In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney by Toshiki Tsuboi, Keita Hattori, Takuji Ishimoto, Kentaro Imai, Tomohito Doke, Junichiro Hagita, Jumpei Ariyoshi, Kazuhiro Furuhashi, Noritoshi Kato, Yasuhiko Ito, Yukiko Kamiya, Hiroyuki Asanuma, Shoichi Maruyama

“…Furthermore, their practical utility in treating kidney diseases remains unrealized. Recently, we developed a serinol nucleic acid-modified ASO (SNA-ASO) that exhibits significant nuclease resistance. …”
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Antimalarial Activity of Ethyl Acetate Extract and Fraction of Bidens pilosa against Plasmodium berghei (ANKA) by Noumedem Anangmo Christelle Nadia, Yamssi Cédric, Simeni Njonnou Sylvain Raoul, Ngongang Ouankou Christian, Mounvera Abdel Azizi, Gangueu Djape Clotilde Diane, Vanessa Rosine Nkouayep, Yondo Jeanette, Tsila Henri Gabriel, Mpoame Mbida

“…The present study was to investigate the antimalarial efficacy of ethyl acetate extract and one fraction of Bidens pilosa in vivo in order to support the usage of this plant by traditional healers to treat malaria. Methods. The extracts were prepared by maceration of B. pilosa leaf powder in ethyl acetate. …”
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Disruption of VEGF Mediated Flk‐1 Signaling Leads to a Gradual Loss of Vessel Health and Cardiac Function During Myocardial Infarction: Potential Therapy With Pellino‐1 by Mahesh Thirunavukkarasu, Vaithinathan Selvaraju, Mandip Joshi, Vladimir Coca‐Soliz, Leonidas Tapias, IbnalWalid Saad, Craig Fournier, Aaftab Husain, Jacob Campbell, Siu‐Pok Yee, Juan A. Sanchez, J. Alexander Palesty, David W. McFadden, Nilanjana Maulik

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Surface Mesoscopic Characterization and Analysis of Nanosecond-Laser-Processed Molybdenum for the Optimization of Antibacterial Performance by Jie Wang, Qingyu Si, Jia Lv, Ruohan Chen, Qiuyu Sun, Yong Gao, Jing Zhang, Zhiming You, Sheng Wang, Bei Han

“…This study pioneers the investigation of biofilm inhibition by laser-treated molybdenum sheets against <i>Pseudomonas aeruginosa</i> (ATCC27853) and <i>Staphylococcus aureus</i> (ATCC25923). …”
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The biomedical application of inorganic metal nanoparticles in aging and aging-associated diseases by Yuqing Meng, Junzhe Zhang, Yanqing Liu, Yongping Zhu, Haining Lv, Fei Xia, Qiuyan Guo, Qianli Shi, Chong Qiu, Jigang Wang

“…Inorganic metal nanoparticles (IMNPs) predominantly include gold, silver, iron, zinc, titanium, thallium, platinum, cerium, copper NPs, which has been widely used to prevent and treat aging and AAD due to their superior properties (essential metal ions for human body, easily synthesis and modification, magnetism). …”
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Permanently stationed bacteriobots for surveillance and elimination of nascent tumours by Praneshwar Eswaran

“…An extensive literature review was conducted to identify a suitable nanorobot, modifications for detecting BRCA-mutated cancer cells, mechanisms for their elimination and strategies to ensure patient safety. …”
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Evaluation of Efficacy and Safety of Empagliflozin in Bangladeshi Patients with Type 2 Diabetes Mellitus (EFFISAEM Study) by Mohammad Saifuddin, Ajit K. Paul, Sultana M. Shefin, Md. Jahangir Alam, Shahjada Selim, Sunjida Islam, Tanjina Hossain, Sadiqa Tuqan, Nusrat Sultana, Marufa Mustari, Ramen C. Basak, Kazi A. Aftab, Indrajit Prasad, Mohammad R. Uddin, Shoma Sharker, Md. Abu Jar Gaffar, Mohammad M. Rahman, Mohammad A. Hannan, Afsar Ahammed, ABM Kamrul-Hasan

“…Results: Out of 1449 subjects initiating empagliflozin, 1340 subjects [age 50.3 ± 9.0 years, male 52.5%, overweight/obese 94.4%, insulin-treated 25.7%, baseline hemoglobin A1c (Hba1c) 9.9 ± 1.4%] completed the study. …”
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Abstract 173: A Case Series of Basilar Tip Aneurysm Endovascular Treatment – The Barrow Neurological Institute Experience by Yasmin G. Ghochani

“…For ruptured aneurysms, Adjuvant therapy (BAC or SAC) was used to treat larger dimension aneurysms compared to CE (p = 0.046). …”
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Repurposing auranofin combined with colistin to effectively combat fish-pathogenic Edwardsiella piscicida by Jinfang Lu, Yangbin Shi, Yajing Pan, Hans-Peter Grossart, Luyu Mei, Danli Xie, Wanchun Guan, He Zhang, Yongliang Lou

“…The combination of the FDA approved drug auranofin (originally used to treat rheumatoid arthritis) with colistin exerted great bactericidal effects against E. piscicida both in vitro and in vivo. …”
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Targeting metzincins to mitigate jellyfish blooms: a novel approach for conservation by Xuecun Liu, Xuecun Liu, Xiao Peng, Jingqiang Wang, Shuhui Ju, Qing Sun, Wensai Ji, Xiaoyu Hua, Haiyan Zhang, Juan Höfer, Marina Pozzolini, Shuogui Xu, Xueqi Ma, Liang Xiao

“…IntroductionThe modification of the marine ecological environment has led to the frequent occurrence of jellyfish blooms, causing global hazards. …”
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Phage pAEv1: A potential biocontrol agent against Aeromonas veronii infections by Tongping Zhang, Sifan Jiang, Rongsi Dai, Ying Zhou, Su Long, Mingwang He, Boyang Zhou, Tao Tang, Linlin Yang, Weiming Zhong, Wenbin Xiao, YanJiao Fu, Jiajing Guo, Zhipeng Gao

“…Additionally, in vivo experiments demonstrated that grass carp treated with pAEv1 had an 80% survival rate after 7 days of exposure to a double minimum lethal dose (MLD) of the bacterium.…”
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NF-κB-mediated enhancement of H3K27me3 through EZH2: a mechanism to suppress pyocyanin-induced autophagy in macrophages by Ji Wang, Min Bian, Simin Liang, Xiaowei Yi, Yu Du

“…Abstract Background Histone modification is a key mechanism of epigenetic regulation. …”
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FOXOs and their roles in acute and chronic neurological disorders by Yasin Asadi, Yasin Asadi, Yasin Asadi, Rozenn K. Moundounga, Rozenn K. Moundounga, Rozenn K. Moundounga, Anand Chakroborty, Anand Chakroborty, Anand Chakroborty, Augustina Pokokiri, Augustina Pokokiri, Augustina Pokokiri, Hongmin Wang, Hongmin Wang, Hongmin Wang

“…This review will conclude with a brief section on potential therapeutic interventions that can be used to modulate FOXOs’ activities when treating acute and chronic neurological disorders.…”
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The Impact of Carboplatin Dosing Design Using Adjusted Serum Creatinine on Carboplatin Plus Paclitaxel Therapy for Ovarian Cancer by Shu Kato, Kaede Baba, Kanako Mamishin, Mao Uematsu, Mai Shimura, Akira Hirota, Misao Fukuda, Nobuyuki Takahashi, Takehiro Nakao, Hiromichi Nakajima, Chikako Funasaka, Chihiro Kondoh, Kenichi Harano, Yoichi Naito, Nobuaki Matsubara, Ako Hosono, Toshikatsu Kawasaki, Toru Mukohara

“…Methods We retrospectively studied patients with ovarian cancer treated with CBDCA + paclitaxel (PTX) (TC) after primary surgery. …”
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Transposable Elements Contribute to the Regulation of Long Noncoding RNAs in <i>Drosophila melanogaster</i> by Yuli Gan, Lingyan Wang, Guoxian Liu, Xiruo Guo, Yiming Zhou, Kexin Chang, Zhonghui Zhang, Fang Yan, Qi Liu, Bing Chen

“…Additionally, 99 TE-lncRNAs were associated with m⁶A methylation modification sites, and 115 TE-lncRNAs potentially provided candidate small open reading frames through transposon insertions. …”
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Construction of RNA m6A profiles in liver tissue of mice in sepsis-induced liver injury based on m6A MeRIP-seq and RNA-seq by Li Li, Penghui Li, Yuhua He, Ziyi Xu, Yitao Fan, Xueying Jia, Yingru Liu, Lijie Qin

“…N6-methyladenosine (m6A) modification plays a significant role in the pathological processes of SILI, but its specific mechanisms remain unclear and require further elucidation. …”
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Exploration of bioactive variants of the BMP7-derived p[63–82] peptide for ameliorating the OA-associated chondrocyte phenotype by Jessica S. J. Steijns, Tim J. M. Welting, Andy Cremers, Guus G. H. van den Akker, Pieter J. Emans, Lodewijk W. van Rhijn, Marjolein M. J. Caron

“…In this study we aimed to optimize the bioactivity and biostability of this peptide in the intra-articular environment to evaluate the therapeutic potential of these peptides to treat osteoarthritis. Methods 33 peptide modifications of p[63–82] were custom-designed and synthesized to optimize the bioactivity. …”
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IPHILOGENETIC TREE OF ART / ФИЛОГЕНЕТИЧЕСКОЕ ДРЕВО ИСКУССТВ by DRIKKER ALEKSANDR S. / ДРИККЕР А.С.

“…The basis for art modification lies in the emergence of new information media and its coding modes. …”
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Increased Risk of Dermatomyositis in Patients with Psoriasis: A Retrospective Cohort Study by Chen M, Tian N, Cui R, Zhang H, Wang Q, Tong Q, Chen Z, Wang YH, Wei JC, Dai SM

“…Diagnoses of psoriasis, non-psoriasis, dermatomyositis, and associated comorbidities were established using the International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) code. Patients who were diagnosed with dermatomyositis before the index date were excluded. …”
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The divergence of paternity leave across EU countries is surprising: a study for 2023 by Kamila Turečková, Danuta Duda, Ivona Buryová

“…At the same time, similarities were found in both examined factors, which could be an inspiration for the eventual unification and modification of this social policy instrument throughout the EU. …”
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