Key determinants of the chemo-sensitizing activity of novel Telmisartan derivatives by Maximilian Gebhart, Christian A. Elvert, Anna M. Schoepf, Alexandra Scheiber, Stefan Schwaiger, Cornelia A. Karg, Ronald Gust, Stefan Salcher

“…Despite the success of tyrosine kinase inhibitors (TKIs) in treating chronic myeloid leukemia (CML), resistance remains a major challenge due to target mutations and drug efflux. …”
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Effects of a nutrition education intervention on food-provision managerial decisions in Catalan old age nursing homes. by Beatriz Rodríguez-Sánchez, Isaac Aranda-Reneo, Toni Mora

“…There were 53.32 residents per center among the treated group and 40.82 residents in the non-treated institutions. …”
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The synergistic effect of microwave drying and plasma surface treatments on the wettability of green wood by Sauradipta Ganguly, Jure Žigon, Kavyashree Srinivasa, Marko Petrič, Sebastian Dahle

“…The final contact angles on treated specimens was lowest for PT-only specimens as well as specimens treated with plasma after MW. …”
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Luminescence of copper-doped α-quartz crystal after oxygen treatment by A. Trukhin

“…Irradiation of the sample treated with oxygen at 77 K gives a new TSL peak at ∼180 K and a peak at 244 K existing in the untreated sample. …”
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Mechanism of Solubility Enhancement of Soybean Protein by High-Energy Fluidic Microfluidizer by ZHU Qiming, CHEN Jun, CHEN Qiaoyun, DAI Taotao, DENG Lizhen, WANG Yihui, ZHANG Wenhui, LI Ti

“…In order to investigate the modification effect of high-energy fluidic microfluidizer (HEFM) treatment on plant protein after and clarify its solubilization mechanism, a 5% (m/m) aqueous suspension of soybean protein was treated using a HEFM under different pressures (30, 60, 90 and 120 MPa), obtaining modified soybean protein. …”
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Mitochondrial-dependent apoptosis and STAT3 activation induced by oxidative stress in pemphigus vulgaris by Jing-pei Liang, Jia-min Xu, Yu-jie Ou, Yang-jie Xu, Shu-mei Wu, Jia-bao Chen

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Thiol Redox Transitions in Cell Signaling: a Lesson from N-Acetylcysteine by Tiziana Parasassi, Roberto Brunelli, Graziella Costa, Marco De Spirito, Ewa Krasnowska, Thomas Lundeberg, Eugenia Pittaluga, Fulvio Ursini

“…We here review the redox chemistry of NAC, then screen possible mechanisms to explain the effects observed in NAC-treated normal and cancer cells; such effects involve a modification of global gene expression, thus of functions and morphology, with a leitmotif of a switch from proliferation to terminal differentiation. …”
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Development of a unique crosslinked glycosaminoglycan for soft tissue repair: Treatment of interstitial cystitis/bladder pain syndrome. by Richard W Heidebrecht, Thomas H Jozefiak, Harrison C Shain, Eugene M Skrabut, Debra Saunders, Nataliya Smith, Rheal A Towner, Robert Hurst

“…Chemical modification of naturally derived glycosaminoglycans (GAGs) expands their potential utility for applications in soft tissue repair and regenerative medicine. …”
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Nanoparticles Navigating the Intranasal Route: Innovative Approaches in Neurodegenerative Diseases by Fabiola V. Borbolla-Jiménez, Stephany Celeste Gutiérrez-Ruiz, Hector Hernández-Parra, Sheila I. Peña-Corona, Aura A. Tamez, Ricardo D. Rivas-Amores, Jonathan J. Magaña, Gerardo Leyva-Gomez

“…Intranasal drug delivery is emerging as a transformative strategy for treating neurodegenerative diseases, offering a noninvasive route that bypasses the limitations of the blood–brain barrier. …”
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Identification of <i>Peroxiredoxin</i> (<i>PRX</i>) Genes from Pepper Fruits: Involvement in Ripening and Modulation by Nitric Oxide (NO) by Fátima Ramírez-Mellado, Salvador González-Gordo, José M. Palma, Francisco J. Corpas

“…This study analyzes the modulation of these seven <i>CaPRX</i> genes during ripening and after treating fruits with nitric oxide (NO) gas. A time-course expression analysis of sweet pepper fruit during ripening revealed that two genes were upregulated (<i>CaPRX1</i> and <i>CaPRX2E</i>), two were downregulated (<i>CaPRX2B</i> and <i>PRX Q</i>), and three were unaffected (<i>CaPRX2F</i>, <i>CaPRX2-CysBAS1</i>, and <i>CaPRX2-CysBAS2</i>). …”
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Selective Deletion of HLA-B, and -C Class I Genes Promotes Immunocompatibility of Humanized Skin Graft Model by Cobos-Figueroa L, Notario L, Mir C, Molpeceres C, Lauzurica S, López D, Lorente E, Lauzurica P

“…Our findings offer a scalable HLA-compatible skin graft model, potentially improving practices in burn units worldwide.Plain Language Summary: This study addresses a key challenge in treating severe burns: finding suitable skin donors. …”
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Biomimetic Scaffolds Regulating the Iron Homeostasis for Remolding Infected Osteogenic Microenvironment by Mengting Yin, Zhiqing Liu, Zhongyi Sun, Xinyu Qu, Ziyan Chen, Yuying Diao, Yuxuan Cheng, Sisi Shen, Xiansong Wang, Zhuyun Cai, Bingqiang Lu, Shuo Tan, Yan Wang, Xinyu Zhao, Feng Chen

“…In this work, an in situ modification strategy is proposed for printing iron‐active multifunctional scaffolds with iron homeostasis regulation ability for treating IBDs. …”
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Advancing gene editing therapeutics: Clinical trials and innovative delivery systems across diverse diseases by Mozhghan Raigani, Zohre Eftekhari, Ahmad Adeli, Fatemeh Kazemi-Lomedasht

“…Gene editing is a groundbreaking therapeutic approach that can potentially treat a broad spectrum of genetic and acquired diseases. …”
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Alzheimer's disease drug development pipeline: 2019 by Jeffrey Cummings, Garam Lee, Aaron Ritter, Marwan Sabbagh, Kate Zhong

“…Nineteen agents in trials target cognitive enhancement, and 14 are intended to treat neuropsychiatric and behavioral symptoms. There are 96 agents in disease modification trials; of these, 38 (40%) have amyloid as the primary target or as one of several effects. …”
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Cardiovascular and Renal Outcomes with Ertugliflozin by Baseline Use of Renin-Angiotensin-Aldosterone System Inhibitors or Diuretics, Including Mineralocorticoid Receptor Antagonis... by David Z.I. Cherney, Robert Frederich, Richard E. Pratley, Francesco Cosentino, Samuel Dagogo-Jack, Annpey Pong, Ira Gantz, Nilo B. Cater, James P. Mancuso, Urszula Masiukiewicz, Christopher P. Cannon

“…At baseline, 6,686 (81%) participants were being treated with RAAS inhibitors, 3,542 (43%) with diuretics, 1,252 (15%) with loop diuretics, and 674 (8%) with MRAs. …”
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Addressing challenges in vector control: a review of current strategies and the imperative for novel tools in India’s combat against vector-borne diseases by Kuldeep Singh, Amit Sharma, Manju Rahi, Sanjeev Kumar Gupta, Gaurav Kumar, Rajendra Baharia, Sam Joy

“…These range from chemical insecticides used in indoor residual sprays, space sprays, fogging, treated bednets and larvicides to biological control methods such as larvivorus fishes and environmental control and modification measures such as source reduction. …”
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Glucose-dependent insulinotropic polypeptide (GIP) by Timo D. Müller, Alice Adriaenssens, Bo Ahrén, Matthias Blüher, Andreas L. Birkenfeld, Jonathan E. Campbell, Matthew P. Coghlan, David D'Alessio, Carolyn F. Deacon, Stefano DelPrato, Jonathan D. Douros, Daniel J. Drucker, Natalie S. Figueredo Burgos, Peter R. Flatt, Brian Finan, Ruth E. Gimeno, Fiona M. Gribble, Matthew R. Hayes, Christian Hölscher, Jens J. Holst, Patrick J. Knerr, Filip K. Knop, Christine M. Kusminski, Arkadiusz Liskiewicz, Guillaume Mabilleau, Stephanie A. Mowery, Michael A. Nauck, Aaron Novikoff, Frank Reimann, Anna G. Roberts, Mette M. Rosenkilde, Ricardo J. Samms, Philip E. Scherer, Randy J. Seeley, Kyle W. Sloop, Christian Wolfrum, Denise Wootten, Richard D. DiMarchi, Matthias H. Tschöp

“…The numerous beneficial effects of GIPR signal modification render the peptide an interesting candidate for the development of pharmacotherapies to treat obesity, diabetes, drug-induced nausea and both bone and neurodegenerative disorders.…”
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The traditional Chinese medicine formula Zhihan Anshen Tang (ZHAST) against obstructive sleep apnea hypopnea syndrome: network pharmacology and molecular docking approach by Cai-Li Li, Yu-Xiang Zhang, Xing-Jie Zheng, Shuo Li, Jing Feng

“…Traditional Chinese medicine (TCM) has increasingly demonstrated its efficacy and benefits in treating OSAHS. Zhihan Anshen Tang (ZHAST), has been demonstrated its efficacy and clinical metrics for treating OSAHS patients. …”
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Sound Wave Radiation from Partially Lined Duct by Burhan TIRYAKIOGLU, Ahmet DEMIR

“…The radiation of sound waves from partially lined duct is treated by using the mode-matching method in conjunction with the Wiener-Hopf technique. …”
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Identification of key differentially methylated genes regulating muscle development in chickens: insights from Jingyuan breed by Tong Zhang, Jiwei Li, Jiahuan Hu, Yafei Chen, Xi Fu, Wei Zhao, Jinli Tian, Lijuan Yang, Juan Zhang

“…Moreover, myoblasts were used as test material and treated with cycloleucine to investigate the effect of N6-methyladenosine (m6A) modification on their proliferation and differentiation. …”
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