Cerebrovascular reactivity depending on rheumatoid factor and anticitrullinated protein antibody positivity in hypertensive patients with rheumatoid arthritis by N. V. Rebrova, O. L. Sarkisova, T. M. Ripp, R. S. Karpov, V. F. Mordovin

“…The duration of HTN was 12.1±8.6 years. All patients were treated with methotrexate. RA patients were categorized into RF/ACPA seronegative and RF/ACPA seropositive subgroups. …”
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Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis by Jinwang Ye, Suyue Zhong, Huali Wan, Xing Guo, Xuanbao Yao, Qiong Liu, Liming Chen, Jian-Zhi Wang, Shifeng Xiao

“…Immunoprecipitation, immunofluorescence, western blotting, RT-qPCR, mass spectrometric, and luciferase reporter assay were used to identify HDAC7 substrates, modification site and related signaling pathways in astrocyte-tau clearance. …”
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Sensing using SERS-substrate and machine learning approaches by Bakal, Victoria Alexandrovna, Gusliakova, Olga Igorevna, Prikhozhdenko, Ekaterina Sergeevna

“…The highest sensitivity in determining low glucose concentrations (1 mM) has been obtained for substrates with three sequential modifications of PCL fibers with vaterite and the reduction of aggregates of Ag nanoparticles from 5 M solutions of silver nitrate and ammonia hydrate with overall accuracy of 92.2%. …”
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The Mechanism of Sijunzi Decoction Suppresses Gastric Cancer Metastasis via the m6A Methyltransferase METTL14 Based on Untargeted Metabolomics Studies and Network Pharmacology Anal... by Li X, Zhao L, Wang J, Ma T, Zhou J, Bian Y, Guo J

“…We used a xenograft tumor model of gastric cancer and gastric cancer cell lines to explore the effect of SJZ on N6-methyladenosine (m6A) modification. Cell transfection, plate clone formation, scratch migration, and transwell assays were performed in gastric cancer cell lines. …”
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GLUT1-mediated HMGB1 O-GlcNAcylation drives hyperglycemia-Induced neutrophil extracellular trap networks formation via TLR4 signaling and exacerbates fibroblast inflammation by Weijing Sun, Jinlong Xu, Shijie Li, Yue Zhao, Jiachen Fu, Lixia Di, Dezhi Han

“…Mouse peripheral blood neutrophils (MPBN) were treated with high glucose (25 mM) and phorbol ester (PMA) to induce NETs. …”
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Impact of anti-VEGF treatment for diabetic macular oedema on progression to proliferative diabetic retinopathy: data-driven insights from a multicentre study by Usha Chakravarthy, Adnan Tufail, Paul Taylor, Tjebo F C Heeren, R Khan, E Wilkinson, B Paul, Faruque Ghanchi, Haralabos Eleftheriadis, S George, R Mukherjee, C Jones, Abraham Olvera-Barrios, Roy Schwartz, Ashish Patwardhan, C Brand, H Palmer, Alasdair Warwick, C Bailey, U Chakravarthy, F Ghanchi, S Mahmood, A Davis, L Downey, G Menon, N Dhingra, R Antcliff, A Lobo, A Patwardhan, T Akerele, Abdulrahman Alsaedi, P Lip, S Natha, J Talks, Catherine A Egan, Taha Soomro, Watjana Lilaonitkul, Assaf Rozenberg, Darren Thomas, V Kumar Wirral

“…Based on observed data, we show that age and baseline DR severity are relevant predictors of poor outcomes in patients with DMO treated with anti-VEGF.…”
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An Automated Microfluidic Platform for In Vitro Raman Analysis of Living Cells by Illya Klyusko, Stefania Scalise, Francesco Guzzi, Luigi Randazzini, Simona Zaccone, Elvira Immacolata Parrotta, Valeria Lucchino, Alessio Merola, Carlo Cosentino, Ulrich Krühne, Isabella Aquila, Giovanni Cuda, Enzo Di Fabrizio, Patrizio Candeloro, Gerardo Perozziello

“…In fact, it was possible to discriminate spectra deriving from control and hydrogen peroxide-treated cells in terms of DNA backbone and cellular membrane modification effects provoked by reactive oxygen species (ROS) activity. …”
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Association between vitamin B2 intake and female infertility: a cross-sectional study by Zitong Zhao, Zenghui Mao, Min Liu, Ying Liang, Xiaowen Liu, Pan Yang, Zan Liu

“…Our findings suggest that maintaining adequate vitamin B2 levels could help lower infertility risks. Dietary modifications and vitamin supplementation may be key in preventing and treating infertility early on.…”
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Results of propagation of Fagus silvatica L. plants in vitro by Mykola Lisovyi, Andrii Ivaniuk

“…Immediately before the passage, the explants were treated for 10-15 seconds with a 10% solution of the antibiotic "Cefazolin-KMR". …”
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Plant Growth-Promoting Rhizobacteria (PGPR) Reduce Adverse Effects of Salinity and Drought Stresses by Regulating Nutritional Profile of Barley by Sania Zaib, Akmal Zubair, Safdar Abbas, Javed Hussain, Ishaq Ahmad, Samina N. Shakeel

“…The aim of this particular study is to understand what role do plant growth-promoting rhizobacteria (PGPR) play in combating the salinity and drought stresses through modification of nutritional profile. In the current study, inoculated barley (Hordeum vulgare L.) plants were subjected to various stresses such as 200 mM and 1000 mM salinity stress as well as drought stress, and then their various parameters such as seed germination as well as shoot and root biomasses and photosynthetic activity were compared with non-treated stressed barley plants. …”
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Relationship between CTF1 gene expression and prognosis and tumor immune microenvironment in glioma by Hongqing Cai, Shen Tian, Angsi Liu, Guanchao Xie, Hongsheng Zhang, Xiaogang Wu, Jinghai Wan, Sai Li

“…Abstract Objective This study aimed to evaluate CTF1 expression in glioma, its relationship to patient prognosis and the tumor immune microenvironment, and effects on glioma phenotypes to identify a new therapeutic target for treating glioma precisely. Methods We initially assessed the expression of CTF1, a member of the IL-6 family, in glioma, using bioinformatics tools and publicly available databases. …”
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Solcoseryl-enriched biodegradable diplene membrane for lower eyelid reconstruction: A novel bioactive approach by Maria Cervatiuc, Igor Vladimirovich Reshetov, Eldor Jonnazarov, Svetlana Vagovna Saakyan, Dzhakhongir Shavkatdzhonovich Rakhimov, Abusaid Ibodulloevich Sadulloev, Mukhammadnazir Mukhamadzokirovich Normatov, Rustamjon Zoidovich Juraev, Bahodur Bahtiyorovich Abdurahmonov, Abduhakim Abdulatifovich Saidov, Mukhriddin Bahodurovich Mazhitov, Nekruz Rahimovich Rahmatov, Fuzliddin Botirdzhonovich Gadoev, Aminjon Nozimjonovich Shafiev, Uzak Zholdoshovich Zhumakadyrov

“…The outcomes were compared with those of a previously reported cohort treated with Diplene alone. The follow-up period ranged from 3 to 12 months. …”
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The role of melatonin in the regulation of the immune system and reproductive health: mechanisms and prospects for clinical application by M. M. Zhelavskyi, S. P. Kernychnyi, O. Ya. Dmytriv, T. V. Betlinska

“…Future research should focus on clinical applications of melatonin supplementation in treating infertility, pregnancy-related complications, and immune-mediated diseases. …”
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A Comprehensive Review on the Pharmacokinetics and Drug−Drug Interactions of Approved GLP-1 Receptor Agonists and a Dual GLP-1/GIP Receptor Agonist by Min JS, Jo SJ, Lee S, Kim DY, Kim DH, Lee CB, Bae SK

“…To address the extremely short half-life (2 min) of native human GLP-1, structural modifications have been applied to GLP-1 RAs and a dual GLP-1/GIP RA. …”
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Enhancing hemophilia A gene therapy by strategic F8 deletions in AAV vectors by Juan-Juan Zhao, Sai-Ning Tian, Xiang Li, Zu-Yi Peng, Guo-Hua Li, Feng Zhang, Mei Zhao, Jian-Ping Zhang, Xiao-Bing Zhang

“…This study aims to enhance the efficacy of adeno-associated virus serotype 8 (AAV8) vectors, specifically those encoding B-domain-deleted F8 (BDDF8), to treat the condition. We focused on improving therapeutic outcomes by strategically deleting amino acids at the furin cleavage site (RHQR), a modification that is crucial for increasing F8 expression and reducing capsid stress during vector packaging. …”
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The TNFα-binding domain of the therapeutic antibody adalimumab elicits CD4 T-cell responses in rheumatoid arthritis patients by Mateusz Makuch, Josine van Beek, Josine van Beek, Carla A. Wijbrandts, Marja Aalbers, Philippe Stas, Alexander B. Meijer, Anja ten Brinke, Theo Rispens, Paul Peter Tak, Paul Peter Tak, Gertjan Wolbink, Gertjan Wolbink, Janine Schuurman, Paul W. H. I. Parren, Paul W. H. I. Parren, S. Marieke van Ham, S. Marieke van Ham

“…These are observed in most adalimumab-treated rheumatoid arthritis patients, despite the adjuvant-free and human sequence-derived nature of the antibody. …”
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The role of high-dose methotrexate in T-cell acute lymphoblastic leukemia treatment: multicenter study results of ALL IC-BFM 2002 protocol by T. T. Valiev, M. A. Shervashidze, I. V. Osipova, T. I. Burlutskaya, G. A. Aleskerova, S. N. Yuldasheva, S. L. Sabantsev, O. V. Paina, N. A. Batmanova, L. S. Zubarovskaya, K. I. Kirgizov, S. R. Varfolomeeva

“…All the patients were treated according to riskadopted ALL ICFM 2002 protocol. …”
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The E3 ligase RAD18-mediated ubiquitination of henipavirus matrix protein promotes its nuclear-cytoplasmic trafficking and viral egress by Dongning Jin, Linliang Zhang, Cheng Peng, Mingbin He, Weiwei Wang, Zhifei Li, Cong Liu, Jinhong Du, Jin Zhou, Lei Yin, Chao Shan, Yali Qin, Mingzhou Chen

“…Significantly, live NiV and Hendra virus infection is attenuated in RAD18 knockout cells or in cells treated with TZ9, highlighting the critical physiological role of RAD6A-RAD18-mediated M ubiquitination in the henipavirus life cycle. …”
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Antibacterial action of novel zeolite-based compositions depends upon doping with Ag(+) and Сu(2+) cations by N. O. Manko, O. O. Ilkov, O. Yu. Klyuchivska, V. O. Vasylechko, V. V. Sydorchuk, N. P. Kovalska, O. I. Kostiv, S. R. Bagday, A. V. Zelinskiy, O. M. Gromyko, N. V. Skrypchenko, Yа. M. Kalychak, R. S. Stoika

“…These compositions were subjected to mechanochemical modification in ethanol medium and with the addition of plant (Actinidia arguta) extract used as an antioxidant. …”
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MdUGT88F4 involved in the synthesis of isosalipurposide positively regulates the salt stress response of apple plants by Ying Ye, Yanrong Hu, Yuan Liu, Cheng Yu, Kun Zhou, Fengwang Ma, Xiaoqing Gong

“…UGT (UDP-dependent glycosyltransferase) family members are mainly involved in the modification of secondary metabolites, as well as plant stress responses. …”
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