consequences of hyperkalemia on modifications in GDMT have not been fully addressed in patients receiving quadruple therapy.MethodsThis was a retrospective cohort study of outpatients with HFrEF treated at a specialized heart failure clinic. …”
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Surgical treatment of isolated soft tissue gunshot shrapnel injuries by combining primary delayed sutures with platelet-rich autoplasma injections into mine-explosive wounds by S. M. Zavhorodnii, O. I. Kotenko, M. B. Danyliuk, M. A. Kubrak

“…The main group included 30 (50.0 %) patients whose local treatment modification consisted in a combination of primary delayed suturing with platelet-rich autoplasma injection into a wound. …”
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Gene Editing Anxiety by Angelo Osofsky

“…” [14] Harris, “Germline Modification and the Burden of Human Existence.” …”
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Enhancement of anti‐sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2‐targeted CAR by Pui Yeng Lam, Natacha Omer, Josh K. M. Wong, Cui Tu, Louisa Alim, Gustavo R. Rossi, Maria Victorova, Hannah Tompkins, Cheng‐Yu Lin, Ahmed M. Mehdi, Amos Choo, Melissa R. Elliott, Elaina Coleborn, Jane Sun, Timothy Mercer, Orazio Vittorio, Lachlan J. Dobson, Alexander D. McLellan, Andrew Brooks, Zewen Kelvin Tuong, Seth W. Cheetham, Wayne Nicholls, Fernando Souza‐Fonseca‐Guimaraes

“…Enhancements in mRNA stability through chemical modifications, can further optimise protein expression. …”
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Comprehensive analysis of extensive drug-resistant Salmonella Typhi in Gujarat region, India: genomic findings and prospective alternative therapy by Sadanand Dangari Akshay, Heli Upadhyaya, Nitin Shukla, Rohit Bhattacharjee, Sunilkumar Das, Urmi Vyas, Priyank Chavda, Nimesh Patel, Dixsha Jamkhandi, Pritesh Sabara, Neeta Khandelwal, Sumeeta Soni, Kamlesh Upadhyaya, Jayesh Katira, Geeti Maheshwari, Madhvi Joshi, Devarshi Gajjar, Chaitanya Joshi

“…Point mutations in the QRDR region of gyrA identified three distinct modifications: Ser83Phen (91.80%), Ser83Leu (1.64%), and Ser83Tyr (0.82%). …”
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