Enhanced Anti-Melanoma Activity of Nutlin-3a Delivered via Ethosomes: Targeting p53-Mediated Apoptosis in HT144 Cells by Arianna Romani, Giada Lodi, Fabio Casciano, Arianna Gonelli, Paola Secchiero, Giorgio Zauli, Olga Bortolini, Giuseppe Valacchi, Daniele Ragno, Agnese Bondi, Mascia Benedusi, Elisabetta Esposito, Rebecca Voltan

“…Nutlin-3a-loaded ethosomes were characterized for their physicochemical properties and used to treat melanoma cells at different concentrations, considering nutlin-3a solution and empty ethosomes as controls. …”
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Transcriptional, growth factors, components of the AKT/mTOR signaling pathway, receptors and ligands of programmed cell death expression in melanoma by K. V. Nikulnikov, V. A. Bogdanova, L. V. Spirina, S. Yu. Chizhevskaya, I. V. Kondakova, E. L. Choynzonov, V. I. Chernov

“…The study of the molecular features of neoplasms in relation to the tumor thickness according to Breslow revealed the contribution of transcription and growth factors, the intensity of intracellular signaling processes, modification of the microenvironment, autophagy and neoangiogenesis.Conclusion. …”
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NPT100-18A rescues mitochondrial oxidative stress and neuronal degeneration in human iPSC-based Parkinson’s model by Julian E. Alecu, Veronika Sigutova, Razvan-Marius Brazdis, Sandra Lörentz, Marios Evangelos Bogiongko, Anara Nursaitova, Martin Regensburger, Laurent Roybon, Kerstin M. Galler, Wolfgang Wrasidlo, Beate Winner, Iryna Prots

“…NPT100-18A and structurally similar compounds (such as NPT200-11/UCB0599, currently being assessed in clinical studies) point towards a promising new approach for disease-modification. Methods Induced pluripotent stem cell (iPSC)-derived mDANs from PD patients with a monoallelic SNCA locus duplication and unaffected controls were treated with NPT100-18A. αSyn aggregation was evaluated biochemically and reactive oxygen species (ROS) levels were assessed in living mDANs using fluorescent dyes. …”
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SPECIFIC DENTAL TREATMENT OF FEMALE PATIENTS WITH BACTERIAL VAGINOSIS by А. Shulzhenko, E. Krutikova, L. Ostrovska, T. Petrushanko

“…Parodontal status was determined using the РМА indices (in Parma modification), Leus comprehensive parodontal index (CPI), Schiller-Pisarev’s tests, Svrakov’s value at the moment of admission and after 3 months. …”
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Enhancing adoptive cancer immunotherapy with Vγ2Vδ2 T cells through pulse zoledronate stimulation by Hong Wang, Mohanad H. Nada, Grefachew Workalemahu, Yoshimasa Tanaka, Craig T. Morita

“…Adoptive immunotherapy with Vγ2Vδ2 T cells has been used to treat cancer patients with partial and complete remissions. …”
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Unveiling Key Biomarkers and Mechanisms in Septic Cardiomyopathy: A Comprehensive Transcriptome Analysis by Zhao D, Zhuang J, Wang L, Wu L, Xu W, Zhao L, Hong J, Jin W, Miao C

“…Additionally, transcription regulators Irf1 and Stat1 were found to potentially regulate the expression of Gbp2, Cxcl10, Ccl5, and Cd40, linking SCM to immune response, ferroptosis, pyroptosis, cuproptosis, and m6A RNA methylation modification.Conclusion: This study identified nine hub biomarkers and two transcription regulators associated with SCM. …”
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Novel Quinoline- and Naphthalene-Incorporated Hydrazineylidene–Propenamide Analogues as Antidiabetic Agents: Design, Synthesis, and Computational Studies by Osama Alharbi, Wael H. Alsaedi, Mosa Alsehli, Saif H. Althagafi, Hussam Y. Alharbi, Yazeed M. Asiri, Ramith Ramu, Mohammed Al-Ghorbani

“…Numerous drugs have been developed to treat the condition, either as standalone therapies or in combination when glycemic control cannot be achieved with a single medication. …”
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Inhibition of ALKBH5 demethylase of m6A pathway potentiates HIV-1 reactivation from latency by Haider Ali, Jakub Wadas, Maryam Bendoumou, Heng-Chang Chen, Paolo Maiuri, Antoine Dutilleul, Simona Selberg, Lorena Nestola, Kamil Lalik, Veronique Avettand-Fenoël, Coca Necsoi, Alessandro Marcello, Esko Kankuri, Mati Karelson, Stéphane De Wit, Krzysztof Pyrc, Alexander O. Pasternak, Carine Van Lint, Anna Kula-Pacurar

“…N6-methyladenosine (m6A) modification in HIV-1 RNA is emerging as an important post-transcriptional regulator of HIV-1 gene expression, yet its role in latency and reactivation remains largely unrecognized. …”
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Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 ran... by Gerry Rayman, Thomas Yates, Ramzi A Ajjan, Patrick Moore, Pratik Choudhary, Thozhukat Sathyapalan, Parth Narendran, Ahmed Iqbal, Rachel Ann Elliott, Sankalpa Neupane, Mark Evans, Hood Thabit, Lalantha Leelarathna, Emma G Wilmot, Katharine Barnard-Kelly, Iain Cranston, Thinzar Min, Yee S Cheah, Shafie Kamaruddin, Alistair Lumb

“…Introduction Effective management of type 2 diabetes mellitus (T2DM) consists of lifestyle modification and therapy optimisation. While glycaemic monitoring can be used as a tool to guide these changes, this can be challenging with self-monitoring of blood glucose (SMBG). …”
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Impact of immunosuppressive therapy on pulmonary perfusion in kidney transplant recipients after COVID-19 illness by Barbara Infante, Dario Troise, Dario Troise, Matteo Gravina, Bruno Minopoli, Marcella Gambacorta, Carmen Montanile, Luca Macarini, Silvia Mercuri, Annalisa Cappiello, Maddalena Panico, Elena Ranieri, Giuseppe Stefano Netti, Francesca Fortunato, Carlo Alfieri, Giuseppe Castellano, Giovanni Stallone

“…However, the prognosis and suggested treatment for these types of patients are still debated.MethodsWe retrospectively analyzed 48 KTRs with stable graft function on calcineurin inhibitor therapy who underwent transient modification of the maintenance immunosuppressive regimen with withdrawal of mycophenolic acid/mycophenolate mofetil or mTOR inhibitor (mTORi) during COVID-19 infection and their reintroduction after healing. …”
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Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials pa... by Keith W Muir, Gary Ford, Philip M Bath, Adnan I Qureshi, Thompson G Robinson, Rustam Al-Shahi Salman, Hisatomi Arima, Lisa J Woodhouse, Eivind Berge, Nikola Sprigg, Xia Wang, Tom J Moullaali, Zhe Kang Law, Candice Delcourt, Kailash Krishnan, Else C Sandset, Craig S Anderson, Yuko Palesch, John Potter, Jeff Saver, Nerses Sanossian, Ken Butcher, Kennedy R Lees, Janneke Horn

“…Meta-analyses of pooled IPD using the intention-to-treat dataset of included trials, including subgroup analyses to assess modification of the effects of BP lowering by time to treatment, treatment strategy and patient’s demographic, clinical and prestroke neuroradiological characteristics.Ethics and dissemination No new patient data will be collected nor is there any deviation from the original purposes of each study where ethical approvals were granted; therefore, further ethical approval is not required. …”
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H3K14 lactylation exacerbates neuronal ferroptosis by inhibiting calcium efflux following intracerebral hemorrhagic stroke by Tingting Sun, Jian-Nan Zhang, Ting Lan, Lei Shi, Liye Hu, Liyan Yan, Chao Wei, Lisha Hei, Weihua Wu, Zhaoli Luo, Meng Liu, Xingmei Ren, Yamei Wang, Yabin Lu, Peipei Wang, Chenguang Zhang, Liheng Bian, Xingquan Zhao, Fei Yang, Qian Li

“…Lactate accumulation correlates with ICH severity, yet the role of lactate-derived histone lactylation, a novel epigenetic modification, in ferroptosis and its mechanisms is not fully understood. …”
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Probiotics in the Management of Chronic Bacterial Prostatitis Patients: A Randomized, Double-Blind Trial to Evaluate a Possible Link Between Gut Microbiota Restoring and Symptom Re... by Cristina Vocca, Diana Marisol Abrego-Guandique, Erika Cione, Vincenzo Rania, Gianmarco Marcianò, Caterina Palleria, Luca Catarisano, Manuela Colosimo, Gregorio La Cava, Italo Michele Palumbo, Giovambattista De Sarro, Tommaso Ceccato, Simone Botti, Tommaso Cai, Alessandro Palmieri, Luca Gallelli

“…Twenty-four patients with CBP were recruited and treated for 3 months with placebo (n. 12) or with <i>Lactobacillus casei</i> DG^® (n. 12). …”
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Catechin-capped silver-doped titanium dioxide nanoparticle enhanced photocatalytic toxic dye degradation by Sougata Ghosh, Sougata Ghosh, Tanawat Imboon, Rashbihari Layek, Gayatri Salunke, Gayatri Salunke, Vijay Singh Parihar, Jeerawan Khumphon, Thomas J. Webster, Thomas J. Webster, Thomas J. Webster, Santosh Sutar, Sutasinne Kityakarn, Chaisak Issro, Dusadee Khamboonrueang, Sirikanjana Thongmee

“…Doping-associated surface modification is a powerful strategy to enhance the photocatalytic potential of n-type semiconductor nanomaterials. …”
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Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10 by Bernard A Fox, Cristina Bergamaschi, George N Pavlakis, Antonio Valentin, Jenifer Bear, Barbara K Felber, Shawn M Jensen, Hrishikesh Pandit, Bethany A Nagy, Dimitris Stellas, Maggie Cam

“…Our study further supports the incorporation of hetIL-15 in tumor immunotherapy approaches to promote the development of antitumor responses by favoring effector over regulatory cells and by promoting lymphocyte and DC localization into tumors through the modification of the tumor chemokine and cytokine milieu.…”
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Deletion of Tfap2a in hepatocytes and macrophages promotes the progression of hepatocellular carcinoma by regulating SREBP1/FASN/ACC pathway and anti-inflammatory effect of IL10 by Zhiwei Li, Chun Zhang, Guixiang Huang, Zixin Zhang, Qinghao Wang, Xiran Liu, Yanling Qin, Hao Zhou, Anyi Hou, Jun He, Limin Li, Xiang Hu, Xiaofeng Ding

“…Tfap2aΔHep and Tfap2aΔMΦ mice treated with DEN/CCl4 for 6 months increased tumor burden compared to Tfap2a flox controls. …”
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Association of habitual glucosamine use with risk of microvascular complications among individuals with type 2 diabetes: a prospective cohort study in UK biobank by Zi-Jian Cheng, Yu-feng Luo, Qing-yun Zhu, Yan-fei Wang, Wen-yan Ren, Fei-yan Deng, Lin Bo, Xi-Yuan Jiang, Shu-feng Lei, Long-Fei Wu

“…Abstract Background Glucosamine is a widely used supplement for treating osteoarthritis and joint pain. New evidence suggests a potential association between glucosamine and type 2 diabetes, inflammation and cardiometabolic risk. …”
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Ultraviolet laser induced periodic surface structures positively influence osteogenic activity on titanium alloys by Luiz Schweitzer, Luiz Schweitzer, Janosch Schoon, Niklas Bläß, Katrin Huesker, Janine V. Neufend, Nikolai Siemens, Sander Bekeschus, Sander Bekeschus, Rabea Schlüter, Peter Schneider, Eckart Uhlmann, Eckart Uhlmann, Georgi Wassilew, Frank Schulze

“…In addition, our results indicate diminished biofilm formation on UV-LIPSS treated Ti6Al7Nb surfaces. These effects might prove beneficial in the context of long-term arthroplasty outcomes.…”
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Effectiveness of food supplements in increasing fat-free tissue accretion in children with moderate acute malnutrition: A randomised 2 × 2 × 3 factorial trial in Burkina Faso. by Christian Fabiansen, Charles W Yaméogo, Ann-Sophie Iuel-Brockdorf, Bernardette Cichon, Maren J H Rytter, Anura Kurpad, Jonathan C Wells, Christian Ritz, Per Ashorn, Suzanne Filteau, André Briend, Susan Shepherd, Vibeke B Christensen, Kim F Michaelsen, Henrik Friis

“…<h4>Background</h4>Children with moderate acute malnutrition (MAM) are treated with lipid-based nutrient supplement (LNS) or corn-soy blend (CSB). …”
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Metformin for covid-19: systematic review and meta-analysis of randomised controlled trials by Gordon Guyatt, Arnav Agarwal, Qi Zhou, Dena Zeraatkar, Thomas Agoritsas, Reed AC Siemieniuk, Romina Brignardello-Petersen, Nazmul Islam, Per Olav Vandvik, Saifur R Chowdhury, Md Kamrul Hasan, Mahmudur Rahman Chowdhury

“…Metformin might reduce the incidence of long covid when used to treat patients with non-severe acute covid-19 infection, but this was suggested by low certainty evidence from a single trial.…”
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