Screening and identification of potential target of 1′-acetoxychavicol acetate (ACA) in acquired lapatinib-resistant breast cancer by Febri Wulandari, Ahmad Fauzi, Muhammad Da'i, Mahmoud Mirzaei, Maryati, Kun Harismah

“…In the PPI network analysis, BCL2, CXCR2, and CDC42 were the three highest-scoring genes. Genetic modification analysis identified PLAU and SSTR3 as the genes most frequently altered in breast cancer samples. …”
Get full text

Randomized clinical trial of thrice-weekly 4-month moxifloxacin or gatifloxacin containing regimens in the treatment of new sputum positive pulmonary tuberculosis patients. by Mohideen S Jawahar, Vaithilingam V Banurekha, Chinnampedu N Paramasivan, Fathima Rahman, Rajeswari Ramachandran, Perumal Venkatesan, Rani Balasubramanian, Nagamiah Selvakumar, Chinnaiyan Ponnuraja, Allaudeen S Iliayas, Navaneethapandian P Gangadevi, Balambal Raman, Dhanaraj Baskaran, Santhanakrishnan R Kumar, Marimuthu M Kumar, Victor Mohan, Sudha Ganapathy, Vanaja Kumar, Geetha Shanmugam, Niruparani Charles, Murugesan R Sakthivel, Kannivelu Jagannath, Chockalingam Chandrasekar, Ramavaram T Parthasarathy, Paranji R Narayanan

“…<h4>Results</h4>Of 416 patients in intent-to-treat analysis, 6 (5%) of 124, 2 (2%) of 110 and 2 (2%) of 137 patients with drug-susceptible TB in the G, M and C arms respectively had unfavorable response at the end of treatment; during the next 24 months, 17 (15%) of 115, 11 (11%) of 104 and 8 (6%) of 132 patients respectively, had TB recurrence. …”
Get full text

Study of Surface Treatment by Ionic Plasma and Self-Protective Pastes of AISI 304 and 316L Stainless Steels: Chemical, Microstructural, and Nanohardness Evaluation by Francisco Martínez-Baltodano, Juan C. Díaz-Guillén, Lizsandra López-Ojeda, Gregorio Vargas-Gutiérrez, Wilian Pech-Rodríguez

“…This work studied the effect of self-protective paste nitriding (SPN) and ion plasma nitriding (IPN) on the surface chemistry, microstructure, and nanohardness of AISI 304 and 316L stainless steels, with both treated at 440 °C for 5 h. Surface modifications analyzed using SEM and nanoindentation revealed distinct outcomes. …”
Get full text

Cardiovascular toxicity in testicular germ cell tumor survivors by Zuzana Orszaghova, Beata Mladosievicova, Michal Mego, Michal Chovanec

“…Integrating cardiometabolic monitoring, risk factor modification, and tailored follow-up strategies into survivorship care is vital. …”
Get full text

Effect of temperature on the rheological properties with shear stress limit of iron oxide nanoparticle modified bentonite drilling muds by Ahmed S. Mohammed

“…The results also showed that 1% of nanoFe2O3 increased the rheological properties of the drilling mud. The nanoFe2O3 modification increased the yield stress (τo) and plastic viscosity (PV) by 45–200% and 20–105% respectively based on the bentonite content and temperature of the drilling mud. …”
Get full text

Mechanisms underlying the estradiol mediated protection of yak oviduct epithelial cells against ER-Ca2+ imbalance by Xiaolin Ye, Meng Wang, Yangyang Pan, Tianhao Li, Jinglei Wang, Ling Zhao, Rui Zhang, Yan Cui, Sijiu Yu

“…Proteomic sequencing was employed to analyze protein level changes in TG treated YOECs with ER–Ca²⁺ imbalance before and after E2 treatment, elucidating the mechanism whereby E2 mitigates YOEC injury. …”
Get full text

Unknown issues of digitalizing the tax domain by Dimitrijević Marina

“…The resulting digital innovations of the organization and business model of tax administration generate prerequisites for basic modification of tax procedures and taxpayers' behaviour in relation to tax compliance. …”
Get full text

Is the treatment of ankle osteoarthritis changing over time in Italy? Analysis of temporal trends for fusion and arthroplasty in a population-based study from 2001 to 2022 on the N... by Adriano Cuccu, Elena Manuela Samaila, Enrico Ciminello, Umberto Alfieri Montrasio, Fabrizio Cortese, Stefania Ceccarelli, Tiziana Falcone, Marina Torre

“…Materials and methods International Classification of Diseases, 9th Revision, Clinical Modification (ICD9-CM) codes of interest were identified to browse the Italian National Hospital Discharge Record database. …”
Get full text

Glutathione promotes aluminum tolerance in rice through cell wall remodeling and nitrogen metabolic regulation by Muhammad Riaz, Saddam Hussain, Qurban Ali, Lei Yan

“…In this work, we fill this knowledge gap by conducting a thorough study of the possible ameliorative effects of exogenous GSH on rice seedlings subjected to Al stress, with a specific focus on exploring the potential effects of exogenous GSH on Al distribution, pectin modification, antioxidant defense, and nitrogen metabolism. …”
Get full text

Identification of individual-level clinical factors associated with increased risk of death during heatwaves: a time-stratified case-crossover study using national primary care rec... by Shakoor Hajat, Ross Thompson, Sari Kovats, Emer O’Connell, Helen Macintyre

“…Individuals prescribed medications to treat heart failure and high blood pressure also have increased odds of death during heatwaves. …”
Get full text

Clinical and pathological analysis of indolent T-cell lymphoproliferative disease of the gastrointestinal tract by Dan Yuan, Na Liang, Dong-Yue Wang, Jin-Jing Wang, Cong-Wei Jia

“…Treatment and prognosis: Supportive therapy (five cases): Dietary modification, immunosuppression, immunomodulation, and anti-infective agents. …”
Get full text

Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials by Xiaohang Guo, Weikang Luo, Lingyu Wu, Lianglin Zhang, Yuxuan Chen, Teng Li, Haigang Li, Wei Zhang, Yawei Liu, Jun Zheng, Yang Wang

“…Abstract Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties in preparation, side effects, and clinical translation. …”
Get full text

Energy metabolism: An emerging therapeutic frontier in liver fibrosis by Iram Irshad, Saleh A Alqahtani, Kenichi Ikejima, Ming-Lung Yu, Manuel Romero-Gomez, Mohammed Eslam

“…Altering energy metabolism to decrease energy release may represent a promising approach for treating liver fibrosis and chronic liver diseases.…”
Get full text

Delivery of LOXL1-AS1-siRNAs using targeting peptide-engineered extracellular vesicles with focused ultrasound to suppress medulloblastoma metastasis by Anh Duy Do, Shing-Shung Chu, Le Hien Giang, Pei-Lin Huang, Yu-Ling Lin, Che-Chang Chang, Tai-Tong Wong, Shian-Ying Sung, Chia-Ling Hsieh

“…Abstract Background Metastasis of medulloblastomas (MBs) is difficult to treat and remains the primary cause of death in children with this brain tumor. …”
Get full text

The Novel Elemene Derivative, OMe-Ph-Elemene, Attenuates Oxidative Phosphorylation and Facilitates Apoptosis by Inducing Intracellular Reactive Oxygen Species by Jianhua Guo, Jiayi Wang, Shuhao Fan, Mucong Gao, Guodu Liu, Yong Xia

“…Although current chemotherapy drugs have shown some efficacy in treating this disease, their associated side effects necessitate the development of more effective treatments and medications. …”
Get full text

Research Progress on the Mechanism of Biochar and Microorganisms on Fraction Transformation of Heavy Metals in Farmland Soil by Feng JIANG, Zhiyuan LIN, Yuyao LUO, Miaoting ZHOU, Rongbo XIAO, Peng WANG, Fei HUANG

“…The synergistic biochar-microorganism approach enhances remediation efficacy by using the protective effect of biochar on microorganisms and microbial-induced modifications to the physicochemical properties of biochar. …”
Get full text

Ocular Toxicity Associated with Tamoxifen Administration in Patients with Breast Cancer: A Systematic Review by Tejaswi Vadde, Neha Narayan, Amulya Varshini Banka, Shravani Divity, Yethindra Vityala

“…Introduction: Tamoxifen (TAM), a selective Oestrogen Receptor (ER) modulator, is widely used for treating and preventing ER-positive Breast Cancer (BC). …”
Get full text

Ozone Treatment Inhibited the Blue Mold Development and Maintained the Main Active Ingredient Content in <i>Radix astragali</i> Infected by <i>Penicillium polonicum</i> Through Act... by Jihui Xi, Qili Liu, Qingru Zhang, Zhiguang Liu, Huali Xue, Yuqin Feng

“…In addition, the amount of active ingredients of astragaloside I, calycosin-7-glucoside, and ononin in the ozone-treated group was higher than that in the control group during the storage period. …”
Get full text

The Efficacy of a Combination of Milk Thistle, Artichoke, and Green Tea in the Treatment of Biliary Sludge: An Interventional Prospective Open Study by Angela Saviano, Ida Sicilia, Alessio Migneco, Carmine Petruzziello, Mattia Brigida, Marcello Candelli, Francesco Franceschi, Veronica Ojetti

“…Results: In Group A, we observed a disappearance of biliary sludge in 32.4% (12/37) of patients compared to 8.7% in the control group (<i>p</i> < 0.05). In 32.4% of treated patients, we report a reduction in biliary sludge. …”
Get full text

The cultural adaptation of the Friendship Bench Intervention to address perinatal psychological distress in Sierra Leone: an application of the ADAPT-ITT framework and the Ecologic... by Abdulai Jawo Bah, Abdulai Jawo Bah, Haja Ramatulai Wurie, Mohamed Samai, Rebecca Horn, Alastair Ager

“…We screened the FBI for modifications based on the data from the formative study and EVM. …”
Get full text